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OVERDOSE and Fluoxetine

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OVERDOSE Symptoms and Causes

What are opioids?

Opioids, sometimes called narcotics, are a type of drug. They include strong prescription pain relievers, such as oxycodone, hydrocodone, fentanyl, and tramadol. The illegal drug heroin is also an opioid.

A health care provider may give you a prescription opioid to reduce pain after you have had a major injury or surgery. You may get them if you have severe pain from health conditions like cancer. Some health care providers prescribe them for chronic pain.

Prescription opioids used for pain relief are generally safe when taken for a short time and as prescribed by your health care provider. However, people who take opioids are at risk for opioid dependence and addiction, as well as an Overdose. These risks increase when opioids are misused. Misuse means you are not taking the medicines according to your provider's instructions, you are using them to get high, or you are taking someone else's opioids.

What is an opioid Overdose?

Opioids affect the part of the brain that regulates breathing. When people take high doses of opioids, it can lead to an Overdose, with the slowing or stopping of breathing and sometimes death.

What causes an opioid Overdose?

An opioid Overdose can happen for a variety of reasons, including if you

  • Take an opioid to get high
  • Take an extra dose of a prescription opioid or take it too often (either accidentally or on purpose)
  • Mix an opioid with other medicines, illegal drugs, or alcohol. An Overdose can be fatal when mixing an opioid and certain anxiety treatment medicines, such as Xanax or Valium.
  • Take an opioid medicine that was prescribed for someone else. Children are especially at risk of an accidental Overdose if they take medicine not intended for them.

There is also a risk of Overdose if you are getting medication-assisted treatment (MAT). MAT is a treatment for opioid abuse and addiction. Many of the medicines used for MAT are controlled substances that can be misused.

Who is at risk for an opioid Overdose?

Anyone who takes an opioid can be at risk of an Overdose, but you are at higher risk if you

  • Take illegal opioids
  • Take more opioid medicine than you are prescribed
  • Combine opioids with other medicines and/or alcohol
  • Have certain medical conditions, such as sleep apnea, or reduced kidney or liver function
  • Are over 65 years old
What are the signs of an opioid Overdose?

The signs of an opioid Overdose include

  • The person's face is extremely pale and/or feels clammy to the touch
  • Their body goes limp
  • Their fingernails or lips have a purple or blue color
  • They start vomiting or making gurgling noises
  • They cannot be awakened or are unable to speak
  • Their breathing or heartbeat slows or stops
What should I do if I think that someone is having an opioid Overdose?

If you think someone is having an opioid Overdose,

  • Call 9-1-1 immediately
  • Administer naloxone, if it is available. Naloxone is a safe medication that can quickly stop an opioid Overdose. It can be injected into the muscle or sprayed into the nose to rapidly block the effects of the opioid on the body.
  • Try to keep the person awake and breathing
  • Lay the person on their side to prevent choking
  • Stay with the person until emergency workers arrive
How can I prevent an opioid Overdose?

There are steps you can take to help prevent an Overdose:

  • Take your medicine exactly as prescribed by your health care provider. Do not take more medicine at once or take medicine more often than you are supposed to.
  • Never mix pain medicines with alcohol, sleeping pills, or illegal substances
  • Store medicine safely where children or pets can't reach it. Consider using a medicine lockbox. Besides keeping children safe, it also prevents someone who lives with you or visits your house from stealing your medicines.
  • Dispose of unused medicine promptly

If you take an opioid, it is also important to teach your family and friends how to respond to an Overdose. If you are at high risk for an Overdose, ask your health care provider about whether you need a prescription for naloxone.

Check out the latest treatments for OVERDOSE

OVERDOSE treatment research studies

Fluoxetine clinical trials, surveys and public health registries


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OVERDOSE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting "Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke"
Condition: Cerebral Infarction
Interventions: Drug: Fluoxetine;   Drug: Placebo of Fluoxetine
Outcome Measures: Slope of the curve of recruitment of the PEMs;   Slope of recruitment of the PEMs;   Index finger force control in paretic hand under time-course of treatment of Fluoxetine;   in index finger force control in non-paretic hand under time-course of treatment of Fluoxetine
2 Not yet recruiting Fluoxetine Prevention Trial
Condition: Cognitive Dysfunction
Interventions: Drug: Fluoxetine;   Drug: Placebo
Outcome Measures: Change from baseline in regional cerebral metabolism;   Durability of the protective effect of Fluoxetine;   Change from baseline in neuropsychological (cognitive, functional) test results;   Correlation between cognitive functioning and cerebral metabolism by correlating neuropsychological testing results with PET imaging;   Correlation between inflammatory cytokines and cerebral metabolism by correlating blood cytokine marker levels with PET imaging
3 Unknown  Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure
Condition: Posttraumatic Stress Disorder, Combat-related
Interventions: Drug: Fluoxetine;   Drug: Placebo
Outcome Measures: Clinician Administered PTSD Scale;   PTSD Symptom Checklist
4 Recruiting A Study of Olanzapine and Fluoxetine for Treatment-resistant Depression
Condition: Treatment Resistant Depression
Interventions: Drug: Olanzapine;   Drug: Fluoxetine;   Drug: Placebo
Outcome Measures: Mean Change from Baseline to 8 Week Endpoint in Montgomery-Äsberg Depression Rating Scale (MADRS);   Mean Change from Baseline to 8 Week Endpoint in Clinical Global Impressions-Severity of Depression (CGI-S) Scale;   Mean Change from Baseline to 8 Week Endpoint in the Simpson-Angus Scale (SAS);   Mean Change from Baseline to 8 Week Endpoint in the Short-Form 36 Health Survey (SF-36);   Mean Change from Baseline to 8 Week Endpoint in the Sheehan Disability Scale (SDS);   Percentage of Participants who Achieve a Response Based on a ≥50% Reduction from Baseline in MADRS Total Score;   Percentage of Participants who Achieve Remission Based on MADRS Total Score ≤10 at 8 Weeks;   Mean Change from Baseline to 8 Week Endpoint in the Barnes Akathisia Scale (BAS);   Mean Change from Baseline to 8 Week Endpoint in the Abnormal Involuntary Movement Scale (AIMS)
5 Recruiting Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke
Condition: Stroke
Interventions: Drug: Fluoxetine;   Drug: placebo
Outcome Measures: Fugl-Meyer Motor Scale (FMMS);   Western Aphasia Battery;   Behavioral Inattention Test (BIT);   Functional Independence Measure
6 Recruiting Effectiveness Study to Compare Venlafaxine With Fluoxetine in the Treatment of Postmenopausal Women With Major Depression
Condition: Major Depression
Intervention: Drug: venlafaxine,Fluoxetine
Outcome Measures: change of 24-item Hamilton Rating Scale for Depression total score;   the mean change of HAMD-24 subscale score in items 10, 11, 12, 13 (anxiety and somatizations) at endpoint
7 Recruiting Role of Inflammation Factors and Insulin Resistance in Major Depressive Disorder
Condition: Major Depressive Disorder
Interventions: Drug: Fluoxetine + Valsartan;   Drug: Fluoxetine + Placebo
Outcome Measures: Hamilton Depression Rating Scale (HDRS);   fasting plasma glucose;   fasting serum insulin;   C-reactive Protein, and IL-6
8 Recruiting Fluoxetine for Motor Recovery After Acute Intracerebral Hemorrhage
Conditions: Intracerebral Hemorrhage;   Motor Impairment
Interventions: Drug: Fluoxetine;   Drug: Placebo
Outcome Measures: Fugl Meyer Motor Scale score;   Barthel Index;   modified Rankin Scale;   NIH Stroke Scale
9 Unknown  Safety and Efficacy of Fluoxetine in Pulmonary Arterial Hypertension
Condition: Pulmonary Arterial Hypertension
Intervention: Drug: Fluoxetine
Outcome Measures: The primary endpoint will be change in pulmonary vascular resistance (PVR) measured by right heart catheterization after three months of therapy.;   Efficacy, Safety and tolerability endpoints will include change between baseline and three month QIDS-SR depression scale, systolic and diastolic blood pressure (systemic) and tabulation of adverse events
10 Unknown  Pharmacogenomics Studies of Antidepressants
Conditions: Major Depressive Disorder;   Antidepressive Agents;   Pharmacogenetics;   Venlafaxine;   Fluoxetine
Interventions: Drug: Venlafaxine;   Drug: Fluoxetine
Outcome Measures: Hamilton Depression Rating Scale (HDRS);   C-reactive Protein and IL-6;   fasting blood glucose, lipid profiles
11 Recruiting Characterization and Sequential Pharmacotherapy of Severe Mood Dysregulation
Condition: Severe Mood Dysregulation
Interventions: Drug: lisdexamfetamine;   Drug: Placebo;   Drug: Fluoxetine
Outcome Measures: Clinical Global Impression-Improvement-Severe Mood Dysregulation;   Pediatric Anxiety Rating Scale (PARS);   Children's Depression Rating Scale;   ADHD-IV Rating Scale;   ADHD IV Rating Scale;   Columbia Suicide Severity Scales;   Barnes Akathisia Scale;   Children's Affective Lability Scale;   Physical Symptom Checklist;   Revised Modified Overt Aggression Scale;   Screen for Children's Affective Reactivity;   Affective Reactivity Index
12 Not yet recruiting RCT of a Neuroplasticity Agent and CI Therapy for Severe Arm Paresis After Stroke
Condition: Severe Stroke With Affected Arm Motor Function
Interventions: Drug: Fluoxetine;   Drug: Placebo;   Procedure: eCMIT;   Procedure: Usual Care
Outcome Measures: Grade 4/5 Motor Activity Log (MAL) Arm Use Scale;   Grade 4/5 MAL Arm Use scale;   Grade 4/5 Wolf Motor Function Test Performance Rate score
13 Recruiting Developing Adaptive Treatment Strategies for Children and Adolescents With Obsessive-compulsive Disorder.
Condition: Obsessive-Compulsive Disorder
Interventions: Drug: Fluoxetine;   Behavioral: Group cognitive-behavioral therapy
Outcome Measures: Treatment response status at week 28;   Treatment response status at week 14;   Predictors of treatment response at week 28
14 Recruiting Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes
Conditions: Depression;   Mood Disorder;   Anxiety Disorder;   Healthy
Intervention:
Outcome Measure:
15 Recruiting A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDD
Condition: Major Depressive Disorder
Interventions: Drug: desvenlafaxine succinate sustained release;   Drug: Fluoxetine;   Drug: placebo
Outcome Measures: Change from baseline to Week 8 visit in the Children's depression rating scale, revised (CDRS-R) total score;   Clinical Global Impression Improvement (CGI-I) score at the Week 8 visit;   CGI-S score change from baseline at the Week 8 visit;   CGI-I response (1 or 2)
16 Recruiting Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)
Conditions: Type 1 Diabetes;   Hypoglycemia Associated Autonomic Failure
Interventions: Drug: Fluoxetine;   Drug: Placebo control
Outcome Measure: Change in Catecholamines
17 Recruiting A Positron Emission Topographic (PET) Study on Depression Patient With Electroacupuncture
Conditions: Major Depressive Disorder;   Depression
Interventions: Drug: Fluoxetine;   Procedure: DCEAS (Hwato®/ Dongbang®);   Procedure: n-CEA (Strietberger®)
Outcome Measures: HAMD-17;   SDS;   PET scanning;   Clinical response;   Remission;   Latency;   Adverse events
18 Recruiting Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients
Conditions: Obsessive-Compulsive Disorder;   Anxiety Disorders;   Mental Disorders
Interventions: Drug: Fluoxetine;   Drug: Sertraline;   Drug: Paroxetine;   Drug: Citalopram;   Drug: Fluvoxamine;   Behavioral: Exposure and Response Prevention
Outcome Measures: The change of Yale-Brown Obsessive-Compulsive Scale score;   The change of Beck Depression Inventory(BDI-II) score;   The change of Beck Anxiety Inventory(BAI) score;   The change of Stress Perceived Questionnaire (PSS-10) score;   The change of Behavioral Inhibition/Behavioral Activation System Scales score;   The change of Barratt Impulsiveness Scale 11 (BIS-11) score;   The change of Obsessive Beliefs Questionnaire-44(OBQ-44) score;   The NEO-Five Factor Inventory-Revised (NEO-FFI-R);   The Early Trauma Inventory Self Report-Short Form(ETISR-SF)
19 Recruiting Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder
Conditions: Borderline Personality Disorder;   Suicide
Interventions: Drug: Fluoxetine;   Behavioral: DBT;   Drug: Citalopram
Outcome Measure: Suicidal and self-injurious behavior
20 Recruiting Investigation of the Serotoninergic System in Multiple System Atrophy: a Positron Emission Tomography (PET) Study
Condition: Multiple System Atrophy
Interventions: Radiation: PET (Positron Emission Tomography) Study;   Other: Brain MRI (magnetic resonance imaging);   Drug: Fluoxétine / Placebo
Outcome Measures: 18F-MPPF binding potential - Biding potential (BP) under placebo in the raphe nucleus;   18F-MPPF binding potential - Biding potential (BP) in other brain areas;   Clinical parameters (motor handicap, orthostatic hypotension, quality of life, sleep, pain, tiredness);   18F-MPPF binding potential - Biding potential (BP) under placebo in other brain areas;   18F-MPPF binding potential - BP under Fluoxetine in all brain areas