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PLEURAL EFFUSION and Benadryl

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PLEURAL EFFUSION Symptoms and Causes

Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. Between the layers of the pleura is a very thin space. Normally it's filled with a small amount of fluid. The fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out.

Disorders of the pleura include

  • Pleurisy - inflammation of the pleura that causes sharp pain with breathing
  • Pleural effusion - excess fluid in the pleural space
  • Pneumothorax - buildup of air or gas in the pleural space
  • Hemothorax - buildup of blood in the pleural space

Many different conditions can cause pleural problems. Viral infection is the most common cause of pleurisy. The most common cause of pleural effusion is congestive heart failure. Lung diseases, like COPD, tuberculosis, and acute lung injury, cause pneumothorax. Injury to the chest is the most common cause of hemothorax. Treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for PLEURAL EFFUSION

PLEURAL EFFUSION treatment research studies

Benadryl clinical trials, surveys and public health registries


Find Drug Side Effect reports



Benadryl Side Effects

Off Label Use (181)
Dyspnoea (162)
Nausea (142)
Hypersensitivity (139)
Urticaria (126)
Somnolence (119)
Vomiting (116)
Loss Of Consciousness (113)
Rash (110)
Pain (109)
Pruritus (108)
Headache (108)
Overdose (105)
Dizziness (102)
Product Quality Issue (102)
Insomnia (96)
Heart Rate Increased (86)
Hallucination (80)
Feeling Abnormal (79)
Condition Aggravated (78)
Anxiety (46)
Infusion Related Reaction (46)
Tremor (45)
Fatigue (45)
Diarrhoea (43)
Convulsion (42)
Erythema (38)
Malaise (38)
Pyrexia (38)
Asthenia (37)
Swelling Face (37)
Blood Pressure Increased (37)
Pharyngeal Oedema (35)
Throat Tightness (34)
Dehydration (32)
Chest Pain (31)
Swollen Tongue (30)
Pain In Extremity (30)
Cough (30)
Oedema Peripheral (29)
Hypoaesthesia (29)
Chest Discomfort (29)
Incorrect Dose Administered (28)
Abdominal Pain Upper (27)
Eye Swelling (27)
Flushing (26)
Fall (26)
Confusional State (25)
Lip Swelling (24)
Syncope (24)

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Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Can I die from taking this many. Is it physicly addicting? Sorry about my spelling.

Convulsions and seizures sometimes for up to a week and a half at a time

Does taking too much benadryl cause a person to fall asleep and not wake up?

Hi i like know about heavy dosage of benadryl side effects can anybody please give feedback waiting for positive response regards vijay

I loved these strips. I have had allergic reactions to my own allergy shots. After waiting at the Dr.'s office for 15 minutes after my allergy shot, I leave to go shopping. Sometimes I can feel a little thickening in my throat, similar to when I'v

I take up to 50 Benadryl a day. How many should I take? I like how it makes me feel.

I've noticed that it when I am with my partner it makes me sensitive, but I am not able to be aroused. Is anyone else having the same issue. I've been taking it for alergies since I was a teenager. Its the only thing that has ever worked for me.

It was given to me in a hospital through emergency room, for nauseau. Nusrse said that they use it for that as well. Is true and can it be usedat home for the same?

My son is allergic to children's Benadryl. It causes him to develop eye infections (conjunctivitus).

Unresponsive to 5mg/kg q 8wks; increased to 10mg/kg q6wks. After 3 doses at that strength noted fatigue, occasional night sweats, joint aches, sudden onset of chest pain and dyspnea (pleurisy, small pleuraleffusion) Had just taper

54y/o, WM, Status post quadruple coronary artery bypass graft surgery(10 months ago). Surgery went well, only complication was a pretty large left pleural effusion requiring chest tube placement. Resolved well, no further problems

Experienced weakness and fatigue, diagnosed with pericardial effusion and anemia, hospitalized for 14 days. Surgical thorectomy and drainage.

Feb 2009 hospitalized for pericardal effusion then suffered with reaccuring pericarditis for a year march 2101 sent to mayo clinic in minnasota for a radical pericardectomy

Hi am a nursing student and my pt has pneumonia and pleural effusion and empyema withlarge abcessand the hostpital is giving him perfalgan is that wrong?

My father died last week after suffering from: fluid buildup in the lining of the lungs (pleural effusion), heart (pericardial effusion), led to hard breathing, fatigueandvery low oxygen in

When people receive a lung transplant, the pleural cavity is destroyed. How are people able to breathe following a lung transplant when there is no pleural cavity???

PLEURAL EFFUSION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
Condition: Drug Metabolism, Poor, CYP2D6-RELATED
Interventions: Drug: Diphenhydramine;   Drug: Metoclopramide
Outcome Measures: Area under curve of metoclopramide (MCP);   Area under curve of diphenhydramine(DPH);   Cmax of metoclopramide;   Tmax of metoclopramide;   Cmax of diphenhydramine;   Tmax of diphenhydramine
2 Recruiting Diphenhydramine for Acute Migraine
Condition: Migraine
Interventions: Drug: metoclopramide;   Drug: diphenhydramine;   Drug: placebo
Outcome Measure: Sustained headache relief
3 Not yet recruiting Study of Promethazine for Treatment of Diabetic Gastroparesis
Condition: Diabetic Gastroparesis
Interventions: Drug: Promethazine;   Drug: Sugar pill
Outcome Measures: Change in patient-reported symptoms as measured by the Gastroparesis Cardinal Symptom Index score (GCSI, 14) from week 0 to week 4.;   Occurrence of adverse events;   Use of rescue medication;   The impact on work activity as measured by the Work Productivity and Activity Impairment Questionnaire. (WPAI).
4 Unknown  Adjunct Sedatives in Procedures Involving Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP)
Conditions: Endoscopic Ultrasound (EUS);   Endoscopic Retrograde Cholangiopancreatography (ERCP)
Interventions: Drug: Saline;   Drug: Diphenhydramine;   Drug: Promethazine
Outcome Measures: Sedation Level;   Time to achieve adequate level of sedation to begin procedure;   Time for Recovery;   Adverse Symptoms From Sedative Agents
5 Not yet recruiting Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids
Conditions: Colonoscopy;   Adjunct Anesthesia Medication
Interventions: Drug: Diphenhydramine;   Drug: Placebo
Outcome Measures: Dosage of Fentanyl and Midazolam;   Quality of sedation;   Duration of Procedure;   Adverse events;   24 hour follow up
6 Unknown  Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department
Condition: Low Back Pain
Interventions: Drug: Morphine-Promethazine;   Drug: morphine
Outcome Measures: Pain relief;   Ambulatory status
7 Recruiting Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo
Condition: Cough Reflex Sensitivity
Interventions: Drug: Phenylephrine;   Drug: Diphenhydramine;   Drug: Dextromethorphan
Outcome Measure: change in cough reflex sensitivity to capsaicin
8 Not yet recruiting Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy
Conditions: Sedation;   Endoscopy
Interventions: Drug: Diphenhydramine;   Drug: Midazolam
Outcome Measure: Proportion of patients who achieve adequate sedation to allow colonoscopy (defined as MOAA/S ≤3)
9 Recruiting Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
Condition: Depression
Interventions: Drug: Ketamine;   Drug: Diphenhydramine
Outcome Measures: Evaluate the effects of ketamine on depressive symptomatology;   Evalaute the effects of ketamine on treatment alliance;   Evalaute the effects of ketamine on suicidal ideation
10 Unknown  Does Thiamine Help Vomiting and Nausea in Pregnancy?
Condition: Hyperemesis Gravidarum
Intervention: Drug: thiamine & promethazine
Outcome Measure: the improvement in nausea and/or vomiting after treatment
11 Not yet recruiting Histamine Glutamate Antagonism in Stroke
Conditions: Acute Cerebrovascular Accident;   Cerebral Edema
Interventions: Drug: Diphenhydramine;   Drug: Pantoprazole;   Drug: Famotidine;   Drug: Dextromethorphan
Outcome Measures: Modified Rankin Score;   National Institutes of Health Stroke Severity (NIHSS) Scale;   Neurological examination of the subject;   All cause mortality data
12 Recruiting Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC)
Condition: Kidney Cancer
Interventions: Drug: Pazopanib;   Drug: Temsirolimus;   Behavioral: Quality of Life Assessment;   Drug: Benadryl
Outcome Measure: Progression Free Survival (PFS)
13 Not yet recruiting Psilocybin-facilitated Treatment for Cocaine Use
Condition: Cocaine-Related Disorders
Interventions: Drug: Psilocybin;   Drug: Diphenhydramine
Outcome Measure: The difference between the treatment and placebo groups in the number of participants with biochemically verified cocaine abstinence.
14 Recruiting FUS1-nanoparticles and Erlotinib in Stage IV Lung Cancer
Condition: Lung Cancer
Interventions: Drug: DOTAP:Chol-fus1;   Drug: Erlotinib;   Drug: Dexamethasone;   Drug: Diphenhydramine
Outcome Measures: Maximum Tolerated Dose (MTD) Level for Drug Treatment Combination;   Response Rate
15 Recruiting The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
Condition: Neuropathic Pain
Interventions: Drug: Lidocaine;   Drug: Diphenhydramine
Outcome Measures: Changes from Baseline Pain scores on the Visual Analog Scale at 6 weeks;   Hospital Anxiety and Depression Scale;   Modified Brief Pain Inventory;   Leeds Sleep Evaluation Questionnaire;   Patient Global Satisfaction with Treatment and Impression of Change;   Side Effects;   Quality of Life Health Outcome Instrument
16 Not yet recruiting Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Condition: Vestibular
Interventions: Drug: Promethazine;   Behavioral: Hyper gravity training;   Drug: Placebo;   Behavioral: No hypergravity training
Outcome Measure: Rate of recovery of roll tilt perception errors after exposure to hypergravity
17 Not yet recruiting First-time-in-man, to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BP1.5375
Condition: Healthy Male Volunteers
Interventions: Drug: BP1.5375 suspension;   Drug: Diphenhydramine;   Drug: Placebo
Outcome Measures: Single Ascending Dose - safety and tolerability (Part 1);   Proof of Concept - effect on polysomnography (Part 2)
18 Not yet recruiting A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence
Condition: Alcohol Dependence
Interventions: Drug: Psilocybin;   Drug: Diphenhydramine;   Behavioral: Motivational Enhancement and Taking Action (META)
Outcome Measures: percent heavy drinking days;   Changes in vital signs;   adverse events;   Percent days abstinent;   drinks per drinking day;   days to first drinking day;   Days to first heavy drinking day;   consequences of drinking;   craving;   self efficacy;   Motivation to change drinking behavior
19 Recruiting Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)
Condition: Acute Mountain Sickness
Interventions: Device: Theravent;   Device: Control
Outcome Measures: Incidence of acute mountain sickness;   number of nocturnal desaturations;   acute mountain sickness severity;   nocturnal awakenings;   subjective quality of sleep
20 Recruiting Treatment of Orthostatic Hypotension in Autonomic Failure
Conditions: Autonomic Failure;   Orthostatic Hypotension
Interventions: Drug: Atomoxetine;   Drug: Acarbose;   Drug: Pyridostigmine Bromide;   Drug: Yohimbine;   Drug: Midodrine HCl;   Drug: placebo;   Drug: Modafinil;   Drug: Octreotide;   Other: water intake;   Drug: Diphenhydramine Hydrochloride;   Drug: Ranitidine HCL;   Drug: Tranylcypromine;   Drug: Ergotamine/ Caffeine;   Drug: Celecoxib;   Drug: Pseudoephedrine;   Drug: Methylphenidate;   Drug: Indomethacin;   Drug: Ibuprofen;   Drug: Oxymetazoline 0.05% nasal solution;   Dietary Supplement: Bovril;   Drug: Acetazolamide;   Drug: Rivastigmine tartrate;   Drug: Carbidopa/levodopa;   Device: Inflatable abdominal binder;   Device: inflatable abdominal binder (sham)
Outcome Measures: Increase in seated systolic blood pressure 1-hr post drug compared to baseline.;   Increase in standing time 1-hr post drug compared to baseline