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PLEURAL EFFUSION and Doxycycline

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PLEURAL EFFUSION Symptoms and Causes

Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. Between the layers of the pleura is a very thin space. Normally it's filled with a small amount of fluid. The fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out.

Disorders of the pleura include

  • Pleurisy - inflammation of the pleura that causes sharp pain with breathing
  • Pleural effusion - excess fluid in the pleural space
  • Pneumothorax - buildup of air or gas in the pleural space
  • Hemothorax - buildup of blood in the pleural space

Many different conditions can cause pleural problems. Viral infection is the most common cause of pleurisy. The most common cause of pleural effusion is congestive heart failure. Lung diseases, like COPD, tuberculosis, and acute lung injury, cause pneumothorax. Injury to the chest is the most common cause of hemothorax. Treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for PLEURAL EFFUSION

PLEURAL EFFUSION treatment research studies

Doxycycline clinical trials, surveys and public health registries


Find Drug Side Effect reports



Doxycycline Side Effects

Headache (176)
Nausea (172)
Rash (127)
Pain (125)
Vomiting (125)
Dyspnoea (124)
Dizziness (123)
Haemorrhage (116)
Malaise (114)
Diarrhoea (111)
Oesophageal Ulcer (100)
Pyrexia (97)
Chest Pain (95)
Fatigue (93)
Anxiety (92)
Pruritus (92)
Abortion Incomplete (91)
Photosensitivity Reaction (88)
Asthenia (82)
Abdominal Pain Upper (71)
Depression (41)
Abdominal Pain (40)
Anaemia (38)
Stevens-johnson Syndrome (35)
Suicidal Ideation (34)
Muscle Spasms (32)
Confusional State (32)
Vision Blurred (31)
Oesophagitis (31)
Oedema Peripheral (31)
Dyspepsia (30)
Hypotension (30)
Pancreatitis (30)
Syncope (30)
Benign Intracranial Hypertension (29)
Paraesthesia (28)
Palpitations (28)
Arthralgia (27)
Erythema (27)
Visual Impairment (27)
Intracranial Pressure Increased (27)
Pulmonary Embolism (27)
Dysphagia (26)
Blister (26)
Abdominal Discomfort (25)
Pancreatitis Acute (25)
Renal Failure Acute (25)
Panic Attack (25)
Hypersensitivity (24)
Swollen Tongue (24)

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Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

I am 11 days into a 20 day regime of Doxycycline for Staph. I am 51 and have not had a period in 2 years. 2 days ago I had some breast tenderness and this morning I woke to classic menstrual bleeding with abdominal cramps. Could the Doxycyclin

I am a 45 year old women who developed acne 4 years agao after my hysterectomy.Ihave been using doxycycline for the last 10 months......the only side effects I have experienced are nausea if pill tkn in empty stomach and weight gain ( which

I am anaemic and i've been treating my acne with doxycycline but instead my anaemia got worse i'm drowzy,my head feels heavy and i have a headache from hell.

I had these 100mg tablets for a sinus infection its gone now i take the last 1 tomorrow but after the few few days on them i ad to take 8 2 to start with then 1 a day. so after a few days on them i got 2 complaints my anus was a bit sore and neck an

I have just taken myself off Doxycycline. I had so much pressure in my skull - unable to stand for very long, felt really weak and thought I was going to pass out..A Few pains in my kidney area.

I took doxycycline for 10 days for perioral dermatitis. A week after completing the medicine I went to the ER with a burning in my chest. Then I lost my appetite, was nauseousand started losing weight. Three weeks later I was diagnosed with

I was taking doxycycline for an MRSA staph infection. I had tightness in my chest and worsening difficulty breathing, sore tongue, burning palms and soles of my feet, and extreme exhaustion. At the end of my 9th day on the medication, I had excruti

I was taking doxycycline for meibomitis and a little over 2 weeks after I started I came ill with severe head pressure,tinnitus,chills,nausea,flulike symptoms and after 2 emergency room visits and 6 different doctors (who were trying to treat me for

I was taking them as an anti-malarial. Caused a duodenal ulcer and a bleed on the brain, either of which could have killed me. Both nearly did, I had 3 months in hospital and 8 operations before I was discharged. I will probably never be properly wel

I'm currently taking doxycycline for Lyme disease, and about a week into my month prescription, I started having severe itching all over my body. It keeps me up at night, and when I asked if there was anything else I could switch to, I was told that

Unresponsive to 5mg/kg q 8wks; increased to 10mg/kg q6wks. After 3 doses at that strength noted fatigue, occasional night sweats, joint aches, sudden onset of chest pain and dyspnea (pleurisy, small pleuraleffusion) Had just taper

54y/o, WM, Status post quadruple coronary artery bypass graft surgery(10 months ago). Surgery went well, only complication was a pretty large left pleural effusion requiring chest tube placement. Resolved well, no further problems

Experienced weakness and fatigue, diagnosed with pericardial effusion and anemia, hospitalized for 14 days. Surgical thorectomy and drainage.

Feb 2009 hospitalized for pericardal effusion then suffered with reaccuring pericarditis for a year march 2101 sent to mayo clinic in minnasota for a radical pericardectomy

Hi am a nursing student and my pt has pneumonia and pleural effusion and empyema withlarge abcessand the hostpital is giving him perfalgan is that wrong?

My father died last week after suffering from: fluid buildup in the lining of the lungs (pleural effusion), heart (pericardial effusion), led to hard breathing, fatigueandvery low oxygen in

When people receive a lung transplant, the pleural cavity is destroyed. How are people able to breathe following a lung transplant when there is no pleural cavity???

PLEURAL EFFUSION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease
Conditions: Kawasaki Disease;   Coronary Aneurysm
Interventions: Drug: Doxycycline;   Drug: Standard care
Outcome Measures: Coronary artery diameter change;   Assess the change in MMP-9 level;   Assess a change in TIMP level
2 Unknown  Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population
Condition: Malignant Pleural Effusion
Interventions: Drug: Doxycycline;   Other: normal saline
Outcome Measures: Time to pleurodesis;   Pleurodesis rates at 90 days post Pleurx insertion;   Number of participants with adverse events;   Effects on pulmonary function
3 Unknown  Safety, Efficacy and Pharmacokinetics of Doxycycline Plus Tauroursodeoxycholic Acid in Transthyretin Amyloidosis
Condition: Transthyretin Amyloidosis
Intervention: Drug: Doxycycline + Tauroursodeoxycholic acid
Outcome Measures: Response rate to Doxycycline + tauroursodeoxycholic acid treatment;   Number of patients experiencing treatment-emergent adverse events;   Change in quality of life;   Doxycycline pharmacokinetics (PK);   response in autonomic dysfunction, sensory-motor peripheral neuropathy and visceral organ involvement;   neurologic response;   Incidence of patients discontinuing from the study because of clinical or laboratory adverse events
4 Recruiting Doxycycline in Therapy of Erythema Migrans
Condition: Lyme Borreliosis
Intervention: Drug: Doxycycline
Outcome Measures: Comparing of objective sequelae and post-treatment subjective symptoms in three groups of erythema migrans patients treated with Doxycycline: with no accompanying symptoms, with mild and with severe symptoms at the beginning.;   Comparison of subjective symptoms between erythema migrans patients treated with Doxycycline and control subjects without a history of Lyme borreliosis.
5 Recruiting Combining Doxycycline With Bone-Targeted Therapy in Patients With Metastatic Breast Cancer
Condition: Pain
Intervention: Drug: Doxycycline
Outcome Measures: palliative benefit;   changes to bone formation markers
6 Recruiting Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy
Conditions: Non-ischemic Cardiomyopathy;   Systolic Heart Failure (NYHA II-III)
Interventions: Drug: Doxycycline;   Drug: placebo
Outcome Measure: Peak aerobic exercise capacity
7 Recruiting Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study
Conditions: Chronic Pelvic Pain Syndrome;   Bladder Pain Syndrome
Interventions: Drug: Doxycycline;   Drug: placebo
Outcome Measures: Change in the O'Leary-Sant IC symptom and problem index total score from baseline;   Changes of patient reported pain, urgency, frequency, functional bladder capacity documented in 72-hour pain and bladder diary, completed during the 3 days before the particular follow-up visit.;   Changes in sexual function assessed by the Female Sexual Function Index (FSFI) at the time of the particular follow-up visit
8 Unknown  Double-blind-randomized,Placebo Controlled Trial for Chemotherapy-associated Oral Mucositis Using Doxycycline Hyclate
Condition: Mucositis
Intervention: Drug: Doxycycline hyclate
Outcome Measures: Complete response;   Partial resolution of oral lesions, incidence of infections and mortality.
9 Unknown  Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
Conditions: Chronic Obstructive Pulmonary Disease;   Inflammation;   Pulmonary Emphysema
Interventions: Drug: Doxycycline;   Drug: Placebo
Outcome Measures: myeloperoxidase in induced sputum;   MMP-8, MMP-9, IL-6 levels and differential cell counts in induced sputum.;   Lung function (FEV1);   Symptom scores
10 Recruiting Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy
Condition: Thyroid Associated Opthalmopathies
Interventions: Drug: Prednisone+placebo of Doxycycline;   Drug: Doxycycline+placebo of Prednisone
Outcome Measures: Overall treatment response;   • Health related quality of life questionnaires (GO-QoL);   • Safety and tolerability as assessed by adverse events, vital signs;   • Quantitative changes of rectus diameter measured by MRI scan;   Relapse
11 Recruiting Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome
Conditions: Polycystic Ovarian Syndrome (PCOS);   Irregular Menstrual Cycles;   Androgen Excess
Interventions: Drug: Doxycycline;   Drug: Sugar Pill
Outcome Measures: Assess the effectiveness of daily Doxycycline use in the primary outcome of reduction of serum testosterone and in women with PCOS during and beyond the treatment course.;   Assess the effectiveness of daily Doxycycline use in the secondary outcome of restoring ovulation in women with PCOS during and beyond the treatment course.
12 Unknown  Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis
Condition: Suspected Early Lyme Neuroborreliosis
Interventions: Drug: Doxycycline;   Drug: ceftriaxone
Outcome Measure: Objective sequelae and post-treatment subjective symptoms in patients treated for suspected early Lyme neuroborreliosis with normal CSF cell count with Doxycycline or ceftriaxone for 14 days.
13 Recruiting Doxycycline, Temozolomide and Ipilimumab in Melanoma
Condition: Melanoma
Interventions: Drug: Doxycycline;   Drug: Ipilimumab;   Drug: Temozolomide
Outcome Measure: Overall Response Rate
14 Unknown  Oral Contraceptives and Subantimicrobial Doxycycline: Effect on Endometrial MMPs
Condition: Breakthrough Bleeding
Intervention: Drug: Doxycycline
Outcome Measures: Determine the effect of combined oral contraceptives on endometrial MMP expression.;   Determine the effect of sub-antimicrobial Doxycycline on MMP expression and activity in continuous oral contraceptive users.
15 Recruiting Antibiotic Treatment of Multiple Erythema Migrans
Condition: Multiple Erythema Migrans
Interventions: Drug: ceftriaxone;   Drug: Doxycycline;   Other: erythema migrans patients treated with Doxycycline
Outcome Measures: Objective sequelae and post-treatment subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, dizziness, or irritability in patients treated for multiple erythema migrans with ceftriaxone or Doxycycline for 15 days.;   Comparison of subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, or irritability between patients treated with antibiotic for multiple erythema migrans and control subjects without a history of Lyme borreliosis.;   Objective sequelae and post-treatment subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, dizziness, or irritability in patients with solitary versus multiple erythema migrans after antibiotic treatment.
16 Recruiting A Phase II Study of Doxycycline in Relapsed NHL
Conditions: Adult Diffuse Large B-Cell Lymphoma;   Mantle Cell Lymphoma Recurrent;   Lymphoma, Follicular;   Marginal Zone B-Cell Lymphoma;   Malignant Lymphoma - Lymphoplasmacytic;   Waldenstrom Macroglobulinemia;   Small Lymphocytic Lymphoma;   Chronic Lymphocytic Leukemia (CLL);   T-Cell Lymphoma
Intervention: Drug: Doxycycline
Outcome Measures: Overall response rate;   Progression free survival
17 Unknown  The Effect of Doxycycline 100mg and Doxycycline 20mg in Treatment of Mild and Moderate Acne
Conditions: Acne;   Inflammation
Intervention: Drug: Doxycycline
Outcome Measure:
18 Recruiting Doxycycline for COPD in HIV-Infected Patients
Conditions: HIV;   Chronic Obstructive Pulmonary Disease (COPD);   Emphysema
Intervention: Drug: Doxycycline
Outcome Measures: Safety and tolerability;   Larger phase II clinical trial
19 Recruiting Tolerability and Efficacy of a Combination of Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy
Conditions: Amyloidosis; Heart (Manifestation);   Senile Cardiac Amyloidosis
Intervention: Drug: Tauroursodeoxycholic Acid and Doxycycline
Outcome Measures: The rate of progression of transthyretin cardiac amyloidosis, as measured by changes in strain echocardiography, in a group of patients taking a combination of Doxycycline and TUDCA.;   Number of patients with adverse events to the medications over the period of therapy (18 months);   To evaluate general and health related quality of life (QoL) in SSA and ATTR subjects.
20 Recruiting Management of Etonogestrel Subdermal Implant-related Bleeding
Condition: ESI-related Bleeding
Interventions: Drug: Doxycycline;   Drug: Placebo
Outcome Measures: Efficacy and safety of Doxycycline compared to placebo for unacceptable bleeding;   Patient Satisfaction;   Method Continuation rate