| Rank |
Status |
Study |
| 1 |
Not yet recruiting
|
Efficacy and Safety of Amantadine HCl Extended Release Tablets in Parkinson's Disease Subjects With Levodopa-Induced Dyskinesias
| Conditions: |
Parkinson's Disease; Levodopa Induced Dyskinesia (LID) |
| Interventions: |
Drug: Amantadine HCl ER (ALLAY-LID II); Drug: Placebo |
| Outcome Measures: |
Unified Dyskinesia Rating Scale; Mobility State Self Assessment (Subject Diary Cards); Mobility State Self-Assessment (Subject Diary Cards); MDS-Unified Parkinson's Disease Rating Scale; Fatigue Severity Scale |
|
| 2 |
Not yet recruiting
|
Efficacy and Safety of Amantadine ER Tablets to Treat Parkinson's Disease Patients With Levodopa Induced Dyskinesia.
| Conditions: |
Parkinson's Disease; Levodopa Induced Dyskinesia (LID) |
| Interventions: |
Drug: Amantadine ER Tablets; Drug: Placebo Tablets for Amantadine ER Tablets |
| Outcome Measures: |
Unified Dyskinesia Rating Scale (UDysRS); Mobility State Self-Assessment (Subject Diary Cards); MDS-UPDRS; Fatigue Severity Scale |
|
| 3 |
Recruiting
|
Phase III Study of the Safety and Efficacy of Cl-108 in the Treatment of Moderate to Severe Pain
| Conditions: |
Pain; Nausea; Vomiting |
| Interventions: |
Drug: CL-108; Drug: Placebo |
| Outcome Measures: |
To compare the occurrence and severity of opioid-induced nausea and vomiting (OINV) associated with CL-108 to Norco.; To demonstrate the efficacy of CL-108 when compared to placebo for the relief of pain following surgical removal of impacted third molar teeth.; Reduction of the severity of nausea in patients treated with an opioid-containing pain reliever.; Reduction of vomiting in patients treated with an opioid-containing pain reliever. |
|
| 4 |
Recruiting
|
Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer
| Conditions: |
Head and Neck Cancer; Oral Mucositis |
| Interventions: |
Dietary Supplement: Grape extract; Drug: Lortab, Fentanyl patch, mouthwash |
| Outcome Measures: |
Pain caused by oral mucositis; Level of immune biomarkers in blood; Level of immune biomarkers in mucosal tissue |
|
| 5 |
Not yet recruiting
|
Ureteral Stent-related Pain and Mirabegron (SPAM) Trial
| Condition: |
Nephrolithiasis |
| Interventions: |
Drug: Mirabegron; Drug: Tamsulosin; Drug: Percocet |
| Outcome Measures: |
Ureteral stent related pain and lower urinary tract symptoms (LUTS) as measured by the Ureteral Stent Symptom Questionnaire.; Quality of life impact of mirabegron for stent symptoms as measured with the Ureteral Stent Symptoms Questionnaire. |
|
| 6 |
Unknown †
|
Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain
| Condition: |
Pain, Fracture, Sprain |
| Interventions: |
Drug: Fentanyl rapid dissolving tablet 100mcg; Drug: lansoprazole 15mg rapidly dissolving tablet + Percocet PO |
| Outcome Measures: |
Time to analgesia; Occurrence of untoward opioid side effects |
|
| 7 |
Not yet recruiting
|
An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.
| Condition: |
Post Operative Pain |
| Interventions: |
Drug: Percocet; Drug: Xartemis |
| Outcome Measures: |
Non Inferiority; Patient Global Assessment |
|
| 8 |
Recruiting
|
Adductor Canal Nerve Block Following Total Knee Arthroplasty
| Condition: |
Post-op Pain |
| Interventions: |
Drug: Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed.; Drug: For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA. |
| Outcome Measures: |
Total Opiate pain medication; Patient satisfaction with pain control |
|
| 9 |
Recruiting
|
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (AATD)
| Conditions: |
Liver Fibrosis; Alpha-1 Antitrypsin Deficiency; AAT Deficiency; AATD |
| Interventions: |
Device: Abdominal ultrasound; Procedure: History and physical; Procedure: Intravenous catheter; Procedure: Blood draw; Other: Liver questionnaire; Procedure: Liver Biopsy; Drug: Midazolam; Drug: Fentanyl; Drug: Lidocaine; Drug: Acetaminophen; Drug: Lorazepam; Drug: Oxycodone/Acetaminophen; Drug: Ondansetron |
| Outcome Measures: |
To estimate the prevalence and histologic spectrum of liver injury in an adult with Alpha-1 Antitrypsin deficiency and a genotype of ZZ.; To identify environmental and host risk factors for clinically significant liver fibrosis.; To define the diagnostic accuracy of non-invasive markers of fibrosis in AAT liver disease.; To explore epigenetic markers for the development of liver fibrosis.; To quantify liver fibrosis progression. |
|
| 10 |
Not yet recruiting
|
The Effect of NSAIDs After a Rotator Cuff Repair Surgery.
| Condition: |
Rotator Cuff Tear |
| Interventions: |
Procedure: Rotator cuff repair; Drug: Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole; Drug: Hydrocodone/Acetaminophen |
| Outcome Measures: |
American Shoulder and Elbow Surgeons (ASES) Shoulder Score; Ultrasound evaluation of retear rate |
|
| 11 |
Recruiting
|
Safety and Efficacy Study of Fentanyl Buccal Tablet Use in the Emergency Department for Isolated Extremity Injury
| Condition: |
Pain |
| Interventions: |
Drug: Fentanyl; Drug: Oxycodone/acetaminophen; Drug: oxycodone/acetaminophen |
| Outcome Measures: |
Pain Level; Nausea level; Occurrence of adverse events |
|
| 12 |
Recruiting
|
Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge
| Condition: |
Analgesia After ED Discharge for Extremity Injuries |
| Intervention: |
Drug: Oral Opioid Pain Medicine |
| Outcome Measures: |
Difference in pain score before and after last dose.; Overall Satisfaction with the pain medicine; Side Effects |
|
| 13 |
Recruiting
|
Safety and Efficacy of Gabapentin for Neuropathic Pain in Fabry Disease
| Conditions: |
Fabry Disease; Neuropathic Pain |
| Interventions: |
Drug: Gabapentin; Drug: placebo |
| Outcome Measures: |
average reduction in hydrocodone-acetaminophen use; Number and type of adverse events; Pain levels; Define therapeutic level for gabapentin |
|
| 14 |
Not yet recruiting
|
Equality Study of Ofirmev vs Oral Acetaminophen
| Condition: |
Pain, Postoperative |
| Interventions: |
Drug: IV acetaminophen; Drug: oral acetaminophen |
| Outcome Measures: |
Primary outcome will measure total opioid consumption while the patient is in the PACU; time from PACU admission to request for first opioid dose |
|
| 15 |
Not yet recruiting
|
Local Anesthesia and Analgesics in Endodontic Pain
| Condition: |
Odontalgia |
| Interventions: |
Drug: Oral placebo; Drug: Oral ibuprofen; Drug: oral naproxen; Drug: oral acetaminophen/hydrocodone + ibuprofen |
| Outcome Measures: |
Effect of long acting anesthesia and analgesics on endodontic pain; Effect of gender and age on post-operative endodontic pain treatment |
|
| 16 |
Recruiting
|
Clinical Research of the Prognostic Influence of NSAIDS's Anti-inflammatory Effect on Senior Patients With Hip Fracture
| Condition: |
Hip Fracture |
| Interventions: |
Drug: celecoxib; Drug: Acetaminophen oxycodone |
| Outcome Measure: |
|
|
| 17 |
Recruiting
|
Tracking & Feedback Registry to Reduce Breast Cancer Treatment Disparities
| Condition: |
Breast Cancer |
| Intervention: |
Other: Tracking & Feedback |
| Outcome Measures: |
Change in intervention effect of adjuvant treatment; Organizational Characteristics |
|
| 18 |
Not yet recruiting
|
Post-operative Analgesia in Elective, Soft-tissue Hand Surgery
| Conditions: |
Carpal Tunnel; Ganglion Cyst; Trigger Finger |
| Interventions: |
Drug: Acetaminophen/Hydrocodone; Drug: Acetaminophen/Ibuprofen |
| Outcome Measures: |
Efficacy comparison utilizing Visual Analog Scale (VAS), Likert Pain Score and Mean daily pain values; Incidence of adverse effects |
|
| 19 |
Recruiting
|
Narcotic vs. Non-narcotic Pain Study Protocol
| Condition: |
Carpal Tunnel |
| Interventions: |
Drug: Narcotic; Drug: non-narcotic |
| Outcome Measure: |
Pain relief |
|
| 20 |
Not yet recruiting
|
Comprehensive Opioid Management
| Condition: |
Chronic Pain |
| Interventions: |
Behavioral: IVR self-management; Behavioral: Opioid monitoring; Other: Enhanced usual care |
| Outcome Measures: |
Brief Pain Inventory; Concordance with opioid treatment practice guidelines |
|
