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RESPIRATORY FAILURE and Metoprolol

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RESPIRATORY FAILURE Symptoms and Causes

What is respiratory failure?

Respiratory failure is a condition in which your blood doesn't have enough oxygen or has too much carbon dioxide. Sometimes you can have both problems.

When you breathe, your lungs take in oxygen. The oxygen passes into your blood, which carries it to your organs. Your organs, such as your heart and brain, need this oxygen-rich blood to work well.

Another part of breathing is removing the carbon dioxide from the blood and breathing it out. Having too much carbon dioxide in your blood can harm your organs.

What causes respiratory failure?

Conditions that affect your breathing can cause respiratory failure. These conditions may affect the muscles, nerves, bones, or tissues that support breathing. Or they may affect the lungs directly. These conditions include

  • Lung diseases such as COPD (chronic obstructive pulmonary disease), cystic fibrosis, pneumonia, and pulmonary embolism
  • Conditions that affect the nerves and muscles that control breathing, such as amyotrophic lateral sclerosis (ALS), muscular dystrophy, spinal cord injuries, and stroke
  • Problems with the spine, such as scoliosis (a curve in the spine). They can affect the bones and muscles used for breathing.
  • Damage to the tissues and ribs around the lungs. An injury to the chest can cause this damage.
  • Drug or alcohol overdose
  • Inhalation injuries, such as from inhaling smoke (from fires) or harmful fumes
What are the symptoms of respiratory failure?

The symptoms of respiratory failure depend on the cause and the levels of oxygen and carbon dioxide in your blood.

A low oxygen level in the blood can cause shortness of breath and air hunger (the feeling that you can't breathe in enough air). Your skin, lips, and fingernails may also have a bluish color. A high carbon dioxide level can cause rapid breathing and confusion.

Some people who have respiratory failure may become very sleepy or lose consciousness. They also may have arrhythmia (irregular heartbeat). You may have these symptoms if your brain and heart are not getting enough oxygen.

How is respiratory failure diagnosed?

Your health care provider will diagnose respiratory failure based on

  • Your medical history
  • A physical exam, which often includes
    • Listening to your lungs to check for abnormal sounds
    • Listening to your heart to check for arrhythmia
    • Looking for a bluish color on your skin, lips, and fingernails
  • Diagnostic tests, such as
    • Pulse oximetry, a small sensor that uses a light to measure how much oxygen is in your blood. The sensor goes on the end of your finger or on your ear.
    • Arterial blood gas test, a test that measures the oxygen and carbon dioxide levels in your blood. The blood sample is taken from an artery, usually in your wrist.

Once you are diagnosed with respiratory failure, your provider will look for what is causing it. Tests for this often include a chest x-ray. If your provider thinks you may have arrhythmia because of the respiratory failure, you may have an EKG (electrocardiogram). This is simple, painless test that detects and records your heart's electrical activity.

What are the treatments for respiratory failure?

Treatment for respiratory failure depends on

  • Whether it is acute (short-term) or chronic (ongoing)
  • How severe it is
  • What is causing it

Acute respiratory failure can be a medical emergency. You may need treatment in intensive care unit at a hospital. Chronic respiratory failure can often be treated at home. But if your chronic respiratory failure is severe, you might need treatment in a long-term care center.

One of the main goals of treatment is to get oxygen to your lungs and other organs and remove carbon dioxide from your body. Another goal is to treat the cause of the condition. Treatments may include

  • Oxygen therapy, through a nasal cannula (two small plastic tubes that go in your nostrils) or through a mask that fits over your nose and mouth
  • Tracheostomy, a surgically-made hole that goes through the front of your neck and into your windpipe. A breathing tube, also called a tracheostomy, or trach tube, is placed in the hole to help you breathe.
  • Ventilator, a breathing machine that blows air into your lungs. It also carries carbon dioxide out of your lungs.
  • Other breathing treatments, such as noninvasive positive pressure ventilation (NPPV), which uses mild air pressure to keep your airways open while you sleep. Another treatment is a special bed that rocks back and forth, to help you breathe in and out.
  • Fluids, often through an intravenous (IV), to improve blood flow throughout your body. They also provide nutrition.
  • Medicines for discomfort
  • Treatments for the cause of the respiratory failure. These treatments may include medicines and procedures.

If you have respiratory failure, see your health care provider for ongoing medical care. Your provider may suggest pulmonary rehabilitation.

If your respiratory failure is chronic, make sure that you know when and where to get help for your symptoms. You need emergency care if you have severe symptoms, such as trouble catching your breath or talking. You should call your provider if you notice that your symptoms are worsening or if you have new signs and symptoms.

Living with respiratory failure may cause fear, anxiety, depression, and stress. Talk therapy, medicines, and support groups can help you feel better.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for RESPIRATORY FAILURE

RESPIRATORY FAILURE treatment research studies

Metoprolol clinical trials, surveys and public health registries


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Metoprolol Side Effects

Bradycardia (410)
Dizziness (389)
Hypotension (291)
Blood Pressure Increased (282)
Dyspnoea (271)
Fatigue (258)
Completed Suicide (244)
Syncope (220)
Nausea (195)
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Chest Pain (166)
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Feeling Abnormal (86)
Renal Failure (83)
Renal Failure Acute (83)
Depression (83)
Confusional State (78)
Blood Pressure Decreased (77)
Arthralgia (76)
Death (73)
Chest Discomfort (73)
Tachycardia (71)
Loss Of Consciousness (69)
Somnolence (69)
Hyperhidrosis (65)
Cardiogenic Shock (63)
Condition Aggravated (63)
Weight Decreased (62)

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Recent Reviews

<strong>I was put on Metoprolol ER 2 years ago after having cancer. I was </strong><span style='text-decoration: underline;'>tired all day could not sleep at night, had anxiety attacks, co

I have been taking Toprol XL 100 for 7 yrs with no issues or changes in my EKGs. I was switched to the Generic Metoprolol 50mg twice a day 3 months ago. I started experiencing PVCs and stomach trouble. Went to the ER twice becaus

i've been on the generic metoprolol for 3 days. dr. started me on 25mg 2x per day and i've been experiencing shortness of breath, chest discomfort and dizziness. i cut the dosage down to 6.5mg per day and feel a little better (palpations&

<strong>Tired all the time. Sleep poorly. Dry hacking cough and I am cold all the time. I can't seem to keep warm. I doubleup on my clothing and socks.</strong> <strong>Honestly, I have never

Can i take Acetaminophen W/Codeine #3 with Metoprolol er succinate 25 mg ?

Does anyone have a nagging cough while taking metaprolol?

Does it hurt in your legs real bad, you can't sleep and your chest hurts? See your Doctor.

EVERYONE SHOULD TAKE NATURAL HERBS ITS GODS MEDICINE FOR EVERYBODY IT MAKES YOU WELL ;;ALL PERSRIPTION DRUGS IS NUMBER 1 KILLER IN THE WORLD .

Evil drug. Side effects in order are, coughing, extreme lethargy, horrible dreams like ones where demons are torturing me that leave me with night terror as I wake up that takes a few minutes to go away, blurred vision, reduced sex drive, horrible he

Fatigue was the biggest problem while taking Metoprolol. It was so bad that when I would come home from work I had to go straight to bed.I also had severe joint pains associated with this medication. I have since changed to Toprol XL, which has made

i had heart failure last august 2010, among other tablets i have been taking emconcor. i wonder whether these tablets are responsible for making my limbs feel weak, and lightheaded.

&lt;b&gt;Describe Your Tazocin Experience Here:&lt;/b&gt;after it was administered to my farther in hospital for the first time on day he was due to be released he had a cardiac arrest with multiple organ failure and subsequently died

had my first shot of aranesp one week ago for anemia , i have renal failure, I'm 62 , and I am a working nurse. I will be getting aranesp every 2 weeks if my blood count is less than 11. well out of no where I have becom

2 weeks after second infusion for Hodgkin's Lymphome (&amp; RA), I had an extreme respiratory problem (BOOP). I was hospitalized twice &amp; had high steroid does IV along with IV antiobiotics administered. After 1 year of decreasing steroi

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A report-I had a suppression dose of Macrobid; after 8 months much worse and after a year in fulminant hepatic failure leading to a transplant. How can these changes be spotted for women like me.

AGGRENOX SIDE EFFECT. PATIENT WAS PRESCRIBED PLAVIX. AGGRENOX WAS SUBSTITUTED. PATIENT SUFFERED ACUTE RESPIRATORY FAILURE AND CARDIO-RESPIRATORY ARREST. PATIENT WAS HOSPITALIZED. PATIENT DIED 3/29/09.

An injection of toradol in hattiesburg Forrest general Hospital resulted in complete Kidney failure with 5 days in hospital. medical records are available if proof is needed. recovered

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RESPIRATORY FAILURE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Comparative Effects of Nebivolol and Metoprolol on Femal Sexual Function
Conditions: Hypertension;   Female Sexual Dysfunction
Interventions: Drug: nebivolol and Metoprolol succinate;   Drug: Metoprolol succinate and nebivolol
Outcome Measures: Change in FSF and CSFQ, two validated questionnaires for assessment of sexual function.;   The effects of nebivolol and Metoprolol on sexual function and to compare the effects of both drugs on vitality, work and life performance, and work and life satisfaction.
2 Recruiting Influence of CPB and Mini CPB to the Absorption of the Metoprolol
Condition: Drug Absorption
Intervention: Drug: blood concentration of Metoprolol
Outcome Measures: absorbtion of the Metoprolol;   atrial fibrillation
3 Not yet recruiting A Crossover Study to Evaluate the Effect of JNJ-54452840 on Pharmacodynamics of Metoprolol Tartrate Immediate-Release in Healthy Participants
Condition: Healthy
Interventions: Drug: Metoprolol tartrate immediate-release (Metoprolol IR);   Drug: JNJ-54452840;   Drug: Placebo
Outcome Measures: Exercise Heart Rate;   Exercise Blood Pressure
4 Recruiting Randomized Trial Comparing Diltiazem and Metoprolol For Atrial Fibrillation Rate Control
Conditions: Atrial Fibrillation;   Atrial Flutter
Interventions: Drug: Metoprolol;   Drug: Diltiazem
Outcome Measures: Conversion to sinus rhythm;   Heart rate control;   Home discharges from Emergency Department (ED);   Total hospital cost;   Rehospitalization for Atrial Fibrillation
5 Not yet recruiting Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects
Condition: Vasovagal Syncope
Interventions: Drug: Metoprolol;   Drug: Matching Placebo
Outcome Measures: The primary outcome measure will be the proportion of patients having at least one syncope recurrence.;   A secondary outcome will be the time between the first and second syncope recurrences.;   A secondary outcome will be the frequency of syncopal spells.;   A secondary outcome is the number, duration, and severity of presyncopal spells (as measured with the Calgary Presyncope Scale);   A secondary outcomes will be quality of life as measured by the EQ-5D and the ISQL.
6 Not yet recruiting Comparison of Efficacy of Ivabradine Versus Metoprolol
Condition: Coronary Artery Disease
Intervention: Drug: Ivabradine and Metoprolol
Outcome Measures: Heart rate of patient before CT coronary;   safety and side effect of Metoprolol and Ivabradine
7 Recruiting Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart Failure
Conditions: Atrial Fibrillation;   Atrial Flutter
Interventions: Drug: bucindolol hydrochloride;   Drug: Metoprolol succinate
Outcome Measures: Time to first event of symptomatic atrial fibrillation/atrial flutter (AF/AFL) or all cause mortality (ACM) during the 24-week Follow-up Period after conversion to stable sinus rhythm (SR);   Time to first event of AF/AFL (i.e., symptomatic or asymptomatic) or ACM during the 24-week Follow-up Period;   Proportion of patients during the 24-week Follow-up Period with ventricular tachycardia (VT), ventricular fibrillation (VF), or symptomatic supraventricular tachycardia (SVT);   Total number of hospitalization (all-cause) days per patient during the Total Study Period;   Time to first event of ACM or heart failure (HF) hospitalization (as assessed by the Investigator) during the Total Study Period;   Proportion of patients who have AF on ECG at the end of the study who demonstrate ventricular response rate (VRR) control
8 Recruiting A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement
Condition: Myocardial Ischemia
Interventions: Drug: Metoprolol;   Drug: Esmolol;   Drug: Placebo
Outcome Measures: Our objective is to clarify if Metoprolol, in a dose range used for perioperative cardiac protection, decreases anesthetic requirement.;   Administration of esmolol, a short-acting beta-receptor antagonist, might reduce the actual anesthetic requirement.
9 Recruiting Metoprolol Succinate in Cardiac Remodeling Related to Cirrhosis
Conditions: Cirrhosis;   Cirrhotic Cardiomyopathy;   Cardiac Remodeling
Interventions: Drug: Metoprolol succinate;   Drug: placebo
Outcome Measures: Improvement of systolic function;   Improvement in left ventricular diastolic function;   Renal function;   Serum level of BNP, catecholamines, plasmatic renin activity;   Mortality;   Quality of life;   Electrophysiologic modifications
10 Unknown  Metoprolol and Formoterol in Chronic Obstructive Pulmonary Disease (COPD)
Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention: Drug: Metoprolol
Outcome Measures: Difference in airway reactivity after treatment with Metoprolol compared to placebo.;   Effect of formoterol on airway reactivity comparing Metoprolol with placebo.;   Borg-scores during provocation test;   Peak-flow measurements;   CCQ-scores;   Exacerbation rate and rescue medication use
11 Recruiting Sarpogrelate Drug Interaction
Conditions: Hypertension;   Peripheral Artery Disease
Interventions: Drug: Sarpogrelate pretreatment;   Drug: Sarpogrelate;   Drug: Metoprolol
Outcome Measures: Plasma concentration of Metoprolol and metabolites;   Blood pressure and pulse rate changes
12 Recruiting Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure
Conditions: Peripheral Artery Disease;   Hypertension
Interventions: Drug: nebivolol;   Drug: Metoprolol succinate
Outcome Measures: Peak Walking Time;   Walking Impairment Questionnaire;   Ankle-brachial index;   markers of inflammation.;   Claudication Onset Time
13 Recruiting Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
Condition: Hypertension
Interventions: Drug: Metoprolol succinate;   Drug: Nebivolol;   Drug: Hydrochlorothiazide;   Drug: DEFINITY®;   Procedure: Non-invasive measurement of Cardiac Output (CO);   Procedure: Flow mediated vasodilation;   Procedure: Endothelial cell collection;   Procedure: Microvascular perfusion assessment using Definity
Outcome Measures: Endothelial cell protein expression;   Microvascular blood flow;   Flow mediated dilation (FMD)
14 Recruiting PREvention of Atrial Fibrillation in patientS Undergoing thorAcic surGEry for Lung Cancer
Conditions: Lung Cancer;   Atrial Fibrillation
Interventions: Drug: Metoprolol;   Drug: Losartan
Outcome Measures: Incidence of postoperative atrial fibrillation;   Evaluation of NT-proBNP in the days following the start of treatment and post surgery duration of hospital stay
15 Unknown  Combined Antihypertensive Therapy and Sexual Dysfunction
Conditions: Hypertension;   Sexual Dysfunction
Interventions: Drug: Felodipine add Irbesartan;   Drug: Felodipine add Metoprolol
Outcome Measures: Female Sexual Function Index (FSFI);   International Index of Erectile Function(IIEF);   Change of Systolic Blood Pressure in 2 Weeks;   Change of Systolic Blood Pressure in 4 Weeks;   Change of Systolic Blood Pressure in 8 Weeks;   Change of Systolic Blood Pressure in 12 Weeks;   Change of Systolic Blood Pressure in 24 Weeks;   Change of Systolic Blood Pressure in 48 Weeks;   Change of Diastolic Blood Pressure in 2 Weeks;   Change of Diastolic Blood Pressure in 4 Weeks;   Change of Diastolic Blood Pressure in 8 Weeks;   Change of Diastolic Blood Pressure in 12 Weeks;   Change of Diastolic Blood Pressure in 24 Weeks;   Change of Diastolic Blood Pressure in 48 Weeks;   Serum Estradiol in 24 Weeks;   Serum Estradiol in 48 Weeks;   Serum Testosterone in 24 Weeks;   Serum Testosterone in 48 Weeks;   Serum MDA in 24 Weeks;   Serum MDA in 48 Weeks;   Serum 8-OHdG in 24 Weeks;   Serum 8-OHdG in 48 Weeks;   Serum HNE in 24 Weeks;   Serum HNE in 48 Weeks
16 Unknown  Coreg CR, Blood Vessel Stiffness and Blood Vessel Function
Conditions: Endothelial Function;   Diabetes Mellitus;   Hypertension
Interventions: Drug: carvedilol;   Drug: Metoprolol extended release
Outcome Measure: Effect of Coreg CR compared to Toprol XL on endothelial function, vascular compliance, and parameters of oxidative stress from time of randomization to study drug termination
17 Recruiting A Phase Ⅲ Study of Extended-Release Carvedilol Sulfate for the Treatment of Heart Failure
Condition: Heart Failure
Interventions: Drug: Extended-Release Carvedilol Sulfate;   Drug: Sustained-release Metoprolol Succinate
Outcome Measures: Change From Baseline in left ventricular ejection fraction(LVEF) by ultrasound cardiogram;   Change From Baseline in Left Ventricular End Systolic Volume Index;   Change From Baseline in Left Ventricular End Diastolic Volume Index;   Incidence of Hospitalizations From Exacerbation of Heart Failure;   Incidence of Hospitalizations From All Causes;   Incidence of Deaths From All Causes;   Change From Baseline in New York Heart Association(NYHA)classification
18 Unknown  Beta-Blocker Before Extubation
Condition: Myocardial Ischemia
Intervention: Drug: Metoprolol
Outcome Measures: The rate of ischemia as judged by ST segment analysis in the 4h following extubation;   Rate-pressure product following extubation;   Troponin T elevations, the incidence of cardiogenic edema, and the rate of reintubation;   Pro-BNP levels
19 Recruiting Nebivolol Versus Sustained Release Metoprolol Succinate in Patients With Chronic Kidney Disease
Condition: Chronic Kidney Disease
Intervention:
Outcome Measures: Primary Efficacy;   Secondary Efficacy
20 Unknown  Nebivolol and the Endothelin (ET)-1 System
Conditions: Prehypertension;   Hypertension
Interventions: Drug: Nebivolol;   Drug: Metoprolol;   Drug: Placebo
Outcome Measure: ET-1-mediated vasoconstrictor tone