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RESTLESSNESS and Adderall

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RESTLESSNESS Symptoms and Causes

For most adults, moderate alcohol use is probably not harmful. However, about 18 million adult Americans have an alcohol use disorder (AUD). This means that their drinking causes distress and harm. It includes alcoholism and alcohol abuse.

Alcoholism, or alcohol dependence, is a disease that causes

  • Craving - a strong need to drink
  • Loss of control - not being able to stop drinking once you've started
  • Physical dependence - withdrawal symptoms
  • Tolerance - the need to drink more alcohol to feel the same effect

With alcohol abuse, you are not physically dependent, but you still have a serious problem. The drinking may cause problems at home, work, or school. It may cause you to put yourself in dangerous situations, or lead to legal or social problems.

Another common problem is binge drinking. It is drinking about five or more drinks in two hours for men. For women, it is about four or more drinks in two hours.

Too much alcohol is dangerous. Heavy drinking can increase the risk of certain cancers. It can cause damage to the liver, brain, and other organs. Drinking during pregnancy can harm your baby. Alcohol also increases the risk of death from car crashes, injuries, homicide, and suicide.

You may have an AUD if you can answer yes to two or more of these questions:

In the past year, have you

  • Ended up drinking more or for a longer time than you had planned to?
  • Wanted to cut down or stop drinking, or tried to, but couldn't?
  • Spent a lot of your time drinking, or recovering from drinking?
  • Felt a strong need to drink?
  • Found that drinking - or being sick from drinking - often interfered with your family life, job, or school?
  • Kept drinking even though it was causing trouble with your family or friends?
  • Given up or cut back on activities that you enjoyed just so you could drink?
  • Gotten into dangerous situations while drinking or after drinking? Some examples are driving drunk and having unsafe sex.
  • Kept drinking even though it was making you feel depressed or anxious? Or when it was adding to another health problem?
  • Had to drink more and more to feel the effects of the alcohol?
  • Had withdrawal symptoms when the alcohol was wearing off? They include trouble sleeping, shakiness, irritability, anxiety, depression, Restlessness, nausea, and sweating. In severe cases, you could have a fever, seizures, or hallucinations.

If you have any of these symptoms, your drinking may already be a cause for concern. The more symptoms you have, the more serious the problem is. If you think you might have an AUD, see your health care provider for an evaluation. Your provider can help make a treatment plan, prescribe medicines, and if needed, give you treatment referrals.

NIH: National Institute on Alcohol Abuse and Alcoholism

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RESTLESSNESS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Adderall XR and Processing Speed in Multiple Sclerosis (MS)
Conditions: Impaired Processing Speed;   Cognitive Impairment;   Multiple Sclerosis
Interventions: Drug: Adderall XR 5mg;   Drug: Adderall XR 10 mg;   Drug: Placebo
Outcome Measures: Change in score of Paced Auditory Serial Addition Test (PASAT);   Change in Score of Symbol Digit Modalities Test (SDMT);   Change in Score of Stroop Colour Word Test;   Blood Pressure;   Heart Rate
2 Recruiting Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
Condition: Cocaine Dependence
Interventions: Drug: Adderall-ER;   Drug: Topiramate;   Other: Placebo
Outcome Measures: Three weeks of Cocaine abstinence;   Proportion of negative urine samples
3 Recruiting Stimulant Enhancement of Well-Being Therapy for Depression
Condition: Major Depressive Disorder
Interventions: Drug: Amphetamine-dextroamphetamine (AMPH);   Drug: Placebo;   Behavioral: Well-being therapy
Outcome Measures: Change in Hamilton-Depression Rating Scale(SIGH-D)-17 items;   Change in Hamilton-Depression Rating Scale(SIGH-D)-31 item;   Change in Psychological Well-being Scale (PWB);   Change in the Snaith-Hamilton Pleasure Scale (SHAPS);   Change in Behavioral inhibition/activation scale (BIS/BAS);   Change in Positive and Negative Affective Scale (PANAS);   Change in functioning on Short Form-12(SF-12)
4 Recruiting Follow up Treatment of Children With Attention Deficit Hyperactivity Disorder (ADHD)
Condition: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: Behavioral: Academic and Organization skills;   Behavioral: Parent Training;   Behavioral: Social Skills Training;   Drug: Long-acting stimulant
Outcome Measures: Attention Deficit Hyperactivity Disorder (ADHD) symptomatology (measured via Conners' Global Index - Parent and Teacher Version);   Social skills (measured via Parent and Teacher Social Skills Rating Scale);   Academic achievement (measured via Wechsler Individual Achievement Test (WIAT));   Emotional and symptomatic functioning (measured via the Achenbach Child Behavior Check List (CBCL));   Overall functioning (measured via the Weiss Functional Impairment Scale (WFIRS));   Overall functioning (measured via the Clinical Global Impression Scale (CGI))
5 Recruiting Adjunctive Mixed Salts Amphetamine (MSA) for Depressed Adults With Incomplete Response to Current Antidepressant Therapy (ADT)
Condition: Major Depressive Disorder
Intervention: Drug: mixed salts amphetamine
Outcome Measures: Change in scores on the Massachusetts General Hospital Cognitive and Physical Functioning Questionaire;   Change in scores on the Montgomery Asberg Depression Rating Scale;   Change in scores on the Quick Inventory of Depressive Symptomatology Self Report 16
6 Recruiting Omega-3 Fatty Acid Supplementation to ADHD Pharmacotherapy in ADHD Adults With Deficient Emotional Self-Regulation Traits
Conditions: Attention Deficit Hyperactivity Disorder (ADHD);   Deficient Emotional Self-Regulation (DESR)
Interventions: Drug: ADHD Medication;   Drug: Omega-3 Fatty Acids
Outcome Measures: Efficacy assessed by mean change from baseline to endpoint on the BRIEF-A Emotional Control scale;   Efficacy measured by mean change from baseline to endpoint on AISRS total score;   Efficacy measured by mean change from baseline to endpoint on CGI;   Efficacy measured by mean change from baseline to endpoint on BRIEF-A subscales;   Efficacy measured by mean change from baseline to endpoint on GAF
7 Recruiting Interventions for Children With Attention and Reading Disorders
Conditions: Attention Deficit Hyperactivity Disorder;   Reading Disabilities
Interventions: Drug: Methylphenidate;   Behavioral: Intensive reading instruction;   Behavioral: Parent Training;   Drug: Mixed Salt Amphetamine;   Drug: Atomoxetine;   Drug: Guanfacine
Outcome Measures: Wechsler Individual Achievement Test of Word Reading and Pseudoword Decoding;   Swanson, Nolan, and Pelham checklist for DSM-IV;   Stop-Signal Test;   Test of Word Reading Efficiency;   Wechsler Individual Achievement Test of Reading Comprehension;   Dynamic Indicators of Basic Early Literacy Skills Oral Reading Fluency
8 Not yet recruiting A Sequenced Behavioral and Medication Intervention for Cocaine Dependence
Condition: Cocaine Dependence
Interventions: Behavioral: Computer-assisted behavior therapy;   Drug: Mixed amphetamine salts;   Drug: Computer-assisted therapy plus placebo (for mixed amphetamine salts)
Outcome Measures: Three weeks of cocaine abstinence;   Proportion of cocaine positive urines
9 Recruiting Efficacy of Intuniv Extended Release as Adjunctive Therapy With Psycho-stimulant on Executive Function in Children With ADHD
Condition: Attention Deficit Hyperactivity Disorder
Interventions: Drug: Guanfacine extended release;   Drug: Placebo
Outcome Measures: To evaluate the effect of adjunctive INTUNIV extended release treatment on executive function as assessed by the BRIEF-parent questionnaires;   To evaluate the effect of adjunctive INTUNIV extended release treatment on quality of life as assessed by the KINDL®-child and KINDL®-parent questionnaires.;   To examine the congruency of the perceived effect of treatment on EF and quality of life from the perspective of the subject, parent, and teacher.;   To evaluate the effect of adjunct therapy on ADHD symptom control as assessed by the ADHD Rating Scale (ADHD-RS-IV) and Clinical Global Impression (CGI) of Severity (CGI-S) and of Improvement (CGI-I) questionnaires.;   To compare the percentage of subjects experiencing suicidal ideation, suicidal behaviour and self-injurious behaviour without suicidal intent and incident of Serious Adverse Events in each treatment arm
10 Recruiting IMPAACT P1080: Psychiatric and Antiretroviral Medication Concentrations in HIV-infected and Uninfected Children and Adolescents
Conditions: ADHD;   HIV
Intervention:
Outcome Measure: Estimation of steady-state oral clearance (Cl/F) for each psychiatric study medication is the primary outcome.