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RESTLESSNESS and Gabapentin

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RESTLESSNESS Symptoms and Causes

For most adults, moderate alcohol use is probably not harmful. However, about 18 million adult Americans have an alcohol use disorder (AUD). This means that their drinking causes distress and harm. It includes alcoholism and alcohol abuse.

Alcoholism, or alcohol dependence, is a disease that causes

  • Craving - a strong need to drink
  • Loss of control - not being able to stop drinking once you've started
  • Physical dependence - withdrawal symptoms
  • Tolerance - the need to drink more alcohol to feel the same effect

With alcohol abuse, you are not physically dependent, but you still have a serious problem. The drinking may cause problems at home, work, or school. It may cause you to put yourself in dangerous situations, or lead to legal or social problems.

Another common problem is binge drinking. It is drinking about five or more drinks in two hours for men. For women, it is about four or more drinks in two hours.

Too much alcohol is dangerous. Heavy drinking can increase the risk of certain cancers. It can cause damage to the liver, brain, and other organs. Drinking during pregnancy can harm your baby. Alcohol also increases the risk of death from car crashes, injuries, homicide, and suicide.

You may have an AUD if you can answer yes to two or more of these questions:

In the past year, have you

  • Ended up drinking more or for a longer time than you had planned to?
  • Wanted to cut down or stop drinking, or tried to, but couldn't?
  • Spent a lot of your time drinking, or recovering from drinking?
  • Felt a strong need to drink?
  • Found that drinking - or being sick from drinking - often interfered with your family life, job, or school?
  • Kept drinking even though it was causing trouble with your family or friends?
  • Given up or cut back on activities that you enjoyed just so you could drink?
  • Gotten into dangerous situations while drinking or after drinking? Some examples are driving drunk and having unsafe sex.
  • Kept drinking even though it was making you feel depressed or anxious? Or when it was adding to another health problem?
  • Had to drink more and more to feel the effects of the alcohol?
  • Had withdrawal symptoms when the alcohol was wearing off? They include trouble sleeping, shakiness, irritability, anxiety, depression, Restlessness, nausea, and sweating. In severe cases, you could have a fever, seizures, or hallucinations.

If you have any of these symptoms, your drinking may already be a cause for concern. The more symptoms you have, the more serious the problem is. If you think you might have an AUD, see your health care provider for an evaluation. Your provider can help make a treatment plan, prescribe medicines, and if needed, give you treatment referrals.

NIH: National Institute on Alcohol Abuse and Alcoholism

Check out the latest treatments for RESTLESSNESS

RESTLESSNESS treatment research studies

Gabapentin clinical trials, surveys and public health registries


Find Drug Side Effect reports



Gabapentin Side Effects

Completed Suicide (332)
Dizziness (329)
Somnolence (306)
Pain (288)
Headache (282)
Confusional State (265)
Nausea (256)
Off Label Use (227)
Tremor (223)
Fatigue (221)
Depression (214)
Fall (195)
Convulsion (184)
Feeling Abnormal (183)
Toxicity To Various Agents (176)
Suicidal Ideation (171)
Malaise (171)
Respiratory Arrest (163)
Cardiac Arrest (145)
Condition Aggravated (144)
Dyspnoea (113)
Pain In Extremity (112)
Myoclonus (108)
Anxiety (108)
Asthenia (107)
Amnesia (104)
Diarrhoea (102)
Insomnia (97)
Vision Blurred (90)
Gait Disturbance (85)
Vomiting (84)
Death (84)
Oedema Peripheral (83)
Disorientation (82)
Back Pain (80)
Rash (80)
Weight Increased (79)
Agitation (78)
Paraesthesia (74)
Memory Impairment (73)
Dyskinesia (73)
Abdominal Pain (73)
Hallucination (72)
Muscular Weakness (71)
Sedation (71)
Myalgia (70)
Loss Of Consciousness (70)
Renal Failure Acute (69)
Hypoaesthesia (66)
Muscle Spasms (66)

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Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Be careful! Avoid Gabapentin at all costs! My mother's doctor ordered a 900 mg/day dose. In the 2 years she was under this dose, she fell 5 times! No doctor 'suspected' this drug! Then, he increased the dose to...1800 mg/day! I almost lost her! I am

Dose Gabapantin have any ting to do with the nearves in your body

For the last two weeks I have been taking a lowish dose of Gabapentin for night-time nerve pain (100gm three times a day and then 200mg at night.) It has worked brilliantly for the pain and I was ecstatic BUT I have now wet the bed two nights in a r

GABAPENTIN noticed that medication got worsen n Nurgloist n don't listin. My problem n even rash n stomach ach n was getting stress out n decided go different doctor n was. Going take that chance with my n stop going to Nurgloist n been two.n bo

Great so far for my anxiety... just side effects has ... sexually saticfied,nausea little bit.. dizzynezz! lolz.. but great medication/ i think..

Having racing thoughts and unmotivated *DONT_KNOW*

Hear voices

Hello, I've been taking a cocktail of meds for 9 years to help treat acute nerve pain from a severe Brachial Plexus nerve avulsion C 7, 8, T1 and Spinal cord injury. Medications: Gabapentin 3600 mg., Methadone 100 mg. , Baclofen 20 mg. every 8 hour

I am having trouble falling to sleep, and I feel like I' having anxiety attacks I stopped the 400 Mg and I am taking 2 100 MGS now. I am doing this on my own , until I see my Dr next week. .

I am just starting Gabapentin to help with phantom pain from a BKA (below-knee-amputation). I am taking 600 mg and am scheduled to increase to 900 mg, then review results with my doctors. One of the side effects I seem to have is

I am Aged 46, and have been On Kliovance for 6 weeks, have gained weight, bloated stomach, extreme tiredness,aching bones, restlessness...,edgy...The sweats have gone but thats all.I find there is not enough relevant information for women f

.Skin burning, restlessness, restlessness of arms and legs, Diarrohea.

16, ADHD, hate my dependency on adderall, depression, random euphoria, aggression, slight tics, restlessness, irritability, antisocial, anger, all day the only thing i'm able to think about is the list of shit that needs to get done and if it's a lon

2 patients given thiocolchicoside reported of muscular stiffness,uneasiness,insomnia,breathlessness and feeling of restlessness, 2 out of 5 patients have reported such experiences after consuming thiocolchicoside.i strongly recommend to withdraw this

After taking Ganatone 50 I sufferpain in abdomen, chest discomfort and some restlessness in the body.

Day 1: Smoked as per usual, VERY difficult to fall asleep d/t pruritis, RLS, as well as geralized restlessness Day 2 : Smoking decreased by half. Did not get much pleasure from it...nor anything else. Felt like a complete zombie,

Ever since i stated taking Gycopyrrolate 2mg i stated to haves restlessness, itchy eyes, congestion, awful imsomina.

First two months were fine but I have noticed recently after a day or two of not taking them that I have severe restlesnness in my legs and twitching, tingling feelings running up and down my legs at night. Insomnia when taking them. The restlessness

Had cortisone injections in both shoulders one week ago. Within 24 hours was experiencing more severe pain in shoulders, insomnia and headaches. Within 3 days above symptoms continuing also bloating, nausea, anxiety, restlessness,

Hi, i am diagnosed with anxiety and deppresion, i have been taking molipaxin for 4 month now and i have sleepless nights, blurred vision, restlessness and i am very hyper active. was on c lifts and could not cope as i felt druged permanatly and dizyy

RESTLESSNESS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Vasculaire Leg Compression Device for the Treatment of Restless Legs Syndrome - A Prospective Clinical Study
Conditions: Restless Legs Syndrome,;   Restless Legs,;   Ekbom Syndrome
Intervention: Device: Venous Health Systems Vasculaire Leg Compression Device
Outcome Measures: The Restless Legs Syndrome Rating Scale;   The Restless Legs Syndrome-Quality of Life Instrument (RLS-QLI);   The Epworth Sleepiness Scale (ESS);   The Johns Hopkins Restless Legs Severity Scale (JHRLS);   The International Restless Legs Syndrome Rating Scale
2 Not yet recruiting Ketamine Versus Haloperidol for Severe Agitation Outside the Hospital
Condition: Agitation
Interventions: Drug: Ketamine;   Drug: Haloperidol
Outcome Measures: Time from injection of drug to adequate sedation, defined as a score of 0 or less on the AMSS.;   Number of participants intubated.;   venous pH;   serum potassium;   Total time the participant is a patient in the Emergency Department.;   Number of patients admitted versus number of patients discharged.;   venous lactate;   Number of patients experiencing laryngospasm.;   Number of patients experiencing dystonia.
3 Not yet recruiting Effect of Deksmedetomidine and Remifentanil in Extubation Agitation
Condition: Agitation
Interventions: Drug: deksmedetomidine;   Drug: Remifentanil;   Drug: Saline
Outcome Measures: To asses postoperative agitation score by Riker sedation agitation scale;   Yo asses postoperative side effects emesis, vomitting or pain
4 Unknown  Pre-hospital Agitation and Sedation Trial: A Randomized Controlled Trial of Haloperidol Versus Midazolam for the Sedation of the Agitated Patient
Condition: Agitation
Interventions: Drug: Haloperidol;   Drug: Midazolam
Outcome Measure: Time to sedation
5 Recruiting Loxapine in the Management of Restlessness During Mechanical Ventilation Weaning
Condition: Restlessness
Interventions: Drug: loxapine;   Drug: Placebo
Outcome Measures: Weaning period;   total duration of mechanical ventilation;   incidence of unexpected extubations;   clinical and biological respiratory parameters;   incidence of mechanical ventilation related complications;   incidence of adverse events, related and non related to the treatment;   mortality rate;   factors associated to weaning failure
6 Recruiting Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency Department
Conditions: Agitation;   Excited Delirium;   Pain
Intervention:
Outcome Measures: Change in Altered Mental Status Score;   Change in Visual Analog Scale Pain Score;   Change in Serum Total Catecholamines;   Length of Hospital Stay;   Mortality;   Complications;   Change in Heart Rate;   Change in Systolic Blood Pressure;   Change in Mean Arterial Pressure;   Disposition;   Change in Body Temperature;   Change in end tidal carbon dioxide;   Change in Oxygen Saturation
7 Recruiting Reducing Agitation in People With Dementia: the Customized Activity Trial
Condition: Dementia
Interventions: Behavioral: Tailored Activity Program;   Other: Home Safety and Education Program
Outcome Measures: Frequency of Agitated Behavior in person with dementia;   Frequency of agitated behaviors and quality of life in person with dementia;   Caregiver wellbeing and time spent providing care;   Cost effectiveness
8 Unknown  The Effect of Intramuscular Dexmedetomidine on Emergence Agitation in Children Undergoing With or Without Tube Insertion Under General Anesthesia
Condition: Myringotomy
Intervention: Drug: Dexmedetomidine
Outcome Measures: Participant's Severity of Emergent Agitation (EA) using the Pediatric Anesthesia Emergence Delirium (PAED) scale in PACU (Post-Op Area).;   Participant's Severity of Emergent Agitation (EA) in PACU (Post-Op Area) through Day 3 Post-Op using the Postanesthesia Discharge Scoring System (PADSS) score.;   Participant's Severity of Emergent Agitation (EA) in PACU (Post-Op Area) through Day 3 Post-Op using the PADSS score.
9 Recruiting Blinded, Randomized Study of Gabapentin (Neurontin®) and Gabapentin Enacarbil (Horizant™) in Restless Leg Syndrome
Condition: Restless Leg Syndrome
Interventions: Drug: Gabapentin immediate release (Neurontin);   Drug: Gabapentin enacarbil extended release (Horizant)
Outcome Measures: International Restless Leg Syndrome Rating Scale (IRLS);   Restless Leg Syndrome Quality of Life Scale (RLSQoL)
10 Recruiting Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
Conditions: Agitation Associated With;   Alzheimer's Disease;   Alzheimer's Type;   Mental Disorder;   Nervous System Diseases
Intervention: Drug: Brexpiprazole, OPC-34712
Outcome Measures: Change in the Cohen-Mansfield Agitation Inventory (CMAI) total score;   Change in the Clinical Global Impression Severity of Illness (CGI-S) score, as related to symptoms of agitation
11 Recruiting A Study of Three Fixed-doses of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
Conditions: Agitation Associated With;   Alzheimer's Disease;   Alzheimer's Type;   Mental Disorder;   Nervous System Diseases
Intervention: Drug: Brexpiprazole, OPC-34712
Outcome Measures: The primary outcome is the change in the Cohen-Mansfield Agitation Inventory (CMAI) total score;   The secondary outcome is the change in the Clinical Global Impression-Severity of Illness (CGI-S) score, as related to symptoms of agitation
12 Unknown  Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy
Conditions: Restless Leg Syndrome;   Iron Deficiency Anemia
Intervention: Drug: ferric carboxymaltose
Outcome Measures: Primary endpoint: = 50% reduction of RLS symptoms as measured by International Restless Legs Study Group (IRLSS);   Reduction of Periodic Limb Movements in Sleep (PLMS) ≥50% as measured with actimetry;   Improvement of sleep according to the Pittsburgh Sleep Quality Questionnaire (PSQI);   Improvement of sleepiness using Epworth Sleepiness Scale (ESS);   Improvement of fatigue using Fatigue Severity Scale (FSS);   Safety of ferric carboxymaltose during pregnancy in the 3rd trimester;   Parameters of the newborn baby (apgar, umbilical artery pH, weight, mode of delivery)
13 Unknown  Treatment Routes for Exploring Agitation
Conditions: Dementia;   Behavior Problems
Interventions: Behavioral: TREA (Treatment Routes for Exploring Agitation);   Behavioral: Placebo Control Group
Outcome Measures: Agitation Behavior Mapping Instrument (ABMI);   affect/mood measured by Lawton's behavior stream assessment
14 Recruiting Dexmedetomidine to Prevent Agitation After Free Flap Surgery
Conditions: Agitation;   Delirium
Interventions: Drug: Dexmedetomidine;   Drug: Saline placebo
Outcome Measures: agitation in PACU;   postoperative delirium
15 Recruiting Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia?
Conditions: Emergence Agitation;   Pain
Intervention: Drug: Acetaminophen
Outcome Measures: Emergence Agitation;   Pain
16 Recruiting Restless Leg Syndrome and Severe Preeclampsia
Conditions: Restless Leg Syndrome;   Severe Preeclampsia
Intervention:
Outcome Measure: Restless Leg Syndrome
17 Unknown  Neuroma Injections to Treat Restless Legs Syndrome - RCT
Condition: Restless Legs Syndrome
Interventions: Drug: equal parts of 0.5% plain Marcaine and 2% lidocaine mixed with 0.8 mg Depo-medrol/4% absolute alcohol in a total injection volume of 1 ml;   Drug: Normal saline - 1ml
Outcome Measure: International Restless Legs Rating Scale
18 Recruiting Investigation of Efficacy of incobotulinumtoxinA (Xeomin) in Relieving Symptoms of Restless Leg Syndrome.
Condition: Restless Leg Syndrome
Interventions: Drug: incobotulinumtoxinA;   Drug: Placebo
Outcome Measures: Restless Leg Syndrome Rating Scale;   Epworth Sleep Scale
19 Recruiting Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome
Conditions: Iron Deficiency;   Restless Leg Syndrome
Interventions: Dietary Supplement: Probiotics;   Dietary Supplement: Placebo
Outcome Measures: Change in Ferritin and CRP Levels;   Restless Leg Questionnaire
20 Unknown  IM Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia
Conditions: Schizophrenia;   Schizoaffective Disorder;   Agitation
Interventions: Drug: IM olanzapine;   Drug: haloperidol plus lorazepam IM
Outcome Measures: Positive and Negative Symptom Scale Excited Component (PANSS-EC);   Agitation-Calmness Evaluation Scale (ACES)