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RHEUMATOID ARTHRITIS and Simvastatin

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RHEUMATOID ARTHRITIS Symptoms and Causes

Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. It can affect any joint but is common in the wrist and fingers.

More women than men get rheumatoid arthritis. It often starts in middle age and is most common in older people. You might have the disease for only a short time, or symptoms might come and go. The severe form can last a lifetime.

Rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. RA can affect body parts besides joints, such as your eyes, mouth and lungs. RA is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues.

No one knows what causes rheumatoid arthritis. Genes, environment, and hormones might contribute. Treatments include medicine, lifestyle changes, and surgery. These can slow or stop joint damage and reduce pain and swelling.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Check out the latest treatments for RHEUMATOID ARTHRITIS

RHEUMATOID ARTHRITIS treatment research studies

Simvastatin clinical trials, surveys and public health registries


Find Drug Side Effect reports



Simvastatin Side Effects

Rhabdomyolysis (1169)
Myalgia (1039)
Renal Failure Acute (504)
Fatigue (491)
Blood Creatine Phosphokinase Increased (489)
Pain In Extremity (449)
Muscular Weakness (445)
Asthenia (394)
Arthralgia (375)
Muscle Spasms (346)
Pain (328)
Dyspnoea (311)
Dizziness (304)
Nausea (281)
Fall (261)
Diarrhoea (257)
Gait Disturbance (243)
Alanine Aminotransferase Increased (241)
Headache (240)
Myositis (238)
Malaise (187)
Myopathy (180)
Back Pain (166)
Amnesia (163)
Vomiting (160)
Insomnia (157)
Depression (156)
Rash (154)
Aspartate Aminotransferase Increased (152)
Renal Failure (143)
Liver Function Test Abnormal (141)
Abdominal Pain (140)
Chest Pain (134)
Blood Creatinine Increased (133)
Confusional State (130)
Paraesthesia (126)
Hypoaesthesia (126)
Feeling Abnormal (123)
Memory Impairment (122)
Anxiety (117)
Myocardial Infarction (112)
Weight Decreased (111)
Pruritus (107)
Cough (107)
Condition Aggravated (106)
Cerebrovascular Accident (104)
Tendon Rupture (103)
Hepatic Enzyme Increased (101)
Mobility Decreased (98)
Abasia (98)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

<span style='color: #808080;'>Took Diprophos for rheumatoid arthritis. Side effects: insomnia for 2 nights, perspiring during night, redness in face. Increased need to urinate.

I been on simastatin 20gms for 4 yrs. I remember I did had a rash last Aug 09 and it was realy itch. After 2 wks of suffering. I finally made Appt. with my Dr.. They schelule me for the following week. The day I planed t

:(vvery dissy imsoniac light headness.................. =-O

A few months ago my doctor prescribed 40mg simvastatin to take one before bedtime ,and he never told me anything about the side efect of thid drug,I have started feeling some muscle pain and abdomnel paint that was later on after I started taking the

Blurred vision, like I was looking through water around the outside of my eyes, then very dizz, faint but not fainting--this has happened twice, I was shaky and weak after--it was frightening.....

Dear one and all, i am a 20yrs married girl, in India I am not well educated so please dont mind if i wrote any mistakes in English. is it possible if my husband having the rheumatoid artritis then it goes to my baby( now i am 8 th month Preg

Extreme muscle pain in legs, shoulders, neck and back. already had fibromyalgia and this was worse than any pain had previous to taking simvastatin. I was on it a yr. I had chonic insomnia, chest pain like pneumonia, so tired couldn't hardly move. co

Hair loss

Has anyone taking this medication after a year,expierenced headaches?

Have been on Zocor for almost 10 years with no problems but 6 months ago started getting rash on my left side which seems to be less annoying with good skin lotion. I also take some vitamin pills that have 1000% niacin(for building good HDL) and Niac

Arthritis Treatment Safe, Natural Cure for Adults. Synflex Liquid Glucosamine, Rheumatoid Arthritis Joint Pain Relief Remedy, Diet Supplements. Synflex, Glucosamine for Dogs. Free Shipping! &lt;a href='http://www.healthyjointcare.com/'&g

&lt;!--StartFragment--&gt; I have advanced Rheumatoid Arthritis. My Left wrist swelled painfully. Had a negative X-ray so Dr (fully informed for current drug regimens and allergies--Aspirin, Penicillin, Thoradamides, Ornate, Iodine, Latex)

<b>Describe Your Pradaxa Experience Here:</b>itching that last five minutes and goes away i have swelled knee pain also arthritis

<b>My wife had a stroke in 2002. The doctor prescribed meloxicam 15mg in July 2010 for arthritis. In August 2010 she had a silent heart attack diminishing heart pumps to 25%.</b>

<span style='color: #808080;'>Took Diprophos for rheumatoid arthritis. Side effects: insomnia for 2 nights, perspiring during night, redness in face. Increased need to urinate.

12 weeks on Sulfasalazine for Rheumatoid Arthritis and I have more joint pain than I ever had more fatigue and the most horrendous hot flashes all day long and at night sweats as well .... the nausea too is horrible .....

After being on Fosamax for approximately four and one half years suddenly I developed severe medial bilateral knee pain. Have pain when walking down and up stairs. I have NO history of arthritis, no inflammation or redness at the location of pain. I

After being on zolidex for endometriosis i now hae rheumatoid arthritis and other problems being investigated i feel cheated for a few months of less pain im now heading for a lifetime of more pain and operations.

After taking novatrex for over 8 weeks for rhumathiod arthritis or psoriatic arthritis i could hardly breathe and my voice was hoarse , i also was spitting lots os foamy stuff ,

Arthritis and dysfunction of the temporomandibular joint. Alleviated by cessation (over cca. 8 days). Worsened again by taking champix again.

RHEUMATOID ARTHRITIS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids on p38 MAPK in Asthma
Condition: Asthma
Interventions: Drug: Simvastatin;   Drug: B1-6-12
Outcome Measures: Sputum eosinophils;   Phosphorylated p38 MAPK in sputum cells
2 Recruiting Study of Metformin With Simvastatin for Men With Prostate Carcinoma
Condition: Prostate Carcinoma
Interventions: Drug: Metformin;   Drug: Simvastatin
Outcome Measures: Efficacy, as measured by an improvement in PSA doubling time (PSADT) between baseline and 6 months, of the combination of metformin plus Simvastatin in patients with recurrent prostate cancer following definitive treatment.;   Time to protocol-specified event for men treated with the combination of metformin plus Simvastatin.;   Pattern of change in log PSA levels and PSA velocity over time during treatment with metformin plus Simvastatin.;   Associations between changes in metabolic parameters (fasting glucose/insulin/lipid panel/leptin/adiponectin and others) with the pattern of change in log PSA levels.
3 Unknown  Trial of XELIRI/FOLFIRI + Simvastatin Followed by Simvastatin Maintenance in Metastatic Colorectal Cancer
Condition: Colorectal Cancer
Intervention: Drug: Simvastatin
Outcome Measure: Progression free survival
4 Recruiting Safety of Simvastatin in LAM and TSC
Conditions: Lymphangioleiomyomatosis;   Tuberous Sclerosis Complex
Intervention: Drug: Simvastatin
Outcome Measures: Safety of Simvastatin in the treatment of LAM-S and LAM-TS patients on a stable (for at least 3 months) dose of sirolimus or everolimus.;   FEV1, FVC, DLCO, VEGF-D, and QOL; signs of clinical benefit.
5 Not yet recruiting Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin
Conditions: Breast Cancer;   Stage I Breast Cancer;   Stage II Breast Cancer;   Stage III Breast Cancer
Interventions: Drug: Simvastatin;   Drug: Doxorubicin/cyclophosphamide
Outcome Measures: Change in echocardiographic Global Longitudinal Strain (GLS);   Number of participants with adverse events as a measure of safety and tolerability;   Recurrence free survival (RFS) with concurrent Simvastatin
6 Recruiting Stroke Treatment With Acute Reperfusion and Simvastatin
Condition: Stroke, Acute
Intervention: Drug: Simvastatin
Outcome Measures: The primary outcome of this study is to determine whether Simvastatin treatment started within the first 12 hours from stroke onset improves neurological and functional outcomes, evaluated at seventh day/discharge or at the third month.;   The secondary outcome of this study is to demonstrate that Simvastatin is safe and not associated with higher rates of hemorrhagic transformation in patients who receive thrombolysis.
7 Recruiting Simvastatin and Fenofibrate vs Simvastatin Alone in Patients With Type 2 Diabetes Mellitus and Acute Coronary Syndrome
Conditions: Acute Coronary Syndrome;   Diabetes Mellitus, Type 2;   Hypertriglyceridemia
Interventions: Drug: Fenofibrate;   Drug: Simvastatin
Outcome Measures: Percentage change from baseline in triglycerides (TG) at week 12;   Percentage of patients who achieved non-High-Density Lipoprotein-Cholesterol (non-HDL-C) level less than 2,6 mmol/l at week 12;   Percentage changes from baseline in apoB/apoA1 ratio at week 12;   Percentage changes from baseline in non-High-Density Lipoprotein-Cholesterol (non-HDL-C) at week 12;   Percentage changes from baseline in High-Density Lipoprotein-Cholesterol (HDL-C) at week 12;   Percentage changes from baseline in Low-Density Lipoprotein-Cholesterol (LDL-C) at week 12;   Percentage changes from baseline in uric acid at week 12;   Percentage of patients who achieved non-High-Density Lipoprotein-Cholesterol (non-HDL-C) level less than 2,6 mmol/l at week 52;   Percentage changes from baseline in apoB/apoA1 ratio at week 52;   Percentage changes from baseline in non-High-Density Lipoprotein-Cholesterol (non-HDL-C) at week 52;   Percentage changes from baseline in High-Density Lipoprotein-Cholesterol (HDL-C) at week 52;   Percentage changes from baseline in Low-Density Lipoprotein-Cholesterol (LDL-C) at week 52;   Percentage changes from baseline in uric acid at week 52
8 Recruiting Efficacy Study of Simvastatin to Treat Chronic Rhinosinusitis After Failure of Optimal Treatment
Condition: Rhinosinusitis
Intervention: Drug: Simvastatin
Outcome Measures: Sino-Nasal symptomatology;   Bacterial culture;   Assessemt of liver and kidney functions;   RNA measurement of inflammatory biomarkers;   Sinus-Specific Quality of Life (22 questions Sino-nasal outcome test; SNOT-22);   Aspect of sinus mucosa aspect assessed by sinus endoscopy
9 Unknown  Simvatstatin Used to Treat Pulmonary Hypertension
Condition: Hypertension, Pulmonary
Intervention: Drug: Simvastatin
Outcome Measures: the Simvastatin can alleviate pulmonary hypertension;   pulmonary pressure;   Simvastatin can highten the perioperative and long term survaval rate and the living quality
10 Recruiting Effects of Simvastatin on Biomarkers
Condition: Alzheimer's Disease
Interventions: Drug: Simvastatin;   Drug: Placebo
Outcome Measures: Cerebral Spinal Fluid Biomarker measurements;   Measures of inflammation or oxidative stress in cerebral spinal fluid.
11 Recruiting Simvastatin Addition for Patients With Recent-onset Schizophrenia
Conditions: Schizophrenia;   Schizoaffective Disorder;   Schizophreniform Disorder;   Psychosis NOS
Interventions: Drug: Simvastatin;   Drug: Placebo
Outcome Measures: Change in Positive And Negative Syndrome Scale (PANSS) total score;   Change in PANSS positive, negative and general psychopathology scale scores;   Change in Global Assessment of functioning scale (GAF) score;   Change in cognitive functioning;   Presence and severity of metabolic syndrome;   Change in presence and severity of movement disorders using validated scales
12 Unknown  Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT)
Conditions: Dyslipidemia;   Atherosclerosis
Interventions: Drug: Simvastatin;   Drug: Nicotinic Acid
Outcome Measures: change of carotid and femoral IMT from baseline to 6 and 12 months follow up and occurrence of major adverse cardiovascular events (MACE);   changes of grey scale median (GSM) score from baseline to follow-up, and changes of serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), triglycerides and lipoprotein (a).
13 Not yet recruiting The Short-term Effects of Simvastatin on the Vision of Males Affected by Choroideremia
Condition: Choroideremia
Intervention: Drug: Simvastatin
Outcome Measures: Full-field scotopic threshold;   Microperimetry, OCT, fundus autofluorescence, ERG, VA
14 Recruiting Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: Simvastatin
Outcome Measures: Vaso-occlusive pain events;   Correlation of plasma biomarkers with clinical measures of vaso-occlusive pain;   Clinical safety of Simvastatin
15 Recruiting Simvastatin Augmentation of Lithium Treatment in Bipolar Depression
Condition: Bipolar Disorder
Interventions: Drug: Simvastatin;   Drug: Placebo
Outcome Measure: Change in MADRS (4 weeks)
16 Recruiting Simvastatin for mTBI
Condition: TBI-Traumatic Brain Injury
Interventions: Drug: Simvastatin;   Drug: placebo
Outcome Measures: cerebrospinal fluid (CSF) tau concentration;   Concentration of cerebrospinal fluid (CSF) Brain-derived neurotrophic factor (BDNF)
17 Unknown  Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin.
Conditions: Diabetes Mellitus;   Hypertension
Interventions: Drug: atrorvastatin 10mg;   Drug: Simvastatin 40mg
Outcome Measures: Reduction in oxLDL levels;   Reduction in plasma malondialdehydes and urine isoprostanes;   Reduction in plasma endothelial function parameters such as soluble Vascular Adhesion Molecule (sVCAM) and von Willebrand factor
18 Unknown  Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers
Conditions: Cystic Fibrosis;   Anti Inflammatory Non-Steroidal;   Neutrophils
Interventions: Drug: Pioglitazone;   Drug: Simvastatin;   Drug: Ibuprofen
Outcome Measure: Neutrophil delivery to the oral mucosa using a noninvasive mouth wash technique
19 Recruiting Simvastatin Effect on Radiation Therapy of Brain Metastases
Condition: Brain Metastases
Interventions: Drug: Simvastatin in addition to radiation therapy;   Radiation: radiation therapy
Outcome Measures: a- Response rate;   progression free and overall survival;   adverse effects
20 Recruiting Sarilumab Effect on the Pharmacokinetics of Simvastatin
Condition: Rheumatoid Arthritis
Interventions: Drug: sarilumab SAR153191 (REGN88);   Drug: Simvastatin
Outcome Measures: Assessment of PK parameters - area under curve from zero time until the last measurable concentration (AUClast) and AUC for Simvastatin;   Assessment of PK parameters - maximum concentration (Cmax), time to maximum concentration (tmax), and terminal half-life associated with the terminal slope (t1/2z) for Simvastatin;   Assessment of PK parameters - Cmax, AUClast, AUC, tmax, t1/2z for Simvastatin acid;   Number of participants with adverse events