SEDATION and Methadone


SEDATION Symptoms and Causes

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Methadone Side Effects

Toxicity To Various Agents (601)
Cardiac Arrest (334)
Respiratory Arrest (316)
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Death (147)
Electrocardiogram Qt Prolonged (142)
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Respiratory Depression (82)
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Somnolence (65)
Accidental Overdose (59)
Nausea (57)
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Loss Of Consciousness (54)
Vomiting (51)
Confusional State (47)
Pneumonia (40)
Dyspnoea (39)
Syncope (39)
Mental Status Changes (38)
Pain (37)
Fall (37)
Sedation (36)
Bronchopneumonia (36)
Dizziness (35)
Hypotension (31)
Convulsion (31)
Hyperhidrosis (31)
Malaise (30)
Depressed Level Of Consciousness (30)
Coma (29)
Unresponsive To Stimuli (27)
Intentional Overdose (27)
Constipation (27)
Feeling Abnormal (26)
Hypokalaemia (26)
Pulmonary Congestion (26)
Renal Failure Acute (26)
Ventricular Tachycardia (25)
Headache (25)
Fatigue (25)
Brain Oedema (25)
Lethargy (24)
Rhabdomyolysis (24)
Respiratory Failure (24)
Incorrect Dose Administered (23)
Bradycardia (23)
Accidental Poisoning (23)
Miosis (22)

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Recent Reviews

Good afternoon doc,my name dimasautisme,i comefrom indonesia ? im methadoners with 120 mg,im drink ARV to?please private my status? i just want quesstion i want to detox,where i must go to hospital doc? please help me :-D :)

I have been on methadone for two years. Went fro 70 mgs a day to 20. I do for pain and I have been prescribed klonipin also recently for severe panic attacks and I read online that it's a deadly combo. I take my methadone at 9 am. And have panic

Ive been takeing 90mls of methadone for approxamitley 2 years on and off but properly this time for a total off 7 months i get servere sweating from taking my methadone and feel very hot like im burning up and dripping with sweat why is this happenin

Methodone Side Effects, I have had many trips to Emergency Unit at my Town, having tight painful heart problems. But when they do the Tests for Heart attacks, I jave always been told I have no problem my heart is fine. I have had ECG Tests, all fine.

Narcan administered in-hospital after adverse reaction (extreme sedation + supressed respiration) to Demerol + Dilaudid injections for pain. Female 130lbs, 47 years of age. Side effects: withdrawl symptoms, convulsions, vomiting, memory impairment, c

No. Etomidate has what some would call a larger side effect profile than some similar drugs, however, it is perfectly safe for use as an induction agent in RSI or as an adjunct for conscious sedation. I'd just say you're about the unluckiest guy in t

Not sure how that is stupid, especially if you are given instruction by a gastro doctor to take 3 which is the recommended dosage for an endoscopy without sedation. Also the package states to take 1-3

SEDATION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Development and Evaluation of Strategies to Improve Sedation Quality in InTensive Care
Condition: Critical Illness
Interventions: Other: Bespoke on-line Sedation education package;   Other: Sedation specific outcome process feedback;   Device: Responsiveness monitoring; novel Sedation monitor
Outcome Measures: Change from baseline the effect of individual and combinations of the interventions named on achievement of optimal Sedation practice;   Number of ventilation days;   ICU stay duration;   Number of days on Sedation
2 Recruiting Non-anesthesiologist Administered Propofol Sedation for Colonoscopy - a Randomized Clinical Trial
Conditions: Digestive System Diseases;   Colonoscopy Sedation
Interventions: Drug: Non-anesthesiologist propofol Sedation;   Drug: Propofol Sedation administered by an anesthesiologist;   Procedure: Colonoscopy
Outcome Measures: Minor adverse events;   Propofol dosage;   Patient satisfaction;   colonoscopy quality indicators;   Patient satisfaction 2
3 Recruiting Comparison of Respiratory Tolerance to I.V. Versus Sublingual Sedation During Bronchoscopy. (TORSIV)
Condition: Sedation During Bronchoscopy
Interventions: Drug: I.V Sedation;   Drug: sublingual Sedation
Outcome Measures: Intensity of dyspnea;   VAS Individual scores;   Blood pressure;   Desaturation frequency;   heart rate;   OAAS Score;   Bronchoscopy duration;   Comparison of midazolam total dose
4 Unknown  Enteral Versus Intravenous Sedation in Critically Ill High-risk ICU Patients
Conditions: Critical Illness;   Mechanical Ventilation Complication
Interventions: Procedure: Enteral Sedation (EN);   Procedure: Control group: Intravenous Sedation (IV)
Outcome Measures: Percent of efficacy, measured by observed RASS = desired RASS ± 1.;   Sedation protocol effectiveness: percentage of "protocol violation days" on the total of ICU days.;   Delirium and coma free days (respectively negative CAM-ICU and RASS > - 3 in all daily observations until 28° ICU day) (11);   Ventilation free days (12);   Nursing evaluation of Sedation adequacy (communication skills, cooperation, environment tolerance) (13);   Overall ICU and hospital mortality, absolute mortality after 1 year from ICU discharge.;   Sedative drugs costs.;   Indirect inefficacy markers
5 Recruiting BIS-Guided Sedation Monitoring
Condition: Patients Who Are Mechanically Ventilated and Sedated
Interventions: Other: Sedation monitoring with RASS score;   Other: Sedation monitoring with BIS-Guided monitoring
Outcome Measures: duration of mechanical ventilation;   total Sedation medication dose;   underSedation
6 Unknown  Propofol Patient-controlled Sedation for Endoscopic Retrograde Cholangiopancreatography
Condition: Endoscopic Retrograde Cholangiopancreatography
Interventions: Drug: Propofol Sedation by nurse anaesthestist;   Drug: Patient-controlled propofol Sedation
Outcome Measures: treatability;   safety
7 Recruiting Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
Condition: Procedural Sedation
Interventions: Drug: Propofol;   Drug: 1:1 Propofol/Ketamine;   Drug: 4:1 Propofol/Ketamine
Outcome Measures: Clinical interventions during Sedation;   Hypoxia;   Respiratory depression;   Procedural pain and recall
8 Recruiting Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation
Condition: Sedation
Interventions: Drug: Propofol;   Drug: Alfentanil;   Drug: Nitrous Oxide
Outcome Measures: Sub-clinical respiratory depression and clinical events associated with respiratory depression;   Time to return of baseline mental status;   Depth of Sedation;   Patient reported pain;   Patient reported recall of the procedure
9 Recruiting Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial
Condition: Sedation
Interventions: Procedure: 1:1 ketamine-propofol mixture Sedation;   Procedure: Propofol Sedation
Outcome Measures: airway complications;   subclinical respiratory depression;   satisfaction
10 Unknown  Evaluation of Sedation in Newborns
Condition: Sedation
Interventions: Device: Bispectral Index;   Device: Amplitude-integrated EEG
Outcome Measures: Correlation between clinical Sedation score (N-PASS) and the bispectral index (BIS) and the amplitude-integrated EEG (aEEG);   Differences of the values of the BIS, the aEEG and the Sedation scores in the group of mechanically ventilated / sedated newborns and the group of non-ventilated /non-sedated neonates;   Relationship between daily doses of sedatives / analgesics and Sedation levels
11 Not yet recruiting The Psychological Effects of Different Sedation Protocol on Mechanically Ventilated Critically Ill Adults.
Condition: Sedative Withdrawal Delirium
Interventions: Drug: Deep Sedation(midazolam and fentanyl );   Drug: Deep and daily interruption of Sedation(midazolam and fentanyl );   Drug: Light Sedation(midazolam and fentanyl )
Outcome Measures: The incident rate of delirium;   The incident rates of PTSD;   The duration of delirium;   Incidence rate of unexpected extubation;   Dosage of analgesics and sedatives;   The duration of mechanical ventilation;   Duration of ICU;   The whole hospitalization time;   Patients' death rates within ICU stay;   Patients' death rates within hospitalized stay;   The cost in ICU;   The total cost in hospital
12 Recruiting Sevoflurane- Safety in Long-term Sedation Procedures
Conditions: Poisoning by Inhaled Anaesthetic;   Fluoride Poisoning;   Recovery From Sedation;   Renal Function;   Hepatic Function
Interventions: Drug: Sevoflurane;   Drug: Midazolam
Outcome Measures: Maintenance of renal function.;   Assessment of liver function;   Plasma pharmacokinetics of fluoride;   Incidence of delirium
13 Recruiting "Light" Versus "Deep" Bispectral Index (BIS) Guided Sedation for Colonoscopy
Condition: Anaesthesia
Intervention: Other: Sedation depth
Outcome Measures: Recall of procedure;   Complications;   Speed and quality of recovery;   Satisfaction;   Dreaming
14 Not yet recruiting Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU.
Condition: Mechanical Ventilation Complication
Interventions: Drug: Fentanyl;   Procedure: Sedation assessment;   Procedure: Screen of weaning;   Drug: Propofol;   Drug: Midazolam;   Drug: Dexmedetomidine
Outcome Measures: Ventilation duration;   Delirium;   Blood pressure;   Cost of Sedation drug;   Cost of narcotics;   Cost of ICU stay;   Heart rate;   Respiration Rate;   Pulse blood oxygen saturation
15 Recruiting Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients
Condition: Critical Illness and Mechanical Ventilation
Interventions: Other: Early goal Directed Sedation;   Other: Standard care Sedation
Outcome Measures: Mortality;   Ventilation free days;   Proportion of RASS measurements in target range;   Incidence and duration of delirium measured by delirium free days;   Length of ICU stay;   Proportion of patients who receive a tracheostomy Proportion of patients who require: re-intubation, physical restraints,or unplanned extubation,;   Cumulative dose of midazolam, propofol, dexmedetomidine, fentanyl, and morphine;   Duration of treatment with midazolam, propofol, dexmedetomidine, fentanyl, and morphine;   Mortality at hospital discharge;   Length of hospital stay;   Readmission to ICU;   EQ-5D questionnaire;   Cognitive function;   Mortality at ICU discharge;   Full time institutional dependency at 180 days;   Discharge destination
16 Not yet recruiting Ketofol Versus Fentofol for Procedural Sedation in the Pediatric Emergency Department
Conditions: Emergency Department Procedural Sedation;   Fracture Reduction
Interventions: Drug: Ketofol;   Drug: Fentofol
Outcome Measures: Duration of Sedation;   Recovery Time;   Additional analgesia or Sedation medications;   Efficacy of Sedation for completion of procedure;   Satisfaction with Sedation;   Incidence of adverse events
17 Unknown  Ketamine-propofol Versus Ketamine Alone for Procedural Sedation in Adults
Conditions: Fracture;   Dislocation
Interventions: Drug: Procedural Sedation with ketamine-propofol combination;   Drug: Procedural Sedation with ketamine alone
Outcome Measures: Proportion of recovery agitation;   Time from first injection to optimal Sedation;   Proportion of respiratory depression;   Proportion of arterial hypotension;   Proportion of vomiting;   Recovery time;   Proportion of procedural failures;   Level of patient's satisfaction;   Level of care giver's satisfaction
18 Not yet recruiting Assessment of Sedation During Endoscopy
Condition: Sedation
Intervention: Device: Bispectral Index
Outcome Measure: level of Sedation
19 Recruiting Sedation During Bronchoscopy:Dexmedetomidine vs Alfentanil
Conditions: Bronchoscopy;   Conscious Sedation
Interventions: Drug: xylocain;   Drug: Alfentanil;   Drug: Dexmedetomidine
Outcome Measures: Bronchoscopy score;   Level of Sedation for bronchoscopy
20 Recruiting AnaConDa Long Term Sedation Study
Condition: Intubated Requiring Sedation for Greater Than 48 Hours
Interventions: Drug: Isoflurane;   Drug: Propofol/midazolam
Outcome Measures: atmospheric volatile concentration;   Sedation;   Feasibility;   Education Tool;   serum fluoride levels