SEPSIS and Metronidazole


SEPSIS Symptoms and Causes

Sepsis is a serious illness. It happens when your body has an overwhelming immune response to a bacterial infection. The chemicals released into the blood to fight the infection trigger widespread inflammation. This leads to blood clots and leaky blood vessels. They cause poor blood flow, which deprives your body's organs of nutrients and oxygen. In severe cases, one or more organs fail. In the worst cases, blood pressure drops and the heart weakens, leading to septic shock.

Anyone can get Sepsis, but the risk is higher in

  • People with weakened immune systems
  • Infants and children
  • The elderly
  • People with chronic illnesses, such as diabetes, AIDS, cancer, and kidney or liver disease
  • People suffering from a severe burn or physical trauma

Common symptoms of Sepsis are fever, chills, rapid breathing and heart rate, rash, confusion, and disorientation. Doctors diagnose Sepsis using a blood test to see if the number of white blood cells is abnormal. They also do lab tests that check for signs of infection.

People with Sepsis are usually treated in hospital intensive care units. Doctors try to treat the infection, sustain the vital organs, and prevent a drop in blood pressure. Many patients receive oxygen and intravenous (IV) fluids. Other types of treatment, such as respirators or kidney dialysis, may be necessary. Sometimes, surgery is needed to clear up an infection.

NIH: National Institute of General Medical Sciences

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Metronidazole Side Effects

Dysarthria (124)
Dizziness (124)
Vomiting (119)
Nausea (108)
Encephalopathy (106)
Diarrhoea (102)
Paraesthesia (93)
Headache (88)
Confusional State (80)
Ataxia (80)
Toxic Encephalopathy (71)
Pruritus (67)
Gait Disturbance (62)
Neuropathy Peripheral (60)
Pain (60)
Pyrexia (58)
Cerebellar Syndrome (58)
Rash (56)
Urticaria (51)
Malaise (49)
Neurotoxicity (44)
Anaphylactic Reaction (44)
Abdominal Pain (43)
Dyspnoea (42)
Anxiety (41)
Dysgeusia (41)
International Normalised Ratio Increased (39)
Asthenia (38)
Hypoaesthesia (37)
Fatigue (37)
Convulsion (34)
Somnolence (34)
Nuclear Magnetic Resonance Imaging Brain Abnormal (32)
Pain In Extremity (31)
Coordination Abnormal (31)
Arthralgia (31)
Abdominal Pain Upper (30)
Balance Disorder (30)
Clostridium Difficile Colitis (30)
Depression (30)
Chest Pain (30)
Cerebellar Ataxia (29)
Insomnia (28)
Dysphagia (27)
Condition Aggravated (27)
Feeling Abnormal (27)
Psychotic Disorder (27)
Nystagmus (26)
Liver Function Test Abnormal (26)
Muscular Weakness (25)

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Recent Reviews

<b>Describe Your Metronidazole Experience Here:</b> after taking a total of 4 pills, 1 first day 2 second day and 1 in third day. I had symptoms begin on that second day. There was tingling in my lips with burning in my lips and tongue. T

Can I take Flagyl for a UTI?

Dentist gave me 400mg of metronidazole for toothache i feel sick and dizzy i keep going hot and cold and my skin goes red

Diagnosed with BV and started taking Flagyl orally twice per day for 7 days. In the 4th day of my treatment my period started. Had very heavy flow. No cramps but very heavy menstrual bleeding and passed large blood clots

Diahorrea, metallic taste in the mouth, burning vagina feeling sick bad stomach

Experienced palpitation

Hello All. I am a 39 yr old male. I contracted MRSA from a spot on my right little toe which had to be amputated. All was going well for the next month and then I turn very sick, running high fevers with chills, almost like I was getting the flu.

Hi just been discharged from A&amp;E. Meronidazeole 400mg. I had severe racing heart beats (resting pulse normally 53 became 90-100! and would go to 140 with no prompting). Blood pressure usually 120/60 became 135/90&gt;. Breathing was di

Hi,am 21 years old from phil. am engaging sex so many times for ten guys,time came that am discharging something unpleasant and yellow in color am shy to check a doctor so i just try to search some knowledge on net then am trying using metronidazole

I am a 18 yr old, i was pescribed metro for a infection.... 2 days into i was feeling very paranoid and frightened, last night i experienced two encounters of wide awake, shaking, grunting, crying and coldness. scareyyy :'(

Could this 'fluid' be secondary to an LRTI? Sepsis? or an allergic/anaphylactic reaction? ARDS? Why would a selective COX 2 inhibitor be the first choice for her? What ever happened to simple things like paracetamol? What did the autopsy say?

I had surgery with a terrible complication eleven months ago called sepsis. Since then I have right sided tremors, chronic right side pain, pain in my right shoulder, just to name a few complication. I wonder if I will ever be over the complications.

I have been in hospital for 5 days with sepsis and was treated with intravenus antibiotics.on my release i still have a bad cough, sore head and no energy. how long will this last?

I was rencently hospitalized with sepsis for 4 days. It was the result of UTI which is a constant plague in my life. Treatment with antibiotics and IV did the trick and my white blood count went down and blood pressure went from 40 to over 100 duri

My dad passed last week of sepsis with in 24 hour time frame on sunday he was laughing and joking around at at night felt like he had flu , slight throwing up and l00. temp during the night my mother said his fever spiked and she thought th

My father died of biliary sepsis in december what causes it?


My mom developed Sepsis following hernia surgery. Nurse forgot to take out IV. She didnt realize it till shw got home. 10 days later she was admitt ed for kidney failure.

What is best filter to use in sepsis?

While taking Imuran be sure your Doctor keeps an eye on your WBC... Small infections could end up as Sepsis...

SEPSIS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact
Conditions: Septic Shock;   Severe Sepsis
Outcome Measures: Sinusal variability analysis and myocardic fixation of MIBG performed in 48 hours post admission;   plasmatic measure of NT-ProBNP and catecholamine at admission, day 2 and last day of hospitalisation
2 Recruiting An Observational Study of the Causes, Management, and Outcomes of Community-acquired Sepsis and Severe Sepsis in Southeast Asia
Conditions: Sepsis;   Severe Sepsis
Outcome Measures: The etiology of community-acquired Sepsis and severe Sepsis expressed in percentages of enrolled subjects.;   The time from hospital admission to any systemic antibiotic administration.;   Percentage of initial systemic antimicrobial effective to treat the cause of the infection.;   Percentage of subjects receiving fluid challenge (giving bolus of fluid) if the patient has hypotension.;   Percentage of subjects receiving adequate ventilatory support (including percentage of subjects receiving supplemental oxygen, percentage of subjects receiving Positive-end Expiratory Pressure (PEEP).;   Percentage of subjects receiving low-volume lung-protective ventilation.;   Percentage of subjects receiving arterial blood gas evaluation).;   Percentage of subjects receiving renal replacement therapies (including hemodialysis and peritoneal dialysis).;   Percentage of subjects receiving imaging to determine source or deep foci of infection (including chest radiography, ultrasonogram, CT scan and MRI).;   Percentage of subjects receiving evaluation by scoring system.;   Percentage of subjects receiving stress prophylaxis.;   Percentage of patients receiving deep vein thrombosis (DVT) prophylaxis.;   Percentage of subjects receiving treatment in ICUs.;   28-day mortality rate.;   Percentage of subjects developing major organ dysfunction; for example ventilatory failure and renal failure.;   Risk factors associated with Sepsis or severe Sepsis;   Prevalence of antimicrobial resistance and its association with appropriate empirical therapy and outcomes.;   Sensitivities and specificities of selected RDTs in determining the causes of community-acquired Sepsis and severe Sepsis
3 Not yet recruiting Simplified Severe Sepsis Protocol-2 (SSSP-2) in Zambia
Conditions: Sepsis;   Severe Sepsis;   Tuberculosis
Interventions: Other: Simplified severe Sepsis protocol;   Other: Usual care
Outcome Measures: In-hospital all cause mortality;   28-day all-cause mortality;   In-hospital all cause mortality adjusted for illness severity;   28-day all cause mortality adjusted for baseline illness severity;   Cumulative adverse events;   Treatment cost per patient;   Antibiotic changed due to culture results
4 Unknown  Simplified Severe Sepsis Protocol in Zambia
Conditions: Sepsis;   Severe Sepsis
Intervention: Other: Simplified Severe Sepsis Protocol
Outcome Measures: In-hospital all cause mortality;   28-day all-cause mortality;   In-hospital all cause mortality adjusted for illness severity;   28-day all cause mortality adjusted for baseline illness severity;   Cumulative adverse events;   Treatment cost per patient;   Antibiotic changed due to culture results
5 Unknown  Neonatal Sepsis, Evaluation, Bangladesh
Condition: Sepsis
Interventions: Other: Amoxycillin, Gentamicin;   Other: Counselling
Outcome Measures: Appropriate management of all cases of neonatal Sepsis in the community by community level health care provider;   Newborns will be dried and wrapped immediately after birth;   Newborns receiving breast feeding within one hour after birth;   Newborns first bathed at least three days after birth
6 Not yet recruiting Utility of High-Fidelity Simulation In the Education and Assessment of Residents in the Recognition and Management of the Sepsis Syndrome
Conditions: Medical Knowledge;   Clinical Performance
Intervention: Other: Debriefing of high-fidelity Sepsis simulation scenarios
Outcome Measures: Performance on a written assessment of the recognition and management of early Sepsis in the hospitalized patient.;   Performance on a practical assessment of the recognition and management of early Sepsis in the hospitalized patient.;   Self-assessment of knowledge and ability in the recognition and management of early Sepsis in the hospitalized patient.
7 Unknown  Endothelium in Severe Sepsis
Conditions: Sepsis;   Severe Sepsis;   Septic Shock
Outcome Measures: Mortality;   Organ Dysfunction assessed by Sepsis-related Organ Failure Assessment (SOFA) Score
8 Unknown  Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests
Conditions: Sepsis;   Septicemia;   Sepsis Syndrome;   Shock, Septic;   Community Acquired Pneumonia
Outcome Measures: Death;   Septic Shock;   Severe Sepsis;   Time to death;   Time to severe Sepsis;   Severe Sepsis;   Time to septic shock;   Septic shock;   Cryptic shock (ScvO2<65 or Lactate >2.5 and MAP >65 mmHg [>18 years of age] or SBP >90 [<18 years of age]);   Time to Cryptic shock (ScvO2<65 or Lactate >2.5 and MAP >65 mmHg [>18 years of age] or SBP >90 [<18 years of age]);   Hospitalization;   Length of hospital stay;   ICU admission;   Length of ICU admission;   Disposition;   Renal dysfunction;   Respiratory dysfunction;   Hematology dysfunction;   Metabolic dysfunction;   Renal SOFA score;   Lung SOFA score;   Coagulation SOFA score;   Liver SOFA score;   CVS SOFA score;   Time to respiratory SOFA Score;   Time to coagulation SOFA score;   Time to liver SOFA score;   Time to CVS SOFA score;   Time to Renal SOFA score;   DIC score >5 (modified ISTH scoring system);   Time to DIC score > 5;   Development of ALI;   Development of ARDS;   Time to ALI;   Time to ARDS;   Ventilator;   Ventilator days;   MELD score;   Effect of early goal directed therapy on primary and secondary end-points;   Effect of Activated Protein C on primary and secondary end-points;   Effect of stress-dose corticosteroids on primary and secondary end-points;   Effect of intensive glycemic control on primary and secondary end-points;   APACHE II score;   PRISM III score;   SOFA score;   CAP mortality;   CAP and severe Sepsis;   CAP and septic shock;   Severe CAP (ATS criteria);   Severe CAP (BTS criteria);   Pneumococcal Sepsis;   Staphylococcus aureus Sepsis;   Gram negative rod Sepsis;   Fungal Sepsis;   SeptiFast result;   Microbiologic culture result;   Urinary legionella antigen;   Microbiologic culture;   CAP, time to death;   CAP, mortality;   CAP, time to severe Sepsis;   CAP, severe Sepsis;   CAP, time to septic shock;   CAP, septic shock;   Time to severe CAP (ATS and BTS criteria);   Severe CAP (ATS and BTS criteria);   CAP, mechanical ventilation;   CAP, time to mechanical ventilation;   CAP, length of mechanical ventilation;   CAP, SOFA respiratory score > 2;   CAP, respiratory component of severe Sepsis criteria;   CAP, hospitalized;   CAP, length of hospitalization;   CAP, ICU admission;   CAP, length of ICU stay;   CAP, Disposition;   CAP, ALI;   CAP, ARDS;   CAP, time to ARDS;   CAP, time to ALI;   CAP, PORT score
9 Unknown  Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study
Conditions: Paediatric Sepsis;   Pediatric Sepsis
Intervention: Drug: hydrocortisone
Outcome Measures: primary efficacy endpoint is all cause mortality;   primary toxicity endpoint is Serious Adverse Events, excluding Sepsis-related events specified as secondary outcomes;   PIM2;   PELOD;   ICU mortality;   time until shock reversal, defined as cessation of inotropic support for 24 hours;   time to resolution of multiorgan dysfunction;   time to resolution of base deficit;   time to resolution of lactate;   time to decision to discharge from ICU;   laboratory analysis of adrenal function;   laboratory analysis of inflammatory parameters (defined in protocol);   laboratory analysis of coagulation parameters (defined in protocol)
10 Recruiting Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients
Condition: Sepsis
Intervention: Other: Severe Sepsis vs. non-severe Sepsis
Outcome Measure: This study evaluates epidemiology, microbiology and outcome of neutropenic fever and severe Sepsis in haematological patients with special reference to the kinetics of inflammatory markers.
11 Unknown  Urinary Proteomics Analysis for Sepsis and Prognosis
Conditions: SIRS;   Sepsis
Outcome Measure: Survival status
12 Unknown  Serum Proteomics Analysis for Sepsis
Conditions: SIRS;   Sepsis;   Severe Sepsis;   Death
Outcome Measure: Survival status
13 Recruiting Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock
Conditions: Severe Sepsis;   Septic Shock;   Bacteremia
Outcome Measure: The effect of antibiotic administration on blood culture positivity in patients with severe Sepsis and septic shock: a prospective multicenter observational trial.
14 Unknown  Muscle Atrophy in Sepsis
Conditions: Atrophy;   Sepsis;   Weakness
Outcome Measures: Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes within skeletal muscle of patients with Sepsis;   Electrical stimulation will be associated with improvement of histologic and electrophysiologic and strength parameters within skeletal muscle of patients with Sepsis
15 Recruiting Lotta Alla Sepsi Ospedaliera - Fighting Hospital Sepsis
Condition: Severe Sepsis
Outcome Measures: An improvement in Sepsis Six Bundle implementation for Severe Sepsis and Septic Shock;   All cause Mortality
16 Unknown  Assessment of Peritoneal Immune Response in Patients With Severe Intra-abdominal Sepsis Managed With Laparostomy and Vacuum Assisted Closure (VAC)
Condition: Abdominal Sepsis
Outcome Measures: Measure peritoneal immune response to intra-abdominal Sepsis;   General characteristics
17 Recruiting Identification Sepsis Related Single Nucleotide Polymorphism (SNP) by Whole Exome Sequencing
Condition: Sepsis
Outcome Measure: Sepsis related SNP site
18 Unknown  Neonatal Sepsis and GBS Carriage Study
Conditions: Neonatal Sepsis;   Maternal GBS Carriage
Outcome Measures: Incidence of early onset neonatal Sepsis (including the prevalence of culture positive and culture negative EO GBS Sepsis);   Perinatal risk factors for early onset neonatal Sepsis;   Prevalence of maternal GBS carriage;   GBS serotype specific antibody prevalence;   serotypes and antibiotic susceptibility profile of carried and invasive GBS strains
19 Recruiting The AVERT Sepsis Investigation
Conditions: Sepsis;   Severe Sepsis
Outcome Measure: Progressive organ failure
20 Not yet recruiting Angiotensin II Antagonist in Severe Sepsis
Condition: Severe Sepsis
Intervention: Drug: Irbesartan
Outcome Measures: mortality;   Incidence of altered organ function in Sepsis patients measured by SOFA score (Sequential Organ Failure Assessment score)