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SOMNOLENCE and Lorazepam

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SOMNOLENCE Symptoms and Causes

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Check out the latest treatments for SOMNOLENCE

SOMNOLENCE treatment research studies

Lorazepam clinical trials, surveys and public health registries


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Lorazepam Side Effects

Completed Suicide (220)
Somnolence (138)
Poisoning (137)
Suicide Attempt (121)
Overdose (105)
Anxiety (104)
Agitation (100)
Tachycardia (84)
Cardiac Arrest (81)
Confusional State (80)
Nausea (79)
Respiratory Arrest (73)
Dizziness (70)
Coma (68)
Sopor (68)
Hypotension (66)
Fall (66)
Toxicity To Various Agents (65)
Intentional Overdose (64)
Dyspnoea (61)
Fatigue (57)
Vomiting (56)
Depression (56)
Insomnia (56)
Cardio-respiratory Arrest (55)
Death (55)
Sedation (52)
Headache (49)
Loss Of Consciousness (48)
Asthenia (45)
Convulsion (45)
Diarrhoea (43)
Metabolic Acidosis (42)
Condition Aggravated (39)
Tremor (37)
Pyrexia (34)
Product Substitution Issue (34)
Unresponsive To Stimuli (34)
Suicidal Ideation (33)
Psychotic Disorder (33)
Feeling Abnormal (33)
Catatonia (33)
Pain (33)
Gait Disturbance (32)
Disorientation (31)
Respiratory Failure (31)
Syncope (30)
Malaise (30)
Depressed Level Of Consciousness (29)
Oxygen Saturation Decreased (29)

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SOMNOLENCE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting A Double-Blind, Placebo-Controlled, Cross-over Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia
Conditions: Nocturia;   Daytime Sleepiness
Intervention: Drug: Armodafinil 50 - 250 mg pills
Outcome Measures: Change in Epworth Sleepiness Scale;   Clinical Global Impressions, change in severity of excessive daytime sleepiness (EDS);   Number of naps;   Number of minutes napped based on sleep diary
2 Recruiting Sleepiness and Sleep-disordered Breathing in Fabry Disease. A Prospective Cohort Study.
Condition: Fabry Disease
Intervention: Device: ResMed Apnea Link plus
Outcome Measure: Prevalence and type of sleep-related breathing disorder in Fabry patients.
3 Recruiting SleepTrackTXT Feasibility and Pilot Study
Conditions: Fatigue;   Sleepiness
Intervention: Behavioral: Text-message strategies
Outcome Measures: Self-Reported Fatigue at end of shift work;   Self-reported perceptions of behaviors and beliefs about fatigue and sleepiness during shift work
4 Recruiting Post-prandial Hypotension and Sleepiness in Parkinson's Disease and Other Synucleinopathies
Conditions: Parkinsonian Patients;   Post-prandial Sleepiness;   Orthostatic Hypotension
Interventions: Other: V1: HGPO + meal and V2: placebo + meal;   Other: V1: placebo 75mg + meal and V2: HGPO 75mg + meal
Outcome Measures: Rate of patients presenting a "sleep onset";   rate of patients without arterial hypotension nor a sleep episode within 120 minutes after oral solution administration ;;   rate of patients that show a sleep episode but without arterial hypotension within 120 minutes after oral solution administration ;;   rate of patients that show arterial hypotension within 120 minutes after oral solution administration but not a sleep episode;;   Occurrence of arterial hypotension and a sleep episode within 120 minutes following a standardized meal;   Changes in intestine-pancreatic neuropeptides including incretins (GLP-1 - GIP) following an oral glucose load, placebo fructose load, or standardized meal - correlation with the post-prandial BP drop.
5 Recruiting Continuous Positive Airway Pressure (CPAP) After Adenotonsillectomy in Children
Conditions: Sleep Apnea, Obstructive;   Sleep Apnea Syndromes;   Child Behavior Disorders;   Attention Deficit Disorder With Hyperactivity;   Disorders of Excessive Somnolence
Interventions: Procedure: CPAP treatment;   Other: No CPAP treatment
Outcome Measures: Neurobehavioral improvement after AT;   Improvement in cognition after AT;   Improvement in sleepiness and other sleep apnea symptoms after AT;   Residual SDB, associated symptoms, and associated neurobehavioral problems after AT;   CPAP Adherence and Safety Monitoring
6 Recruiting Sleep, Cognition and Memory Disorder
Conditions: Sleep Architecture;   Sleep Disorders;   Cognitive Impairment
Interventions: Other: 2 night polysomnography;   Other: battery of neuropsychological tests;   Other: virtual reality test;   Other: subjective evaluation of sleep and Somnolence
Outcome Measures: Polysomnography of night 1;   Subjective evaluation of sleep and Somnolence;   Evaluation of Memory disorder
7 Recruiting Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP)
Conditions: Narcolepsy With Cataplexy;   Excessive Daytime Sleepiness
Interventions: Drug: Pitolisant;   Drug: Placebo
Outcome Measures: Measure of anticataplectic efficacy;   Excessive Daytime Sleepiness assessment;   Safety assessment
8 Recruiting Amylase and Hypersomnia
Condition: Hypersomnia in Children
Intervention: Procedure: saliva collection
Outcome Measures: Determination of the expression and enzymatic activity of salivary amylase.;   Measurement of the mean sleep onset latency using the Multiple Sleep Latency Test (MSLT);   Measurement of the Somnolence using Epworth and Karolinska scales
9 Recruiting Palliative Morphine With or Without Concurrent Modafinil
Conditions: Cancer;   Pain Palliation;   Excessive Sleepiness
Interventions: Drug: Modafinil;   Drug: Placebo
Outcome Measures: Patient reported sleepiness scores;   Mood changes
10 Unknown  Comparison of RT in Patients With Sleep Apnea With and Without Complaints of Daytime Sleepiness
Condition: Sleep Apnea
Intervention:
Outcome Measure:
11 Recruiting Randomized Controlled Trial to Assess Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy
Condition: Partial Epilepsy
Interventions: Drug: Lacosamide;   Drug: Placebo
Outcome Measures: Change in Epworth Sleepiness Scale score from Baseline to Visit 4;   Change in mean sleep latency on the maintenance of wakefulness test from Baseline to Visit 4.
12 Unknown  Comparing Fluticasone-Salmeterol in Chronic Obstructive Pulmonary Disease (COPD) and Sleep
Condition: COPD
Interventions: Drug: fluticasone/salmeterol 250/50;   Drug: placebo
Outcome Measures: The aim of this study is to determine the effect of fluticasone/salmeterol on sleep quality in patients with COPD and to compare efficacy of Advair 250 compared to placebo on sleep.;   daytime Somnolence
13 Recruiting Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Armodafinil in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy
Condition: Narcolepsy
Intervention: Drug: Armodafinil
Outcome Measures: Maximum observed plasma drug concentration (Cmax) by inspection;   Time to maximum observed plasma drug concentration (tmax) by inspection;   Area under the plasma drug concentration by time curve from time 0 to infinity;   Area under the plasma drug concentration by time curve from time 0 to the time of the last measurable drug concentration;   Terminal half-life;   Terminal elimination rate constant;   Apparent total plasma clearance;   Apparent volume of distribution;   Predicted accumulation ratio;   Maximum observed plasma drug concentration (Cmax);   Time to maximum observed plasma drug concentration;   AUC over 1 dosing interval;   AUC 0-t;   Observed accumulation ratio;   Steady-state accumulation ratio;   Mean sleep latency;   Clinical Global Impression of Change (CGI-C)
14 Recruiting Multidimensional Assessment of Fatigue in Multiple Sclerosis- Observational Study - Ticino
Condition: Multiple Sclerosis
Intervention:
Outcome Measures: Fatigue Severity Scale;   Modified Fatigue Impact Scale;   Fatigue Scale for Motor and Cognitive functions;   Visual analogue scale for fatigue;   Maintenance of wakefulness test;   Epworth Sleepiness Scale;   Visual analogue scale for Somnolence;   Beck depression inventory II;   Mongomery Asberg Depression Rating Scale;   Symbol Digit Modalities Test;   Paced Auditory Serial Addition Test;   Stroop Test
15 Recruiting Patient Narcoleptic Treated With BF2.649 (Pitolisant) in add-on to Sodium Oxybate (HARMONY IV)
Condition: Narcolepsy
Intervention: Drug: BF2.649
Outcome Measure: Efficacy on EDS as measured by ESS ( Epworth Sleepiness Scale)
16 Recruiting The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old
Condition: Sleep Deprivation
Intervention: Behavioral: Partial sleep deprivation allowing 3 h sleep at night
Outcome Measure: Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)
17 Recruiting Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
Condition: Parkinson's Disease
Intervention: Other: Light exposure
Outcome Measures: circadian rhythm of melatonin;   Sleep Efficiency;   Daytime Somnolence
18 Recruiting Study of the Symptomatic Effects of Nocturnal Sodium Oxybate in Parkinson's Disease
Condition: Sleep-wake Disturbances in Motor-phase Parkinson`s Disease
Intervention: Drug: Sodium Oxybate
Outcome Measures: Objective excessive daytime sleepiness;   effect on night-time breathing;   Motor function;   Subjective quality of nocturnal sleep;   Objective quality of nocturnal sleep including breathing indices;   Quality of life;   Mood;   Cognition;   Impulse control;   Vigilance;   Subjective Daytime sleepiness;   Sleep wake rhythm;   Quality of life for caregivers
19 Recruiting SWS And Daytime Functioning in Chronic FatiguE Syndrome (SAFFE)
Condition: Chronic Fatigue Syndrome
Interventions: Drug: Sodium Oxybate;   Other: placebo (fresh potable water)
Outcome Measures: EEG slow wave activity during sleep;   Daytime sleepiness
20 Recruiting Continuous Positive Airway Pressure and Oral Appliances Treatments in Mild Obstructive Sleep Apnea
Condition: Mild Obstructive Sleep Apnea Syndrome
Interventions: Device: Continuous Positive Airway Pressure (CPAP);   Device: Oral Appliance (BRD)
Outcome Measures: Excessive Daytime Sleepiness;   Evaluations of fatigue.;   Evaluation of cognition.;   Evaluation of depression.;   Evaluation of quality of life.;   Evaluation of inflammation.;   Evaluation of blood pressure.;   Evaluation of sexual dysfunction.;   Evaluation of anxiety;   Evaluation of metabolism;   Evaluation of hormonal alterations.;   Evaluation of heart rate variability;   Evaluation of endothelial disfunction.