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THERAPY CESSATION and Baclofen

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THERAPY CESSATION Symptoms and Causes

Tobacco use is the most common preventable cause of death. About half of the people who don't quit smoking will die of smoking-related problems. Quitting smoking is important for your health.

Soon after you quit, your circulation begins to improve, and your blood pressure starts to return to normal. Your sense of smell and taste return, and it's easier for you to breathe. In the long term, giving up tobacco can help you live longer. Your risk of getting cancer decreases with each year you stay smoke-free.

Quitting is not easy. You may have short-term affects such as weight gain, irritability, and anxiety. Some people try several times before they succeed. There are many ways to quit smoking. Some people stop "cold turkey." Others benefit from step-by-step manuals, counseling, or medicines or products that help reduce nicotine addiction. Some people think that switching to e-cigarettes can help you quit smoking, but that has not been proven. Your health care provider can help you find the best way for you to quit.

NIH: National Cancer Institute

Check out the latest treatments for THERAPY CESSATION

THERAPY CESSATION treatment research studies

Baclofen clinical trials, surveys and public health registries


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Baclofen Side Effects

Overdose (180)
Coma (125)
Muscle Spasticity (122)
Pain (99)
Confusional State (96)
Muscle Spasms (94)
Convulsion (92)
Completed Suicide (92)
Fatigue (82)
Fall (77)
Somnolence (76)
Pyrexia (75)
Nausea (73)
Hypertension (73)
Dizziness (72)
Headache (70)
Death (70)
Vomiting (69)
Mental Status Changes (68)
Poisoning (68)
Pneumonia (66)
Hypotension (65)
Delirium (63)
Asthenia (62)
Bradycardia (62)
Neurotoxicity (62)
Agitation (60)
Urinary Tract Infection (59)
Dyspnoea (58)
Loss Of Consciousness (55)
Condition Aggravated (54)
Cardiac Arrest (52)
Intentional Overdose (51)
Hypotonia (49)
Implant Site Effusion (48)
Gait Disturbance (47)
Malaise (47)
Depressed Level Of Consciousness (46)
Multiple Sclerosis Relapse (45)
Respiratory Arrest (45)
Withdrawal Syndrome (45)
Medical Device Complication (44)
Hallucination (43)
Tremor (43)
Pain In Extremity (42)
Suicide Attempt (42)
Respiratory Failure (42)
Disorientation (40)
Muscular Weakness (39)
Toxicity To Various Agents (39)

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Recent Reviews

Alopecia areata

Husbnd is a 15 yr. stroke survivor who had a baclofen pump since about 2001. It was replaced Nov. 2009 and nothing but trouble... passing out, weakness, falling, etc. 4 ER trips and not one dr. ever mentioned b

I had a devastating experience with this drug. I had been using Flexeril for back and neck pain but found it no longer as effective. I asked my doctor if there was something stronger. He prescribed Baclofen. Having not read the label carefully, m

I have experience hads spasm,diziness,headaches,shallow or hard breathing,slepiness,pain in the side (new)

I too had a nasty bite from baclofen.I had a craving for alcohol and was on 10 mg TID.I took 90mg at once. within one hour I feel like i was on shrooms! Very vivid CEVs(closed eyed visuals) and some ope eyed visuals(OEVs).Actually I enjoyed this.But

Just was looking around and saw your post. We experienced a very similar situation with our child. Was the pump just installed?

Male 42 prescribed baclofen 30-60mg daily for the control of cervical dystonia, great for first week then started to get pain and discumfort in my bowels by week two i was being physicaly sick and unable to control the pain , had to stop taking the m

My mom 77 years old suddenly becomes weaksinceshe started taking baclofen..she's having a difficulty in walking and maintaning her balance..that wasnt her condition before..

My son was overdosed on baclofen, they doubled his does and then took him back down to a lower dose all in a day and a half. he started taking 5 breaths a minute, and the doctor said it was not the pump. duh i am no rocket scientest, but it

What are all side effects of baclofen?

<span style='color: #808080;'>I've been on the therapy for 6 months.I've lost some. However, I've devloped an ever increasing midrift buldge. It's getting worse not better. Any answers

<span style='background-color: #ebeff9;'>After 6 months of therapy with pills bonviva began to hurt me terribly, all joints and all the muscles. <span style='background-color: #fff;'>horror<

Afer five years of Famera treatment for breast cancer, I was anticipating feeling so much better. Now diagnosed with CFS and Fibromyalgia my doctor is trying to treat me lately with Chronic Behavorial Therapy. Yesterday my daughter took me to another

Am a 76 year-old hypertensive with CKD; was given 'Cozaar' and 6 months into therapy developed excessive swelling of ankles/feet. Asked for GFR., and the result was 38, when I had been at a level of 54 for the previous 5 years. Ceased 'Cozaar' 4 mont

April 10,2012 I recieved a zostevax iimmunization,suggested by my physician because of my age(68) On June 15,2012 I was diagnosed with Guillain barre' and hospitalized for a week, followed by 5 weeks of physical therapy to learn how to walk and cope

Arthritis and dysfunction of the temporomandibular joint. Alleviated by cessation (over cca. 8 days). Worsened again by taking champix again.

Been doing ferrlecit infusions therapy for just about 10 years, but I've got to say, the more I do it, which is every 6-9 months for 2-3 weeks, it is just making me so sick. I cannot function. I feel like vomitting most of the time and have lost anot

Dear sir I'm asking about CO2 foot bath therapy devices JAPANESE TECHNOLOGY FROM MITSUBISHI DIABETIC PATIENTS coast please Regards Safa Azawi Iraq

Does seroxat cause photosensitivity if light therapy is used for hair removal

Funny, Campral is only indicated for alcohol cessation.

THERAPY CESSATION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Safety Study of 3 mg/mL Baclofen Injection (Intrathecal) Using A Programmable Pump
Condition: Severe Spasticity
Intervention: Drug: Gablofen® 3 mg/mL (Baclofen injection)
Outcome Measures: The rate of inflammatory granulomas in patients given 3 mg/mL Gablofen® (Baclofen injection) 3mg/mL by the intrathecal route of administration.;   Overall safety of 3 mg/mL Gablofen® (Baclofen injection) given by the intrathecal route of administration
2 Recruiting Preventing Alcohol Withdrawal With Oral Baclofen
Conditions: Alcoholism;   Alcohol Withdrawal
Intervention: Drug: Baclofen
Outcome Measures: Alcohol withdrawal severity as measured on CIWA-AR (Clinical Institute for Withdrawal Assessment) scale;   Total benzodiazepine dose required
3 Not yet recruiting Oral and IV Baclofen in Adult Volunteers
Condition: Baclofen Withdrawal Syndrome
Interventions: Drug: Oral Baclofen;   Drug: Intervenous Baclofen
Outcome Measures: oral bioavailability;   Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - ∞)];   Plasma Decay Half-Life (t1/2);   Maximum concentration (Cmax);   Tmax;   assessment of sedation;   Ataxia;   Nystagmus;   blood pressure
4 Not yet recruiting Dose Escalation Study of Intravenous Baclofen in Healthy Adult Volunteers
Condition: Safety and Pharmacokinetics of Intravenous Baclofen
Intervention: Drug: Intravenous Baclofen
Outcome Measures: Safety assessments;   Maximum Concentration(Cmax);   AUC(0-inf);   Plasma Decay Half-life (T1/2)
5 Not yet recruiting Action of Baclofen Capsules in Spasticity Due to Multiple Sclerosis
Condition: Spasticity
Interventions: Drug: Baclofen dose 1;   Drug: Baclofen dose 2;   Drug: Placebo
Outcome Measures: Primary efficacy outcome: Improvement in Ashworth score;   Spasm frequency;   Nighttime awakening score;   Clinical global impression of change;   Subject's global impression of change
6 Recruiting Baclofen Effects in Cigarette Smokers
Condition: Nicotine Dependence
Interventions: Drug: Baclofen;   Drug: placebo
Outcome Measures: fMRI response in the ventral striatum/medial orbitofrontal cortex during smoking cue exposure;   Urine cotinine;   Cigarettes smoked per day
7 Recruiting Efficacy and Safety of Baclofen ER Capsules (GRS) in Subjects With Spasticity Due to Multiple Sclerosis
Condition: Spasticity
Interventions: Drug: Baclofen ER Capsules;   Drug: Placebo GRS
Outcome Measures: The primary efficacy outcome is the proportion of subjects who become a treatment failure during double-blind randomized withdrawal;   Determining the safety profile when administered over >12 weeks;   Subject Global Impression of Severity (SGIS)assessment
8 Recruiting Efficacy and Safety of High Dose Baclofen for Alcohol Dependence
Condition: Alcoholism
Interventions: Drug: Baclofen;   Drug: Placebo
Outcome Measures: Mean % Heavy Drinking Days;   Mean % Abstinent Drinking Days;   Anxiety level based on Spielberger Scale for State Anxiety
9 Recruiting Baclofen Effects on Marijuana Dependence
Condition: Marijuana Dependence
Interventions: Drug: Baclofen;   Behavioral: Psychosocial;   Drug: Placebo
Outcome Measure: Change in brain and behavioral responses during reward and inhibitory tasks at fMRI 1, fMRI 2, and fMRI 3; A composite measure
10 Recruiting A Clinical Evaluation Of The Safety Of Baclofen Er Capsules (Grs) When Administered Once Daily To Subjects With Spasticity Due To Multiple Sclerosis (Ms): An Open Label, Long Term, Safety Trial
Condition: Spasticity
Intervention: Drug: Baclofen
Outcome Measures: No. of participants with adverse events;   No. of participants with adverse vital signs;   Number of participants with adverse laboratory parameters
11 Not yet recruiting Preventing Alcohol Withdrawal Syndrome With Oral Baclofen
Condition: Alcohol Withdrawal Syndrome
Interventions: Drug: Baclofen;   Drug: Placebo
Outcome Measures: Prevention of Progression to Severe Alcohol withdrawal;   Reduced Severity of alcohol withdrawal (measured be SEWS score);   Reduced benzodiazepine administration in treatment group
12 Unknown  Baclofen as Add-On to Standard Treatment of Alcohol- Dependent Patients
Condition: Alcohol Dependence
Intervention: Drug: Baclofen (as add-on to standard treatment of alcohol dependence)
Outcome Measures: clinical efficacy and safe side-effect profile of Baclofen in patients suffering from alcohol dependence;   an improvement of the quality of life and associated psychosocial variables such as self-perceptions
13 Not yet recruiting A Study of Baclofen ER
Condition: Cocaine Dependence
Interventions: Drug: Baclofen ER;   Drug: Placebo
Outcome Measure: Urines positive for benzoylecgonine (BE), (a metabolite of cocaine)
14 Unknown  Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy
Conditions: Cerebral Palsy;   GERD
Interventions: Drug: Baclofen;   Drug: placebo
Outcome Measures: Symptom control;   GERD control;   side effects of Baclofen
15 Recruiting A Study to Examine the, Safety, Tolerability and Pharmacokinetics Co-Administered Baclofen and Memantine in Obese and Lean, Otherwise Healthy Adults
Conditions: Healthy Volunteers;;   Obese, Otherwise Healthy Volunteers
Interventions: Drug: Baclofen;   Drug: Memantine;   Drug: Placebo
Outcome Measures: Safety and tolerability of co-administered Baclofen and memantine via C-SSRS;   Safety and tolerability of co-administered Baclofen and memantine via Adverse Events;   Safety and tolerability of co-administered Baclofen and memantine via Vital Signs;   Safety and tolerability of co-administered Baclofen and memantine via ECG;   Safety and tolerability of co-administered Baclofen and memantine via Clinical Laboratory Tests;   Pharmacokinetic parameters of co-administered Baclofen and memantine via Cmax;   Pharmacokinetic parameters of co-administered Baclofen and memantine via Tmax;   Pharmacokinetic parameters of co-administered Baclofen and memantine via AUC;   Pharmacokinetic parameters of co-administered Baclofen and memantine via MRT;   Pharmacokinetic parameters of co-administered Baclofen and memantine via CL/F;   Pharmacokinetic parameters of co-administered Baclofen and memantine via T1/2;   Pharmacokinetic parameters of co-administered Baclofen and memantine via CLR
16 Recruiting Baclofen in the Treatment of Alcoholic Liver Disease
Condition: Alcoholic Liver Disease
Interventions: Drug: Baclofen 30mg/day;   Drug: Baclofen 75mg/day;   Drug: Placebo
Outcome Measures: alcohol consumption;   clinical markers of liver injury;   incidence of hepatic side effects;   craving for alcohol;   early termination due to side effects
17 Recruiting Baclofen for Treating Anxiety and Alcoholism
Conditions: Alcoholism;   Alcohol Dependence;   Alcohol Drinking Related Problems;   Alcohol Drinking;   Anxiety Disorder
Intervention: Drug: Baclofen
Outcome Measures: Alcohol drinking during the Alcohol Self-Administration, expressed as Standard Drinking Units (SDUs) will be measured as the primary outcome during the CR/ASA session.;   Secondary objectives include Baclofen s effects on alcohol cue-induced responses (urge to drink, attention to cues, blood pressure, heart rate, saliva), on the subjective effects of alcohol and on anxiety levels.
18 Unknown  Open Label Treatment of Severe Tactile Defensiveness With Intrathecal Baclofen
Conditions: Tactile Defensiveness;   Autism Spectrum Disorder
Intervention: Drug: Baclofen, intrathecal
Outcome Measures: Modified Short Sensory Profile.;   Clinical Global Impression of Change in Autism Symptoms
19 Unknown  Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes?
Condition: Cerebral Palsy
Interventions: Drug: oral Baclofen + placebo;   Drug: placebo + oral Baclofen
Outcome Measure: care and comport questionnaires
20 Recruiting GABA-B Receptor Function in Healthy Volunteers
Conditions: No Condition;   Brain GABA-B Function
Interventions: Drug: Baclofen 10mg;   Drug: Baclofen 60mg;   Drug: placebo
Outcome Measure: EEG spectral power in theta band