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TOXICITY TO VARIOUS AGENTS and Promethazine

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TOXICITY TO VARIOUS AGENTS Symptoms and Causes

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TOXICITY TO VARIOUS AGENTS treatment research studies

Promethazine clinical trials, surveys and public health registries


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Promethazine Side Effects

Poisoning (63)
Toxicity To Various Agents (47)
Pain (45)
Nausea (37)
Completed Suicide (36)
Cardiac Arrest (36)
Cholecystitis Chronic (36)
Respiratory Arrest (34)
Confusional State (33)
Anxiety (27)
Vomiting (24)
Dyspnoea (24)
Exposure Via Ingestion (23)
Cholelithiasis (21)
Convulsion (21)
Injury (20)
Gallbladder Disorder (19)
Death (19)
Abdominal Pain (19)
Agitation (18)
Cardio-respiratory Arrest (18)
Dizziness (18)
Pain In Extremity (18)
Tremor (16)
Dystonia (16)
Diarrhoea (16)
Abdominal Pain Upper (15)
Dehydration (15)
Dyskinesia (15)
Mental Status Changes (15)
Headache (15)
Unresponsive To Stimuli (14)
Hallucination (14)
Emotional Distress (13)
Fatigue (13)
Hypotension (12)
Gait Disturbance (12)
Extrapyramidal Disorder (11)
Somnolence (11)
Oedema Peripheral (11)
Dysarthria (10)
Depression (10)
Deep Vein Thrombosis (10)
Burning Sensation (10)
Erythema (10)
Hypertension (10)
Pulmonary Embolism (10)
Lethargy (10)
Injection Site Pain (10)
Hypoaesthesia (10)

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TOXICITY TO VARIOUS AGENTS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Study of Promethazine for Treatment of Diabetic Gastroparesis
Condition: Diabetic Gastroparesis
Interventions: Drug: Promethazine;   Drug: Sugar pill
Outcome Measures: Change in patient-reported symptoms as measured by the Gastroparesis Cardinal Symptom Index score (GCSI, 14) from week 0 to week 4.;   Occurrence of adverse events;   Use of rescue medication;   The impact on work activity as measured by the Work Productivity and Activity Impairment Questionnaire. (WPAI).
2 Unknown  Morphine Versus Morphine-Promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department
Condition: Low Back Pain
Interventions: Drug: Morphine-Promethazine;   Drug: morphine
Outcome Measures: Pain relief;   Ambulatory status
3 Recruiting Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
Condition: Drug Metabolism, Poor, CYP2D6-RELATED
Interventions: Drug: Diphenhydramine;   Drug: Metoclopramide
Outcome Measures: Area under curve of metoclopramide (MCP);   Area under curve of diphenhydramine(DPH);   Cmax of metoclopramide;   Tmax of metoclopramide;   Cmax of diphenhydramine;   Tmax of diphenhydramine
4 Unknown  Does Thiamine Help Vomiting and Nausea in Pregnancy?
Condition: Hyperemesis Gravidarum
Intervention: Drug: thiamine & Promethazine
Outcome Measure: the improvement in nausea and/or vomiting after treatment
5 Unknown  Adjunct Sedatives in Procedures Involving Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP)
Conditions: Endoscopic Ultrasound (EUS);   Endoscopic Retrograde Cholangiopancreatography (ERCP)
Interventions: Drug: Saline;   Drug: Diphenhydramine;   Drug: Promethazine
Outcome Measures: Sedation Level;   Time to achieve adequate level of sedation to begin procedure;   Time for Recovery;   Adverse Symptoms From Sedative Agents
6 Recruiting Diphenhydramine for Acute Migraine
Condition: Migraine
Interventions: Drug: metoclopramide;   Drug: diphenhydramine;   Drug: placebo
Outcome Measure: Sustained headache relief
7 Recruiting Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo
Condition: Cough Reflex Sensitivity
Interventions: Drug: Phenylephrine;   Drug: Diphenhydramine;   Drug: Dextromethorphan
Outcome Measure: change in cough reflex sensitivity to capsaicin
8 Not yet recruiting Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids
Conditions: Colonoscopy;   Adjunct Anesthesia Medication
Interventions: Drug: Diphenhydramine;   Drug: Placebo
Outcome Measures: Dosage of Fentanyl and Midazolam;   Quality of sedation;   Duration of Procedure;   Adverse events;   24 hour follow up
9 Not yet recruiting Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy
Conditions: Sedation;   Endoscopy
Interventions: Drug: Diphenhydramine;   Drug: Midazolam
Outcome Measure: Proportion of patients who achieve adequate sedation to allow colonoscopy (defined as MOAA/S ≤3)
10 Recruiting Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
Condition: Depression
Interventions: Drug: Ketamine;   Drug: Diphenhydramine
Outcome Measures: Evaluate the effects of ketamine on depressive symptomatology;   Evalaute the effects of ketamine on treatment alliance;   Evalaute the effects of ketamine on suicidal ideation
11 Not yet recruiting Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Condition: Vestibular
Interventions: Drug: Promethazine;   Behavioral: Hyper gravity training;   Drug: Placebo;   Behavioral: No hypergravity training
Outcome Measure: Rate of recovery of roll tilt perception errors after exposure to hypergravity
12 Not yet recruiting Histamine Glutamate Antagonism in Stroke
Conditions: Acute Cerebrovascular Accident;   Cerebral Edema
Interventions: Drug: Diphenhydramine;   Drug: Pantoprazole;   Drug: Famotidine;   Drug: Dextromethorphan
Outcome Measures: Modified Rankin Score;   National Institutes of Health Stroke Severity (NIHSS) Scale;   Neurological examination of the subject;   All cause mortality data
13 Not yet recruiting Psilocybin-facilitated Treatment for Cocaine Use
Condition: Cocaine-Related Disorders
Interventions: Drug: Psilocybin;   Drug: Diphenhydramine
Outcome Measure: The difference between the treatment and placebo groups in the number of participants with biochemically verified cocaine abstinence.
14 Recruiting Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC)
Condition: Kidney Cancer
Interventions: Drug: Pazopanib;   Drug: Temsirolimus;   Behavioral: Quality of Life Assessment;   Drug: Benadryl
Outcome Measure: Progression Free Survival (PFS)
15 Not yet recruiting First-time-in-man, to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BP1.5375
Condition: Healthy Male Volunteers
Interventions: Drug: BP1.5375 suspension;   Drug: Diphenhydramine;   Drug: Placebo
Outcome Measures: Single Ascending Dose - safety and tolerability (Part 1);   Proof of Concept - effect on polysomnography (Part 2)
16 Not yet recruiting A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence
Condition: Alcohol Dependence
Interventions: Drug: Psilocybin;   Drug: Diphenhydramine;   Behavioral: Motivational Enhancement and Taking Action (META)
Outcome Measures: percent heavy drinking days;   Changes in vital signs;   adverse events;   Percent days abstinent;   drinks per drinking day;   days to first drinking day;   Days to first heavy drinking day;   consequences of drinking;   craving;   self efficacy;   Motivation to change drinking behavior
17 Recruiting Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)
Condition: Acute Mountain Sickness
Interventions: Device: Theravent;   Device: Control
Outcome Measures: Incidence of acute mountain sickness;   number of nocturnal desaturations;   acute mountain sickness severity;   nocturnal awakenings;   subjective quality of sleep
18 Recruiting The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
Condition: Neuropathic Pain
Interventions: Drug: Lidocaine;   Drug: Diphenhydramine
Outcome Measures: Changes from Baseline Pain scores on the Visual Analog Scale at 6 weeks;   Hospital Anxiety and Depression Scale;   Modified Brief Pain Inventory;   Leeds Sleep Evaluation Questionnaire;   Patient Global Satisfaction with Treatment and Impression of Change;   Side Effects;   Quality of Life Health Outcome Instrument
19 Recruiting FUS1-nanoparticles and Erlotinib in Stage IV Lung Cancer
Condition: Lung Cancer
Interventions: Drug: DOTAP:Chol-fus1;   Drug: Erlotinib;   Drug: Dexamethasone;   Drug: Diphenhydramine
Outcome Measures: Maximum Tolerated Dose (MTD) Level for Drug Treatment Combination;   Response Rate
20 Unknown  Efficacy and Safety of the Herbal Medicine Sominex ® (Passiflora Incarnata L., Valeriana Officinalis L. and Crataegus Oxyacantha L.), Manufactured by the Laboratory EMS S / A in Patients With Psychophysiological Insomnia
Condition: Insomnia
Interventions: Drug: Sominex;   Drug: Placebo
Outcome Measures: Improvement in sleep efficiency;   Improvement of the values obtained by the answers of the questionnaires obtained during the treatment