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TRANSIENT ISCHAEMIC ATTACK and Amitriptyline

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TRANSIENT ISCHAEMIC ATTACK Symptoms and Causes

Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of PAD is atherosclerosis. This happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. Plaque is a substance made up of fat and cholesterol. It causes the arteries to narrow or become blocked. This can reduce or stop blood flow, usually to the legs. If severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg.

The main risk factor for PAD is smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke.

Many people who have PAD don't have any symptoms. If you have symptoms, they may include

  • Pain, numbness, achiness, or heaviness in the leg muscles. This happens when walking or climbing stairs.
  • Weak or absent pulses in the legs or feet
  • Sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all
  • A pale or bluish color to the skin
  • A lower temperature in one leg than the other leg
  • Poor nail growth on the toes and decreased hair growth on the legs
  • Erectile dysfunction, especially among men who have diabetes

PAD can increase your risk of heart attack, stroke, and transient ischemic attack.

Doctors diagnose PAD with a physical exam and heart and imaging tests. Treatments include lifestyle changes, medicines, and sometimes surgery. Lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for TRANSIENT ISCHAEMIC ATTACK

TRANSIENT ISCHAEMIC ATTACK treatment research studies

Amitriptyline clinical trials, surveys and public health registries


Find Drug Side Effect reports



Amitriptyline Side Effects

Completed Suicide (98)
Toxicity To Various Agents (72)
Overdose (61)
Cardiac Arrest (57)
Somnolence (48)
Pain (47)
Convulsion (45)
Anxiety (44)
Headache (44)
Death (42)
Confusional State (40)
Vomiting (40)
Dizziness (39)
Intentional Overdose (39)
Dyspnoea (38)
Loss Of Consciousness (38)
Nausea (35)
Fatigue (35)
Coma (33)
Respiratory Arrest (33)
Depression (32)
Hypotension (31)
Agitation (31)
Hallucination (29)
Malaise (29)
Fall (28)
Cardio-respiratory Arrest (28)
Syncope (27)
Diarrhoea (26)
Insomnia (26)
Tremor (26)
Pyrexia (25)
Grand Mal Convulsion (25)
Delirium (24)
Asthenia (24)
Abdominal Pain (23)
Feeling Abnormal (23)
Suicide Attempt (23)
Dysarthria (22)
Depressed Level Of Consciousness (21)
Constipation (21)
Deep Vein Thrombosis (21)
Electrocardiogram Qt Prolonged (21)
Serotonin Syndrome (21)
Palpitations (21)
Weight Decreased (20)
Gait Disturbance (20)
Dry Mouth (19)
Metabolic Acidosis (19)
Rash (19)

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Recent Reviews

im on amitriptyline 25mg,i have my xmas party this weekend and wanted to drink alchol. i wonder is it a good idea

After having been on elavil for 9 years, mostly at 100mg/night, I spent the last 6 months weaning off. Shortly after stopping amitriptyline I now have high blood pressure. Before stopping, and for years before starting, my usual pressure was 115/65,

Be safe !!

Been on amitrip 25mg at night for 8 nights now and have felt and look alot better. although i have diarrihea now and felt abit of nausea here and there . feel a tad tired throughout the day but i think for me the postives outweigh

Can amitriptyline can cause thrombocytopenia ?

Doc gave me 25mg to help me sleep after quitting the weed. not as good as zoplicone though

Does Amtriptyline help tinnitus. I'm taking it at a low dose for jaw problems and fibromyalgia. the 25 mg dose seems to make my tinnitus worse but my pain better. I don't know what to do?

For the past 18 mnths myfifteen year old takes Pizotifen for migraine.Even on low dose it hasvirtually seen off the migraine episodes and apart from initial tiredness for the first few weeks on it, we are not aware of an

Hey i took 500mg of amitriptyline and overdosed and almost Died.. Dont take that much

I have been taken 2 25mg at night for 6 months my mouth is dry all the time i carry water with me everywhere , i have a bloted tummy all the time ! but i die as soon as my head touches the pillow !!i feel fat all the time !!

Yesterday, after taking Sam-e with Glucosamine. I got a pain between my shoulder blade, jaw pain, dizziness, sweating. felt like a heart attack. I did not go to the hospital because of the money needed. No ins

After using Clobetasol for a two week cycle, my doctor suggested I use it one day during the week, applying it twice that day. Since that time, I have experinced severe chest pain. I recently saw my doctor for heart attack symptoms before I reali

<b>My wife had a stroke in 2002. The doctor prescribed meloxicam 15mg in July 2010 for arthritis. In August 2010 she had a silent heart attack diminishing heart pumps to 25%.</b>

<span style='color: #808080;'><b>Describe Your Henoch-Schonlein purpura from INFLUENZA (H1N1) (H1N1 (MONOVALENT) SANOFI) 2010 Experience Here:</b> Vicious headaches, rash on legs and trunk, transient, cystitis type fee

23 M I JUST HAD METAMUCIL FIBER WAFFERS FOR 1 WEEK AND I JUST GOT CHEST PAIN LIKE HEART ATTACK AND FEEL LIKE STUCK IN MY THROAT (CHOKING) ( LUMP IN THROAT ) AND AFTER 3 WEEKS I HAVE NOW SHORTNESS OF BREATH I WAS HEALTHY BEFORE METAMUCIL BUT NOW I AM

About an hour after getting home from the hospital, I started with the sneezing fits. Lasted the rest of the day and all night an into the next morning. Felt like I had a very bad allergy attack or headcold.

After having cefuroxime before a spinal operation my blood pressure went through the floor and i had a heart attack. I am now left with a damaged heart and am unable to have my back operation.

After my 3rd cycle of granocyte had finished. the following eveing i experienced pains in my chest and back. vey similiar to the symptoms of a heart attack. this was accompained by severe headache. symptoms lasted 18 hours. i am very nervous of next

After several small sips of Benylin DM-E ( regular strength), an episode of transient global amnesia. Same had occurred many years earlier after absorbing a number of throat lozenges on an airplane

After taking midol i felt nauseous, dizzy, i felt like fainting, i was a little shaky, my heart beat seemed a little irregular and i couldn't get to sleep. i kind of had a panic attack, but i dont think it would be considered a panic attack to a doct

TRANSIENT ISCHAEMIC ATTACK Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Amitriptyline to Prevent Headache After Traumatic Brain Injury
Conditions: Brain Injuries;   Post-Traumatic Headache
Intervention: Drug: Amitriptyline
Outcome Measures: Frequency and severity of headaches;   Headache Impact Test - 6;   Rivermead Post-Concussion Symptoms Questionnaire (RPQ);   Short Form-12® Health Survey (SF-12);   Number of participants with adverse events;   Headache characteristic survey;   Insomnia Severity Index;   Patient Health Questionnaire-9 (PHQ-9;   Rey Auditory Verbal Learning Test;   Trail Making Test;   Wechsler Adult Intelligence Scale (WAIS) IV Digit Symbol
2 Recruiting Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age
Condition: Chronic Oral Food Refusal
Interventions: Drug: Amitriptyline 1 mg/kg;   Drug: Placebo
Outcome Measures: To assess the efficacy of Amitriptyline in a 24-week outpatient multi-disciplinary protocol for transitioning children from tube to oral feeding;   To assess the role of pain in the efficacy of Amitriptyline in the 24-week outpatient multidisciplinary protocol.
3 Unknown  Efficacy of Gabapentin or Amitriptyline to Reduce Postoperative Pain After Lumbar Laminectomy and Diskectomy
Conditions: Herniated Disc;   Intervertebral Disc Displacement
Intervention: Drug: Gabapentin , Amitriptyline
Outcome Measures: 30% reduction in opium consumption in either study arms compared to the placebo group;   30% reduction in pain according to visual analogue scale in either study arms compared to the placebo group
4 Unknown  Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer
Conditions: Cancer;   Neuralgia
Interventions: Drug: Amitriptyline;   Drug: pregabalin
Outcome Measures: VAS score;   EQ-5D, McGill, EORTC-C30, HADS
5 Unknown  Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine
Condition: Migraine
Interventions: Drug: Amitriptyline;   Drug: Melatonin;   Drug: Placebo
Outcome Measures: Change in number of headache days from baseline to month 3 after treatment.;   Proportion of patients responding to treatment. Change from Baseline Phase to Double-Blind Phase in number of monthly migraine attacks,monthly migraine days, number of days/month requiring rescue medication.
6 Recruiting The Childhood and Adolescent Migraine Prevention Study
Conditions: Migraine;   Migraine Disorders;   Headache
Interventions: Drug: Amitriptyline;   Drug: Topiramate;   Drug: Placebo
Outcome Measures: Reduction in Migraine Frequency (Amitriptyline and topiramate);   Reduction in absolute migraine disability score on PedMIDAS;   Safety and tolerability of Amitriptyline and topiramate;   Occurrence of treatment-emergent serious adverse events;   Reduction in absolute migraine frequency days
7 Not yet recruiting Prediction of Migraine Prevention Efficacy: Individualization of Treatment by Coupling Drug's Mode of Action With Patient's Mechanism of Pain Modulation
Conditions: Migraine;   Preventive Treatment
Interventions: Drug: Amitriptyline;   Drug: placebo
Outcome Measures: the association between pre-treatment assessment parameter(s) and the reduction in frequency of migraine attacks by Amitriptyline;   the association between pain-related psychological parameters and the reduction in migraine attacks by Amitriptyline
8 Unknown  Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo
Conditions: Cystic Fibrosis;   Pneumonia
Interventions: Drug: Amitriptyline;   Drug: Mannite
Outcome Measures: Improvement of the lung function parameter FEV1 (absolute and relative to baseline) under verum and placebo;   Increase in lung function measurements;   Ceramide concentration in epithelial cells;   Inflammation status;   Bacteriological and cell status;   Side effects
9 Recruiting Safety and Efficacy Study Comparing ETS6103 With Amitriptyline in the Treatment of Major Depressive Disorder (MDD)
Condition: Major Depressive Disorder
Interventions: Drug: ETS6103 (low dose);   Drug: ETS6103 (high dose);   Drug: Amitriptyline
Outcome Measures: The mean difference in baseline-adjusted (Montgomery-Asberg Depression Scale) MADRS score at the end of treatment.;   Assessment of MADRS score throughout the randomised study period;   Assessment of Clinical Global Impression (CGI) of Severity / Improvement Scale
10 Recruiting Alternative Dosing Regimens in the Pharmacotherapy of Insomnia
Condition: Insomnia
Interventions: Drug: Amitriptyline;   Drug: Zolpidem;   Drug: Placebo
Outcome Measures: Objective Total Sleep Time;   Objective Sleep Onset Latency;   Self-reported Total Sleep Time;   Self-Reported Sleep Onset Latency;   Percentage of REM sleep;   REM onset latency;   Objective Sleep Efficiency;   Self-Reported Total Sleep Time;   Self-reported Sleep Onset Latency (min);   Self-reported Sleep Onset Latency (evaluation)
11 Unknown  A Study to Compare the Pharmacokinetic Profiles of Etravil® Tablet 10mg and Etravil® Tablet 25mg
Condition: Depression
Interventions: Drug: Etravil 10mg Tablet;   Drug: Etravil 25mg Tablet
Outcome Measures: Cmax of Amitryptiline in plasma;   AUClast of amityptyline in plasma;   Tmax of amityptyline in plasma;   terminal half-life (t1/2) of amityptyline in plasma;   CL/F of amityptyline in plasma
12 Recruiting Effect of Minocycline on Pain Caused by Nerve Damage
Condition: Neuropathic Pain Caused by Lumbar Radicular Pain
Interventions: Drug: Minocycline;   Drug: placebo;   Drug: Amitriptyline
Outcome Measures: Pain intensity;   neuropathic pain diagnostic questionnaire (DN4) score;   Amount of rescue medication taken
13 Recruiting Immune-Pineal Axis Function in Fibromyalgia
Condition: Fibromyalgia
Interventions: Drug: Melatonin and Placebo;   Drug: Amitriptyline and Placebo;   Drug: Melatonin and Amitriptylin
Outcome Measures: Change from Baseline in pain on Fibromyalgia Impact Questionnaire (FIQ) at week 6;   Change from Baseline in Pain Pressure Threshold (PPT) at week 6;   Change from Baseline Brain-derived neurotrophic factor at week 6;   Change from Baseline of the Pittsburgh Sleep Quality Index (PSQI) at week 6;   Change from Baseline of the Pain Catastrophizing Scale at week 6
14 Unknown  Tricyclic Antidepressants (TCAs) on Gastric Emptying
Condition: Functional Dyspepsia
Interventions: Drug: Desipramine;   Drug: Amitriptyline
Outcome Measures: Gastric emptying;   Gastric volume
15 Recruiting Interpersonal Psychotherapy for Treatment Resistant Depression
Condition: Treatment Resistant Depression
Interventions: Other: IPT+ antidepressant drugs;   Drug: fluoxetine;   Drug: sertraline;   Drug: paroxetine;   Drug: Citalopram;   Drug: escitalopram;   Drug: fluvoxamine;   Drug: Venlafaxine;   Drug: Duloxetine;   Drug: Bupropion;   Drug: Lithium;   Drug: Risperidone;   Drug: tranylcypromine;   Drug: Imipramine;   Drug: Amitriptyline;   Drug: Clomipramine;   Drug: nortriptyline;   Drug: trazodone;   Drug: Mirtazapine;   Drug: sulpiride
Outcome Measures: Hamilton Depression Scale (HAM-D) - continuous;   Beck depression Inventory (BDI)
16 Recruiting Open Label Pharmacokinetic-Pharmacogenetic Study on Polymorphisms in the Organic Cation Transporter OCT1
Conditions: Drug Metabolism;   Membrane Transport
Interventions: Drug: Drug application Amitriptyline;   Drug: Drug application Desvenlafaxine;   Drug: Drug application Sumatriptan;   Drug: Drug application Proguanil
Outcome Measures: Area under the plasma concentration-time curve (AUC) of the investigational drugs;   Total clearance, Cmax, Tmax, Mean AbsorptionTime, Alpha and Beta half-lives, Mean Residence Time (MRT) and Volume of distribution of the investigated drugs and their metabolites;   Dry mouth, fatigue, nausea, headache, vertigo, tinnitus, chills, anxiety and difficulties to read on Visual Analog Scales.;   Sedation on Stanford sedation scale;   Pupil diameter, latency, diameter at maximal constriction, amplitude and time for 33% recovery of initial pupil diameter measured by pupillometrie;   Genetic variants in OCT1, CYP2C19, CYP2D6 and MAO A
17 Recruiting Pharmacological Conditioning of Sleep Patterns in Healthy Participants Using Amitriptylin
Condition: Healthy Participants
Interventions: Drug: Amitriptyline;   Drug: Placebo
Outcome Measures: Objective Total Sleep Time;   Percentage of rapid eye movement (REM) sleep
18 Unknown  Lidocaine on Pain Relief and IL and Substance P in Fibromyalgia
Condition: Fibromyalgia
Interventions: Drug: Lidocaine;   Drug: lidocaine
Outcome Measure: Evaluation of the effect of intravenous lidocaine on pain relief and plasma concentrations of interleukins (IL-1 and IL-6) and substance P in patients with fibromyalgia
19 Recruiting Cyclobenzaprine Extended Release (ER) for Fibromyalgia
Conditions: Fibromyalgia;   Pain;   Sleep;   Fatigue
Interventions: Drug: cyclobenzaprine ER (AMRIX);   Drug: placebo
Outcome Measures: Visual Analogue Pain Scale;   Brief Fatigue Inventory;   Analogue sleep/wakefulness scale;   Fibromyalgia Impact Questionnaire;   Sheehan Disability SCale;   Quick Inventory of Depression;   Reported Adverse Effects
20 Unknown  A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol
Condition: Low Back Pain
Interventions: Drug: Tandrilax;   Drug: Dolamin Flex
Outcome Measures: Pain average reduction;   Identification of possible gastrointestinal effects