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VISION BLURRED Symptoms and Causes

What is high blood pressure in pregnancy?

Blood pressure is the force of your blood pushing against the walls of your arteries as your heart pumps blood. High blood pressure, or hypertension, is when this force against your artery walls is too high. There are different types of high blood pressure in pregnancy:

  • Gestational hypertension is high blood pressure that you develop while you are pregnant. It starts after you are 20 weeks pregnant. You usually don't have any other symptoms. In many cases, it does not harm you or your baby, and it goes away within 12 weeks after childbirth. But it does raise your risk of high blood pressure in the future. It sometimes can be severe, which may lead to low birth weight or preterm birth. Some women with gestational hypertension do go on to develop preeclampsia.
  • Chronic hypertension is high blood pressure that started before the 20th week of pregnancy or before you became pregnant. Some women may have had it long before becoming pregnant, but didn't know it until they got their blood pressure checked at their prenatal visit. Sometimes chronic hypertension can also lead to preeclampsia.
  • Preeclampsia is a sudden increase in blood pressure after the 20th week of pregnancy. It usually happens in the last trimester. In rare cases, symptoms may not start until after delivery. This is called postpartum preeclampsia. Preeclampsia also includes signs of damage to some of your organs, such as your liver or kidney. The signs may include protein in the urine and very high blood pressure. Preeclampsia can be serious or even life-threatening for both you and your baby.
What causes preeclampsia?

The cause of preeclampsia is not known.

Who is at risk for preeclampsia?

You are at higher risk of preeclampsia if you

  • Had chronic high blood pressure or chronic kidney disease before pregnancy
  • Had high blood pressure or preeclampsia in a previous pregnancy
  • Have obesity
  • Are over age 40
  • Are pregnant with more than one baby
  • Are African American
  • Have a family history of preeclampsia
  • Have certain health conditions, such as diabetes, lupus, or thrombophilia (a disorder which raises your risk of blood clots)
  • Used in vitro fertilization, egg donation, or donor insemination
What problems can preeclampsia cause?

Preeclampsia can cause

  • Placental abruption, where the placenta separates from the uterus
  • Poor fetal growth, caused by a lack of nutrients and oxygen
  • Preterm birth
  • A low birth weight baby
  • Stillbirth
  • Damage to your kidneys, liver, brain, and other organ and blood systems
  • A higher risk of heart disease for you
  • Eclampsia, which happens when preeclampsia is severe enough to affect brain function, causing seizures or coma
  • HELLP syndrome, which happens when a woman with preeclampsia or eclampsia has damage to the liver and blood cells. It is rare, but very serious.
What are the symptoms of preeclampsia?

Possible symptoms of preeclampsia include

  • High blood pressure
  • Too much protein in your urine (called proteinuria)
  • Swelling in your face and hands. Your feet may also swell, but many women have swollen feet during pregnancy. So swollen feet by themselves may not be a sign of a problem.
  • Headache that does not go away
  • Vision problems, including blurred vision or seeing spots
  • Pain in your upper right abdomen
  • Trouble breathing
  • Eclampsia can also cause seizures, nausea and/or vomiting, and low urine output. If you go on to develop HELLP syndrome, you may also have bleeding or bruising easily, extreme fatigue, and liver failure.

    How is preeclampsia diagnosed?

    Your health care provider will check your blood pressure and urine at each prenatal visit. If your blood pressure reading is high (140/90 or higher), especially after the 20th week of pregnancy, your provider will likely want to run some tests. They may include blood tests other lab tests to look for extra protein in the urine as well as other symptoms.

    How is preeclampsia treated?

    Delivering the baby can often cure preeclampsia. When making a decision about treatment, your provider take into account several factors. They include how severe it is, how many weeks pregnant you are, and what the potential risks to you and your baby are:

    • If you are more than 37 weeks pregnant, your provider will likely want to deliver the baby.
    • If you are less than 37 weeks pregnant, your health care provider will closely monitor you and your baby. This includes blood and urine tests for you. Monitoring for the baby often involves ultrasound, heart rate monitoring, and checking on the baby's growth. You may need to take medicines, to control your blood pressure and to prevent seizures. Some women also get steroid injections, to help the baby's lungs mature faster. If the preeclampsia is severe, you provider may want you to deliver the baby early.

    The symptoms usually go away within 6 weeks of delivery. In rare cases, symptoms may not go away, or they may not start until after delivery (postpartum preeclampsia). This can be very serious, and it needs to be treated right away.

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VISION BLURRED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting A Comparison of Midazolam and Zolpidem as Oral Premedication in Children
Conditions: Parental/Caregiver Anxiety;   Child's Anxiety
Interventions: Drug: zolpidem;   Drug: Midazolam
Outcome Measures: Patient anxiety at the time of separation;   Other comparison measures will include preoperative parent/caregiver anxiety, anesthesia mask acceptance characteristics at the time of induction, and time to full recovery in the post operative period.
2 Recruiting Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T
Condition: Psychotropic Drugs Effects
Interventions: Drug: Zolpidem;   Drug: Alprazolam;   Drug: Caffeine;   Other: Placebo
Outcome Measures: Change in blood oxygen level-dependent (BOLD) signal as measured with fMRI;   Change in subjective drug effects as measured by self-report questionnaires
3 Recruiting Effects of Zolpidem CR® in Sleep and Heart Recovery in Cardiac Intensive Care Unit Patients
Conditions: Acute Coronary Syndrome;   Sleep Deprivation
Interventions: Drug: Zolpidem CR 12.5mg;   Drug: Placebo
Outcome Measures: Sleep efficiency;   Troponin T;   Creatine-kinase MB
4 Unknown  The Role of Partial Reinforcement in the Long Term Management of Insomnia
Condition: Primary Insomnia
Intervention: Drug: Zolpidem
Outcome Measures: sleep diary;   Sleep Diary
5 Recruiting The Role of Sleep in the Treatment of Cannabis Use Disorders
Condition: Drug Addiction
Interventions: Drug: Zolpidem extended-release;   Behavioral: MET/CBT
Outcome Measures: Sleep Efficiency;   Cannabis Abstinence
6 Recruiting Reducing Suicidal Ideation Through Insomnia Treatment
Conditions: Insomnia;   Depression;   Suicidal Ideation
Interventions: Drug: Zolpidem-CR;   Drug: Placebo
Outcome Measures: Suicide Severity Index (SSI);   Dysfunctional Beliefs and Attitudes About Sleep;   Disturbing Dreams and Nightmares Severity Index (DDNSI);   Beck Hopelessness Scale (BHS);   Hamilton Rating Scale for Depression (HAM-D);   Insomnia Severity Index (ISI)
7 Not yet recruiting Polysomnographic Study Comparing the Use of Dexmedetomidine and Zolpidem to Induce Natural Sleep
Condition: Insomnia
Interventions: Drug: Dexmedetomidine;   Drug: Zolpidem;   Drug: Oral Placebo;   Drug: Normal Saline placebo.
Outcome Measures: Subjective and objective measures of sleep quality;   Performance on a word-pair cognitive task after waking up from sleep
8 Recruiting Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance
Condition: Healthy Volunteers
Interventions: Drug: Almorexant;   Drug: Zolpidem 10mg;   Drug: Placebo
Outcome Measure: A comparison between dosing groups on performance on neurocognitive measures
9 Recruiting Alternative Dosing Regimens in the Pharmacotherapy of Insomnia
Condition: Insomnia
Interventions: Drug: Amitriptyline;   Drug: Zolpidem;   Drug: Placebo
Outcome Measures: Objective Total Sleep Time;   Objective Sleep Onset Latency;   Self-reported Total Sleep Time;   Self-Reported Sleep Onset Latency;   Percentage of REM sleep;   REM onset latency;   Objective Sleep Efficiency;   Self-Reported Total Sleep Time;   Self-reported Sleep Onset Latency (min);   Self-reported Sleep Onset Latency (evaluation)
10 Unknown  Risperidone and Zotepine in the Treatment of Delirium
Condition: Delirium
Intervention: Drug: Risperidone and Zolpidem for delirium
Outcome Measures: Delirium rating scale;   MMSE, CGI, side effect profile, HRV
11 Unknown  Memory Consolidation in Pharmacologically Enhanced Naps
Condition: Sleep
Interventions: Drug: Low-dose sodium oxybate;   Drug: High-dose sodium oxybate;   Drug: Low-dose zolpidem;   Drug: High-dose zolpidem;   Drug: Placebo
Outcome Measures: Pharmacological enhancement of specific sleep parameters in a dose-dependent manner;   Correlation of pharmacological interventions with changes in sleep-stage-specific memory tasks
12 Unknown  Age-Dependent Memory Benefits From Pharmacologically Enhanced Naps?
Condition: Older Adults
Interventions: Drug: Sodium Oxybate;   Drug: Zolpidem;   Drug: placebo
Outcome Measure:
13 Recruiting Sequenced Therapies for Comorbid and Primary Insomnias
Conditions: Insomnia Comorbid to Psychiatric Disorder;   Primary Insomnia
Interventions: Behavioral: Behavioral Insomnia Therapy;   Drug: Zolpidem;   Drug: Trazodone;   Behavioral: Cognitive Therapy
Outcome Measure: Insomnia Severity Index- Change from Baseline (Remission)
14 Recruiting Use of Benzodiazepines and Z Drugs in the Elderly
Condition: Chronic Benzodiazepines and Related Drugs Users
Intervention:
Outcome Measures: Dependence according to DSM IV criteria;   withdrawal syndrome;   psychiatric comorbidities;   Dependence scores
15 Not yet recruiting Effects of GABA Modulator AZD7325 on Cortical Excitability
Condition: Healthy
Interventions: Drug: 2 mg AZD7325;   Drug: 10 mg AZD7325;   Drug: Placebo
Outcome Measures: Change in conventional measure of percentage short interval intracortical inhibition (SICI) at an interstimulus interval (ISI) of 2.5 ms and conditioning stimulus intensity of 70 percent of resting motor threshold;   Change in the variables of kinematic analysis of circle drawing;   Change in the rating on a 0-100 mm Visual Analogue Scale (VAS) of degree of sedation and the score of Symbol Digit Modalities Test (SDMT);   Safety and tolerability of a single dose of AZD7325 by assessment of adverse events, vital signs, physical examination, ECG, and laboratory variables
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