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VISION BLURRED and FOSAMAX

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VISION BLURRED Symptoms and Causes

What is high blood pressure in pregnancy?

Blood pressure is the force of your blood pushing against the walls of your arteries as your heart pumps blood. High blood pressure, or hypertension, is when this force against your artery walls is too high. There are different types of high blood pressure in pregnancy:

  • Gestational hypertension is high blood pressure that you develop while you are pregnant. It starts after you are 20 weeks pregnant. You usually don't have any other symptoms. In many cases, it does not harm you or your baby, and it goes away within 12 weeks after childbirth. But it does raise your risk of high blood pressure in the future. It sometimes can be severe, which may lead to low birth weight or preterm birth. Some women with gestational hypertension do go on to develop preeclampsia.
  • Chronic hypertension is high blood pressure that started before the 20th week of pregnancy or before you became pregnant. Some women may have had it long before becoming pregnant, but didn’t know it until they got their blood pressure checked at their prenatal visit. Sometimes chronic hypertension can also lead to preeclampsia.
  • Preeclampsia is a sudden increase in blood pressure after the 20th week of pregnancy. It usually happens in the last trimester. In rare cases, symptoms may not start until after delivery. This is called postpartum preeclampsia. Preeclampsia also includes signs of damage to some of your organs, such as your liver or kidney. The signs may include protein in the urine and very high blood pressure. Preeclampsia can be serious or even life-threatening for both you and your baby.
What causes preeclampsia?

The cause of preeclampsia is not known.

Who is at risk for preeclampsia?

You are at higher risk of preeclampsia if you

  • Had chronic high blood pressure or chronic kidney disease before pregnancy
  • Had high blood pressure or preeclampsia in a previous pregnancy
  • Have obesity
  • Are over age 40
  • Are pregnant with more than one baby
  • Are African American
  • Have a family history of preeclampsia
  • Have certain health conditions, such as diabetes, lupus, or thrombophilia (a disorder which raises your risk of blood clots)
  • Used in vitro fertilization, egg donation, or donor insemination
What problems can preeclampsia cause?

Preeclampsia can cause

  • Placental abruption, where the placenta separates from the uterus
  • Poor fetal growth, caused by a lack of nutrients and oxygen
  • Preterm birth
  • A low birth weight baby
  • Stillbirth
  • Damage to your kidneys, liver, brain, and other organ and blood systems
  • A higher risk of heart disease for you
  • Eclampsia, which happens when preeclampsia is severe enough to affect brain function, causing seizures or coma
  • HELLP syndrome, which happens when a woman with preeclampsia or eclampsia has damage to the liver and blood cells. It is rare, but very serious.
What are the symptoms of preeclampsia?

Possible symptoms of preeclampsia include

  • High blood pressure
  • Too much protein in your urine (called proteinuria)
  • Swelling in your face and hands. Your feet may also swell, but many women have swollen feet during pregnancy. So swollen feet by themselves may not be a sign of a problem.
  • Headache that does not go away
  • Vision problems, including blurred vision or seeing spots
  • Pain in your upper right abdomen
  • Trouble breathing
  • Eclampsia can also cause seizures, nausea and/or vomiting, and low urine output. If you go on to develop HELLP syndrome, you may also have bleeding or bruising easily, extreme fatigue, and liver failure.

    How is preeclampsia diagnosed?

    Your health care provider will check your blood pressure and urine at each prenatal visit. If your blood pressure reading is high (140/90 or higher), especially after the 20th week of pregnancy, your provider will likely want to run some tests. They may include blood tests other lab tests to look for extra protein in the urine as well as other symptoms.

    How is preeclampsia treated?

    Delivering the baby can often cure preeclampsia. When making a decision about treatment, your provider take into account several factors. They include how severe it is, how many weeks pregnant you are, and what the potential risks to you and your baby are:

    • If you are more than 37 weeks pregnant, your provider will likely want to deliver the baby.
    • If you are less than 37 weeks pregnant, your health care provider will closely monitor you and your baby. This includes blood and urine tests for you. Monitoring for the baby often involves ultrasound, heart rate monitoring, and checking on the baby's growth. You may need to take medicines, to control your blood pressure and to prevent seizures. Some women also get steroid injections, to help the baby's lungs mature faster. If the preeclampsia is severe, you provider may want you to deliver the baby early.

    The symptoms usually go away within 6 weeks of delivery. In rare cases, symptoms may not go away, or they may not start until after delivery (postpartum preeclampsia). This can be very serious, and it needs to be treated right away.

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FOSAMAX Side Effects

Femur Fracture (5674)
Anxiety (3177)
Osteonecrosis (2820)
Fall (2638)
Depression (2384)
Arthralgia (1887)
Dental Caries (1636)
Arthropathy (1621)
Back Pain (1566)
Low Turnover Osteopathy (1355)
Anaemia (1283)
Osteomyelitis (1270)
Hypertension (1242)
Blood Cholesterol Increased (1236)
Impaired Healing (1123)
Abscess (1121)
Adverse Event (1103)
Bone Density Decreased (1051)
Bone Disorder (1050)
Chest Pain (1022)
Bronchitis (915)
Tooth Disorder (890)
Arthritis (849)
Gastrooesophageal Reflux Disease (838)
Intramedullary Rod Insertion (835)
Osteonecrosis Of Jaw (834)
Cataract (805)
Osteoarthritis (784)
Osteoporosis (749)
Pain In Extremity (719)
Stress Fracture (715)
Jaw Disorder (708)
Asthma (706)
Cellulitis (697)
Chronic Obstructive Pulmonary Disease (679)
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Pain (544)
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Fatigue (522)
Oral Infection (505)
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Dizziness (502)
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Hip Fracture (497)
Headache (477)

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VISION BLURRED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting The Effect of Alendronate on the Immune Response to Hepatitis B Vaccine in Healthy Adults
Condition: Healthy Volunteers
Interventions: Drug: Alendronate;   Drug: Hepatitis B Vaccine;   Drug: Placebo
Outcome Measures: Safety/Adverse events;   Efficacy
2 Recruiting Testosterone and Alendronate in Hypogonadal Men
Conditions: Hypogonadism;   Osteopenia;   Osteoporosis
Interventions: Drug: Testosterone;   Drug: Alendronate;   Drug: Placebo Alendronate;   Drug: Placebo Testosterone
Outcome Measure: Spine Bone Mineral Density by DXA
3 Unknown  Alendronate for Vascular Calcification in Peritoneal Dialysis Patients?
Condition: Peritoneal Dialysis
Intervention: Drug: alendronate (Fosamax)
Outcome Measures: 1.Changes of calcification score of coronary arteries and aorta;   2.Changes of bone density;   changes of parathyroid hormone;   changes of serum calcium and phosphate level;   changes of C reactive protein;   changes of lipid profile;   adverse reactions
4 Unknown  Fosamax for Childhood Cancer Survivors
Condition: Osteoporosis
Interventions: Drug: Alendronate;   Drug: Placebo
Outcome Measures: The percent change in bone mineral density (BMD) at lumbar spine at 36-weeks in subjects who receive active and control treatments;   Changes in BMD at femoral neck;   Changes in biochemical markers of bone turnover;   Occurrence of clinical bone-related symptoms at 12-weeks and end of this study
5 Not yet recruiting RA Denosumab on Bone Microstructure Study
Condition: Rheumatoid Arthritis
Interventions: Drug: Denosumab;   Drug: Alendronate
Outcome Measures: Changes from baseline in bone volumetric density at distal radius at 6th month;   Changes from baseline in trabecular bone microarchitecture at distal radius at 6th month;   Changes from baseline in bone volumetric density at the 2nd metacarpal bone at 6th month;   Changes from baseline in trabecular bone microarchitecture at 2nd metacarpal bone at 6th month;   Changes from baseline in areal bone density at total hip at 6th month;   Changes from baseline in areal bone density at lumbar spine at 6th month;   Changes in areal bone density at distal radius at 6th month;   Changes from baseline in bone volumetric density at distal radius at 3rd month;   Changes from baseline in trabecular bone microarchitecture at distal radius at 3rd month;   Changes from baseline in bone volumetric density at the 2nd metacarpal bone at 3rd month;   Changes from baseline in trabecular bone microarchitecture at 2nd metacarpal bone at 3rd month;   Changes from baseline in areal bone density at total hip at 3rd month;   Changes from baseline in areal bone density at lumbar spine at 3rd month;   Changes in areal bone density at distal radius at 3rd month
6 Recruiting Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis
Condition: Postmenopausal Women With Osteoporosis
Interventions: Drug: Romosozumab;   Drug: Alendronate
Outcome Measures: Incidence of clinical fracture;   Incidence of new vertebral fracture;   Incidence of fracture;   Percent changes in DXA Bone Mineral Density from baseline to 12 months;   Percent changes in DXA Bone Mineral Density from baseline to 24 months;   Percent changes in DXA Bone Mineral Density from baseline to 36 months
7 Not yet recruiting Bone Antiresorptive Therapy With Antiretroviral Initiation (BATARI) Pilot Trial
Condition: HIV
Intervention: Drug: alendronate/vitamin D
Outcome Measures: Percentage changes in BMD at a) the lumbar spine and b) proximal femur;   Feasibility;   Acceptability;   Safety/Tolerability;   Adherence;   Bone Biomarkers
8 Not yet recruiting Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis.
Condition: Calcific Aortic Stenosis
Interventions: Drug: Denosumab;   Drug: Alendronic Acid;   Drug: Denosumab Placebo;   Drug: Alendronic Acid Placebo
Outcome Measures: Change in aortic valve calcium score;   Change in aortic valve 18F-NaF uptake;   Change in aortic-jet velocity;   Change in thoracic aortic and coronary artery calcium score;   Change in thoracic spine bone mineral density;   Change in quality of life determined by Short Form 36 Questionnaire
9 Recruiting Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy
Condition: Osteoporosis
Interventions: Drug: Alendronate;   Drug: Placebo
Outcome Measures: Incidence of new osteoporotic fractures;   Equivalence of deaths with and without continued bisphosphonate therapy;   Incidence of the combination of fractures and deaths
10 Recruiting Bone Healing After Dental Extraction in Postmenopausal Osteoporotic Women Treated With Alendronate Per os Weekly
Condition: Alveolar Bone Healing After Dental Extraction
Intervention: Procedure: Dental extraction
Outcome Measures: Alveolar socket filled by new bone;   Mucosal injury
11 Unknown  The Study of the Early Administration of Alendronate on Prevention of Bone Loss After Hip Fracture.
Condition: Osteoporosis
Intervention: Drug: Alendronate
Outcome Measure:
12 Unknown  Osteoporosis and Dental Implant
Condition: Osteoporosis
Interventions: Drug: alendronate once weekly 70mg;   Drug: placebo
Outcome Measure: Dental CT
13 Unknown  Randomized Study of Alendronate in Adult Patients With Cystic Fibrosis Related Osteoporosis
Conditions: Osteoporosis;   Cystic Fibrosis
Interventions: Drug: alendronate sodium;   Drug: calcium carbonate;   Drug: cholecalciferol
Outcome Measure:
14 Unknown  Phase II Randomized Study of Alendronate Sodium for Osteopenia in Patients With Gaucher's Disease
Conditions: Gaucher's Disease;   Osteopenia
Interventions: Drug: alendronate sodium;   Drug: calcium carbonate;   Drug: cholecalciferol
Outcome Measure:
15 Unknown  Pharmacokinetics of Maxmarvil® in Healthy Postmenopausal Women
Condition: Osteoporosis
Intervention: Drug: Maxmarvil®
Outcome Measure: analysis of Alendronate concentrate
16 Recruiting Stem Cell Recruitment in Osteoporosis Therapy
Condition: Low Bone Density
Interventions: Drug: Teriparatide;   Drug: Alendronate;   Dietary Supplement: calcium and vitamin D
Outcome Measures: Number of Stro-1+ MSCs at bone resorption sites in bone biopsies of subjects treated with PTH or ALN.;   Number of p-Smad 2/3+ cells/mm2 at active resorption sites on bone biopsy specimens of subjects treated with PTH or ALN.;   The percent increase in Stro-1+/CD146+ cells in the blood before and after treatment with PTH or ALN.;   Number of human Stro-1+ MSCs at bone resorption sites in bone of Rag2-/- mice reconstituted with human bone marrow derived from subjects treated with PTH or ALN.
17 Recruiting Twenty Four Month Extension Study of BA058-05-003
Condition: Postmenopausal Osteoporosis
Intervention: Drug: Alendronate
Outcome Measures: Safety;   Vertebral Fracture Incidence;   Non-vertebral Fracture Incidence
18 Recruiting Bisphosphonate Biomarker Study
Conditions: Osteoporosis, With or Without Treatment;   Bisphosphonate Treatment;   Atypical Femur Fracture;   Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ);   Healthy Volunteers
Intervention:
Outcome Measures: Absorption, Distribution, Metabolism, Excretion (ADME) Profiling of DNA from all sample types vs. normative data for the ADME panel and across study groups;   Differential expression of miRNA biomarkers across participant groups within the study
19 Recruiting Effectiveness of DiscontinuinG bisphosphonatEs Study: R21 Pilot Study
Condition: Osteoporosis
Intervention: Drug: Alendronate
Outcome Measures: Clinical site recruitment rate;   Participant recruitment rate;   Contracting and procedures;   Administrative procedures;   Osteonecrosis of the jaw;   Atypical femoral fracture;   Clinical fracture rate
20 Recruiting Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption
Condition: Postmenopausal Osteoporosis
Intervention: Drug: Teriparatide 40-mcg subcutaneous injection
Outcome Measure: Bone turnover marker (blood sample)