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VISION BLURRED and Lyrica

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VISION BLURRED Symptoms and Causes

What is high blood pressure in pregnancy?

Blood pressure is the force of your blood pushing against the walls of your arteries as your heart pumps blood. High blood pressure, or hypertension, is when this force against your artery walls is too high. There are different types of high blood pressure in pregnancy:

  • Gestational hypertension is high blood pressure that you develop while you are pregnant. It starts after you are 20 weeks pregnant. You usually don't have any other symptoms. In many cases, it does not harm you or your baby, and it goes away within 12 weeks after childbirth. But it does raise your risk of high blood pressure in the future. It sometimes can be severe, which may lead to low birth weight or preterm birth. Some women with gestational hypertension do go on to develop preeclampsia.
  • Chronic hypertension is high blood pressure that started before the 20th week of pregnancy or before you became pregnant. Some women may have had it long before becoming pregnant, but didn't know it until they got their blood pressure checked at their prenatal visit. Sometimes chronic hypertension can also lead to preeclampsia.
  • Preeclampsia is a sudden increase in blood pressure after the 20th week of pregnancy. It usually happens in the last trimester. In rare cases, symptoms may not start until after delivery. This is called postpartum preeclampsia. Preeclampsia also includes signs of damage to some of your organs, such as your liver or kidney. The signs may include protein in the urine and very high blood pressure. Preeclampsia can be serious or even life-threatening for both you and your baby.
What causes preeclampsia?

The cause of preeclampsia is not known.

Who is at risk for preeclampsia?

You are at higher risk of preeclampsia if you

  • Had chronic high blood pressure or chronic kidney disease before pregnancy
  • Had high blood pressure or preeclampsia in a previous pregnancy
  • Have obesity
  • Are over age 40
  • Are pregnant with more than one baby
  • Are African American
  • Have a family history of preeclampsia
  • Have certain health conditions, such as diabetes, lupus, or thrombophilia (a disorder which raises your risk of blood clots)
  • Used in vitro fertilization, egg donation, or donor insemination
What problems can preeclampsia cause?

Preeclampsia can cause

  • Placental abruption, where the placenta separates from the uterus
  • Poor fetal growth, caused by a lack of nutrients and oxygen
  • Preterm birth
  • A low birth weight baby
  • Stillbirth
  • Damage to your kidneys, liver, brain, and other organ and blood systems
  • A higher risk of heart disease for you
  • Eclampsia, which happens when preeclampsia is severe enough to affect brain function, causing seizures or coma
  • HELLP syndrome, which happens when a woman with preeclampsia or eclampsia has damage to the liver and blood cells. It is rare, but very serious.
What are the symptoms of preeclampsia?

Possible symptoms of preeclampsia include

  • High blood pressure
  • Too much protein in your urine (called proteinuria)
  • Swelling in your face and hands. Your feet may also swell, but many women have swollen feet during pregnancy. So swollen feet by themselves may not be a sign of a problem.
  • Headache that does not go away
  • Vision problems, including blurred vision or seeing spots
  • Pain in your upper right abdomen
  • Trouble breathing
  • Eclampsia can also cause seizures, nausea and/or vomiting, and low urine output. If you go on to develop HELLP syndrome, you may also have bleeding or bruising easily, extreme fatigue, and liver failure.

    How is preeclampsia diagnosed?

    Your health care provider will check your blood pressure and urine at each prenatal visit. If your blood pressure reading is high (140/90 or higher), especially after the 20th week of pregnancy, your provider will likely want to run some tests. They may include blood tests other lab tests to look for extra protein in the urine as well as other symptoms.

    How is preeclampsia treated?

    Delivering the baby can often cure preeclampsia. When making a decision about treatment, your provider take into account several factors. They include how severe it is, how many weeks pregnant you are, and what the potential risks to you and your baby are:

    • If you are more than 37 weeks pregnant, your provider will likely want to deliver the baby.
    • If you are less than 37 weeks pregnant, your health care provider will closely monitor you and your baby. This includes blood and urine tests for you. Monitoring for the baby often involves ultrasound, heart rate monitoring, and checking on the baby's growth. You may need to take medicines, to control your blood pressure and to prevent seizures. Some women also get steroid injections, to help the baby's lungs mature faster. If the preeclampsia is severe, you provider may want you to deliver the baby early.

    The symptoms usually go away within 6 weeks of delivery. In rare cases, symptoms may not go away, or they may not start until after delivery (postpartum preeclampsia). This can be very serious, and it needs to be treated right away.

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Lyrica Side Effects

Dizziness (2971)
Pain (2819)
Weight Increased (2414)
Somnolence (2054)
Oedema Peripheral (1606)
Vision Blurred (1487)
Feeling Abnormal (1476)
Fall (1266)
Fatigue (1245)
Insomnia (1182)
Malaise (1160)
Gait Disturbance (1146)
Nausea (1143)
Headache (1132)
Pain In Extremity (1082)
Confusional State (942)
Dyspnoea (930)
Depression (783)
Off Label Use (740)
Tremor (737)
Hypoaesthesia (679)
Asthenia (676)
Balance Disorder (669)
Dry Mouth (664)
Anxiety (619)
Diarrhoea (597)
Disturbance In Attention (577)
Arthralgia (559)
Memory Impairment (550)
Convulsion (542)
Paraesthesia (530)
Muscle Spasms (487)
Rash (486)
Withdrawal Syndrome (462)
Loss Of Consciousness (458)
Activities Of Daily Living Impaired (456)
Muscular Weakness (453)
Joint Swelling (452)
Amnesia (447)
Pruritus (430)
Back Pain (421)
Vomiting (413)
Hypertension (412)
Myalgia (407)
Speech Disorder (405)
Constipation (402)
Suicidal Ideation (397)
Weight Decreased (396)
Burning Sensation (392)
Hyperhidrosis (382)

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Recent Reviews

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VISION BLURRED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
Interventions: Drug: Pregabalin (Lyrica);   Drug: Placebo
Outcome Measures: Primary aim: Collect preliminary data comparing effects of Pregabalin and placebo on abdominal pain/discomfort on bowel symptom score (BSS), overall BSS score, and adequate relief of irritable bowel syndrome (IBS) symptoms in patients with IBS;   To compare the effect of Pregabalin and placebo on self-reported overall and individual BSS scores;   compare effect of Pregabalin and placebo on adequate relief of IBS pain or discomfort at least 50% of the time;   To compare effect of Pregabalin and placebo on overall and individual BSS scores;   To compare the effect of Pregabalin and placebo on the proportion of patients with at least 3 point changes in 11 point pain and IBS scores
2 Recruiting A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder
Condition: Obsessive-Compulsive Disorder
Interventions: Drug: pregabalin;   Drug: Placebo
Outcome Measures: Yale-Brown-Obsessive-Compulsive-Scale;   Clinical Global Impression - Improvement;   Montgomery Asberg Depression Rating Scale;   Sheehan Disability Scale;   Beck Depression Inventory;   Clinical Global Impression - Severity;   Saving Inventory - Revised;   Dimensional Yale-Brown-Obsessive Compulsive Scale (D-Y-BOCS);   Padua Inventory
3 Not yet recruiting Efficacy and Safety of KW21052 Compared to Lyrica in the Diabetic Patients With Neuropathic Pain
Condition: Diabetic Neuropathy
Interventions: Drug: KW21052;   Drug: Lyrica;   Drug: Lyrica (low dose);   Drug: Placebo of KW21052;   Drug: Placebo of Lyrica
Outcome Measures: Numerical pain rating scale (NRS);   Change on on the numerical pain rating scale (NRS);   Response rate;   Clinical Global Impression of Change (CGIC);   Improved quality of life (QoL);   Drug compliance;   Adverse events
4 Recruiting The Effects of Pregabalin on Postoperative Pain After Cardiac Surgery
Condition: Postoperative Pain
Interventions: Drug: Pregabalin 75mg;   Drug: pregabalin 150 mg;   Drug: Placebo
Outcome Measures: opioid consumption and other analgesics after surgery;   Remaining surgery related pain and analgesics consumption
5 Unknown  Imipramine and Pregabalin Combination in Painful Polyneuropathy
Condition: Polyneuropathy
Interventions: Drug: Imipramine;   Drug: Pregabalin;   Drug: Imipramine, pregabalin;   Drug: Placebo
Outcome Measures: Total pain intensity as measured by numeric rating scale 0-10 points.;   Verbal pain relief scale with 6 classes;   Specific pain symptom rated by numeric rating scales 0-10 points;   Rating of evoked pains symptoms (pressure, brush, repetitive pin-prick, cold) as measured by numeric rating scales 0-10 points;   Sleep disturbance as measured by numeric rating scale 0-10 points;   Consumption of escape medication (number of tablets of paracetamol);   Health related quality of life (SF-36);   Major Depression Inventory (MDI)
6 Recruiting A Study Evaluating the Efficacy and Safety of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis
Conditions: Muscle Cramp;   Liver Cirrhosis
Interventions: Drug: Pregabalin;   Drug: Placebo
Outcome Measures: mean reduction rates of the frequency of muscle cramps between pregabalin and placebo groups;   Response rates , Mean change in the average cramp pain intensity , peripheral nerve excitability , the quality of life, quality of sleep , safety
7 Recruiting A Safety, Efficacy and Tolerability Trial of Pregabalin as Add-On Treatment in Pediatric and Adult Subjects With Primary Generalized Tonic-Clonic (i.e., Grand Mal) Seizures.
Condition: Generalized Tonic Clonic Seizures
Interventions: Drug: Pregabalin Dose Level 1;   Drug: Pregabalin Dose Level 2;   Drug: Placebo
Outcome Measures: Percent reduction of 28 day seizure rate for all PGTC seizures relative to placebo during the double blind assessment phase.;   Responder rate, defined as the proportion of subjects who had at least a 50% reduction in 28 day PGTC seizure.
8 Unknown  Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus
Condition: Uremic Pruritus
Interventions: Drug: Pregabalin;   Drug: Placebo
Outcome Measures: Reduction of UP by more than 50% after Pregabalin administration;   Reduction of chronic pain of various origin and improvement in insomnia after Pregabalin administration
9 Recruiting Study To Evaluate Efficacy, Safety And Tolerability Of Lyrica In Patients With Painful Diabetic Peripheral Neuropathy
Condition: Diabetic Neuropathy, Painful
Interventions: Drug: Pregabalin;   Drug: Placebo matched with pregabalin
Outcome Measures: Endpoint mean pain score based on the pain scores from the subject's daily pain rating scale;   Weekly mean pain scores from the subject's daily pain rating scale;   Weekly mean sleep interference scores from the subject's daily sleep interference scale;   Responder rates with at least a 30% reduction from baseline in weekly mean pain score;   Change from baseline in Short-Form McGill Pain Questionnaire at week 9;   Change from baseline in Pain Visual Analogue Scale at week 9;   Change from baseline in Medical Outcomes Study -Sleep Scale at week 9;   The Subject Global Impression of Change at week 9;   The Clinical Global Impression of Change at week 9;   Change from baseline in Hospital Anxiety and Depression Scale at week 9
10 Recruiting Effects of Pregabalin on Post-cesarean Pain
Condition: Uncomplicated Singleton Pregnancies
Interventions: Drug: Placebo;   Drug: Pregabalin 300 mg group;   Drug: Pregabalin 150 mg group
Outcome Measures: cumulative patient controlled morphine consumptions;   postoperative pain scores;   neonatal Apgar scores;   Neurologic and adaptive capacity scores;   Maternal sedation;   Maternal nausea and vomiting
11 Recruiting Safety, Tolerability and Preliminary Efficacy of AZD5213 in Combination With Pregabalin in Subjects With PDN and Good Pain Reporting Ability
Condition: Diabetic Neuropathy, Painful; Diabetic Neuropathies
Interventions: Drug: AZD5213 + pregabalin;   Drug: Placebo;   Drug: pregabalin capsules
Outcome Measures: Change in Item 5 of Brief Pain Inventory Diabetic Peripheral Neuropathy version (BPI-DPN);   Incidence and severity of Treatment Emergent Adverse Events;   Vital signs ( blood pressure, heart rate, weight and temperature);   Clinical Laboratory Evaluations;   Medical Outcomes Study (Revised) Sleep Scale (MOS-R);   Columbia Suicide Severity Rating Scale (CSSR-S);   Neuropathic Pain Symptom Inventory (NPSI);   Sleep Interference Scale (SIS)
12 Unknown  Perioperative Administration of Pregabalin for Pain After Septoplasty
Condition: Deviated Nasal Septum
Interventions: Drug: Pregabalin (Lyrica);   Drug: Vitamin complex (placebo)
Outcome Measures: Pain score (Verbal numerical rating scale, VNRS and Visual Analogue Scale, VAS);   The number of patients with side effects including Nausea and vomiting, sedation, headache, dizziness;   The number of patients who required additional analgesics during admission
13 Not yet recruiting Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain
Conditions: Neuropathic Pain;   Spinal Cord Injuries
Interventions: Drug: Pregabalin;   Drug: Placebo
Outcome Measures: Daily at-level non-evoked pain intensity measured with the numerical rating scale (0-10) expressed as the mean 7-day pain intensity;   Weekly below-level non-evoked pain intensity measured with the numerical rating scale (0-10);   Weekly evaluation of at-level neuropathic pain symptoms using the "Neuropathic Pain Symptoms Inventory" (NPSI);   Weekly evaluation of at-level neuropathic pain intensity and interference using the "Brief Pain Inventory" (BPI);   Weekly evaluation of the change in at-level non-evoked neuropathic pain using the "Patient Global Impression Change" (PGIC);   Weekly evaluation of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS);   Weekly evaluation of spasm frequency below the spinal cord injury using the Penn questionnaire;   Measurement of the amplitude of cold and heat sensory evoked potentials (Cz-Fz) studied above (C4) and at-level of the SCI;   Serum TNF-R1 level;   Weekly at-level non-evoked pain intensity measured with the numerical rating scale (0-10) 28 days after the termination of the clinical trial;   Number of Paracetamol tablets used as rescue medication during the week;   Prevalence and type of adverse events in patients treated with pregabalin;   Unblinding testing: patient and investigator will be asked for the treatment they think to have received. Reasons for their judgement (efficacy and safety) will also be asked.
14 Recruiting Adolescent Fibromyalgia Study
Condition: Fibromyalgia
Interventions: Drug: placebo;   Drug: pregabalin (Lyrica)
Outcome Measures: Endpoint mean pain score from daily pain diary;   Endpoint mean sleep quality score from the daily sleep diary;   Pain Numeric Rating Scale (Pain-NRS) at Termination Visit;   Patient Global Impression of Change at Termination;   Parent Global Impression of Change at Termination Visit;   Fibromyalgia Impact Questionnaire for Children at Termination Visit;   Frequency and severity of adverse events at every visit.;   Physical and neurological exams.;   Vital signs.;   Suicidality Tracking Scale (STS).;   12-Lead Electrocardiogram (ECG).;   Laboratory tests: hematology, chemistry, serum pregnancy, urinalysis.;   Reproductive hormone monitoring (females only);   Tanner staging-assessment of pubertal status (females only);   Pharmacokinetic endpoint: A population pharmacokinetic analysis will be performed using the sparse PK samples obtained at V6.
15 Recruiting Effect of Pregabalin in Patients With Radiation-Induced Peripheral Neuropathic Pain
Condition: Neuropathic Pain
Interventions: Drug: Pregabalin;   Drug: Placebo
Outcome Measures: Daily Pain Rating Scale (DPRS) at week 12;   The modified Brief Pain Inventory-short form (mBPI);   Daily Sleep Interference Scale(DSIS)
16 Unknown  Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain
Conditions: Inguinal Hernia;   Postoperative Pain
Intervention: Drug: Pregabalin
Outcome Measures: Study is constructed to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy for post operative pain at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3.;   Opiod Sparing;   Side effect of medication
17 Not yet recruiting Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia
Conditions: Taxane;   Drug-related Side Effects and Adverse Reactions;   Pain;   Breast Cancer
Interventions: Drug: Pregabalin;   Drug: Placebo
Outcome Measures: Integrated Numeric Pain Scores and Rescue Analgesic Medication Requirement as calculated by the method proposed by Silverman et al (Silverman, O'Connor et al. 1993).;   Numeric Pain Score (NPS);   The additional number of hours spent in horizontal position (∆HHP**);   FACT-taxane score
18 Recruiting Evaluation of Preoperative Use of Pregabalin on Postoperative Analgesia After Laparoscopic Colorectal Surgery
Condition: Postoperative Pain
Interventions: Drug: Pregabalin;   Drug: Placebo;   Drug: Morphine
Outcome Measures: Postoperative opioid consumption;   Postoperative pain;   Side- effects;   Chronic Pain;   Hospital stay
19 Unknown  Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia
Conditions: Critical Limb Ischemia;   Arterial Occlusive Disease;   Pain;   Ischemia
Interventions: Drug: pregabalin;   Drug: placebo
Outcome Measures: Reduction in Rating Scale (RS) pain compared to baseline. RS Pain will be assessed at 7, 14 days for all participants and after 28 and 56 days for patients continuing the extended phase of study.;   Improvement in the Short Form 36 (SF-36) parameter "bodily pain".;   The amount, dose and duration of concomitant pain medication use during study compared to use before study.;   Safety outcomes and adverse events will be examined and recorded throughout the study. Patient reported dizziness will be recorded separately in the CRF, as well as blood pressure at visits.
20 Unknown  Pain Relief Following Arthroscopic Rotator Cuff Repair: Perioperative Pregabalin Administration Versus Interscalene Brachial Plexus Block
Condition: Pain
Interventions: Drug: Pregabalin;   Procedure: ISBPB - interscalene brachial plexus block
Outcome Measure: To compare postoperative pain relief by pregabalin versus ISBPB following arthroscopic rotator cuff repair