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VISION BLURRED and Mirtazapine

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VISION BLURRED Symptoms and Causes

What is high blood pressure in pregnancy?

Blood pressure is the force of your blood pushing against the walls of your arteries as your heart pumps blood. High blood pressure, or hypertension, is when this force against your artery walls is too high. There are different types of high blood pressure in pregnancy:

  • Gestational hypertension is high blood pressure that you develop while you are pregnant. It starts after you are 20 weeks pregnant. You usually don't have any other symptoms. In many cases, it does not harm you or your baby, and it goes away within 12 weeks after childbirth. But it does raise your risk of high blood pressure in the future. It sometimes can be severe, which may lead to low birth weight or preterm birth. Some women with gestational hypertension do go on to develop preeclampsia.
  • Chronic hypertension is high blood pressure that started before the 20th week of pregnancy or before you became pregnant. Some women may have had it long before becoming pregnant, but didn't know it until they got their blood pressure checked at their prenatal visit. Sometimes chronic hypertension can also lead to preeclampsia.
  • Preeclampsia is a sudden increase in blood pressure after the 20th week of pregnancy. It usually happens in the last trimester. In rare cases, symptoms may not start until after delivery. This is called postpartum preeclampsia. Preeclampsia also includes signs of damage to some of your organs, such as your liver or kidney. The signs may include protein in the urine and very high blood pressure. Preeclampsia can be serious or even life-threatening for both you and your baby.
What causes preeclampsia?

The cause of preeclampsia is not known.

Who is at risk for preeclampsia?

You are at higher risk of preeclampsia if you

  • Had chronic high blood pressure or chronic kidney disease before pregnancy
  • Had high blood pressure or preeclampsia in a previous pregnancy
  • Have obesity
  • Are over age 40
  • Are pregnant with more than one baby
  • Are African American
  • Have a family history of preeclampsia
  • Have certain health conditions, such as diabetes, lupus, or thrombophilia (a disorder which raises your risk of blood clots)
  • Used in vitro fertilization, egg donation, or donor insemination
What problems can preeclampsia cause?

Preeclampsia can cause

  • Placental abruption, where the placenta separates from the uterus
  • Poor fetal growth, caused by a lack of nutrients and oxygen
  • Preterm birth
  • A low birth weight baby
  • Stillbirth
  • Damage to your kidneys, liver, brain, and other organ and blood systems
  • A higher risk of heart disease for you
  • Eclampsia, which happens when preeclampsia is severe enough to affect brain function, causing seizures or coma
  • HELLP syndrome, which happens when a woman with preeclampsia or eclampsia has damage to the liver and blood cells. It is rare, but very serious.
What are the symptoms of preeclampsia?

Possible symptoms of preeclampsia include

  • High blood pressure
  • Too much protein in your urine (called proteinuria)
  • Swelling in your face and hands. Your feet may also swell, but many women have swollen feet during pregnancy. So swollen feet by themselves may not be a sign of a problem.
  • Headache that does not go away
  • Vision problems, including blurred vision or seeing spots
  • Pain in your upper right abdomen
  • Trouble breathing
  • Eclampsia can also cause seizures, nausea and/or vomiting, and low urine output. If you go on to develop HELLP syndrome, you may also have bleeding or bruising easily, extreme fatigue, and liver failure.

    How is preeclampsia diagnosed?

    Your health care provider will check your blood pressure and urine at each prenatal visit. If your blood pressure reading is high (140/90 or higher), especially after the 20th week of pregnancy, your provider will likely want to run some tests. They may include blood tests other lab tests to look for extra protein in the urine as well as other symptoms.

    How is preeclampsia treated?

    Delivering the baby can often cure preeclampsia. When making a decision about treatment, your provider take into account several factors. They include how severe it is, how many weeks pregnant you are, and what the potential risks to you and your baby are:

    • If you are more than 37 weeks pregnant, your provider will likely want to deliver the baby.
    • If you are less than 37 weeks pregnant, your health care provider will closely monitor you and your baby. This includes blood and urine tests for you. Monitoring for the baby often involves ultrasound, heart rate monitoring, and checking on the baby's growth. You may need to take medicines, to control your blood pressure and to prevent seizures. Some women also get steroid injections, to help the baby's lungs mature faster. If the preeclampsia is severe, you provider may want you to deliver the baby early.

    The symptoms usually go away within 6 weeks of delivery. In rare cases, symptoms may not go away, or they may not start until after delivery (postpartum preeclampsia). This can be very serious, and it needs to be treated right away.

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Mirtazapine Side Effects

Completed Suicide (237)
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Depression (160)
Overdose (148)
Anxiety (147)
Fall (136)
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Nausea (96)
Oedema Peripheral (93)
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Tremor (84)
Malaise (82)
Vomiting (75)
Restless Legs Syndrome (75)
Myalgia (73)
Alanine Aminotransferase Increased (72)
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Inappropriate Antidiuretic Hormone Secretion (71)
Feeling Abnormal (70)
Toxicity To Various Agents (69)
Asthenia (69)
Diarrhoea (67)
Syncope (62)
Hyperhidrosis (61)
Neuroleptic Malignant Syndrome (61)
Pain In Extremity (61)
Electrocardiogram Qt Prolonged (60)
Pyrexia (59)
Aspartate Aminotransferase Increased (58)
Pulmonary Embolism (57)
Arthralgia (56)
Hypotension (56)
Irritability (56)
Pain (55)
Gait Disturbance (54)

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Recent Reviews

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VISION BLURRED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Evaluation of Mirtazapine and Folic Acid for Schizophrenia:
Conditions: Schizophrenia;   Negative Symptoms
Interventions: Drug: Mirtazapine and folic acid;   Drug: Mirtazapine, folic acid placebo;   Drug: Mirtazapine placebo, folic acid;   Drug: Mirtazapine placebo, folic acid placebo
Outcome Measures: To compare the efficacy of Mirtazapine and placebo for treatment of symptoms associated with schizophrenia;   To compare the efficacy of folic acid and placebo for treatment of symptoms of schizophrenia;   To compare the efficacy of Mirtazapine and placebo for treatment of negative symptoms of schizophrenia;   To compare the efficacy of folic acid and placebo for treatment of negative symptoms of schizophrenia;   To compare the safety and tolerability of Mirtazapine and placebo in patients with schizophrenia;   To compare the safety and tolerability of folic acid and placebo in patients with schizophrenia
2 Recruiting Effectiveness Study of Mirtazapine Combined With Paroxetine in Major Depressive Patients Without Early Improvement
Condition: Major Depression
Interventions: Drug: Mirtazapine, paroxetine;   Drug: Mirtazapine;   Drug: paroxetine 20mg QD
Outcome Measures: Change of 17-item Hamilton Depression Scale (HAMD-17) total score;   The proportion of subjects at endpoint with HAMD-17≤7;   The incidence and nature of overall adverse events;   The incidence and nature of drug-related adverse events;   The number of subject withdrawal due to adverse events during double-blind phase
3 Recruiting Pharmacogenetic Study of Mirtazapine Response in Depressed Patients
Condition: Depression
Intervention: Drug: Mirtazapine
Outcome Measures: Mirtazapine response at 2,4,6 weeks and adverse events (A/E) monitoring at 1,2,4,6 weeks;   Biological value at 0 and 6 weeks
4 Unknown  Mirtazapine Versus Placebo in Functional Dyspepsia
Condition: Functional Dyspepsia
Intervention: Drug: Mirtazapine
Outcome Measures: Difference in dyspepsia symptom scores week 8 versus week 0;   Individual symptom severities;   Nepean dyspepsia index for quality of life in functional dyspepsia
5 Recruiting Mirtazapine Plus Gemcitabine Versus Gemcitabine in Metastasis Pancreatic Cancer
Condition: Pancreatic Cancer
Interventions: Drug: Mirtazapine plus gemcitabine;   Drug: Gemcitabine, placebo
Outcome Measures: quality of life;   anxiety and depression scores;   objective response rate;   progress free survival,;   overall Survival;   chemotherapy induced nausea and vomiting
6 Recruiting Mirtazapine for Sleep Disorders in Alzheimer's Disease
Conditions: Alzheimer's Disease;   Sleep Disorders
Intervention: Drug: Mirtazapine
Outcome Measures: Change From Baseline in Nighttime Total Sleep Time;   Change From Baseline in Nighttime Number Of Awakenings;   Change From Baseline in Nighttime Wake After Sleep Onset;   Change From Baseline in in Daytime Total Sleep Time;   Change From Baseline in Number of Daytime Naps;   Change in Cognitive Function (as Measured by the Mini-Mental State Examination);   Change in Activities of Daily Living (The Index of ADL - Katz);   Change of Baseline in Behavioral Variables (BAHAVE-AD Scale);   Change From Baseline in Cognitive Function (Digit Symbol Substitution Test)
7 Recruiting LEPR Polymorphism Weight Gain by Mirtazapine in Late Life Depression
Condition: Major Depressive Disorder
Intervention: Drug: Mirtazapine
Outcome Measures: increase in weight as measured in the clinic;   Proportion of population achieving clinical response as measured by rate of fall in HAM-D 24 item scores;   Proportion of patients achieving remission at end of study on HAM-D 24 (<11);   Frequency of adverse events;   Percentage adhering to medication
8 Recruiting Efficacy Study of Mirtazapine to Treat Interferon-related Depression During Antiviral Therapy for Hepatitis C
Condition: Depression
Interventions: Drug: Mirtazapine;   Other: Supportive psychotherapy
Outcome Measures: Change from baseline in Hamilton Depression Rating Scale (HAMD)-17 at 8 weeks;   Change from baseline in quality of life at 8 weeks;   Genetic polymorphism
9 Recruiting Mirtazapine for the Treatment of Methamphetamine Dependence Among MSM (M2.0)
Condition: Methamphetamine
Interventions: Drug: Mirtazapine;   Drug: Placebo
Outcome Measures: Number of methamphetamine-positive urine tests;   Sexual risk (see description)
10 Recruiting Mirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders
Condition: Autism Spectrum Disorders
Interventions: Drug: Placebo;   Drug: Mirtazapine
Outcome Measures: Pediatric Anxiety Rating Scale (PARS);   Clinical Global Impressions (CGI)
11 Unknown  Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy
Condition: Depressive Disorder, Major
Interventions: Drug: Mirtazapine;   Drug: Venlafaxine
Outcome Measures: Categorial response to the medication. Categorial response is defined on the basis of CGI Improvement scale and 50% reduction in MADR-S score;   Tolerability of treatment as assessed using the DOTES scale;   Cognitive deficits as judged by the SKT system;   Self assessment of depression and anxiety using Beck's Depression/Anxiety Inventory (BDI/BAI);   Changes is blood levels of homocysteine, folate, vit B12, P11
12 Recruiting Algorithm Guided Treatment Strategies for Major Depressive Disorder
Condition: Major Depressive Disorder
Interventions: Drug: Escitalopram;   Drug: Mirtazapine;   Other: modified electroconvulsive therapy;   Other: repetitive transcranial magnetic stimulation;   Drug: Fluoxetine;   Drug: Citalopram;   Drug: Paroxetine;   Drug: Sertraline;   Drug: Fluvoxamine;   Drug: Venlafaxine;   Drug: Duloxetine;   Drug: Bupropion;   Drug: Trazodone
Outcome Measures: Remission defined as endpoint 17-item Hamilton Rating Scale for Depression (HRSD-17) total score ≤ 7;   Remission defined as endpoint the Quick Inventory of Depressive Symptomatology (16-item) (QIDS-SR16) total score ≤ 5;   Frequency and intensity of adverse events;   Quality of life
13 Unknown  Study of Methylphenidate as Add on Therapy in Depressed Cancer Patients
Condition: Depression
Interventions: Drug: Methylphenidate;   Drug: Placebo
Outcome Measures: depressive symptoms;   Distress level
14 Recruiting Strategic Use of New Generation Antidepressants for Depression
Condition: Unipolar Major Depressive Episode
Interventions: Drug: Sertraline;   Drug: Mirtazapine
Outcome Measures: Observer-rated depression severity (PHQ-9);   Self-rated depression severity (BDI-II);   Global rating of side effects (FIBSER)
15 Recruiting Predict Antidepressant Responsiveness Using Pharmacogenomics
Conditions: Depression;   Depressive Symptoms
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measure: Presences of each individual symptom of depression at 1,2,4,6,12 weeks
16 Recruiting Pharmacogenomic Study to Predict Antidepressant Responsiveness in Depressed Patients
Conditions: Depression;   Adverse Reaction to Drug
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measures: Antidepressant Response at 2,4,6 weeks A/E monitoring at 1,2,4,6 weeks;   Biological value at 0 and 6 weeks
17 Recruiting Development of Pharmacogenomic Method to Predict Antidepressant Responsiveness
Conditions: Depression;   Antidepressant Drug Adverse Reaction
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measures: all pharmacogenetic and biological marker variables cause drug response;   all clinical cause drug response
18 Recruiting Interpersonal Psychotherapy for Treatment Resistant Depression
Condition: Treatment Resistant Depression
Interventions: Other: IPT+ antidepressant drugs;   Drug: fluoxetine;   Drug: sertraline;   Drug: paroxetine;   Drug: Citalopram;   Drug: escitalopram;   Drug: fluvoxamine;   Drug: Venlafaxine;   Drug: Duloxetine;   Drug: Bupropion;   Drug: Lithium;   Drug: Risperidone;   Drug: tranylcypromine;   Drug: Imipramine;   Drug: amitriptyline;   Drug: Clomipramine;   Drug: nortriptyline;   Drug: trazodone;   Drug: Mirtazapine;   Drug: sulpiride
Outcome Measures: Hamilton Depression Scale (HAM-D) - continuous;   Beck depression Inventory (BDI)
19 Recruiting Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)
Condition: Lumbar Spinal Stenosis
Interventions: Drug: NSAIDs; adjunctive analgesics; adjunctive anti-depressants;   Procedure: Lumbar epidural injection;   Other: Joint Mobilizations (spine, sacroiliac, hip);   Other: Individualized exercises: clinical setting;   Other: Group Exercise: community setting
Outcome Measures: Swiss Spinal Stenosis Questionnaire Score;   Self Paced Walking Test
20 Unknown  Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression
Condition: Depression
Interventions: Device: Thrymatron System IV device (CONSOLIDATION ELECTROCONVUsLIVE THERAPY) plus PHARMACOTHERAPY;   Drug: PHARMACOTHERAPY
Outcome Measures: Hamilton Depression Rating Scale 21 items (HDRS-21);   Mini-Mental State Examination (MMSE 35);   UKU - Adverse effects rating scales;   Demographical Data Memory (MEDABI-20);   Rey Figure;   Trail Making Test A;   Trail Making Test B;   Stroop Test;   Direct and inverse digits (WAIS, Weschler Adults Intelligence Sacle).;   Vocabulary WAIS (Weschler Adults Intelligence Scale);   Frequency Hospitalization Quotient;   Hospital Day Quotient (HDQ)