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VISION BLURRED and Prilosec

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VISION BLURRED Symptoms and Causes

What is high blood pressure in pregnancy?

Blood pressure is the force of your blood pushing against the walls of your arteries as your heart pumps blood. High blood pressure, or hypertension, is when this force against your artery walls is too high. There are different types of high blood pressure in pregnancy:

  • Gestational hypertension is high blood pressure that you develop while you are pregnant. It starts after you are 20 weeks pregnant. You usually don't have any other symptoms. In many cases, it does not harm you or your baby, and it goes away within 12 weeks after childbirth. But it does raise your risk of high blood pressure in the future. It sometimes can be severe, which may lead to low birth weight or preterm birth. Some women with gestational hypertension do go on to develop preeclampsia.
  • Chronic hypertension is high blood pressure that started before the 20th week of pregnancy or before you became pregnant. Some women may have had it long before becoming pregnant, but didn't know it until they got their blood pressure checked at their prenatal visit. Sometimes chronic hypertension can also lead to preeclampsia.
  • Preeclampsia is a sudden increase in blood pressure after the 20th week of pregnancy. It usually happens in the last trimester. In rare cases, symptoms may not start until after delivery. This is called postpartum preeclampsia. Preeclampsia also includes signs of damage to some of your organs, such as your liver or kidney. The signs may include protein in the urine and very high blood pressure. Preeclampsia can be serious or even life-threatening for both you and your baby.
What causes preeclampsia?

The cause of preeclampsia is not known.

Who is at risk for preeclampsia?

You are at higher risk of preeclampsia if you

  • Had chronic high blood pressure or chronic kidney disease before pregnancy
  • Had high blood pressure or preeclampsia in a previous pregnancy
  • Have obesity
  • Are over age 40
  • Are pregnant with more than one baby
  • Are African American
  • Have a family history of preeclampsia
  • Have certain health conditions, such as diabetes, lupus, or thrombophilia (a disorder which raises your risk of blood clots)
  • Used in vitro fertilization, egg donation, or donor insemination
What problems can preeclampsia cause?

Preeclampsia can cause

  • Placental abruption, where the placenta separates from the uterus
  • Poor fetal growth, caused by a lack of nutrients and oxygen
  • Preterm birth
  • A low birth weight baby
  • Stillbirth
  • Damage to your kidneys, liver, brain, and other organ and blood systems
  • A higher risk of heart disease for you
  • Eclampsia, which happens when preeclampsia is severe enough to affect brain function, causing seizures or coma
  • HELLP syndrome, which happens when a woman with preeclampsia or eclampsia has damage to the liver and blood cells. It is rare, but very serious.
What are the symptoms of preeclampsia?

Possible symptoms of preeclampsia include

  • High blood pressure
  • Too much protein in your urine (called proteinuria)
  • Swelling in your face and hands. Your feet may also swell, but many women have swollen feet during pregnancy. So swollen feet by themselves may not be a sign of a problem.
  • Headache that does not go away
  • Vision problems, including blurred vision or seeing spots
  • Pain in your upper right abdomen
  • Trouble breathing
  • Eclampsia can also cause seizures, nausea and/or vomiting, and low urine output. If you go on to develop HELLP syndrome, you may also have bleeding or bruising easily, extreme fatigue, and liver failure.

    How is preeclampsia diagnosed?

    Your health care provider will check your blood pressure and urine at each prenatal visit. If your blood pressure reading is high (140/90 or higher), especially after the 20th week of pregnancy, your provider will likely want to run some tests. They may include blood tests other lab tests to look for extra protein in the urine as well as other symptoms.

    How is preeclampsia treated?

    Delivering the baby can often cure preeclampsia. When making a decision about treatment, your provider take into account several factors. They include how severe it is, how many weeks pregnant you are, and what the potential risks to you and your baby are:

    • If you are more than 37 weeks pregnant, your provider will likely want to deliver the baby.
    • If you are less than 37 weeks pregnant, your health care provider will closely monitor you and your baby. This includes blood and urine tests for you. Monitoring for the baby often involves ultrasound, heart rate monitoring, and checking on the baby's growth. You may need to take medicines, to control your blood pressure and to prevent seizures. Some women also get steroid injections, to help the baby's lungs mature faster. If the preeclampsia is severe, you provider may want you to deliver the baby early.

    The symptoms usually go away within 6 weeks of delivery. In rare cases, symptoms may not go away, or they may not start until after delivery (postpartum preeclampsia). This can be very serious, and it needs to be treated right away.

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VISION BLURRED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Management of Myocardial Injury After Noncardiac Surgery Trial
Condition: Myocardial Injury After Noncardiac Surgery (MINS)
Interventions: Drug: Dabigatran;   Drug: Placebo (for Dabigatran);   Drug: Omeprazole;   Drug: Placebo (for Omeprazole)
Outcome Measures: Major vascular complication (for Dabigatran);   Major upper gastrointestinal complication (for Omeprazole);   Individual secondary outcomes for Dabigatran;   Upper gastrointestinal complication for Omeprazole;   Major vascular complication for Omeprazole;   Individual secondary outcomes for Omeprazole;   Safety outcomes for Dabigatran;   Safety outcomes for Omeprazole
2 Unknown  Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding
Condition: Nonvariceal Upper Gastrointestinal Bleeding
Interventions: Drug: Intravenous Omeprazole;   Drug: Oral Rabeprazole
Outcome Measure: This study aims to compare the effect of three-day oral rabeprazole and iv omeprazole on bleeding control in patients with mild to moderate non-variceal UGIB.
3 Not yet recruiting Omeprazole and Pantoprazole Antiplatelet Effect of Clopidogrel Clinical Trials(OPEN)
Condition: Acute Coronary Syndromes
Interventions: Drug: omeprazole;   Drug: Pantoprazole
Outcome Measures: Platelet aggregation rate(AA 、ADP);   clinical adverse events
4 Recruiting Pilot Trial Of Omeprazole in Idiopathic Pulmonary Fibrosis (IPF)
Condition: Idiopathic Pulmonary Fibrosis
Interventions: Drug: Omeprazole;   Drug: Matched placebo
Outcome Measures: objectively measured cough frequency;   symptoms of cough;   reflux symptoms;   acid and non-acid reflux;   vital capacity (VC) & transfer factor for carbon monoxide (Tco);   6 minute walk distance;   assess amount of inflammation in lung;   lung infection rate;   adverse events rate
5 Recruiting Gastroesophageal Reflux Treatment in Scleroderma
Conditions: Gastroesophageal Reflux Disease;   Systemic Sclerosis;   Scleroderma
Interventions: Drug: Alginic acid;   Drug: placebo (for domperidone);   Drug: Domperidone;   Drug: placebo (of alginic acid)
Outcome Measures: Changing severity of heart burn and regurgitation of SSc related omeprazole resistant GERD evaluated by visual analogue score (VAS);   changing of frequency of symptoms in SSc related omeprazole resistant GERD evaluated by frequency scale for the symptoms of GERD (FSSG) and the quality of life which is evaluated by EQ-5DTM (by EuroQol Group);   the prevalence of omeprazole-resistant GERD in SSc after 4 weeks treatment with omeprazole
6 Recruiting Comparison of the Gastric Acid Suppressive Effects of Esomeprazole and Generic Omeprazole
Condition: Gastric Acid
Interventions: Drug: Esomeprazole first;   Drug: Generic omeprazole first
Outcome Measures: Median intragastric pH and percentage of time that intragastric pH is above 4;   Nocturnal acid breakthrough, defined as at least 60 continuous minutes of intragastric pH below 4 occurring between 10pm and 6 am and adverse events
7 Recruiting Compliance With Antidepressant Medication in Treatment of Functional Dyspepsia
Conditions: Dyspepsia;   Compliance;   Depression
Interventions: Drug: Omeprazole;   Drug: Flupentixol and Melitracen Tablets(for dyspepsia symptoms) + Omeprazole;   Drug: Flupentixol and Melitracen Tablets(for depression symptoms) + Omeprazole;   Drug: Flupentixol and Melitracen Tablets(without explanation) + Omeprazole
Outcome Measures: compliance of antidepressant medication;   dyspepsia symptom questionnaire;   psychiatric symptom on Hospital Anxiety and Depression Scale;   quality of life rating;   adverse reaction
8 Unknown  Impact of Omeprazole and Fluvoxamine on Platelet Response to Clopidogrel
Condition: Drug Interaction of Clopidogrel
Interventions: Drug: omeprazole;   Drug: fluvoxamine;   Drug: placebo
Outcome Measure: platlet reactivity in response to clopidogrel
9 Recruiting Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study
Condition: Barrett's Esophagus
Interventions: Drug: Omeprazole;   Drug: Melatonin
Outcome Measures: Oxidative stress;   Biological markers of diseases progression;   The presence of DNA anomalies (tetraploidy and aneuploidy.
10 Recruiting CYP2C19 Genotype Predictor of Gastric Acid Suppression
Condition: Esophagitis
Intervention: Drug: Omeprazole
Outcome Measures: The correlation specific to CYP2C19 genotype with gastric acid suppression by omeprazole.;   To assess patients gastrointestinal symptoms, in patients with EoE by means of standard validated questionnaires
11 Unknown  Evaluation of Omeprazole Effect on Glaucoma
Condition: Glaucoma
Interventions: Drug: Omeprazole;   Drug: Placebo
Outcome Measure:
12 Not yet recruiting "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER-
Condition: Coronary Artery Disease
Interventions: Drug: Pantoprazole,;   Drug: Omeprazole
Outcome Measures: Assessment of platelet reaction units;   Frequency of high platelet reactivity
13 Not yet recruiting Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC
Condition: CDA Type I
Intervention: Drug: omeprazole
Outcome Measure: evaluate number of adverse effects per patient treated with LOSEC + levels of iron, ferritin,complete blood count and chemistry panel.
14 Recruiting Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.
Conditions: Gastroesophageal Reflux;   Esophageal Atresia;   Hernia, Diaphragmatic
Intervention: Drug: Omeprazole suppository
Outcome Measures: Therapeutic efficacy;   Intragastric pH, Pharmacokinetic parameters, PK-PD-relation,;   Pharmacogenetic parameters
15 Unknown  Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus
Conditions: Barrett Esophagus;   Gastroesophageal Reflux
Interventions: Drug: Zegerid (proton pump inhibitor);   Procedure: Bravo pH monitoring
Outcome Measures: Control of esophageal pH;   Control of GERD symptoms
16 Unknown  Role of CYP2C19 Polymorphism in the Drug Interaction Between Clopidogrel and Omeprazole
Condition: Coronary Artery Disease
Intervention:
Outcome Measures: To test whether concomitant administration of omeprazole will decrease the platelet inhibitory properties of clopidogrel in subjects with loss of function (LOF) mutation of CYP2C19 (known as *2 and *3).;   To test whether concomitant administration of omeprazole will decrease the conversion of clopidogrel to its active metabolite in subjects with loss of function (LOF) mutation of CYP2C19 (known as *2 and *3).
17 Not yet recruiting Laryngomalacia Study
Condition: Laryngomalacia
Interventions: Drug: Omeprazole;   Drug: Placebo
Outcome Measures: Laryngomalacia Symptom Score;   Caring For a Child with Laryngomalacia Family Impact Questionnaire;   Revised Infant Gastro-Esophageal Reflux Questionnaire;   Reflux Finding Score;   End of treatment 24-hour double-probe pH monitoring;   Weight
18 Not yet recruiting Placebo In Chronic Pain
Condition: Chronic Back Pain
Interventions: Drug: Naproxen;   Drug: Placebo;   Drug: Omeprazole
Outcome Measure: VAS pain scale
19 Unknown  Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, or Famotidine
Conditions: Coronary Heart Disease;   GI Bleeding
Intervention: Drug: PPI Platelet Inhibitory
Outcome Measure: Platelet function as assessed by a CPA system
20 Not yet recruiting The Effect of NSAIDs After a Rotator Cuff Repair Surgery.
Condition: Rotator Cuff Tear
Interventions: Procedure: Rotator cuff repair;   Drug: Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole;   Drug: Hydrocodone/Acetaminophen
Outcome Measures: American Shoulder and Elbow Surgeons (ASES) Shoulder Score;   Ultrasound evaluation of retear rate