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VISION BLURRED and RECLAST

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VISION BLURRED Symptoms and Causes

What is high blood pressure in pregnancy?

Blood pressure is the force of your blood pushing against the walls of your arteries as your heart pumps blood. High blood pressure, or hypertension, is when this force against your artery walls is too high. There are different types of high blood pressure in pregnancy:

  • Gestational hypertension is high blood pressure that you develop while you are pregnant. It starts after you are 20 weeks pregnant. You usually don't have any other symptoms. In many cases, it does not harm you or your baby, and it goes away within 12 weeks after childbirth. But it does raise your risk of high blood pressure in the future. It sometimes can be severe, which may lead to low birth weight or preterm birth. Some women with gestational hypertension do go on to develop preeclampsia.
  • Chronic hypertension is high blood pressure that started before the 20th week of pregnancy or before you became pregnant. Some women may have had it long before becoming pregnant, but didn't know it until they got their blood pressure checked at their prenatal visit. Sometimes chronic hypertension can also lead to preeclampsia.
  • Preeclampsia is a sudden increase in blood pressure after the 20th week of pregnancy. It usually happens in the last trimester. In rare cases, symptoms may not start until after delivery. This is called postpartum preeclampsia. Preeclampsia also includes signs of damage to some of your organs, such as your liver or kidney. The signs may include protein in the urine and very high blood pressure. Preeclampsia can be serious or even life-threatening for both you and your baby.
What causes preeclampsia?

The cause of preeclampsia is not known.

Who is at risk for preeclampsia?

You are at higher risk of preeclampsia if you

  • Had chronic high blood pressure or chronic kidney disease before pregnancy
  • Had high blood pressure or preeclampsia in a previous pregnancy
  • Have obesity
  • Are over age 40
  • Are pregnant with more than one baby
  • Are African American
  • Have a family history of preeclampsia
  • Have certain health conditions, such as diabetes, lupus, or thrombophilia (a disorder which raises your risk of blood clots)
  • Used in vitro fertilization, egg donation, or donor insemination
What problems can preeclampsia cause?

Preeclampsia can cause

  • Placental abruption, where the placenta separates from the uterus
  • Poor fetal growth, caused by a lack of nutrients and oxygen
  • Preterm birth
  • A low birth weight baby
  • Stillbirth
  • Damage to your kidneys, liver, brain, and other organ and blood systems
  • A higher risk of heart disease for you
  • Eclampsia, which happens when preeclampsia is severe enough to affect brain function, causing seizures or coma
  • HELLP syndrome, which happens when a woman with preeclampsia or eclampsia has damage to the liver and blood cells. It is rare, but very serious.
What are the symptoms of preeclampsia?

Possible symptoms of preeclampsia include

  • High blood pressure
  • Too much protein in your urine (called proteinuria)
  • Swelling in your face and hands. Your feet may also swell, but many women have swollen feet during pregnancy. So swollen feet by themselves may not be a sign of a problem.
  • Headache that does not go away
  • Vision problems, including blurred vision or seeing spots
  • Pain in your upper right abdomen
  • Trouble breathing
  • Eclampsia can also cause seizures, nausea and/or vomiting, and low urine output. If you go on to develop HELLP syndrome, you may also have bleeding or bruising easily, extreme fatigue, and liver failure.

    How is preeclampsia diagnosed?

    Your health care provider will check your blood pressure and urine at each prenatal visit. If your blood pressure reading is high (140/90 or higher), especially after the 20th week of pregnancy, your provider will likely want to run some tests. They may include blood tests other lab tests to look for extra protein in the urine as well as other symptoms.

    How is preeclampsia treated?

    Delivering the baby can often cure preeclampsia. When making a decision about treatment, your provider take into account several factors. They include how severe it is, how many weeks pregnant you are, and what the potential risks to you and your baby are:

    • If you are more than 37 weeks pregnant, your provider will likely want to deliver the baby.
    • If you are less than 37 weeks pregnant, your health care provider will closely monitor you and your baby. This includes blood and urine tests for you. Monitoring for the baby often involves ultrasound, heart rate monitoring, and checking on the baby's growth. You may need to take medicines, to control your blood pressure and to prevent seizures. Some women also get steroid injections, to help the baby's lungs mature faster. If the preeclampsia is severe, you provider may want you to deliver the baby early.

    The symptoms usually go away within 6 weeks of delivery. In rare cases, symptoms may not go away, or they may not start until after delivery (postpartum preeclampsia). This can be very serious, and it needs to be treated right away.

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RECLAST Side Effects

Arthralgia (599)
Pain (418)
Myalgia (402)
Headache (341)
Bone Pain (334)
Pyrexia (332)
Influenza Like Illness (315)
Nausea (272)
Chills (241)
Asthenia (234)
Fatigue (233)
Back Pain (228)
Pain In Extremity (213)
Dizziness (181)
Dyspnoea (177)
Chest Pain (163)
Vomiting (163)
Malaise (141)
Gait Disturbance (136)
Diarrhoea (128)
Death (122)
Pain In Jaw (121)
Muscle Spasms (112)
Feeling Abnormal (101)
Abasia (99)
Musculoskeletal Pain (99)
Oedema Peripheral (98)
Blood Creatinine Increased (95)
Fall (89)
Joint Swelling (84)
Neck Pain (83)
Dehydration (79)
Confusional State (76)
Muscular Weakness (73)
Blood Pressure Increased (69)
Abdominal Pain (67)
Renal Failure Acute (67)
Musculoskeletal Stiffness (66)
Paraesthesia (66)
Hypoaesthesia (65)
Decreased Appetite (63)
Insomnia (60)
Erythema (59)
Eye Pain (58)
Chest Discomfort (57)
Atrial Fibrillation (56)
Activities Of Daily Living Impaired (55)
Hypocalcaemia (54)
Syncope (53)
Osteonecrosis (52)

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Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
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Cipro (8580)
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Crestor (18839)
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Flexeril (435)
Flomax (2177)
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Gabapentin (4593)
Hydrocodone (2469)
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Medrol (650)
Mirena (41254)
Mobic (957)
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Recent Reviews

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VISION BLURRED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting The Use of Zoledronic Acid to Complex Regional Pain Syndrome
Condition: Complex Regional Pain Syndromes
Interventions: Drug: Zoledronic acid;   Drug: Placebo
Outcome Measures: Pain measured on Visual Analog Scale;   Lower Limbs vertical force on Wii platform;   American Orthopaedic Foot and Ankle Scale (AOFAS);   36-Item Short Form Health Survey (SF-36)
2 Recruiting Pilot Study of Bisphosphonate Therapy (Zoledronic Acid) in Patients With Malignant Mesothelioma (UAB 0901)
Condition: Mesothelioma
Intervention: Drug: Zometa (zoledronic acid)
Outcome Measures: Evaluation of the tumor response rate following zoledronic acid;   Evaluation of the duration of tumor response
3 Recruiting Biomarkers in Tissue Samples From Patients With Newly Diagnosed Breast Cancer Treated With Zoledronic Acid
Conditions: Estrogen Receptor-negative Breast Cancer;   Estrogen Receptor-positive Breast Cancer;   Invasive Ductal Breast Carcinoma;   Progesterone Receptor-negative Breast Cancer;   Progesterone Receptor-positive Breast Cancer;   Stage IA Breast Cancer;   Stage IB Breast Cancer;   Stage II Breast Cancer
Interventions: Drug: zoledronic acid;   Other: laboratory biomarker analysis;   Procedure: therapeutic conventional surgery
Outcome Measures: Changes in biomarkers of tumor growth and metastasis in women with newly diagnosed ER and/or PR positive invasive ductal breast cancer receiving zoledronic acid;   Changes in immunologic function after a single dose of zoledronic acid;   Changes in the expression of tumor markers important to breast cancer progression and metastasis in women receiving zoledronic acid
4 Recruiting Zoledronic Acid in Acute Spinal Cord Injury
Condition: Complete Traumatic Spinal Cord Injury
Interventions: Drug: Zoledronic acid;   Drug: normal saline 0.9%
Outcome Measures: change in bone mineral density;   Biomarkers of bone formation and resorption;   safety and tolerability of zoledronic acid
5 Unknown  Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma
Condition: Osteosarcoma
Interventions: Drug: Zoledronic acid;   Drug: Standard chemotherapy
Outcome Measure: histological response disease free interval
6 Recruiting The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfecta
Condition: Osteogenesis Imperfecta
Interventions: Drug: Zoledronic acid;   Drug: Teriparatide;   Drug: placebo zoledronic acid;   Drug: placebo teriparatide
Outcome Measures: Bone Mineral Density (BMD);   Fracture risk
7 Recruiting Bone Loss Treatment From Adjuvant Zoledronate Efficacy
Conditions: Breast Neoplasms;   Bone Loss
Intervention: Drug: Zoledronate
Outcome Measures: Change from Baseline in Bone Mineral Density;   Bone metastasis rate;   Disease-Free Survival
8 Recruiting Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Subjects With Multiple Myeloma
Conditions: Cancer;   Hematologic Malignancies;   Multiple Myeloma;   Oncology;   Bone Metastases;   Multiple Myeloma Bone Lesions
Interventions: Drug: Denosumab;   Drug: Zoledronic acid
Outcome Measures: Time to the first on-study skeletal related event (SRE) (non-inferiority test);   Time to the first-and-subsequent SRE (superiority test, using multiple event analysis);   Time to the first on-study SRE (superiority test)
9 Recruiting Effect of the Combination of Bortezomib/Dexamethasone/Zoledronic Acid on Bone Disease in Patients With Multiple Myeloma Who Have Relapsed After 1-3 Prior Lines of Therapy
Condition: Multiple Myeloma
Interventions: Drug: Bortezomib;   Drug: Zoledronic Acid;   Drug: Dexamethasone
Outcome Measures: Bone Mineral Density (BMD);   Bone mineral density (BMD);   Serum values of bone-specific alkaline phosphatase, osteocalcin and C-terminal cross-linking telopeptides of collagen type-I;   Bone pain;   Skeletal-related events (SRE: pathologic fractures, need for bone radiation therapy or surgery);   Improvement of osteolytic lesions
10 Not yet recruiting Genetics in Predicting Risk of Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid
Conditions: Malignant Neoplasm;   Musculoskeletal Complications
Interventions: Drug: zoledronic acid;   Other: pharmacological study
Outcome Measures: Plasma concentrations of Zol collected at visits 2, 3, 4, and 5;   Urine concentrations of Zol collected at visits 2, 3, 4, and 5;   Jawbone tissue concentrations of Zol collected during surgical treatment for BRONJ;   Identify potential risk factors for BRONJ
11 Recruiting Pilot Study of Zoledronic Acid and Interleukin-2 for Refractory Pediatric Neuroblastoma
Condition: Neuroblastoma
Interventions: Drug: Zoledronic Acid;   Biological: Aldesleukin
Outcome Measures: Evaluate the safety and toxicity of zoledronic acid and aldesleukin;   Evaluate the biologic function of autologous expanded/activated gamma delta T cells in neuroblastoma patients receiving therapy with zoledronic acid and aldesleukin;   uoEvaluate immune phenotype of in vivo expanded/activated autologous gamma delta T cells;   To document tumor response in patients with measurable disease.;   Determine the ability of in vivo expanded/activated gamma delta T cells to infiltrate neuroblastoma tissue using immunohistochemical techniques when post-therapy specimens are available.
12 Recruiting The ODYSSEY TRIAL Phase IV Trial Evaluating the Palliative Benefit of Pamidronate or Zoledronic Acid in Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Pamidronate;   Drug: Zoledronic acid;   Drug: placebo
Outcome Measures: sCTX values;   Palliative response
13 Recruiting Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT)
Conditions: Giant Cell Tumor of Bone;   Osteoclastoma
Intervention: Drug: Zoledronic acid
Outcome Measures: Determine if adjuvant zoledronic acid improves the 2 year recurrence rate of 'high risk' GCT as compared to standard care;   Evaluate the usefulness of bone remodelling markers in diagnosing and monitoring GCT;   Determine the relapse free survival
14 Recruiting N2007-02:Bevacizumab,Cyclophosphamide,& Zoledronic Acid in Patients W/ Recurrent or Refractory High-Risk Neuroblastoma
Condition: Neuroblastoma
Interventions: Drug: Bevacizumab;   Drug: cyclophosphamide;   Drug: zoledronic acid
Outcome Measures: Determination of toxicities and feasibility of the combination of bolus plus metronomic cyclophosphamide and zoledronic acid with and without bevacizumab when given to children with refractory or recurrent high risk neuroblastoma.;   Evaluation of response within the confines of a phase I study.;   Analysis of Circulating Endothelial Cells, Circulating Factors, Gene expression and Bone Metabolism Studies.
15 Recruiting FES-Rowing Versus Zoledronic Acid to Improve Bone Health in Spinal Cord Injury (SCI)
Condition: Osteoporosis
Interventions: Other: FES-Rowing;   Drug: Zoledronic acid
Outcome Measures: Improvement of bone mass as measured by sequential evaluation of bone density and bone structure;   Validation of DXA Scanning in patients with SCI
16 Recruiting 1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids for Chronic Inflammatory Conditions
Condition: Osteoporosis
Intervention: Drug: zoledronic acid
Outcome Measures: Safety of zoledronic acid for the treatment of osteoporotic children treated with glucocorticoids for chronic inflammatory conditions by adverse event collection and laboratory results monitoring.;   Change from baseline in LS areal BMD Z-score at Month 18 and 24 by core treatment group by dual energy x-ray absorptiometry (DXA).;   Change from baseline in LS and total body BMC by core treatment group by DXA.;   Change in biochemical marker values (serum P1NP, BSAP, NTx and TRAP-5b) from baseline.;   Change in the number of new clinical vertebral fractures and new morphometric vertebral fractures.;   To evaluate the change from baseline (Visit 1 of the Core study) in pain using the Faces Pain Scale-Revised (FPS-R)by core treatment group.
17 Unknown  Clinical Study of Sorafenib and Zoledronic Acid to Treat Advanced HCC
Condition: Hepatocellular Carcinoma
Intervention: Drug: Sorafenib and Zoledronic Acid
Outcome Measures: numbers of adverse events;   Overall survival (OS), time to progression (TTP)
18 Recruiting Research of Zoledronic Acid and Aromatase Inhibitors as Adjuvant Therapy to Breast Cancer
Condition: Breast Cancer
Intervention: Drug: Zoledronic Acid and Aromatase Inhibitors
Outcome Measures: therapeutic assessment;   Adverse reactions and disease-free survival
19 Recruiting HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer.
Condition: Breast Cancer
Interventions: Drug: tamoxifen;   Drug: triptorelin;   Drug: letrozole;   Drug: zoledronic acid
Outcome Measures: disease free survival in premenopausal patients;   bone mineral density;   Bone mineral density measured;   disease free survival in postmenopausal patients;   overall survival;   toxicity of letrozole + triptorelin and letrozole + zoledronic acid + triptorelin in premenopausal patients
20 Not yet recruiting Zoledronic Acid in Rheumatoid Arthritis
Condition: Arthritis, Rheumatoid
Intervention: Drug: Zoledronic acid
Outcome Measure: Sharp van der Heijde index