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VISION BLURRED and Vicodin

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VISION BLURRED Symptoms and Causes

What is high blood pressure in pregnancy?

Blood pressure is the force of your blood pushing against the walls of your arteries as your heart pumps blood. High blood pressure, or hypertension, is when this force against your artery walls is too high. There are different types of high blood pressure in pregnancy:

  • Gestational hypertension is high blood pressure that you develop while you are pregnant. It starts after you are 20 weeks pregnant. You usually don't have any other symptoms. In many cases, it does not harm you or your baby, and it goes away within 12 weeks after childbirth. But it does raise your risk of high blood pressure in the future. It sometimes can be severe, which may lead to low birth weight or preterm birth. Some women with gestational hypertension do go on to develop preeclampsia.
  • Chronic hypertension is high blood pressure that started before the 20th week of pregnancy or before you became pregnant. Some women may have had it long before becoming pregnant, but didn't know it until they got their blood pressure checked at their prenatal visit. Sometimes chronic hypertension can also lead to preeclampsia.
  • Preeclampsia is a sudden increase in blood pressure after the 20th week of pregnancy. It usually happens in the last trimester. In rare cases, symptoms may not start until after delivery. This is called postpartum preeclampsia. Preeclampsia also includes signs of damage to some of your organs, such as your liver or kidney. The signs may include protein in the urine and very high blood pressure. Preeclampsia can be serious or even life-threatening for both you and your baby.
What causes preeclampsia?

The cause of preeclampsia is not known.

Who is at risk for preeclampsia?

You are at higher risk of preeclampsia if you

  • Had chronic high blood pressure or chronic kidney disease before pregnancy
  • Had high blood pressure or preeclampsia in a previous pregnancy
  • Have obesity
  • Are over age 40
  • Are pregnant with more than one baby
  • Are African American
  • Have a family history of preeclampsia
  • Have certain health conditions, such as diabetes, lupus, or thrombophilia (a disorder which raises your risk of blood clots)
  • Used in vitro fertilization, egg donation, or donor insemination
What problems can preeclampsia cause?

Preeclampsia can cause

  • Placental abruption, where the placenta separates from the uterus
  • Poor fetal growth, caused by a lack of nutrients and oxygen
  • Preterm birth
  • A low birth weight baby
  • Stillbirth
  • Damage to your kidneys, liver, brain, and other organ and blood systems
  • A higher risk of heart disease for you
  • Eclampsia, which happens when preeclampsia is severe enough to affect brain function, causing seizures or coma
  • HELLP syndrome, which happens when a woman with preeclampsia or eclampsia has damage to the liver and blood cells. It is rare, but very serious.
What are the symptoms of preeclampsia?

Possible symptoms of preeclampsia include

  • High blood pressure
  • Too much protein in your urine (called proteinuria)
  • Swelling in your face and hands. Your feet may also swell, but many women have swollen feet during pregnancy. So swollen feet by themselves may not be a sign of a problem.
  • Headache that does not go away
  • Vision problems, including blurred vision or seeing spots
  • Pain in your upper right abdomen
  • Trouble breathing
  • Eclampsia can also cause seizures, nausea and/or vomiting, and low urine output. If you go on to develop HELLP syndrome, you may also have bleeding or bruising easily, extreme fatigue, and liver failure.

    How is preeclampsia diagnosed?

    Your health care provider will check your blood pressure and urine at each prenatal visit. If your blood pressure reading is high (140/90 or higher), especially after the 20th week of pregnancy, your provider will likely want to run some tests. They may include blood tests other lab tests to look for extra protein in the urine as well as other symptoms.

    How is preeclampsia treated?

    Delivering the baby can often cure preeclampsia. When making a decision about treatment, your provider take into account several factors. They include how severe it is, how many weeks pregnant you are, and what the potential risks to you and your baby are:

    • If you are more than 37 weeks pregnant, your provider will likely want to deliver the baby.
    • If you are less than 37 weeks pregnant, your health care provider will closely monitor you and your baby. This includes blood and urine tests for you. Monitoring for the baby often involves ultrasound, heart rate monitoring, and checking on the baby's growth. You may need to take medicines, to control your blood pressure and to prevent seizures. Some women also get steroid injections, to help the baby's lungs mature faster. If the preeclampsia is severe, you provider may want you to deliver the baby early.

    The symptoms usually go away within 6 weeks of delivery. In rare cases, symptoms may not go away, or they may not start until after delivery (postpartum preeclampsia). This can be very serious, and it needs to be treated right away.

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VISION BLURRED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Efficacy and Safety of Amantadine HCl Extended Release Tablets in Parkinson's Disease Subjects With Levodopa-Induced Dyskinesias
Conditions: Parkinson's Disease;   Levodopa Induced Dyskinesia (LID)
Interventions: Drug: Amantadine HCl ER (ALLAY-LID II);   Drug: Placebo
Outcome Measures: Unified Dyskinesia Rating Scale;   Mobility State Self Assessment (Subject Diary Cards);   Mobility State Self-Assessment (Subject Diary Cards);   MDS-Unified Parkinson's Disease Rating Scale;   Fatigue Severity Scale
2 Not yet recruiting Efficacy and Safety of Amantadine ER Tablets to Treat Parkinson's Disease Patients With Levodopa Induced Dyskinesia.
Conditions: Parkinson's Disease;   Levodopa Induced Dyskinesia (LID)
Interventions: Drug: Amantadine ER Tablets;   Drug: Placebo Tablets for Amantadine ER Tablets
Outcome Measures: Unified Dyskinesia Rating Scale (UDysRS);   Mobility State Self-Assessment (Subject Diary Cards);   MDS-UPDRS;   Fatigue Severity Scale
3 Recruiting Phase III Study of the Safety and Efficacy of Cl-108 in the Treatment of Moderate to Severe Pain
Conditions: Pain;   Nausea;   Vomiting
Interventions: Drug: CL-108;   Drug: Placebo
Outcome Measures: To compare the occurrence and severity of opioid-induced nausea and vomiting (OINV) associated with CL-108 to Norco.;   To demonstrate the efficacy of CL-108 when compared to placebo for the relief of pain following surgical removal of impacted third molar teeth.;   Reduction of the severity of nausea in patients treated with an opioid-containing pain reliever.;   Reduction of vomiting in patients treated with an opioid-containing pain reliever.
4 Recruiting Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer
Conditions: Head and Neck Cancer;   Oral Mucositis
Interventions: Dietary Supplement: Grape extract;   Drug: Lortab, Fentanyl patch, mouthwash
Outcome Measures: Pain caused by oral mucositis;   Level of immune biomarkers in blood;   Level of immune biomarkers in mucosal tissue
5 Not yet recruiting Ureteral Stent-related Pain and Mirabegron (SPAM) Trial
Condition: Nephrolithiasis
Interventions: Drug: Mirabegron;   Drug: Tamsulosin;   Drug: Percocet
Outcome Measures: Ureteral stent related pain and lower urinary tract symptoms (LUTS) as measured by the Ureteral Stent Symptom Questionnaire.;   Quality of life impact of mirabegron for stent symptoms as measured with the Ureteral Stent Symptoms Questionnaire.
6 Unknown  Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain
Condition: Pain, Fracture, Sprain
Interventions: Drug: Fentanyl rapid dissolving tablet 100mcg;   Drug: lansoprazole 15mg rapidly dissolving tablet + Percocet PO
Outcome Measures: Time to analgesia;   Occurrence of untoward opioid side effects
7 Not yet recruiting An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.
Condition: Post Operative Pain
Interventions: Drug: Percocet;   Drug: Xartemis
Outcome Measures: Non Inferiority;   Patient Global Assessment
8 Recruiting Adductor Canal Nerve Block Following Total Knee Arthroplasty
Condition: Post-op Pain
Interventions: Drug: Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed.;   Drug: For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.
Outcome Measures: Total Opiate pain medication;   Patient satisfaction with pain control
9 Not yet recruiting Local Anesthesia and Analgesics in Endodontic Pain
Condition: Odontalgia
Interventions: Drug: Oral placebo;   Drug: Oral ibuprofen;   Drug: oral naproxen;   Drug: oral acetaminophen/hydrocodone + ibuprofen
Outcome Measures: Effect of long acting anesthesia and analgesics on endodontic pain;   Effect of gender and age on post-operative endodontic pain treatment
10 Recruiting Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge
Condition: Analgesia After ED Discharge for Extremity Injuries
Intervention: Drug: Oral Opioid Pain Medicine
Outcome Measures: Difference in pain score before and after last dose.;   Overall Satisfaction with the pain medicine;   Side Effects
11 Recruiting Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (AATD)
Conditions: Liver Fibrosis;   Alpha-1 Antitrypsin Deficiency;   AAT Deficiency;   AATD
Interventions: Device: Abdominal ultrasound;   Procedure: History and physical;   Procedure: Intravenous catheter;   Procedure: Blood draw;   Other: Liver questionnaire;   Procedure: Liver Biopsy;   Drug: Midazolam;   Drug: Fentanyl;   Drug: Lidocaine;   Drug: Acetaminophen;   Drug: Lorazepam;   Drug: Oxycodone/Acetaminophen;   Drug: Ondansetron
Outcome Measures: To estimate the prevalence and histologic spectrum of liver injury in an adult with Alpha-1 Antitrypsin deficiency and a genotype of ZZ.;   To identify environmental and host risk factors for clinically significant liver fibrosis.;   To define the diagnostic accuracy of non-invasive markers of fibrosis in AAT liver disease.;   To explore epigenetic markers for the development of liver fibrosis.;   To quantify liver fibrosis progression.
12 Not yet recruiting The Effect of NSAIDs After a Rotator Cuff Repair Surgery.
Condition: Rotator Cuff Tear
Interventions: Procedure: Rotator cuff repair;   Drug: Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole;   Drug: Hydrocodone/Acetaminophen
Outcome Measures: American Shoulder and Elbow Surgeons (ASES) Shoulder Score;   Ultrasound evaluation of retear rate
13 Recruiting Safety and Efficacy Study of Fentanyl Buccal Tablet Use in the Emergency Department for Isolated Extremity Injury
Condition: Pain
Interventions: Drug: Fentanyl;   Drug: Oxycodone/acetaminophen;   Drug: oxycodone/acetaminophen
Outcome Measures: Pain Level;   Nausea level;   Occurrence of adverse events
14 Recruiting Safety and Efficacy of Gabapentin for Neuropathic Pain in Fabry Disease
Conditions: Fabry Disease;   Neuropathic Pain
Interventions: Drug: Gabapentin;   Drug: placebo
Outcome Measures: average reduction in hydrocodone-acetaminophen use;   Number and type of adverse events;   Pain levels;   Define therapeutic level for gabapentin
15 Not yet recruiting Equality Study of Ofirmev vs Oral Acetaminophen
Condition: Pain, Postoperative
Interventions: Drug: IV acetaminophen;   Drug: oral acetaminophen
Outcome Measures: Primary outcome will measure total opioid consumption while the patient is in the PACU;   time from PACU admission to request for first opioid dose
16 Recruiting Clinical Research of the Prognostic Influence of NSAIDS's Anti-inflammatory Effect on Senior Patients With Hip Fracture
Condition: Hip Fracture
Interventions: Drug: celecoxib;   Drug: Acetaminophen oxycodone
Outcome Measure:
17 Recruiting Tracking & Feedback Registry to Reduce Breast Cancer Treatment Disparities
Condition: Breast Cancer
Intervention: Other: Tracking & Feedback
Outcome Measures: Change in intervention effect of adjuvant treatment;   Organizational Characteristics
18 Not yet recruiting Post-operative Analgesia in Elective, Soft-tissue Hand Surgery
Conditions: Carpal Tunnel;   Ganglion Cyst;   Trigger Finger
Interventions: Drug: Acetaminophen/Hydrocodone;   Drug: Acetaminophen/Ibuprofen
Outcome Measures: Efficacy comparison utilizing Visual Analog Scale (VAS), Likert Pain Score and Mean daily pain values;   Incidence of adverse effects
19 Recruiting Narcotic vs. Non-narcotic Pain Study Protocol
Condition: Carpal Tunnel
Interventions: Drug: Narcotic;   Drug: non-narcotic
Outcome Measure: Pain relief
20 Not yet recruiting Comprehensive Opioid Management
Condition: Chronic Pain
Interventions: Behavioral: IVR self-management;   Behavioral: Opioid monitoring;   Other: Enhanced usual care
Outcome Measures: Brief Pain Inventory;   Concordance with opioid treatment practice guidelines