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VITAMIN D DEFICIENCY and RECLAST

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VITAMIN D DEFICIENCY Symptoms and Causes

What is vitamin D deficiency?

Vitamin D deficiency means that you are not getting enough vitamin D to stay healthy.

Why do I need vitamin D and how do I get it?

Vitamin D helps your body absorb calcium. Calcium is one of the main building blocks of bone. Vitamin D also has a role in your nervous, muscle, and immune systems.

You can get vitamin D in three ways: through your skin, from your diet, and from supplements. Your body forms vitamin D naturally after exposure to sunlight. But too much sun exposure can lead to skin aging and skin cancer, so many people try to get their vitamin D from other sources.

How much vitamin D do I need?

The amount of vitamin D you need each day depends on your age. The recommended amounts, in international units (IU), are

  • Birth to 12 months: 400 IU
  • Children 1-13 years: 600 IU
  • Teens 14-18 years: 600 IU
  • Adults 19-70 years: 600 IU
  • Adults 71 years and older: 800 IU
  • Pregnant and breastfeeding women: 600 IU

People at high risk of vitamin D deficiency may need more. Check with your health care provider about how much you need.

What causes vitamin D deficiency?

You can become deficient in vitamin D for different reasons:

  • You don't get enough vitamin D in your diet
  • You don't absorb enough vitamin D from food (a malabsorption problem)
  • You don't get enough exposure to sunlight.
  • Your liver or kidneys cannot convert vitamin D to its active form in the body.
  • You take medicines that interfere with your body's ability to convert or absorb vitamin D
Who is at risk of vitamin D deficiency?

Some people are at higher risk of vitamin D deficiency:

  • Breastfed infants, because human milk is a poor source of vitamin D. If you are breastfeeding, give your infant a supplement of 400 IU of vitamin D every day.
  • Older adults, because your skin doesn't make vitamin D when exposed to sunlight as efficiently as when you were young, and your kidneys are less able to convert vitamin D to its active form.
  • People with dark skin, which has less ability to produce vitamin D from the sun.
  • People with disorders such as Crohn's disease or celiac disease who don't handle fat properly, because vitamin D needs fat to be absorbed.
  • People who have obesity, because their body fat binds to some vitamin D and prevents it from getting into the blood.
  • People who have had gastric bypass surgery
  • People with osteoporosis
  • People with chronic kidney or liver disease.
  • People with hyperparathyroidism (too much of a hormone that controls the body's calcium level)
  • People with sarcoidosis, tuberculosis, histoplasmosis, or other granulomatous disease (disease with granulomas, collections of cells caused by chronic inflammation)
  • People with some lymphomas, a type of cancer.
  • People who take medicines that affect vitamin D metabolism, such as cholestyramine (a cholesterol drug), anti-seizure drugs, glucocorticoids, antifungal drugs, and HIV/AIDS medicines.

Talk with your health care provider if you are at risk for vitamin D deficiency. There is a blood test which can measure how much vitamin D is in your body.

What problems does vitamin D deficiency cause?

Vitamin D deficiency can lead to a loss of bone density, which can contribute to osteoporosis and fractures.

Severe vitamin D deficiency can also lead to other diseases. In children, it can cause rickets. Rickets is a rare disease that causes the bones to become soft and bend. African American infants and children are at higher risk of getting rickets. In adults, severe vitamin D deficiency leads to osteomalacia. Osteomalacia causes weak bones, bone pain, and muscle weakness.

Researchers are studying vitamin D for its possible connections to several medical conditions, including diabetes, high blood pressure, cancer, and autoimmune conditions such as multiple sclerosis. They need to do more research before they can understand the effects of vitamin D on these conditions.

How can I get more vitamin D?

There are a few foods that naturally have some vitamin D:

  • Fatty fish such as salmon, tuna, and mackerel
  • Beef liver
  • Cheese
  • Mushrooms
  • Egg yolks

You can also get vitamin D from fortified foods. You can check the food labels to find out whether a food has vitamin D. Foods that often have added vitamin D include

  • Milk
  • Breakfast cereals
  • Orange juice
  • Other dairy products, such as yogurt
  • Soy drinks

Vitamin D is in many multivitamins. There are also vitamin D supplements, both in pills and a liquid for babies.

If you have vitamin D deficiency, the treatment is with supplements. Check with your health care provider about how much you need to take, how often you need to take it, and how long you need to take it.

Can too much vitamin D be harmful?

Getting too much vitamin D (known as vitamin D toxicity) can be harmful. Signs of toxicity include nausea, vomiting, poor appetite, constipation, weakness, and weight loss. Excess vitamin D can also damage the kidneys. Too much vitamin D also raises the level of calcium in your blood. High levels of blood calcium (hypercalcemia) can cause confusion, disorientation, and problems with heart rhythm.

Most cases of vitamin D toxicity happen when someone overuses vitamin D supplements. Excessive sun exposure doesn't cause vitamin D poisoning because the body limits the amount of this vitamin it produces.

Check out the latest treatments for VITAMIN D DEFICIENCY

VITAMIN D DEFICIENCY treatment research studies

RECLAST clinical trials, surveys and public health registries


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RECLAST Side Effects

Arthralgia (599)
Pain (418)
Myalgia (402)
Headache (341)
Bone Pain (334)
Pyrexia (332)
Influenza Like Illness (315)
Nausea (272)
Chills (241)
Asthenia (234)
Fatigue (233)
Back Pain (228)
Pain In Extremity (213)
Dizziness (181)
Dyspnoea (177)
Chest Pain (163)
Vomiting (163)
Malaise (141)
Gait Disturbance (136)
Diarrhoea (128)
Death (122)
Pain In Jaw (121)
Muscle Spasms (112)
Feeling Abnormal (101)
Abasia (99)
Musculoskeletal Pain (99)
Oedema Peripheral (98)
Blood Creatinine Increased (95)
Fall (89)
Joint Swelling (84)
Neck Pain (83)
Dehydration (79)
Confusional State (76)
Muscular Weakness (73)
Blood Pressure Increased (69)
Abdominal Pain (67)
Renal Failure Acute (67)
Musculoskeletal Stiffness (66)
Paraesthesia (66)
Hypoaesthesia (65)
Decreased Appetite (63)
Insomnia (60)
Erythema (59)
Eye Pain (58)
Chest Discomfort (57)
Atrial Fibrillation (56)
Activities Of Daily Living Impaired (55)
Hypocalcaemia (54)
Syncope (53)
Osteonecrosis (52)

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Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
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VITAMIN D DEFICIENCY Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting The Use of Zoledronic Acid to Complex Regional Pain Syndrome
Condition: Complex Regional Pain Syndromes
Interventions: Drug: Zoledronic acid;   Drug: Placebo
Outcome Measures: Pain measured on Visual Analog Scale;   Lower Limbs vertical force on Wii platform;   American Orthopaedic Foot and Ankle Scale (AOFAS);   36-Item Short Form Health Survey (SF-36)
2 Recruiting Pilot Study of Bisphosphonate Therapy (Zoledronic Acid) in Patients With Malignant Mesothelioma (UAB 0901)
Condition: Mesothelioma
Intervention: Drug: Zometa (zoledronic acid)
Outcome Measures: Evaluation of the tumor response rate following zoledronic acid;   Evaluation of the duration of tumor response
3 Recruiting Biomarkers in Tissue Samples From Patients With Newly Diagnosed Breast Cancer Treated With Zoledronic Acid
Conditions: Estrogen Receptor-negative Breast Cancer;   Estrogen Receptor-positive Breast Cancer;   Invasive Ductal Breast Carcinoma;   Progesterone Receptor-negative Breast Cancer;   Progesterone Receptor-positive Breast Cancer;   Stage IA Breast Cancer;   Stage IB Breast Cancer;   Stage II Breast Cancer
Interventions: Drug: zoledronic acid;   Other: laboratory biomarker analysis;   Procedure: therapeutic conventional surgery
Outcome Measures: Changes in biomarkers of tumor growth and metastasis in women with newly diagnosed ER and/or PR positive invasive ductal breast cancer receiving zoledronic acid;   Changes in immunologic function after a single dose of zoledronic acid;   Changes in the expression of tumor markers important to breast cancer progression and metastasis in women receiving zoledronic acid
4 Recruiting Zoledronic Acid in Acute Spinal Cord Injury
Condition: Complete Traumatic Spinal Cord Injury
Interventions: Drug: Zoledronic acid;   Drug: normal saline 0.9%
Outcome Measures: change in bone mineral density;   Biomarkers of bone formation and resorption;   safety and tolerability of zoledronic acid
5 Unknown  Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma
Condition: Osteosarcoma
Interventions: Drug: Zoledronic acid;   Drug: Standard chemotherapy
Outcome Measure: histological response disease free interval
6 Recruiting The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfecta
Condition: Osteogenesis Imperfecta
Interventions: Drug: Zoledronic acid;   Drug: Teriparatide;   Drug: placebo zoledronic acid;   Drug: placebo teriparatide
Outcome Measures: Bone Mineral Density (BMD);   Fracture risk
7 Recruiting Bone Loss Treatment From Adjuvant Zoledronate Efficacy
Conditions: Breast Neoplasms;   Bone Loss
Intervention: Drug: Zoledronate
Outcome Measures: Change from Baseline in Bone Mineral Density;   Bone metastasis rate;   Disease-Free Survival
8 Recruiting Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Subjects With Multiple Myeloma
Conditions: Cancer;   Hematologic Malignancies;   Multiple Myeloma;   Oncology;   Bone Metastases;   Multiple Myeloma Bone Lesions
Interventions: Drug: Denosumab;   Drug: Zoledronic acid
Outcome Measures: Time to the first on-study skeletal related event (SRE) (non-inferiority test);   Time to the first-and-subsequent SRE (superiority test, using multiple event analysis);   Time to the first on-study SRE (superiority test)
9 Recruiting Effect of the Combination of Bortezomib/Dexamethasone/Zoledronic Acid on Bone Disease in Patients With Multiple Myeloma Who Have Relapsed After 1-3 Prior Lines of Therapy
Condition: Multiple Myeloma
Interventions: Drug: Bortezomib;   Drug: Zoledronic Acid;   Drug: Dexamethasone
Outcome Measures: Bone Mineral Density (BMD);   Bone mineral density (BMD);   Serum values of bone-specific alkaline phosphatase, osteocalcin and C-terminal cross-linking telopeptides of collagen type-I;   Bone pain;   Skeletal-related events (SRE: pathologic fractures, need for bone radiation therapy or surgery);   Improvement of osteolytic lesions
10 Not yet recruiting Genetics in Predicting Risk of Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid
Conditions: Malignant Neoplasm;   Musculoskeletal Complications
Interventions: Drug: zoledronic acid;   Other: pharmacological study
Outcome Measures: Plasma concentrations of Zol collected at visits 2, 3, 4, and 5;   Urine concentrations of Zol collected at visits 2, 3, 4, and 5;   Jawbone tissue concentrations of Zol collected during surgical treatment for BRONJ;   Identify potential risk factors for BRONJ
11 Recruiting Pilot Study of Zoledronic Acid and Interleukin-2 for Refractory Pediatric Neuroblastoma
Condition: Neuroblastoma
Interventions: Drug: Zoledronic Acid;   Biological: Aldesleukin
Outcome Measures: Evaluate the safety and toxicity of zoledronic acid and aldesleukin;   Evaluate the biologic function of autologous expanded/activated gamma delta T cells in neuroblastoma patients receiving therapy with zoledronic acid and aldesleukin;   uoEvaluate immune phenotype of in vivo expanded/activated autologous gamma delta T cells;   To document tumor response in patients with measurable disease.;   Determine the ability of in vivo expanded/activated gamma delta T cells to infiltrate neuroblastoma tissue using immunohistochemical techniques when post-therapy specimens are available.
12 Recruiting The ODYSSEY TRIAL Phase IV Trial Evaluating the Palliative Benefit of Pamidronate or Zoledronic Acid in Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Pamidronate;   Drug: Zoledronic acid;   Drug: placebo
Outcome Measures: sCTX values;   Palliative response
13 Recruiting Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT)
Conditions: Giant Cell Tumor of Bone;   Osteoclastoma
Intervention: Drug: Zoledronic acid
Outcome Measures: Determine if adjuvant zoledronic acid improves the 2 year recurrence rate of 'high risk' GCT as compared to standard care;   Evaluate the usefulness of bone remodelling markers in diagnosing and monitoring GCT;   Determine the relapse free survival
14 Recruiting N2007-02:Bevacizumab,Cyclophosphamide,& Zoledronic Acid in Patients W/ Recurrent or Refractory High-Risk Neuroblastoma
Condition: Neuroblastoma
Interventions: Drug: Bevacizumab;   Drug: cyclophosphamide;   Drug: zoledronic acid
Outcome Measures: Determination of toxicities and feasibility of the combination of bolus plus metronomic cyclophosphamide and zoledronic acid with and without bevacizumab when given to children with refractory or recurrent high risk neuroblastoma.;   Evaluation of response within the confines of a phase I study.;   Analysis of Circulating Endothelial Cells, Circulating Factors, Gene expression and Bone Metabolism Studies.
15 Recruiting FES-Rowing Versus Zoledronic Acid to Improve Bone Health in Spinal Cord Injury (SCI)
Condition: Osteoporosis
Interventions: Other: FES-Rowing;   Drug: Zoledronic acid
Outcome Measures: Improvement of bone mass as measured by sequential evaluation of bone density and bone structure;   Validation of DXA Scanning in patients with SCI
16 Recruiting 1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids for Chronic Inflammatory Conditions
Condition: Osteoporosis
Intervention: Drug: zoledronic acid
Outcome Measures: Safety of zoledronic acid for the treatment of osteoporotic children treated with glucocorticoids for chronic inflammatory conditions by adverse event collection and laboratory results monitoring.;   Change from baseline in LS areal BMD Z-score at Month 18 and 24 by core treatment group by dual energy x-ray absorptiometry (DXA).;   Change from baseline in LS and total body BMC by core treatment group by DXA.;   Change in biochemical marker values (serum P1NP, BSAP, NTx and TRAP-5b) from baseline.;   Change in the number of new clinical vertebral fractures and new morphometric vertebral fractures.;   To evaluate the change from baseline (Visit 1 of the Core study) in pain using the Faces Pain Scale-Revised (FPS-R)by core treatment group.
17 Unknown  Clinical Study of Sorafenib and Zoledronic Acid to Treat Advanced HCC
Condition: Hepatocellular Carcinoma
Intervention: Drug: Sorafenib and Zoledronic Acid
Outcome Measures: numbers of adverse events;   Overall survival (OS), time to progression (TTP)
18 Recruiting Research of Zoledronic Acid and Aromatase Inhibitors as Adjuvant Therapy to Breast Cancer
Condition: Breast Cancer
Intervention: Drug: Zoledronic Acid and Aromatase Inhibitors
Outcome Measures: therapeutic assessment;   Adverse reactions and disease-free survival
19 Recruiting HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer.
Condition: Breast Cancer
Interventions: Drug: tamoxifen;   Drug: triptorelin;   Drug: letrozole;   Drug: zoledronic acid
Outcome Measures: disease free survival in premenopausal patients;   bone mineral density;   Bone mineral density measured;   disease free survival in postmenopausal patients;   overall survival;   toxicity of letrozole + triptorelin and letrozole + zoledronic acid + triptorelin in premenopausal patients
20 Not yet recruiting Zoledronic Acid in Rheumatoid Arthritis
Condition: Arthritis, Rheumatoid
Intervention: Drug: Zoledronic acid
Outcome Measure: Sharp van der Heijde index