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VOMITING and Methotrexate

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VOMITING Symptoms and Causes

Nausea is an uneasy or unsettled feeling in the stomach together with an urge to vomit. Nausea and Vomiting, or throwing up, are not diseases. They can be symptoms of many different conditions. These include morning sickness during pregnancy, infections, migraine headaches, motion sickness, food poisoning, cancer chemotherapy or other medicines.

For Vomiting in children and adults, avoid solid foods until Vomiting has stopped for at least six hours. Then work back to a normal diet. Drink small amounts of clear liquids to avoid dehydration.

Nausea and Vomiting are common. Usually, they are not serious. You should see a doctor immediately if you suspect poisoning or if you have

  • Vomited for longer than 24 hours
  • Blood in the vomit
  • Severe abdominal pain
  • Headache and stiff neck
  • Signs of dehydration, such as dry mouth, infrequent urination or dark urine

Check out the latest treatments for VOMITING

VOMITING treatment research studies

Methotrexate clinical trials, surveys and public health registries


Find Drug Side Effect reports



Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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Common Meds

Abilify (10132)
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Lantus (10968)
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Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
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Recent Reviews

Christmas morning when i first woke i didnt feel like myusual selfi felt tired or i had low energy,later during the day i ate then soon after i had eaten i started feeling nautious for hours until finally when i went to

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

Hi iam 20 years old & this is my third day feeling sick second two be vomiting everything ..today I poop black. What can I have

I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spo

I am 7 years post-op for gastric bypass. I suddenly started frequent nausea. Then sttarted waking up from a sound sleep nauseated and dry heaving. I dry heave so much at time I have stomach spasms. What could this be a sign of? Is my surgery messed u

I can't stop vomiting everything for about 1 week now, and I was told that maybe it was because of my pregnancy, but now I'm 13 weeks and I can't eat anything because it makes me vomit at all times. What can I do?

I dont know what is wrong with me but every morning for the last 3 months i throw up, then i am fine for the rest of the day. I thought that it was just stress at first but the reasons that i were stressed have now been alleviated. I was in perfect g

I have been on methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is

I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause diss

I only took it for 21 days but in that time, it put me into a full panic attack that lasted almost 8 days after I went off the medication. I had mental confusion, could not speak properly (I knew what I wanted to say but the words would not come out

When I eat or drink this burning feeling in my chest going up like I am about vomiting.what is happening? And something I and chest pain too! And I am 14 and a girl

my husband has been on pradaxa for a month he cannot eat has lost 26 lbs gets chills and then feels hot, vomiting.

<strong>My son who is 6 years old, had finished a whole round of a different antibiotic for sinus infection- he is up to 25 days of coughing. 4 days ago he was prescribed Biaxin. He has been vomiting -both ends - diarrhea- with severe rash all

About 5 years ago my son who was around 5, suffered an immediate response to the Flumist vaccine. He and his sister both received the vaccine. She didn't feel great over the next few days (mild nausea and headache). My son, began vomiting within 5

About a year ago i was suscribed Primperan for my rumination syndrome to stop vomiting and feeling nausea. About one hour after i took my medicin my tounge started rolling and swelling, my teeth chattering and i got cramps in my face. I had to go wit

After 1st dose, headache, aches, fatigue, severe vomiting and general unwell feeling for 3 weeks post. After 2nd injection same indications but not as intense, although severe fatigue. I am concerned about my next injection in 4 months!

After 1st injection developed high blood pressure and heart murmer for short time. after 2nd injection along with the above also developed headacheloss of appitite vomiting. canceled my 3rd injection !

After being diagnosed with dermographism, I was prescibed the above drugs, to be taken together. I assume that Zantac offers some protection for the stomach. Unfortunately, I experienced nausea, vomiting, stomach cramps and diarrhoea whithin an hour

After taking first dose before going to bed, found the Tramal caused a hyped up feeling, mind racing and unable to sleep. Next morning the nausea started, dizziness, feeling 'spaced out' followed by severe episodes of vomiting, which continued up to

After taking Floxstat, I had nausea and vomiting along and insomnia for that period.

VOMITING Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Study of Anesthesia Techniques to Reduce Nausea and VOMITING After Jaw Corrective Surgery
Conditions: Post-operative Nausea;   Post-operative VOMITING;   Post-discharge Nausea;   Post-discharge VOMITING
Intervention: Other: Anesthesia and postoperative medication and fluid protocol
Outcome Measures: Post-operative nausea and VOMITING;   Hospital length of stay;   Post-discharge nausea and VOMITING
2 Recruiting Efficacy of Ondansetron on VOMITING Due to Acute Gastroenteritis in Pediatric During Winter
Conditions: VOMITING;   Gastroenteritis
Intervention: Drug: Ondansetron
Outcome Measures: Success will be defined by the absence of VOMITING between 15 minutes and 4 hours after administration of study treatment.;   Hospital admissions for acute gastroenteritis, intravenous infusion for rehydration, return emergency department visit, severity and duration of diarrhea and VOMITING. Treatment safety will also be assessed. These criteria will be assessed within 7 days
3 Recruiting Prevention of Chemotherapy Induced Nausea and VOMITING in Breast Cancer Patients.
Condition: Emesis
Interventions: Drug: Dexamethasone, Ondansetron, Aprepitant;   Other: Arm A: Standard Anti-emetic regimen
Outcome Measures: Incidence of change in acute emesis (nausea and/or VOMITING) in both study arms;   Incidence of change in the delayed emesis (nausea and/or VOMITING) in both study arms
4 Recruiting Effectiveness of Aprepitant in Addition to Ondansetron in the Prevention of Nausea and VOMITING Caused by Upper Abdominal Radiotherapy
Conditions: Nausea;   VOMITING
Interventions: Drug: aprepitant;   Drug: Ondansetron
Outcome Measures: Complete Response rate (no VOMITING and no rescue anti-emetic therapy);   Complete Response rate;   Proportion of patients who did not vomit;   No Significant Nausea: The proportion of patients who did not experience any nausea ≥ 3 on 0 - 10 scale;   No Nausea: The proportion of patients who did not experience any nausea. Nausea = 0 on 0 - 10 scale;   Complete Protection: The proportion of patients who did not vomit, require rescue therapy, or have nausea ≥ 3 on 0 - 10 scale;   Total Protection: The proportion of patients who did not vomit, require rescue therapy, or have any nausea (Nausea = 0 on 0 - 10 scale).;   VOMITING frequency: The frequency of VOMITING (# episodes per week) in patients who did vomit at least once.;   Nausea frequency: The frequency of nausea (Nausea > 0 in a given week/ number of weeks during overall period of radiation treatment);   Significant Nausea frequency: The frequency of significant nausea (Nausea ≥ 3 in a given week/ number of weeks during overall period of radiation treatment);   Frequency of rescue medication use: The number of days in which rescue medication was taken / number of days of radiotherapy;   Time to Failure: The time period in days from the start of radiation until the first VOMITING episode or use of rescue medication for all patients and for the subset of patients who do not have a Complete Response.;   All adverse events that occur during radiation treatment with assessment of severity (CTC v.3) and relationship to study drug.
5 Recruiting A Korean Study of Efficacy and Safety of Aprepitant-based Triple Regimen for the Prevention of Chemotherapy-Induced Nausea and VOMITING in the First Cycle of Moderately Emetogenic Chemotherapy (Non-doxorubicin Hydrochloride [Adriamycin] and Cyclophosphamide Regimens) (MK-0869-225 AM1) (KMEC)
Conditions: Nausea;   VOMITING
Interventions: Drug: Aprepitant;   Drug: Aprepitant Placebo;   Drug: Ondansetron;   Drug: Dexamethasone;   Drug: Ondansetron Placebo;   Drug: Rescue Therapy (granisetron, dolasetron, tropisetron or ondansetron; metoclopramide or alizapride).
Outcome Measures: The Proportion of Participants with Overall No VOMITING for the Overall Stage;   Number of Participants with a Complete Response - Overall, Acute, and Delayed;   Time to First VOMITING Event Overall;   Number of Participants with No VOMITING and No Significant Nausea;   Number of Participants with No Impact on Daily Life - Overall;   Number of Participants with No Use of a Rescue Therapy - Overall, Acute, and Delayed;   Number of Participants with One or More Clinical Adverse Events;   No VOMITING - Acute and Delayed
6 Recruiting Evaluation of Predictive Risk Factors of Chemotherapy-induced Nausea and VOMITING
Conditions: Chemotherapy-induced Nausea and VOMITING;   Moderate Emetogenic Chemotherapy
Intervention:
Outcome Measures: To evaluate the role of some predictive biomarkers for chemotherapy-induced nausea and VOMITING;   To evaluate the clinical characteristics related to chemotherapy-induced nausea and VOMITING in Korean patients
7 Recruiting Intravenous Lidocaine in the Prevention of Postoperative VOMITING in Elective Tonsil Surgery
Conditions: Postoperative Nausea and VOMITING;   Pain After Surgery
Intervention: Drug: Lidocaine
Outcome Measures: Evaluating the effectiveness of intravenous lidocaine during anesthesia to decrease the numbers of events (VOMITING) during the immediate postoperative period up to 24 hours postoperatively, comparing to placebo;   The prevention of the composite "nausea / or VOMITING";   Compare frequency of VOMITING by baseline risk;   Time to first VOMITING;   Time at which discharge criteria are met Postanesthesia care unit (PACU);   Length of stay in PACU unit;   PACU opioid consumption;   Postoperative pain using Children and Infants Postoperative Pain Scale , face or Visual analoge Scale, as appropriate;   Postoperative agitation using Pediatric Anesthesia Emergence Delirium Scale;   Time to first emetic drug administered;   Type and number of doses of antiemetic drug requiered during hospitalization;   Total length of stay;   Analysis of cost-effectiveness.
8 Unknown  Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and VOMITING (PONV) After Elective Laparoscopic Surgeries
Conditions: Nausea;   VOMITING
Interventions: Drug: Dexamethasone;   Drug: Aprepitant;   Drug: Placebo Dexamethasone
Outcome Measures: the incidences of nausea, VOMITING, need for rescue medication;   incidences of unplanned hospital admission; duration of PACU stay
9 Recruiting Fosaprepitant Dimeglumine and Granisetron Transdermal System in Preventing Nausea and VOMITING in Patients With Breast Cancer Undergoing Chemotherapy
Conditions: Breast Cancer;   Nausea;   VOMITING
Interventions: Drug: granisetron transdermal system;   Drug: fosaprepitant dimeglumine;   Other: laboratory biomarker analysis
Outcome Measures: Proportion of patients with complete response, defined as no emesis and no use of rescue medication in acute phase (within first 24 hours of treatment);   Proportion of patients with complete response, defined as no emesis and no use of rescue medication in delayed phase (within 2-4 days of treatment);   Proportion of patients with complete response, defined as no nausea, defined as Visual Analog Scale (VAS) less than 5 mm on a 0-100mm horizontal scale in acute phase (within 24 hours of treatment);   Proportion of patients with complete response, defined as no nausea, defined as VAS less than 5 mm on a 0-100mm horizontal scale in delayed phase (within 2-4 days of treatment);   Proportion of patients with partial response, defined as 2 or fewer episodes of emesis (Common Terminology Criteria for Adverse Events [CTCAE] version 4.0 grade 1-2), regardless of the use of rescue antiemetic medications (in acute and delayed phase);   Proportion of patients with treatment failures, defined as more than 2 episodes of emesis (CTCAE version 4.0 grade 2 or greater), regardless of the use of rescue antiemetic medications;   Proportion of patients with partial response, defined as no significant nausea, defined as VAS less than 25 mm on a 0-100mm horizontal scale (in acute and delayed phase);   Proportion of patients who developed nausea and VOMITING in the first course of treatment out of all enrolled patients;   Proportion of patients who developed grade 1, 2, 3, or 4 nausea and VOMITING with all courses of treatment out of all patients who developed nausea and VOMITING;   Proportion of patients who developed nausea and VOMITING on all courses;   Proportion of patients who experience grade 1, 2, 3, or 4 adverse events out of all patients who have received study drugs;   Proportion of patients who missed 0, 1, or more than 2 doses of scheduled antiemetic medication at home on days 2 to 3, out of all patients
10 Unknown  B6 Treatment for Nausea and VOMITING in Pregnancy
Condition: Nausea and VOMITING Complain in Early Pregnancy
Intervention: Drug: vitamin B6
Outcome Measures: Nausea and VOMITING score;   Vitamin B6 concentration in nausea and VOMITING of pregnancy
11 Not yet recruiting Do Pharyngeal Packs During Orthognathic Surgery Reduce Postoperative Nausea and VOMITING
Conditions: Nausea;   VOMITING
Intervention: Device: pharyngeal pack
Outcome Measures: the incidence and severity of any nausea, emetic episodes (retching or VOMITING), or both (i.e., postoperative nausea and VOMITING) during the first 24 postoperative hours.;   The incidence and severity of throat pain;   the incidence of oral mucosal injury;   satisfactory scores of patients
12 Not yet recruiting Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and VOMITING in Patients With Cancer Receiving Highly Emetogenic Chemotherapy
Conditions: Hematopoietic/Lymphoid Cancer;   Nausea and VOMITING;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: Olanzapine;   Drug: Chemotherapy (cisplatin or cyclophosphamide and doxorubicin);   Drug: Antiemetic treatment (ondansetron or granisetron or palonosetron; plus dexamethasone; plus fosaprepitant or aprepitant);   Other: Placebo
Outcome Measures: Proportion of patients with no nausea, defined as a response of 0 in the nausea item of Nausea and VOMITING Daily Diary/Questionnaire;   Nausea scores measured by the Nausea and VOMITING Daily Diary/Questionnaire;   Complete response, defined as no emetic episodes and no use of rescue medication measured by the Nausea and VOMITING Daily Diary/Questionnaire;   Incidence of potential toxicities related to olanzapine as measured by the Nausea and VOMITING Daily Diary/Questionnaire;   Frequency of rescue medication repeatedly measured by the Nausea and VOMITING Daily Diary/Questionnaire
13 Recruiting Does First Oral Intake After Emergence Predict the Incidence of Post-operative VOMITING in Children?
Condition: Post-operative VOMITING
Interventions: Other: Apple Juice;   Other: Water
Outcome Measure: Post-operative VOMITING
14 Recruiting Nausea and VOMITING in Children Receiving Chemotherapeautic Monotherapy
Condition: Acute Leukemia
Intervention:
Outcome Measures: Acute Chemotherapy-Induced Nausea and VOMITING;   Anticipatory Chemotherapy-Induced Nausea and VOMITING;   Delayed Chemotherapy-Induced Nausea and VOMITING
15 Recruiting Postoperative VOMITING in Children - Is Dextrose Effective for Prevention?
Condition: Postoperative VOMITING
Interventions: Drug: Dextrose (D5NS);   Drug: Ondansetron (Control)
Outcome Measures: Incidence of Postoperative VOMITING;   Type and number of rescue antiemetic medications
16 Unknown  Does Thiamine Help VOMITING and Nausea in Pregnancy?
Condition: Hyperemesis Gravidarum
Intervention: Drug: thiamine & promethazine
Outcome Measure: the improvement in nausea and/or VOMITING after treatment
17 Recruiting Transcutaneous Electrical Acupoint Stimulation (TEAS) of P6 to Prevent Postoperation Nausea and VOMITING (PONV)
Condition: Postoperative Nausea and VOMITING
Interventions: Device: Transcutaneous electrical acupoint stimulation;   Device: Sham transcutaneous electrical acupoint stimulation;   Drug: Tropisetron;   Drug: Dexamethasone
Outcome Measures: Incidence of postoperative nausea and VOMITING;   Incidence of postoperative nausea;   incidence of postoperative VOMITING;   Number of Participants with Adverse Events
18 Recruiting Dexamethasone and Ondansetron Versus Placebo for Postoperative Nausea and VOMITING
Condition: Postoperative Nausea and VOMITING
Interventions: Drug: Dexamethasone and Ondansetron;   Drug: Placebo
Outcome Measures: Postoperative nausea or VOMITING;   incidence of nausea;   incidence of VOMITING;   rescue treatment;   pain;   sedation
19 Recruiting Dexamethasone for the Treatment of Established Postoperative Nausea and VOMITING
Conditions: Postoperative Nausea and VOMITING;   VOMITING
Interventions: Drug: Injection of Placebo (saline 0.9%);   Drug: Dexamethasone 3 mg intravenously;   Drug: Dexamethasone 6 mg;   Drug: Dexamethasone 12 mg
Outcome Measures: Treatment efficacy of Dexamethasone for established PONV;   Evaluation of the potential adverse effect profile of dexamethasone
20 Not yet recruiting Study of Prevention of Postoperative Nausea and VOMITING Using Cesamet
Condition: Postoperative Nausea and VOMITING
Intervention: Drug: Nabilone
Outcome Measures: Incidence of postoperative nausea and/or VOMITING;   Number of antiemetic rescue medications given postoperatively.