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WHEEZING and Methotrexate

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WHEEZING Symptoms and Causes

Asthma is a chronic disease that affects your airways. Your airways are tubes that carry air in and out of your lungs. If you have asthma, the inside walls of your airways become sore and swollen. That makes them very sensitive, and they may react strongly to things that you are allergic to or find irritating. When your airways react, they get narrower and your lungs get less air.

Symptoms of asthma include

  • Wheezing
  • Coughing, especially early in the morning or at night
  • Chest tightness
  • Shortness of breath

Not all people who have asthma have these symptoms. Having these symptoms doesn't always mean that you have asthma. Your doctor will diagnose asthma based on lung function tests, your medical history, and a physical exam. You may also have allergy tests.

When your asthma symptoms become worse than usual, it's called an asthma attack. Severe asthma attacks may require emergency care, and they can be fatal.

Asthma is treated with two kinds of medicines: quick-relief medicines to stop asthma symptoms and long-term control medicines to prevent symptoms.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for WHEEZING

WHEEZING treatment research studies

Methotrexate clinical trials, surveys and public health registries


Find Drug Side Effect reports



Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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Recent Reviews

Dr i have a problem..

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spo

I have been on methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is

I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause diss

I only took it for 21 days but in that time, it put me into a full panic attack that lasted almost 8 days after I went off the medication. I had mental confusion, could not speak properly (I knew what I wanted to say but the words would not come out

I was diagnosed with Rheumatoid Arthritis about 4 years ago when I was 13 or 14, they looked at me and said I had it, they didn't do any blood tests and when they did, nothing showed. But they started me on about 5 mg of Methotrexate, Prednisone, and

I wheeze with any activity; sometimes so loud that my daughter can hear me in the next room. I'm also out of breath often & inhale suddenly as if to catch my breath when I am just relaxing. I have been taking Aleve before I go to bed for pa

Im a 44yrs old female who took methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it

Afteer taking Berodual, difficulat to breath wheezing, etc

All in all very good but I have developed a cough. I have sarcoid which affects breathing and the cough is getting on my nerves but the wheezing is so much better. Not sure if I have an infection now. Taking Spiriva for 2 weeks.

Chest wheezing (never had chest issues prior to taking these drops) Red Sore Swollen eye lids - constantly itchy and very sore and swollen

Forehead looks good but now i can't breathe. So not worth it. Healed myself from asthma 10 years ago and now I'm suffering terribly almost every night I wake up unable to breathe, wheezing and sinus congestion. I refuse to take medicine because I don

I am taking Flixotide on a regular basis. Flixotide has stopped my wheezing at dawn overnight. However, I still suffer from allergy at springtime. Before commencing treatment with Flixotide, I used to take Xyzall (occasionally) to combat allergy i

I experienced severe dry skin around my mouth, shortness of breath and severe wheezing for about a year. I went to my physician who referred me to an allergist who, after a full set of allergy testing, determined I was only mildly allergic to my dog

I had Dysport injections in the glabellar area and for bunny lines in mid-August, 2011. I had approximately 70-80 units total. Two weeks later, I couldn't breathe. I was wheezing so badly my doctor wanted to put me in the hospital and gave me Albu

I was prescribed Seretide 125 after a serious chest infection. It cleared up the wheezing within a day or so but then I became extremely tired and unable to function at work properly ie tired, unable to concentrate so reduced dosage to 2 puffs at nig

I was started on metoprolol in february this year,i colapsed in the street,was hallusiating badly,faint,dizzy,cudnt sleep,was wheezing & breathless,i didnt know who's house i was in yet im NEVER EVER in anyone elses house,to not recognise my

Just been given a blue pump but its not stopping the wheezing and want a good nioghts sleep... Is it ok to take some benylin??

WHEEZING Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Wheezing in Black Preterm Infants: Impact of Vitamin D Supplementation Strategy
Conditions: Wheezing;   Allergy
Interventions: Dietary Supplement: Cholecalciferol;   Drug: Cholecalciferol
Outcome Measures: recurrent Wheezing;   Allergic Sensitization;   Bone Density
2 Recruiting Recurrent Wheezing in Infants: Risk Factors and Prevention With Probiotics.
Conditions: Respiratory Tract Diseases;   Wheezing
Interventions: Drug: Beclomethasone;   Drug: Probiotics;   Drug: Placebo
Outcome Measure: Recurrent Wheezing and cytokine assay.
3 Not yet recruiting Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness
Conditions: Asthma;   Wheezing
Interventions: Drug: Broncho-Vaxom;   Drug: Placebo
Outcome Measures: The time to the occurrence of the first WLRI episode in the third observation year while not receiving study drug;   The time to first WRLI during the two treatment years while receiving study drug;   The annualized rate of WLRI episodes during the two years while receiving study drug;   The annualized rate of WLRI episodes during the third observation year while not receiving study drug;   The annualized rate of severe Wheezing respiratory tract illness (SWLRI) episodes during the two treatment years while receiving study drug.;   The annualized rate of severe Wheezing respiratory tract illness (SWLRI) episodes during the third observation year while not receiving study drug.;   Number of participants with adverse events
4 Unknown  Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children
Condition: Wheezing
Intervention: Drug: prednisolone
Outcome Measures: The time until ready for discharge;   Oxygen saturation during hospital stay;   Wheeze and cough during two weeks after discharge from the hospital;   Readmission to the out-patient clinic or hospital for recurrent Wheezing during a two-month period after discharge;   Blood eosinophil counts at discharge and two weeks later
5 Recruiting Montelukast for Early Life Wheezing
Conditions: Lung Diseases;   Asthma
Interventions: Drug: Montelukast;   Drug: Placebo
Outcome Measures: Number of Wheezing-free days of infant (observed by primary caregiver);   Number of Wheezing episodes during treatment period;   Rate of recurrent Wheezing during follow-up period
6 Recruiting Trial for the Treatment of Acute Asthma in Wheezy Pre-school Aged Children
Condition: Asthma
Interventions: Drug: Azithromycin;   Drug: Suspension Placebo
Outcome Measures: To determine if treatment of pre-school children with a history of wheeze who present to an Emergency department (ED) with an acute Wheezing episode with Azithromycin for 5 days will resolve their symptoms more quickly;   Treatment of pre-school children with acute Wheezing symptoms with 5 days of azithromycin will cause these children to use less rescue beta2 agonists than those treated with placebo;   Treatment of pre-school children with acute Wheezing symptoms with 5 days of azithromycin will allow these children to remain free of subsequent wheezy episodes longer than those treated with placebo.
7 Recruiting Bedside Lung Ultrasound in Young Children Presenting to the Emergency Department (ED) With Wheezing
Conditions: Wheezing;   Bronchiolitis
Intervention:
Outcome Measure:
8 Unknown  Wheeze Detection in Adults During Dynamic Bronchial Situations Measured by PulmoTrack® 2010 With WIM-PC™ Technologies Recording
Condition: Asthma, Bronchial
Intervention: Device: PulmoTrack® 2010 with WIM-PC™ Technologies
Outcome Measures: Study success will be declared if one of the following is met: A correlation of at least 0.25 (R2=0.25) will be found between WR and FEV1 measurements; A correlation of at least 0.7 will be found between clinical parameter and WZ measurements.;   Evaluation of the safety of using the PulmoTrack® 2010 with WIM-PC™ Technologies for wheeze detection. Safety will be established by lack of adverse events. Since this is a Non Significant Risk (NSR) device serious adverse events are not expected
9 Recruiting Intravenous Magnesium in Wheezy Bronchitis
Condition: Wheezy Bronchitis
Interventions: Drug: Magnesium Sulfate;   Drug: Placebo
Outcome Measures: RDAI score;   saturation;   RDAI;   length of hospital stay
10 Recruiting Allergy Immunotherapy for the Reduction of Asthma
Conditions: Wheezing;   Asthma;   Allergy
Interventions: Biological: Allergen extracts (subcutaneous injections);   Other: Standard of care
Outcome Measures: Combined asthma symptom and asthma medication score;   Prevention of new allergic sensitization as determined by blood and/or skin testing to a panel of 9 common environmental and 9 common food allergens;   Observe Frequency and Phenotype of T regulatory cells in response to immunotherapy
11 Not yet recruiting AirSonea Wheeze Detection Study
Conditions: COPD;   Asthma
Intervention: Device: AirSonea
Outcome Measures: Device Efficacy;   Wheeze Rate break points
12 Recruiting Tolerance and Effect of a Prophylactical Treatment With Ivy Leaves Dry Extract in Recurrent Wheezy Bronchitis
Conditions: Acute Wheezy Bronchitis;   Recurrent Bronchitis
Intervention: Drug: Prospan Syrup
Outcome Measures: the time to event (next bronchitis episode) rate during and after treatment period;   days and percentage of days without bronchitis during and after treatment period;   days and percentage of days without bronchitis during treatment period
13 Recruiting Efficacy and Safety of Increasing Doses of Inhaled Albuterol Administered by Metered Dose Inhalers in Children With Acute Wheezing Episodes
Conditions: Asthma;   Children
Interventions: Drug: Albuterol - Experimental;   Drug: Albuterol - Control
Outcome Measures: Hospital Admission;   Forced expiratory volume in the first second;   Change in PRAM score;   Albuterol determination in the plasma;   Dosage of glucose and potassium plasma levels;   Electrocardiogram;   Respiratory frequency;   Need for additional therapies
14 Unknown  Wheezometer™ Exploratory (WM) Field Study
Conditions: Respiratory Sounds;   Wheezing
Intervention:
Outcome Measures: Wz% change in response to BD. Symptom score by e-Diary; Spirometer - FEV1.0/FVC/PEF/MEF50 with automated storage and timing;   Correlate Wz% to FEV1.0: within patient correlation
15 Recruiting Determinants Of Oral Corticosteroid Responsiveness in Wheezing Asthmatic Youth
Condition: Asthma
Intervention: Drug: Oral Corticosteroids
Outcome Measures: Hospital admission;   Length of active treatment in hospital;   Meeting the severity criteria for admission;   PRAM profile in the ED;   Time to meeting discharge criteria;   Change in respiratory resistance;   Unscheduled visits for asthma;   Symptom score;   Duration of asthma symptoms;   Cumulative reliever use;   Duration of use of rescue ß2-agonists
16 Unknown  Documentation of Continuous Wheeze and Cough Dynamics in Pediatric ER SOB Patients
Conditions: Asthma;   Bronchiolitis
Intervention:
Outcome Measures: increase or decrease of WheezeRate (the proportion of Wheezing in the respiratory cycle);   cough count (increase or decrease by more then 1 cough event or unchanged) in response to treatment
17 Recruiting Individualized Therapy For Asthma in Toddlers
Conditions: Asthma;   Wheezing
Interventions: Drug: daily fluticasone propionate;   Drug: Montelukast;   Drug: as-needed fluticasone propionate
Outcome Measure: Differential Response to the Three Therapies Based on Fixed Threshold Criteria for the Following Asthma Control Measures: Use of Oral Prednisone for Acute Asthma Exacerbations and Asthma Control Days.
18 Recruiting Acetaminophen Versus Ibuprofen in Children With Asthma
Conditions: Asthma;   Wheezing
Interventions: Drug: Acetaminophen;   Drug: Ibuprofen
Outcome Measure: exacerbation frequency
19 Recruiting Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function
Conditions: Pulmonary Function; Newborn, Abnormal;   Infant Wheeze;   In-utero Nicotine;   Second Hand Smoke
Interventions: Dietary Supplement: Vitamin C +prenatal vitamin;   Dietary Supplement: Placebo tablet+prenatal vitamin
Outcome Measures: Pulmonary function testing at 3 months of age in infants born to smoking pregnant women randomized to daily vitamin C versus placebo. The measurement of forced expiratory flow at 75% of expired volume (FEF75)will be compared between the groups.;   Incidence of Wheezing through 12 months of age in infants born to pregnant smoking women randomized to vitamin C versus placebo during pregnancy.
20 Recruiting Different End Points for Bronchial Hyperactivity (BHR) Tests.
Condition: Bronchial Hyperreactivity
Intervention:
Outcome Measures: Which of the outcome ends points measures comes first in the diagnosis of BHR.;   Age influence on which comes first outcomes.