Anal and Fluorouracil


Anal Symptoms and Causes

The anus is the opening of the rectum through which stool passes out of your body. Problems with the anus are common. They include hemorrhoids, abscesses, fissures (cracks), and cancer.

You may be embarrassed to talk about your Anal troubles. But it is important to let your doctor know, especially if you have pain or bleeding. The more details you can give about your problem, the better your doctor will be able to help you. Treatments vary depending on the particular problem.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

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anal treatment research studies

Fluorouracil clinical trials, surveys and public health registries

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Fluorouracil Side Effects

Diarrhoea (463)
Nausea (335)
Dehydration (273)
Vomiting (266)
Neutropenia (243)
Febrile Neutropenia (207)
Pyrexia (187)
Mucosal Inflammation (179)
Asthenia (158)
Abdominal Pain (152)
Stomatitis (143)
Fatigue (134)
Dyspnoea (131)
Interstitial Lung Disease (117)
Decreased Appetite (116)
Pulmonary Embolism (111)
Chest Pain (110)
Anaemia (106)
Thrombocytopenia (106)
Hypotension (106)
Neutrophil Count Decreased (99)
Hypokalaemia (95)
Leukopenia (83)
Sepsis (78)
White Blood Cell Count Decreased (78)
Renal Failure Acute (75)
Pneumonia (75)
Malaise (74)
Haemoglobin Decreased (72)
Neuropathy Peripheral (69)
Pain (69)
Renal Failure (64)
Disease Progression (64)
Respiratory Failure (62)
Cardiotoxicity (62)
Dysphagia (61)
Confusional State (57)
Platelet Count Decreased (57)
Pancytopenia (55)
Fall (55)
Deep Vein Thrombosis (54)
Myocardial Infarction (53)
Arteriospasm Coronary (51)
Hyponatraemia (51)
Weight Decreased (51)
Tachycardia (48)
Chills (46)
Dizziness (46)
Septic Shock (46)
Hyperammonaemia (46)

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Recent Reviews

Why do doctors keep the availabilty of the test for DPD deficiency a secret??? My sister is a doctor, infectious disease, at St Francis in Charleston, SC. Our father was treated by an oncologist well known to my sister, a 'colleague' you might s

Recently in the ultrasound by the radio logist the report says I have mild pyelocaliectasia . I am ok except freqiency in urine at night or when i take rice. There as such no visible sign or discomfort.

<span style='mso-bidi-language: AR-QA;'><span style='font-family: Calibri;'>I need help as my daughter 4 years old was

Anal fissure after avastin--problems after 1 treatment and got worse around round 4. Very painful and worse that natural childbirth. Planning on discussing with Oncol as I have vaginal bleeding and I am very concerned with lasting problems.

As your doctor if you are iron, B12, or ferretin deficient, then go from there.

Back pains,dizziness,constipation and stomach pains

Baclofen for cp

Betaloc is a Beta Blocker used to treat hypertension, tachycardia, arrhythmias and most commonly after a heart attack. Adverse side effects may be fatigue, dizziness and low pressure. Zivast is a cholesterol drug that is very effective and well-stud

Blurred vision , severe constipation , shortness of breath, dizzy spells tingling skin , itchy skin , yellow eyes , feeling awake all the time ,

Campral made me QUIT SMOKING I try everything to quit smoking I was chewing so much nicotone gum it was tearing up my treeth. I quit after taken Campral

<span style='font-family: Arial; font-weight: bold;'>From couple of days I am taking daflon 500mg (two tablets daily) for pre-anal haematoma or haemorrhoid for the next 14 days. Is it ok to drink alcohol ?

Anal fissure after avastin--problems after 1 treatment and got worse around round 4. Very painful and worse that natural childbirth. Planning on discussing with Oncol as I have vaginal bleeding and I am very concerned with lasting problems.

Even though i maintain regular defeaication with fibre and senna 2 tabs when i go the toilet i am unable to defecate; the rectum- anal bulges and i cannot push it out even though the faeces is soft.;when i do manage there is a ter


Hello, has anyone developed anal fistula/abscess while taking Accutane? My boyfriend began taking accutane and within a few days he had stomach problems and firstly, chronic diarrhea, then chronic constipation. After a couple of weeks he stopped t

I am 30 year old female. I have painful blister at the anal region. I was prescribed etoricoxib thiocolchicoside as a pain killer. I have been experiencing burning abdominal burning sensation and gastric problems.

I have anal itching after taking Beno. I took it for a few days and it started immediately. I thought maybe it was something else but after not taking it for several days I tried again with the same results. No more Beno for me.

I'm three months post -op rectal surgery. Took two dulcolax tablets,which worked on me,howeverthree hours I'm experiencing anal pain to the point of taking 15mg oxycodone to subdue the effects.

I've been prescribed clarithromycin twice for chest infections. Both times I got an anal fissure on day 5 of the course. I am going to need surgery on account of delayed diagnosis.

Iam a physcian Ihad peptic ulcer symptoms took one capsule of limpidex at 2pm after few hours Ihad very bad toxic rash all over my bodyassociated with very bad disness and feeling of very bad anal spasm ???proctalgia it lasted for

Anal Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Two Step Versus the Standard Three Step Approach of the WHO Analgesic Ladder for Cancer Pain Relief.
Conditions: Cancer;   Pain
Intervention: Other: Analgesic ladder
Outcome Measure: Time to achieving stable pain control, where stable pain control is defined as the first day of three consecutive days with average pain score less than or equal to 3 using scores from the Patient Diary and patient assessments.
2 Recruiting RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder.
Conditions: Cancer;   Cancer Pain
Interventions: Drug: Morphine;   Drug: Fentanyl;   Drug: Buprenorphine;   Drug: Oxycodone
Outcome Measures: Proportion of Non-Responder (NR) patients;   Proportion of full-responder
3 Recruiting Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals
Condition: Analgesic Response
Interventions: Drug: morphine sulfate;   Drug: hydrocodone;   Drug: hydromorphone HCI;   Drug: oxycodone;   Drug: buprenorphine;   Drug: oral tablet placebo;   Drug: sublingual tablet placebo
Outcome Measures: Pain detection;   Pain tolerance;   Pupillometry results
4 Recruiting Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis
Condition: Dysmenorrhea
Interventions: Drug: Sanjie Analgesic capsule;   Drug: placebo
Outcome Measures: dysmenorrhea;   change of Symptom (CPP Dyspareunia Defecate-pain Anal-bulge );   change of Signs(Pelvic-tenderness Tubercle );   change of Menstrual cycle and quantity;   change of serum CA125;   the size of uterus and endometriosis cyst;   change of serum endocrinological hormone;   change of SF-36 score;   Safety assessments will be based on electrocardiogram, physical examinations, and clinical laboratory tests;   Safety assessments will be based on adverse event reports
5 Not yet recruiting Monitoring Side Effects Of Pain Medication Prescribing By Emergency Department In Patients Over 65
Conditions: Acute Pain;   Analgesics;   Elderly
Outcome Measures: To measure side effects of pain medication prescribed by emergency department to patients older 65 years;   To ascertain the number of patients pain free;   Measure the number of patients that follow the therapy prescribed
6 Unknown  Trial of Naproxen to Evaluate Various Methods of Measuring Analgesic Effect in Osteoarthritis Pain of the Knee
Condition: Osteoarthritis, Knee
Interventions: Drug: Naproxen;   Drug: Placebo
Outcome Measures: Efficacy of naproxen vs. placebo;   Safety
7 Recruiting Modifying Virtual Reality Analgesia With Low-Dose Pain Medication
Condition: Virtual Reality Therapy
Intervention: Drug: Low-dose pain medication (Ketalar) and saline placebo
Outcome Measure: Pain responses between placebo and the low-dose pain medication while playing Snow World. We will assess pain responses with subjective questionnaires concerning the participant's experience while playing Snow World.
8 Not yet recruiting Local Anesthesia and Analgesics in Endodontic Pain
Condition: Odontalgia
Interventions: Drug: Oral placebo;   Drug: Oral ibuprofen;   Drug: oral naproxen;   Drug: oral acetaminophen/hydrocodone + ibuprofen
Outcome Measures: Effect of long acting anesthesia and Analgesics on endodontic pain;   Effect of gender and age on post-operative endodontic pain treatment
9 Recruiting Analgesic Effect of IV Acetaminophen in Tonsillectomies
Conditions: Adenotonsillitis;   Tonsillitis
Interventions: Drug: Acetaminophen (paracetamol);   Drug: Morphine (hydromorphone)
Outcome Measures: Analgesic efficacy of single dose intravenous acetaminophen in pediatric patients undergoing tonsillectomy to measure opioid consumption and pain scores in the first 8-12 postoperative hours.;   To observe recovery characteristics in the PACU and floor in patients following tonsillectomy.
10 Recruiting The Effect on Knee Joint Loads of Analgesic Use Compared With Exercise in Patients With Knee Osteoarthritis - An RCT
Condition: Osteoarthritis, Knee
Interventions: Drug: Instruction on Analgesic use for pain relief (acetaminophen and NSAIDs);   Other: Neuromuscular exercise
Outcome Measures: Change from baseline in 1st peak RMS (root mean square) Knee Index.;   Change from baseline in 1st peak Knee adduction moment;   Change from baseline in the KOOS (Knee injury and Osteoarthritis Outcome Score) questionnaire;   Change from baseline in Maximum number of one-leg rises from stool test;   Change from baseline in Maximum number of knee-bendings in 30s test;   Change from baseline in One-leg hop for distance test
11 Recruiting Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty
Conditions: Pain;   Complications
Interventions: Procedure: Local Analgesic;   Procedure: Nerve Block;   Procedure: Intravenous Analgesic;   Drug: ropivacaine;   Drug: opioid
Outcome Measures: pain;   sedation;   complication
12 Recruiting Comparison of Two Kinds of Postoperative Analgesia After Amputation
Conditions: Pain;   Complications
Interventions: Procedure: Local Analgesic;   Procedure: Intravenous Analgesic;   Drug: ropivacaine;   Drug: flurbiprofen
Outcome Measures: pain;   Phantom pain;   complication
13 Unknown  Study To Check The Analgesic And Anti-Inflammatory Effects Of Atorvastatin In Patients Undergoing Abdominal Surgery
Condition: Abdominal Surgery
Interventions: Drug: Atorvastatin;   Drug: Placebo
Outcome Measures: Pain as measured on Visual Analogue Scale;   Pain measured on Wong Pain Scale;   Pain measured by the McGill Pain Questionnaire;   TNF Alpha Levels;   Serum Lipid Levels;   C Reactive Protein Levels
14 Unknown  Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures
Condition: Osteoporosis
Interventions: Dietary Supplement: Gastrolith;   Other: Placebo
Outcome Measures: Reduction of pain assessed by change in NRS from baseline to end of the trial;   Reduction of pain assessed by change in BPI from baseline to end-of-trial;   Reduction of disability assessed by change in ODI from baseline to end-of-trial;   Reduction of ASOC assessed by weekly change in Analgesic consumption diaries from baseline to end of trial;   All adverse events and serious adverse events will be collected and reported
15 Recruiting Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on Abdominal Hysterectomy Patients
Condition: Pain
Interventions: Drug: dexketoprofen trometamol;   Drug: Dexmedetomidine
Outcome Measures: Visual Analog Scale;   Analgesic consumption
16 Recruiting Evaluation of the Analgesic Efficiency of the Transcutaneous Neurostimulation in the Charcot Syndrome Marie Tooth on the Pains of Lower Limbs
Intervention: Device: TENS
Outcome Measure: Visual Analogue Scale
17 Recruiting An Investigator Initiated, Within-Subject, Proof of Concept Study to Assess the Analgesic Efficacy and Safety of Voltaren Gel (1% Diclofenac Sodium) Compared to Placebo in Subjects Experiencing Delayed Onset Muscle Soreness
Condition: Delayed Onset Muscle Soreness
Interventions: Drug: 1% diclofenac sodium gel;   Drug: Placebo
Outcome Measure: To assess Analgesic efficacy of Topical Voltaren® gel compared to placebo
18 Recruiting Opioid-based Analgesic Regimen Versus Non-opioid Analgesic Regimen for Better Immune Responses After Laparoscopic Colorectal Surgery
Condition: Colorectal Surgery
Intervention: Drug: opioid based analgesia (fentanyl and pethidine) versus non-opioid based analgesia (ropivacaine and tramadol)
Outcome Measures: NK cell activity;   Cytokine level
19 Recruiting Analgesic Effect of Intra-articular Dexamethasone and Dexamethasone Added to Bupivacaine in Interscalene Brachial Plexus
Condition: Postoperative Pain
Interventions: Procedure: intraarticular dexamethasone;   Procedure: interscalene dexamethasone
Outcome Measures: Analgesic consumption;   visual analog scale
20 Unknown  Analgesic Effect of Intravenous Patient-Controlled Analgesia (IV PCA) Versus Paravertebral Block After Video Assisted Thoracic Surgery (VATS)
Condition: Postoperative Pain After Video Assisted Thoracic Surgery
Interventions: Procedure: paravertebral block;   Procedure: PCA
Outcome Measure: severity of acute postoperative pain when moving