Gingivitis and Birodogyl


Gingivitis Symptoms and Causes

If you have gum disease, you're not alone. Many U.S. adults currently have some form of the disease. It ranges from simple gum inflammation, called Gingivitis, to serious damage to the tissue and bone supporting the teeth. In the worst cases, you can lose teeth.

In Gingivitis, the gums become red and swollen. They can bleed easily. Gingivitis is a mild form of gum disease. You can usually reverse it with daily brushing and flossing and regular cleanings by a dentist or dental hygienist. Untreated Gingivitis can lead to periodontitis. If you have periodontitis, the gums pull away from the teeth and form pockets that become infected. If not treated, the bones, gums and connective tissue that support the teeth are destroyed.

NIH: National Institute of Dental and Craniofacial Research

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Rash (29)
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Hyperhidrosis (2)
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Hypotension (2)
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Dysuria (2)
Urticaria (2)
Myalgia (2)
Lymphadenopathy (2)
Liver Function Test Abnormal (2)
Neutrophil Count Increased (2)
Paranoia (2)
Vascular Purpura (2)
Transaminases Increased (2)
Inflammation (2)

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Gingivitis Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Assessment of a Probiotic to Treat Pediatric Gingivitis
Conditions: Gingivitis;   Inflammation
Intervention: Dietary Supplement: Probiotic formulation
Outcome Measures: Reduction in Gingivitis;   Reduced plaque;   Reduction in inflammation
2 Not yet recruiting Efficacy of a Mouthwash Containing Propolis
Conditions: Gingivitis;   Periodontitis;   Plaque;   Inflammation
Interventions: Drug: Propolis;   Drug: chlorhexidine
Outcome Measures: Chemical characterization of propolis by HPLC (High-performance liquid chromatography);   PRELIMINARY EVIDENCE OF THE EFFICACY OF A MOUTHWASH CONTAINING 5% PROPOLIS FOR THE CONTROL OF PLAQUE AND Gingivitis
3 Recruiting A Double-Blind, Randomized, Controlled, Dose Escalation Clinical Trial of an Antiplaque Chewing Gum - Phase 1 Safety and Tolerability and Phase 2a Safety, Tolerability, and Proof of Concept in a Gingivitis Population
Conditions: Plaque;   Gingivitis
Interventions: Drug: 2 mg KSL-W;   Drug: 4 mg KSL-W;   Drug: 6 mg KSL-W;   Drug: 10 mg KSL-W;   Drug: 20 mg KSL-W;   Drug: 30 mg KSL-W;   Drug: 50 mg KSL-W;   Drug: 75 mg KSL-W;   Drug: 100 mg KSL-W;   Other: Placebo
Outcome Measures: Safety and tolerability of KSL-W as measured by soft tissue erythema, ulceration and sloughing.;   Proof of concept of KSL-W in reducing plaque as measured by Turesky modification of the Quigley-Hein Plaque Index(PI).;   Proof of concept of KSL-W in reducing Gingivitis as measured by modified gingival index (MGI);   Proof of concept of KSL-W in reducing plaque as measured percent of bleeding sites upon probing (BOP)
4 Unknown  Evaluation Study of a Mouthwash Based on Schinus Terebinthifolius to Treat Gingivitis in Children
Conditions: Gingivitis;   Plaque Accumulation
Intervention: Biological: Use of natural product (Schinus terebinthifolius)
Outcome Measures: Gingival inflammation (Blood gingival index);   Plaque amount;   Gingival inflammation (Blood gingival Index);   Gingival inflammation (blood gingival index)
5 Recruiting Treatment of Human Gingivitis With Amnion-derived Cellular Cytokine Solution (ACCS)
Condition: Gingivitis
Interventions: Drug: Amnion-derived Cellular Cytokine Solution;   Drug: Placebo
Outcome Measures: Incidence of adverse/serious adverse events;   Probing pocket depth;   Modified gingival index;   Bleeding on probing;   Plaque index;   Microbial analysis;   Cytokine analysis
6 Recruiting A Clinical Trial to Evaluate Long-term Efficacy and Safety of Lozenges Containing Lactobacilli Reuteri (Prodentis™) on Gingivitis
Condition: Gingivitis
Intervention: Other: Probiotics
Outcome Measures: Change from Baseline in Modified Gingival Index (MGI);   Change from Baseline in Bleeding on probing (BOP);   Change from Baseline in Plaque Index;   Change from Baseline in Probing Depth
7 Recruiting A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease
Condition: Gingivitis
Interventions: Other: Listerine Advance Gum Defense;   Other: Mouth rinse containing Chlorhexidine;   Other: Mouth rinse containing 5% Hydroalcohol
Outcome Measures: Whole Mouth Mean Bleeding Index (BI) at 4 weeks;   Whole Mouth Mean Bleeding Index (BI) at 1 week;   Whole-mouth Mean Modified Gingival Index (MGI);   Turesky Modification of the Quigley Hein Plaque Index (PI);   Extrinsic Stain
8 Recruiting Efficacy of Iocide Oral Rinse Against Gingival Inflammation
Conditions: Gingivitis;   Investigation of Biological Markers of Inflammation
Interventions: Drug: Iocide Oral Rinse;   Drug: Placebo
Outcome Measures: Change in Mean Gingival Index (GI);   Change in Biological Marker Data
9 Recruiting A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 2
Condition: Early Caries Lesions
Interventions: Device: CPP-ACP (GC Tooth Mousse);   Device: CPP-ACP (GC MI Paste Plus);   Device: Fluoride (Elmex Medical Gel)
Outcome Measure: Prevention of the opacity of white spots during orthodontic treatment with fixed appliances
10 Recruiting A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 1
Condition: Early Caries Lesions
Interventions: Device: CPP-ACP (GC Tooth Mousse);   Device: CPP-ACP (GC MI Paste Plus)
Outcome Measure: Amelioration of the opacity of white spots into a more natural tooth-like translucency
11 Recruiting Experimental Peri-implant Mucositis in Humans
Conditions: Peri-implant Mucositis;   Gingivitis
Intervention: Behavioral: interruption of oral hygiene
Outcome Measure: Gingival Crevicular fluid volume collected at baseline and weekly up to 9 weeks
12 Recruiting Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2).
Conditions: Dental Caries;   Gingivitis
Intervention: Dietary Supplement: lozenges
Outcome Measures: Caries increment by ICDAS method;   salivary mutans streptococci;   plaque pH
13 Recruiting Periodontal Treatment Response in Type II Diabetic Patients
Conditions: Type II Diabetes;   Periodontal Disease
Interventions: Drug: Triclosan containing toothpaste;   Drug: Non-triclosan containing toothpaste
Outcome Measures: Clinical Periodontal Parameters;   Local Inflammatory Markers;   Glycemic Control;   Systemic Inflammatory Markers
14 Unknown  Triclosan, Triclocarban, and the Microbiota
Condition: Triclosan Effects on Microbial Flora.
Intervention: Other: triclosan/triclocarban-containing personal care products
Outcome Measures: Changes in microbial flora;   Microbial resistance;   Time to alteration in flora.
15 Recruiting Bacterial Arrangement on the Teeth
Conditions: Dental Plaque;   Oral Health;   Periodontal Disease and Caries
Outcome Measures: Arrangement of Oral Microflora on Tooth Surfaces;   Effect of Chewing Gum on Arrangement and Type of Oral Microflora;   Molecular Analysis of Oral Microflora Composition
16 Not yet recruiting Metabolic Syndrome and Periodontitis
Conditions: Metabolic Syndrome;   Periodontal Disease;   Inflammatory Response
Intervention: Other: Non surgical periodontal treatment
Outcome Measures: Changes at glycated hemoglobin.;   Changes at Protein C reactive and serum fibrinogen.