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Growth retardation and Somatropin

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Growth Retardation Symptoms and Causes

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growth retardation treatment research studies

Somatropin clinical trials, surveys and public health registries


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Somatropin Side Effects

Craniopharyngioma (59)
Death (54)
Pituitary Tumour Benign (45)
Neoplasm Recurrence (43)
Condition Aggravated (42)
Sleep Apnoea Syndrome (41)
Adenoidal Hypertrophy (33)
Meningioma (29)
Tonsillar Hypertrophy (28)
Headache (27)
Prostate Cancer (23)
Dyspnoea (22)
Germ Cell Cancer (20)
Fall (20)
Scoliosis (19)
Convulsion (18)
Pneumonia (18)
Vomiting (18)
Disease Progression (17)
Osteochondrosis (16)
Abdominal Pain (15)
Osteonecrosis (15)
Brain Neoplasm (15)
Neoplasm Progression (15)
Fatigue (14)
Diabetes Mellitus (14)
Arthralgia (14)
Cardiac Arrest (14)
Asthenia (13)
Astrocytoma (12)
Cerebrovascular Accident (12)
Hypertension (12)
Papillary Thyroid Cancer (12)
Nausea (12)
Fracture (11)
Dysphonia (11)
Epiphysiolysis (11)
Hemiparesis (11)
Tachyarrhythmia (11)
Sudden Death (11)
Laryngocele (10)
Hepatic Function Abnormal (10)
Brain Neoplasm Malignant (10)
Medulloblastoma Recurrent (10)
Gastroenteritis (10)
Renal Cell Carcinoma (10)
Stridor (10)
Somnolence (10)
Respiratory Distress (10)
Pituitary Tumour Recurrent (10)

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Recent Reviews

At what age will be recomended to use HGH for athlete of high level of competence..

Hi i need information toward somatropin label price?

I've been on it for 9 months. I weighed at the beginning 125 and had a body fat of 24. I now weigh 130 I have the same body fat percentage. While I have increased muscle mass, I eat well work out, have increased cardio & workouts, I'm sad tha

Sorry about my poor medical english. I am counselling as a lawyer a young man suffering from liposarcoma, we believe related to Saizen that he received during his childhood.Saizen was the french commercial name for Somatropin. Has anyone got info o

Why do people die after starting Growth Hormone treatment?

3 yrs ago my son (He's 4 1/2 now) was diagnosed with Hypopituitarism, and Septo Optic Dysplasia. Shortly after we found out he was growth hormone deficient, he was prescribed Saizen. We were told it wasn't urgent to start him on it, but after his bl

Does anyone know of the results when monistat is put on the scalp? does it really induce hair growth? has anyone had success?

Had no bad side affects i have hepc got from bodbuilding buy growth homone from china had 7 surgerys tired perocet no help then dilaudid it works get no nausea hardly in pain an i function just normal that god for it cos both my nephew are austic i

Hi I am wondering if abilify can stunt a teenager's height growth, as in making them shorter than they would have been if they never took abilify.

Hi I'm Justice, My gf is wonderful n lovely, but recently she kept complaining of vaginal pains when having sexual intercourse and even says she could feel there's some sought of growth going on in her vaginal, I mean bump which she make me feel it

Hi, I had neck surgery 6 months a go and approx. a month ago I start using the bone growth stimulator, I felt really sick after meaning a lot of headaches, neck and shoulder pain, didn't think it was related but I stopped using it for a week because

I am an adult who has recently, 2 months ago, began taking humatrope. My history with growth hormone deficiency is lon. As an adult, with two children of my own, my advice to any parent is please do not let your child stop taking this exceptionally i

I am finally free of the Mirena, and girls, DON'T be scared to have it taken out because of the Mirena Crash- it's been two weeks, and I haven't experienced that. However, I >have< had the following happen: wierd hair growth is gone, cy

I had bone fusion surgery over a month ago and post operatively was placed on spinalogic bone growth stimulator every twenty four hours at 30 minute intervals. I never had a blood pressure problem in my life, even after the first week of surgery when

I HAVE A 12 YEARS BOY AND THE DOCTOR GAVE HIM ELEQUINE FOR A TREATMENT OF RINOSINUSITIS, HE WEIGHTS 140 LBS, CAN HE HAVE ANYPROBLEMS OF HIS GROWTH

Growth Retardation Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting An Open-label Phase 4 Study to Explore Immunogenicity of the Liquid Formulation of Saizen® in Subjects With Growth Hormone Deficiency (GHD) of Adult Onset
Condition: Growth Hormone Deficiency
Intervention: Drug: Saizen® solution for injection (referred as Saizen®)
Outcome Measures: Percentage of subjects developing Binding Antibodies (BAbs) to Saizen®;   Percentage of subjects with BAbs who become positive for Neutralizing Antibody (NAbs);   Insulin-like growth Factor-I (IGF-I) levels;   Insulin-like growth factor binding Protein-3 (IGFBP-3) levels;   Insulin-like Growth Factor-I Standard Deviation Score (IGF-I SDS) levels;   Treatment adherence rate for each subject as documented using EasypodTM connect;   Number of subjects with treatment-emergent adverse events
2 Unknown  Study of Weekly ALTU-238 Compared With Daily Nutropin AQ in Prepubertal Children With Growth Hormone Deficiency
Condition: Growth Hormone Deficiency
Intervention: Drug: Somatropin
Outcome Measure: Mean change in annualized height velocity from pre-treatment to the first 26 weeks of treatment
3 Recruiting A Trial Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Dose of Long-acting Growth Hormone Compared to Daily Dosing of Norditropin® SimpleXx® in Children With Growth Hormone Deficiency
Conditions: Growth Hormone Disorder;   Growth Hormone Deficiency in Children
Interventions: Drug: NNC0195-0092;   Drug: Somatropin
Outcome Measures: Incidence of adverse events (AEs);   The area under the insulin-like growth factor I (IGF-I) concentration-time curve
4 Recruiting Growth Hormone Use in Albright Hereditary Osteodystrophy
Conditions: Pseudohypoparathyroidism Type 1a;   Albright Hereditary Osteodystrophy
Interventions: Drug: Growth hormone;   Drug: Growth Hormone
Outcome Measure: PHP1a: Effect of GH on height, growth velocity, final height in children. Effect on weight, BMI, lipids, self-esteem in all ages.
5 Not yet recruiting Evaluation of Pharmacokinetic and Pharmacodynamic Parameters of Somatropin Produced by Laboratory Blausiegel Indústria e Comércio Ltda., Compared to Saizen® From Laboratory Merck Serono S.A.
Conditions: GH Deficiency (GHD);   Growth Retardation
Intervention: Drug: Somatropin
Outcome Measures: The primary efficacy endpoint will be based in the investigation of pharmacokinetics and pharmacodynamics of Somatropin in research subjects after administration of single dose, sc, of the drug.;   After administration of the drug will be evaluated for safety and tolerability of the drug through the presence of hematoma, pain, itching and local redness, as well as the incidence of adverse events directly related to Somatropin.
6 Recruiting Growth Hormone in Poor Responders to IVF Trial
Condition: Infertility
Interventions: Drug: Saizen (Human Growth Hormone);   Drug: No Saizen Control (Standard IVF Protocol)
Outcome Measures: Oocyte yield;   Pregnancy rate
7 Unknown  Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency
Condition: Growth Hormone Deficiency
Intervention: Drug: growth hormone (Nutropin)
Outcome Measures: Glucose Production rate,Gluconeogenesis, glycogenolysis.;   Insulin resistance;   Proteolysis;   Glucagon response
8 Recruiting Is There a Sensibility Increased in the Growth Hormone at Child With Prader-Willi Syndrome?
Conditions: Prader-Willi Syndrome;   Growth Hormone Deficiency
Interventions: Drug: Growth hormone (Genotonorm® or Omnitrope®);   Procedure: DEXA, blood tests, H.G.P.O, osseous age.;   Procedure: biopsy
Outcome Measures: Measure of the circulating rates of IGF-I under treatment.;   Measure of the circulating rate of IGFBP-3, GHBP, ghrelin and apelin.;   Measure of physical composition's variation.;   Measure of blood sugar level, H.G.P.O., and hyperglycaemia.;   Measure of the sensibility at the growth hormone in vitro, on fibroblasts and adipocytes obtained by biopsy.
9 Recruiting Safety, PK/PD and Efficacy of ACP-001 Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD)
Condition: Growth Hormone Deficiency (GHD)
Interventions: Drug: ACP-001;   Drug: Human Growth Hormone
Outcome Measures: Safety of ACP-001 on different dosing levels;   Pharmacokinetics of ACP-001;   IGF-I response;   Local tolerability of ACP-001;   Height velocity
10 Recruiting A Phase 2, Safety and Dose-Finding Study in Treatment-Naive, Pre-Pubertal, Growth Hormone-Deficient Children
Condition: Growth Hormone-Deficiency
Interventions: Drug: TV-1106;   Drug: Somatropin
Outcome Measures: Height velocity (HV);   Height velocity standard deviation score (HV-SDS);   Height standard deviation score (H-SDS);   Number of participants with adverse events
11 Unknown  Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism
Condition: Hypothyroidism
Interventions: Drug: Growth hormone;   Drug: Growth hormone treatment and puberty
Outcome Measures: final height;   bone age;   growth factors
12 Recruiting A Canadian, Multi-centre, Observational Registry to Study Adherence and Long Term Outcomes of Therapy in Pediatric Subjects Using SAIZEN® Via Easypod™ Auto-injector for Growth Hormone Treatment
Condition: Growth Disorders
Intervention: Device: Easypod™
Outcome Measures: Mean percent of adherence by subject over a period of time;   Correlation of adherence and growth outcome after each year of SAIZEN® treatment with easypod™;   Subject adherence profile based on age, gender, indication, self-injection or not, time on treatment;   Impact of patient adherence support programme on adherence and outcomes for subjects using easypod™
13 Recruiting A Phase 3 Study to Evaluate the Safety and Efficacy of Saizen® in Children With Idiopathic Short Stature (ISS)
Condition: Idiopathic Short Stature
Intervention: Drug: Saizen®
Outcome Measures: Change from baseline in growth velocity (centimeter/year [cm/yr]) at Month 6;   Change from baseline in growth velocity (cm/yr) at Month 12;   Changes from baseline in height (centimeter [cm]) at Month 6 and 12;   Changes from baseline in height standard deviation score (SDS) at Month 6 and 12;   Changes from baseline in serum concentration of insulin-like growth factor-I (IGF-I) and insulin like growth factor binding protein-3 (IGFBP-3) at Month 6 and 12;   Percentage of participants who adhered to study treatment;   Number of participants with adverse events (AEs)
14 Recruiting Growth Hormone Therapy and Bone Quality in Pediatric Osteoporosis
Condition: Osteoporosis
Interventions: Dietary Supplement: Vitamin D + Calcium + Exercise program;   Drug: Vitamin D + Calcium + Exercise program + Humatrope
Outcome Measures: Test the hypothesis that growth hormone administered daily by subcutaneous injection for 2 years will result in a significantly greater BMD Z-score over optimal standard therapy;   Test the hypothesis that subcutaneous growth hormone administration will significantly improve and/or normalize baseline values of fracture frequency;   Test the hypothesis that subcutaneous growth hormone administration will significantly improve and/or normalize baseline values of bone histomorphometric measures osteoid volume, surface, and width;   Test the hypothesis that subcutaneous growth hormone administration will significantly improve and/or normalize baseline measures of bone quality;   Test the hypothesis that subcutaneous growth hormone administration will significantly improve and/or normalize baseline values of BMC corrected for height
15 Recruiting Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.
Conditions: Diabetes Mellitus Type I;   Ketoacidosis
Interventions: Drug: Insulin withdrawal;   Drug: Norditropin
Outcome Measures: Insulin and growth hormone signalling, expressed as CHANGE in phosphorylation of intracellular target proteins and CHANGE in mRNA expression of target genes in muscle- and fat-tissue.;   Change in Intracellular markers of lipid metabolism in muscle- and fat tissue biopsies.;   Metabolism
16 Recruiting A Prospective Non-Interventional Study Protocol With Primary Data Collection - Assessment Of The Long Term Treatment Outcomes Of Genotropin Treatment In Growth Hormone Deficiency (GHD) Patients
Condition: Growth Hormone Deficiency
Intervention: Other: Non Interventional Study
Outcome Measure: This Non-Interventional study does not include pre-specified endpoints, but collects information from adult subjects recieving Genotropin treatment in a real world clinic setting.
17 Recruiting Growth Hormone and Brain Functioning After Traumatic Brain Injury
Condition: Traumatic Brain Injury
Intervention: Drug: Genotropin (Somatropin)
Outcome Measures: To compare the brain-functioning (fMRI & EEG) and white matter structural integrity (DTI) of persons with mild to severe TBI with and without GH deficiency during cognitive tasks.;   To examine changes in cognitive and motor performance, EEG/fMRI, white matter integrity, associated with growth hormone treatment for one year using an open-label design in persons with GH deficiency/insufficiency following mild to severe TBI.
18 Recruiting Effect of Growth Hormone on Early Brain Development in Girls With Turner Syndrome
Condition: Turner Syndrome
Intervention: Drug: somatotropin
Outcome Measures: Total brain volume;   Volume of brain lobes;   White matter tracts
19 Unknown  Growth Hormone Treatment of Young Growth Hormone-Deficient Adults
Condition: Growth Hormone Deficiency
Intervention: Drug: Growth hormone
Outcome Measure:
20 Recruiting Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ Electromechanical Device for Growth Hormone Treatment
Condition: Growth Disorders
Intervention: Device: easypod ™
Outcome Measures: Mean percent of daily recorded adherence;   Correlation of adherence and growth outcome after each year of SAIZEN® treatment with easypod™;   Subject adherence profile based on age, gender, indication, self-injection or not, time on treatment;   Correlation of adherence with current IGF-1 status (i.e. above, below or within normal ranges)