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Head and Fluorouracil

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Head Symptoms and Causes

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes in the neck. Most begin in the moist tissues that line the mouth, nose, and throat. Symptoms include

  • A lump or sore that does not heal
  • A sore throat that does not go away
  • Trouble swallowing
  • A change or hoarseness in the voice

Head and neck cancers are twice as common in men. Using tobacco or alcohol increases your risk. In fact, around 75 percent of Head and neck cancers are linked to tobacco use, including smoking and smokeless tobacco. Infection with HPV is a risk factor for some Head and neck cancers.

To diagnose Head and neck cancer, your doctor will do a physical exam and diagnostic tests. You will have a biopsy, where a sample of tissue is taken out and examined under a microscope. It is the only test that can tell for sure if you have cancer.

If found early, these cancers are often curable. Treatments may include surgery, radiation therapy, chemotherapy, or a combination. Treatments can affect eating, speaking or even breathing, so patients may need rehabilitation.

NIH: National Cancer Institute

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Fluorouracil clinical trials, surveys and public health registries


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Fluorouracil Side Effects

Diarrhoea (463)
Nausea (335)
Dehydration (273)
Vomiting (266)
Neutropenia (243)
Febrile Neutropenia (207)
Pyrexia (187)
Mucosal Inflammation (179)
Asthenia (158)
Abdominal Pain (152)
Stomatitis (143)
Fatigue (134)
Dyspnoea (131)
Interstitial Lung Disease (117)
Decreased Appetite (116)
Pulmonary Embolism (111)
Chest Pain (110)
Anaemia (106)
Thrombocytopenia (106)
Hypotension (106)
Neutrophil Count Decreased (99)
Hypokalaemia (95)
Leukopenia (83)
Sepsis (78)
White Blood Cell Count Decreased (78)
Renal Failure Acute (75)
Pneumonia (75)
Malaise (74)
Haemoglobin Decreased (72)
Neuropathy Peripheral (69)
Pain (69)
Renal Failure (64)
Disease Progression (64)
Respiratory Failure (62)
Cardiotoxicity (62)
Dysphagia (61)
Confusional State (57)
Platelet Count Decreased (57)
Pancytopenia (55)
Fall (55)
Deep Vein Thrombosis (54)
Myocardial Infarction (53)
Arteriospasm Coronary (51)
Hyponatraemia (51)
Weight Decreased (51)
Tachycardia (48)
Chills (46)
Dizziness (46)
Septic Shock (46)
Hyperammonaemia (46)

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Recent Reviews

Why do doctors keep the availabilty of the test for DPD deficiency a secret??? My sister is a doctor, infectious disease, at St Francis in Charleston, SC. Our father was treated by an oncologist well known to my sister, a 'colleague' you might s

After using debrox i got a really bad headache.

During posterior fossa craniectomy, while my head was stablilized in cranial tongs, the lower half of the Skytron OR table collasped to the floor.As my legs were strapped to the fallen end of the table I sustained nerve injury 'overstretch'

Having heartburn and constant headache

Headaches, shortness of breath, coughing, sneezing

Hi everyone, I'm 28 years old I just discovered 2 weeks ago that I have lice! I don't have kids , I live alone and I have no idea where I got from ! My head was itching for 5 days but I thought it was dry scalp I never thought of lice cuz the last ti

I do not know that my head has a tremor, family and working collegues notified me several times of it had a MR brain scan twice, a lesion was dedected on the left side of my frontal brain i am only 44 years old and the head tremor is becoming a rea

I feel light headed and dizzy my vision is different and i seem to be burping a good bit should i continue to take this medicine i take 3 times a day and have taken 12

I had a headache and horners syndrome initially thought to be infection. One month later diagnosed with right internal carotid artery dissection. Currently on coumadin and bp meds to keep pressure down. I have a 4 mm pseudoaneurysm. Its been 1 month

I have head titubation from 18 yrs now this time i am 38 yrs old this nodding of head is clear in my case it disturbs me a lot i mean i follow serious depression i am taking different medicines for this firstly i used haloperidol for many years o

My son was suffering from Head ache for the past one year. I have taken him to an ENT & he prescribed Sibelium 10 mg. & he was taking sibelium 3 months back for migraine and he was experiencing fatigue and drowsiness every day. Every t

Sharp pain on the right side of my head.

<b>Describe Your Pinaclor Experience Here:</b> was put on pinaclor for surgical wound infection at end of course got lumps on head

...while this was an occassional occurrance for me it has has only become much worse since I started on Remifemin nearly 3 weeks ago. I no longer suffer from the embarrassing hot flushes that used to leave me perspiring profusely all down my head, fa

10 years ago i was in the hospital for appendix surgery was given morphine it knocked me out and when i was awake i was paranoid, crying, and felt like something was wrong with my head but could not explain it it was like nothing i ever felt before.

2/11/2011 My son age 7 months had red splotches on his face and head immediatly after the injection, also had a temp of 100.6 for 2 days, was very lethargic and also irritable.

5/28/2010 i went to work started to bend over and i couldn't breathe so i went to the hospital and they said this is what i had they put me on an inhaluar and now i wake up with head aches so can u please help

58 year old 168 pound male used Bacitacin on incision site on head. After 10 days eyes, nose and incision site began to itch and rash appeared, incision drainage occured. Discontinued use. Eyes and face became puffy. Day

About a year ago i had a stroke also bad dry skin,i also had a full head of hair and a full beard lately my beard and hair are both are both falling out

Afte taking baby aspirin for awhile i felt and still hearing an sssss sound in the back of my head .

Head Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache
Conditions: Episodic Cluster Headache;   Chronic Cluster Headache
Intervention: Drug: Sumatriptan 4mg Statdose injection
Outcome Measures: The primary efficacy parameters will be the percentage of cluster Headache attacks that result in the cluster Headache pain being reduced to mild or none following a single dose of 4 mg subcutaneous sumatriptan at 15 minutes and at 30 minutes.;   The time meaningful relief of cluster Headache.;   The percentage of attacks that produce a pain free response to a single dose of sumatriptan 4 mg subcutaneous at 15 minutes, 30 minutes and at 1 hour.;   The percentage of attacks of migraine that result in resolution of all associated symptoms of cluster Headache present at the time of treatment with the study medication as well as achieving a pain free response within 1hour.;   The number of patients reporting adverse effects to study medication, the type of adverse event reported and the percentage of attacks that are associate with the adverse effect.;   The percentage of patients who achieve pain reduced to mild or none at 15 minutes or at 30 minutes respectively for all three treated Headache attacks.;   The percentage of patients who achieve pain reduced to mild or none at 15 minutes or at 30 minutes respectively for two out of three treated Headaches.;   The percentage of patients who become pain free at 15 minutes or 30 minutes or at 1 hour respectively or at any combination of the three time points for all three Headache attacks.;   Patient evaluation of subcutaneous sumatriptan 4 mg regarding satisfaction with their treatment using the PPMQR assessment.;   The percentage of attacks in which the pain was reduced to moderate or mild and for which the patient took a second and or a third dose of the study medication.;   The percentage of attacks in which the patient became pain free at or before 1 hour and experienced a recurrence of cluster Headache and in which a second or third dose of study medication was taken.;   The percentage of cluster Headaches in which the patient became free at or before 1 hour and experienced a recurrence of cluster Headache.;   The mean time to meaningful pain relief across three treated Headache attacks.
2 Recruiting Frovatriptan as a Transitional Therapy in Medication Overuse Headache
Conditions: Medication Overuse Headache;   Analgesic Overuse Headache
Interventions: Drug: Frovatriptan;   Drug: Placebo
Outcome Measures: The mean Headache intensity in the 10 day transitional period in the Frovatriptan group as compared to the placebo group.;   The difference in mean Headache intensity between the 10 day transitional period and the baseline period.;   The number of day segments with Headache of grade 6 or higher during the 10 day transitional period and during days 11-20 of the study.;   Number of Headache-free days (grade zero) for first two months of study.;   Proportion of patients free of medication overuse for first two months of study (i.e. less than 15 days of simple analgesic use or less than 10 days of other analgesic use per month).
3 Not yet recruiting IndoProCaf Effervescent Tablets Effectiveness in Acute Treatment of Migraine and/or Episodic Tension-type Headache and Patients' Satisfaction With the Treatment in Routine Clinical Practice
Conditions: Headache Disorders, Primary;   Migraine With Aura;   Migraine Without Aura;   Tension-Type Headache
Intervention:
Outcome Measures: Proportion of patients with significant pain reduction;   Proportion of patients who are satisfied with IndoProCaf treatment;   Time to significant pain reduction;   Proportion of patients with significant pain reduction in case of first dose no response;   Proportion of patients with significant pain reduction in case of Headache relapse;   Proportion of patients who are satisfied with different medicines previously used for Headache attack
4 Recruiting A Non-Invasive Neuromodulation Device for Treatment of Migraine Headache
Condition: Migraine Headache, Episodic
Intervention: Device: neuromodulation for episodic migraine Headache
Outcome Measures: Number of monthly migraine Headache days;   Number of monthly migraine Headache days (reduction by by 50% or more);   Total monthly pain score;   Mood and cognition measures - Change in mood scores;   Verify the absence of material dizziness;   Mood and cognition measures - Change in cognitive speed scores;   Mood and cognition measures - Change in memory scores
5 Unknown  Chiropractic and Acupressure for Headaches
Conditions: Cervicogenic Headache;   Tension-type Headache;   Migraine Headache
Interventions: Other: chiropractic treatment;   Device: Dr. Zaxx pillow
Outcome Measures: Headache frequency from a Headache Diary;   Headache disability;   Treatment satisfaction;   Adverse events
6 Not yet recruiting Civamide Nasal Solution for Cluster Headache
Condition: Episodic Cluster Headache
Intervention: Drug: Civamide nasal solution 0.01%
Outcome Measures: The Percent Change in the Number of Cluster Headaches per Week from Baseline to Weeks 1 through 3 of the Post-Treatment Observation Period for the Modified Intent-to-Treat Population;   The Percent Change in the Number of Cluster Headaches per Week from Baseline to Weeks 1 through 3 of the Post-Treatment Observation Period for the Intent-to-Treat and Per Protocol Populations;   The Percent Change in the Number of Cluster Headaches per Week from Baseline to Individual Weeks 1, 2, and 3 of the Post-Treatment Observation Period for the Modified Intent-to-Treat and the Per Protocol Populations;   The Change in the Number of Cluster Headaches per Week from Baseline to Weeks 1 through 3 and to Individual Weeks 1, 2, and 3 for the Post-Treatment Observation Period for the Modified Intent-to-Treat and the Per Protocol Populations
7 Recruiting Amitriptyline to Prevent Headache After Traumatic Brain Injury
Conditions: Brain Injuries;   Post-Traumatic Headache
Intervention: Drug: Amitriptyline
Outcome Measures: Frequency and severity of Headaches;   Headache Impact Test - 6;   Rivermead Post-Concussion Symptoms Questionnaire (RPQ);   Short Form-12® Health Survey (SF-12);   Number of participants with adverse events;   Headache characteristic survey;   Insomnia Severity Index;   Patient Health Questionnaire-9 (PHQ-9;   Rey Auditory Verbal Learning Test;   Trail Making Test;   Wechsler Adult Intelligence Scale (WAIS) IV Digit Symbol
8 Recruiting Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
Conditions: Headache;   Migraine
Interventions: Other: Carbon monoxide;   Other: Placebo
Outcome Measures: Headache scores;   Blood flow velocity;   Artery circumference;   Facial blood flow
9 Unknown  Galantamine in the Treatment of Post-Traumatic Headache
Conditions: Post-Traumatic Headache;   Head Trauma,Closed;   Retention Disorders,Cognitive
Intervention: Drug: Galantamine
Outcome Measures: Primary Headache Efficacy Measure; number of pain free days after 3 months;   Consumption of rescue medication;   Number of days with moderate or severe Headache after 3 months.
10 Unknown  Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache
Condition: Headache
Interventions: Drug: Ibuprofen plus caffeine;   Drug: Ibuprofen
Outcome Measures: Efficacy of study treatment compared with control to relieve Headache symptoms.;   Tolerability of study treatment compared with control to relieve Headache symptoms.
11 Recruiting Cervicogenic Headache Dose-Response
Condition: Cervicogenic Headache
Interventions: Other: Spinal Manipulation;   Other: Light Massage
Outcome Measures: Headache days change from baseline for cervicogenic Headache;   Average pain change from baseline for cervicogenic Headache;   Headache-related disability change from baseline for cervicogenic Headaches;   Headache-related disability days change from baseline;   EuroQol-5D change from baseline;   Average pain change from baseline for neck;   Neck pain days change from baseline;   medication use change from baseline;   Outside Care change from baseline;   Patient Satisfaction;   Objective biomechanical measures change from baseline;   Quality-adjusted life years change from baseline;   Direct & Indirect costs change from baseline;   Perceived Headache average pain change from baseline for cervicogenic Headache;   Perceived Headache improvement from baseline for cervicogenic Headache
12 Recruiting Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care
Condition: Chronic Cluster Headache
Intervention: Device: GammaCore
Outcome Measures: Decrease frequency of cluster Headache attacks per week;   Pain relief of Headache attacks;   Adverse events;   EQ-5D-3L
13 Recruiting Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache
Condition: Cluster Headache
Interventions: Device: GammaCore;   Device: Sham GammaCore device
Outcome Measures: Headache pain intensity;   Sustained Headache intensity pain;   Average mean attack intensities experienced per subject;   Incidence and occurrence of serious adverse events related to active or sham study treatment and / or to cluster Headache events.
14 Unknown  A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache
Condition: Cluster Headache
Intervention: Drug: Oxygen
Outcome Measures: Reduction in Headache pain;   Headache relief and pain free
15 Recruiting Incidence of Headache Following an Unintentional Dural Puncture
Conditions: Postdural Puncture Headache;   Post-Lumbar Puncture Headache;   Cerebrospinal Fluid Leaks
Interventions: Drug: Morphine;   Drug: Saline
Outcome Measures: Incidence of post dural puncture Headaches;   Severity of Headache;   Need for Epidural Blood Patch
16 Recruiting The Effect of Specific Strength-Training on Tension-Type Headache in Children 9-17 Years
Condition: Tension-Type Headache
Interventions: Device: Specific Strength Training;   Behavioral: Lifestyle Counseling
Outcome Measures: Headache;   Muscle Capacity;   TTS;   Physical fitness
17 Recruiting Sumatriptan as Treatment for Post-traumatic Headache
Condition: Post-traumatic Headache
Intervention: Drug: Sumatriptan 100 mg
Outcome Measures: Headache relief;   Adverse events;   Compliance
18 Recruiting Ibudilast in the Treatment of Medication Overuse Headache
Condition: Medication Overuse Headache
Interventions: Drug: Ibudilast;   Drug: Placebo
Outcome Measures: Headache Index;   Medication frequency;   Headache frequency;   Duration of Headache;   Intensity of Headache;   Frequency of probable migraine attacks;   Headache related impact on quality of life;   Allodynia symptom checklist score;   Von Frey filament test;   Brush allodynia test;   Response rate;   Relapse rate
19 Unknown  Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache
Condition: Headache
Interventions: Drug: etoricoxib;   Drug: placebo
Outcome Measure: Incidence of Fasting Headache
20 Recruiting Is Chiropractic Spinal Manipulative Therapy an Efficient Treatment Option in Cervicogenic Headache
Condition: Cervicogenic Headache
Interventions: Other: Chiropractic;   Other: Sham Chiropractic
Outcome Measures: Number of Headache days;   Headache duration;   Self reported VAS;   Headache index;   Headache medication