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High and Plavix

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High Symptoms and Causes

About 1 in 3 adults in the U.S. has High blood pressure, or hypertension, but many don't realize it. High blood pressure usually has no warning signs, yet it can lead to life-threatening conditions like heart attack or stroke. The good news is that you can often prevent or treat High blood pressure. Early diagnosis and simple, healthy changes can keep High blood pressure from seriously damaging your health.

What is blood pressure?

Blood pressure is the force of your blood pushing against the walls of your arteries. Each time your heart beats, it pumps blood into the arteries. Your blood pressure is Highest when your heart beats, pumping the blood. This is called systolic pressure. When your heart is at rest, between beats, your blood pressure falls. This is called diastolic pressure.

Your blood pressure reading uses these two numbers. Usually the systolic number comes before or above the diastolic number.

How do I know if my blood pressure is High?

High blood pressure usually has no symptoms. So the only way to find out if you have High blood pressure is to get regular blood pressure checks from your health care provider. Your provider will use a gauge, a stethoscope or electronic sensor, and a blood pressure cuff. For most adults, blood pressure readings will be in one of four categories:

Normal blood pressure means

  • Your systolic pressure is less than 120 AND
  • Your diastolic pressure is less than 80

Prehypertension means

  • Your systolic pressure is between 120-139 OR
  • Your diastolic pressure is between 80-89

Stage 1 High blood pressure means

  • Your systolic pressure is between 140-159 OR
  • Your diastolic pressure is between 90-99

Stage 2 High blood pressure means

  • Your systolic pressure is 160 or Higher OR
  • Your diastolic pressure is 100 or Higher

For children and teens, the health care provider compares the blood pressure reading to what is normal for other kids who are the same age, height, and gender.

People with diabetes or chronic kidney disease should keep their blood pressure below 130/80.

Why do I need to worry about prehypertension and High blood pressure?

Prehypertension means you're likely to end up with High blood pressure, unless you take steps to prevent it.

When your blood pressure stays High over time, it causes the heart to pump harder and work overtime, possibly leading to serious health problems such as heart attack, stroke, heart failure, and kidney failure.

What are the different types of High blood pressure?

There are two main types of High blood pressure: primary and secondary High blood pressure.

  • Primary, or essential, High blood pressure is the most common type of High blood pressure. For most people who get this kind of blood pressure, it develops over time as you get older.
  • Secondary High blood pressure is caused by another medical condition or use of certain medicines. It usually gets better after you treat the cause or stop taking the medicines that are causing it.
Who is at risk for High blood pressure?

Anyone can develop High blood pressure, but there are certain factors that can increase your risk:

  • Age - Blood pressure tends to rise with age
  • Race/Ethnicity - High blood pressure is more common in African American adults
  • Weight - People who are overweight or have obesity are more likely to develop prehypertension or High blood pressure
  • Gender - Before age 55, men are more likely than women to develop High blood pressure. After age 55, women are more likely than men to develop it.
  • Lifestyle - Certain lifestyle habits can raise your risk for High blood pressure, such as eating too much sodium or not enough potassium, lack of exercise, drinking too much alcohol, and smoking.
  • Family history - A family history of High blood pressure raises the risk of developing prehypertension or High blood pressure
How can I prevent High blood pressure?

You can help prevent High blood pressure by having a healthy lifestyle. This means

  • Eating a healthy diet. To help manage your blood pressure, you should limit the amount of sodium (salt) that you eat, and increase the amount of potassium in your diet. It is also important to eat foods that are lower in fat, as well as plenty of fruits, vegetables, and whole grains. The DASH diet is an example of an eating plan that can help you to lower your blood pressure.
  • Getting regular exercise. Exercise can help you maintain a healthy weight and lower your blood pressure. You should try to get moderate-intensity aerobic exercise at least 2 and a half hours per week, or vigorous-intensity aerobic exercise for 1 hour and 15 minutes per week. Aerobic exercise, such as brisk walking, is any exercise in which your heart beats harder and you use more oxygen than usual.
  • Being at a healthy weight. Being overweight or having obesity increases your risk for High blood pressure. Maintaining a healthy weight can help you control High blood pressure and reduce your risk for other health problems.
  • Limiting alcohol. Drinking too much alcohol can raise your blood pressure. It also adds extra calories, which may cause weight gain. Men should have no more than two drinks per day, and women only one.
  • Not smoking. Cigarette smoking raises your blood pressure and puts you at Higher risk for heart attack and stroke. If you do not smoke, do not start. If you do smoke, talk to your health care provider for help in finding the best way for you to quit.
  • Managing stress. Learning how to relax and manage stress can improve your emotional and physical health and lower High blood pressure. Stress management techniques include exercising, listening to music, focusing on something calm or peaceful, and meditating.

If you already have High blood pressure, it is important to prevent it from getting worse or causing complications. You should get regular medical care and follow your prescribed treatment plan. Your plan will include healthy lifestyle habit recommendations and possibly medicines.

NIH: National Heart, Lung, and Blood Institute

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High Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting A Blinded Comparison Trial of Two Topical Creams to Reduce Thigh Girth and to Smooth Thigh Skin in Women
Condition: Weight Loss
Interventions: Other: Cream A applied to left Thigh and Cream B to right Thigh;   Other: Cream B applied to left Thigh and Cream A to right Thigh
Outcome Measures: Difference in girth of the two Thighs from baseline over the course of the treatment period;   Smoothness of the skin on the Thighs treated with the two lipolytic creams differing in their bases compared to baseline using standardized photographs at baseline and at the end of the treatment.;   Adverse events
2 Recruiting Manual Lymphatic Drainage in Women Undergone to Thigh Lifting
Conditions: Lymphedema;   Obesity
Intervention: Procedure: Thigh Surgery
Outcome Measures: Preoperative measurement.;   Thighs circumference measurement
3 Recruiting Prediction of Growth Restricted Fetuses Using Femur Length to Mid-Thigh Circumference Ratio: A Case-control Study
Condition: Fetal Growth Restriction
Intervention:
Outcome Measure: femur length to mid-Thigh circumference ratio
4 Recruiting Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis
Condition: Peripheral Arterial Disease
Interventions: Procedure: Angioplasty with Zilver PTX;   Other: Best medical treatment;   Device: Zilver PTX
Outcome Measures: Maximal walking distance;   Ankle brachial pressure indices;   Quality of life;   Cost of the treatment
5 Unknown  Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients
Condition: Familial Mediterranean Fever
Intervention:
Outcome Measures: change in spectroscopic appearance of muscle after exertion of muscle Thigh;   change in muscle intensity signal after exertion;   change in joint effusion status after exertion
6 Not yet recruiting Pharmacokinetics And Relative Bioavailability Of PF-04950615 When Administered To The Abdomen, Thigh Or Upper Arm
Condition: Hypercholesterolemia
Interventions: Device: PF-04950615;   Biological: PF-04950615
Outcome Measures: Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - inf)];   Maximum Observed Plasma Concentration (Cmax);   Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast);   Apparent SC Clearance (CL/F);   Time to Reach Maximum Observed Plasma Concentration (Tmax);   Apparent Volume of Distribution (Vz/F);   Plasma Terminal Elimination Half-Life (t1/2);   Area under the LDL-C effect curve;   Maximum LDL-C lowering;   Time to reach maximum LDL-C lowering
7 Recruiting Outer Thigh Study With Varied Treatment Parameters
Condition: Body Fat Disorder
Intervention: Device: The Zeltiq System
Outcome Measures: Evaluate safety and efficacy of treatment;   Reduction measured by ultrasound;   Subject satisfaction
8 Recruiting Acticoat Absorbent and BCT Antimicrobial for STSG Donor Site on Thigh
Conditions: Wound Healing;   Wound Infection;   Pain;   Pruritus;   Cicatrix
Interventions: Device: Acticoat Absorbent;   Device: BCT
Outcome Measures: wound healing rate;   wound infection rate;   scar appearance;   pain and itchiness
9 Recruiting Remote Ischemic PreConditioning Effect on Postsurgical Pain
Condition: Pain
Interventions: Device: Thigh Tourniquet (VBM Single Use Tourniquet Cuff Items 20-34-722SLZ-1);   Device: Sham RIPC
Outcome Measures: Comparison of pain intensity and unpleasantness postoperatively;   Opioid consumption;   Consumption of nonopioid analgesics
10 Recruiting Effect of Remote Ischemic Preconditioning in Patient Undergoing Cardiac Bypass Surgery
Condition: Coronary Heart Disease
Interventions: Procedure: Remote ischemic preconditioning;   Procedure: Placebo
Outcome Measure: Troponin-T release over the perioperative 72-hour period.
11 Recruiting Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients
Conditions: Postural Orthostatic Tachycardia Syndrome (POTS);   Syncope
Intervention: Device: Zoex compression garment
Outcome Measures: Heart-rate elevation;   Symptom onset
12 Recruiting Scleroderma ARFI Study
Condition: Scleroderma
Intervention: Device: ARFI-SVI Ultrasound
Outcome Measures: Skin shear wave speed measurements (forearm and Thigh);   Durometer scoring;   Subjective skin scoring
13 Recruiting Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation
Condition: Asthma
Interventions: Drug: IM epinephrine 1:1000;   Other: No intervention
Outcome Measures: Change in percent of predicted Peak Expiratory Flow Rate (PEFR) or clinical asthma score 15 minutes after the study intervention (t15).;   1. Change in percent of predicted PEFR/CAS at t15;   2. Disposition;   3. Change in percent of predicted PEFR/CAS at t30, t60, t90 and t120;   4. Change in percent of predicted PEFR/CAS at t30, t60, t90 and t120;   5. Change in respiratory rate at t15, t30, t60, t90 and t120;   6. Change in heart rate at t15, t30, t60, t90 and t120;   7. Need for supplemental oxygen at t60, t90 and t120 (defined as a room air pulse oximetry of <93%);   8. Need for albuterol at t60, t90 and t120;   9. Number of hours of albuterol therapy in the emergency department;   10. ED length of stay
14 Recruiting Tourniquet and Quadricepsforce
Conditions: Osteoarthritis;   Total Knee Arthroplasty
Intervention: Device: Tourniquet
Outcome Measures: isometric quadriceps-force measured;   Pain
15 Not yet recruiting Collagenase in the Treatment of Cellulite
Condition: Cellulite
Interventions: Drug: Collagenase;   Biological: Biological
Outcome Measure: Reduction and/or elimination of cellulite in the posterolateral Thigh
16 Recruiting Safety, Tolerability, and Efficacy of BVS857 in Patients With Spinal and Bulbar Muscular Atrophy
Condition: Spinal and Bulbar Muscular Atrophy
Interventions: Drug: BVS857;   Drug: Placebo
Outcome Measures: Number of patients with adverse events as a measure of safety and tolerability;   Number of mild, moderate and severe adverse events as a measure of safety and tolerability;   Change in Thigh muscle volume;   Change in score on the adult myopathy assessment tool.;   Change in lean body mass.;   Plasma Pharmacokinetics (PK) of BVS857: Observed maximum concentration following drug administration (Cmax);   Plasma Pharmacokinetics (PK) of BVS857: Time to reach the maximum concentration after drug administration (Tmax);   Plasma Pharmacokinetics (PK) of BVS857: The area under the serum concentration-time curve from time zero to the time of the last quantifiable concentration (AUClast);   Plasma Pharmacokinetics (PK) of BVS857: The area under the serum concentration-time curve from time zero to the end of the dosing interval tau (AUCtau);   Plasma Pharmacokinetics (PK) of BVS857: The area under the serum concentration-time curve from time zero to infinity (AUCinf);   Plasma Pharmacokinetics (PK) of BVS857: The terminal elimination half-life (T1/2);   Compare dose normalized log-transformed AUCinf following IV and SC administrations.
17 Recruiting BYM338 in Chronic Obstructive Pulmonary Disease (COPD) Patients With Cachexia
Condition: Chronic Obstructive Pulmonary Disease (COPD) With Cachexia
Interventions: Drug: Placebo;   Drug: BYM338
Outcome Measures: Change in Thigh muscle volume compare to placebo as measured by MRI;   Change in 6 minute walk distance compared to placebo;   Safety and tolerability of BYM338 in COPD patients with cachexia;   Pharmacokinetic profile and immunogenicity response to BYM338 in COPD patients with cachexia;   Number of participants with adverse events as a measure of safety and tolerability of BYM338 in COPD patients with cachexia
18 Not yet recruiting Continuous Infusion of Local Anesthetic for Post-operative Pain Control in Ukraine
Condition: Pain
Intervention: Device: Wound Catheter
Outcome Measure: Pain Score with dressing changes
19 Recruiting Patients With Intermittent Claudication Injected With ALDH Bright Cells
Conditions: Peripheral Artery Disease;   Intermittent Claudication
Interventions: Biological: ALD-301;   Biological: Placebo (vehicle)
Outcome Measures: Peak Walking Time (PWT);   Leg collateral artery anatomy (via contrast enhanced-MR);   Vascular Flow (Phase Contrast MRA);   Perfusion (Cuff-induced Ischemia using Perfusion MR);   Pre-exercise Ankle-Brachial Index (ABI);   Post-exercise Ankle-Brachial Index (ABI);   Claudication Onset Time (COT);   Relationship between PWT and leg collateral artery anatomy;   Relationship between PWT and Vascular Flow;   Relationship between PWT and Perfusion;   Walking Impairment Questionnaire (WIQ);   Peripheral Artery Questionnaire (PAQ)
20 Recruiting Elastic Compression Stockings for Prevention of Post-thrombotic Syndrome
Conditions: Deep Vein Thrombosis;   Post-thrombotic Syndrome
Interventions: Device: compression stockings 25mm Hg;   Device: compression stockings 35 mm Hg
Outcome Measures: To show that elastic compression with ankle pressure targeted at 25 mm Hg is not inferior in preventing the onset of clinical post-thrombotic syndrome to a target ankle pressure of 35 mm Hg (recommended pressure being greater than 30 mm Hg);   superiority of targeted pressure at 35 mm Hg for compliant patients. Analysis of the primary endpoint per protocol amongst patients responding to the definition of compliance for compression scheduled by randomization;   Superiority of 25 mm Hg on the therapeutic compliance criterion;   superiority of 25 mm Hg for constraints related to compression and chronic venous insufficiency quality of life (CIVIQ);   non inferiority of 25 mm Hg for the comparative evaluation of the symptomatic effect of short-term compression (pain, sensation of oedema) form baseline to 3 months;   Non-inferiority of 25 mm Hg for changes in overall quality of life evaluated on the basis of the EUROQUOL questionnaire;   non inferiority of 25 mm Hg for the intensity of long term chronic venous insufficiency symptoms (12 months and 24 months);   non inferiority of 25 mm Hg for the onset of permanent trophic disorders;   non inferiority of 25 mm Hg for the onset of sequalae or post thrombotic residues on an duplex scan at 3 months, 12 and 24 months;   testing for the prognostic factors of the onset post thrombotic syndrome and comparison of the onset kinetics of post thrombotic syndrome;   test for key factors in good compliance;   Adverse events;   Subgroups analysis of the primary objective and secondary objectives according to the gender stratification criterion and age;   superiority of 25 mmHg on 35 mmHg in preventing the onset of clinical post thrombotic syndrome;   sensitivity analysis of primary endpoint excluding patients with a differential diagnosis can explain a Villalta score ≥ 5