Hyperthyroidism and Amilorid


Hyperthyroidism Symptoms and Causes

Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. If your thyroid is too active, it makes more thyroid hormones than your body needs. This is called Hyperthyroidism.

Hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. Graves' disease, an autoimmune disorder, is the most common cause. Other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone.

The symptoms can vary from person to person. They may include

  • Being nervous or irritable
  • Mood swings
  • Fatigue or muscle weakness
  • Heat intolerance
  • Trouble sleeping
  • Hand tremors
  • Rapid and irregular heartbeat
  • Frequent bowel movements or diarrhea
  • Weight loss
  • Goiter, which is an enlarged thyroid that may cause the neck to look swollen

To diagnose Hyperthyroidism, your doctor will do a physical exam, look at your symptoms, and do thyroid tests. Treatment is with medicines, radioiodine therapy, or thyroid surgery. No single treatment works for everyone.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

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Hyperthyroidism Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve
Condition: Acute Autoimmune Optic Neuritis
Interventions: Drug: Amiloride hydrochlorothiazide;   Drug: Sugar pill
Outcome Measure: Change in thickness of retinal nerve fiber layer (RNFL)