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Hyperuricaemia and Kremezin

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Hyperuricaemia Symptoms and Causes

Gout is a common, painful form of arthritis. It causes swollen, red, hot and stiff joints.

Gout happens when uric acid builds up in your body. Uric acid comes from the breakdown of substances called purines. Purines are in your body's tissues and in foods, such as liver, dried beans and peas, and anchovies. Normally, uric acid dissolves in the blood. It passes through the kidneys and out of the body in urine. But sometimes uric acid can build up and form needle-like crystals. When they form in your joints, it is very painful. The crystals can also cause kidney stones.

Often, gout first attacks your big toe. It can also attack ankles, heels, knees, wrists, fingers, and elbows. At first, gout attacks usually get better in days. Eventually, attacks last longer and happen more often.

You are more likely to get gout if you

  • Are a man
  • Have family member with gout
  • Are overweight
  • Drink alcohol
  • Eat too many foods rich in purines

Gout can be hard to diagnose. Your doctor may take a sample of fluid from an inflamed joint to look for crystals. You can treat gout with medicines.

Pseudogout has similar symptoms and is sometimes confused with gout. However, it is caused by calcium phosphate, not uric acid.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

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Kremezin Side Effects

Thrombocytopenia (19)
Renal Failure (14)
Blood Urea Increased (12)
Renal Failure Chronic (8)
Face Oedema (7)
Diabetic Neuropathy (6)
Anaemia (5)
Nephrogenic Anaemia (4)
Malaise (4)
Palmar-plantar Erythrodysaesthesia Syndrome (4)
Oedema Peripheral (3)
Hypothyroidism (3)
Angioedema (2)
Thirst (2)
Rectal Perforation (2)
Aspartate Aminotransferase Increased (2)
Peritonitis (2)
Alanine Aminotransferase Increased (2)
Cerebral Haemorrhage (1)
Cerebral Infarction (1)
Vomiting (1)
Cardiac Failure (1)
Bleeding Time Prolonged (1)
Interstitial Lung Disease (1)
Diabetic Ketoacidosis (1)
Blood Creatinine Increased (1)
Blood Pressure Increased (1)

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Recent Reviews

Hyperuricaemia Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease
Condition: Kidney Failure, Chronic
Intervention: Drug: Kremezin
Outcome Measures: Changes of FMD(Flow Mediated Dilatation);   Level of Indoxyl Sulfate