Hypothyroidism and Prilosec


Hypothyroidism Symptoms and Causes

Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. If your thyroid gland is not active enough, it does not make enough thyroid hormone to meet your body's needs. This condition is Hypothyroidism.

Hypothyroidism is more common in women, people with other thyroid problems, and those over 60 years old. Hashimoto's disease, an autoimmune disorder, is the most common cause. Other causes include thyroid nodules, thyroiditis, congenital Hypothyroidism, surgical removal of part or all of the thyroid, radiation treatment of the thyroid, and some medicines.

The symptoms can vary from person to person. They may include

  • Fatigue
  • Weight gain
  • A puffy face
  • Cold intolerance
  • Joint and muscle pain
  • Constipation
  • Dry skin
  • Dry, thinning hair
  • Decreased sweating
  • Heavy or irregular menstrual periods and fertility problems
  • Depression
  • Slowed heart rate

To diagnose Hypothyroidism, your doctor will do a physical exam, look at your symptoms, and do thyroid tests. Treatment is with synthetic thyroid hormone, taken every day.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

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Prilosec Side Effects

Gastrooesophageal Reflux Disease (325)
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Pain (188)
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Diarrhoea (177)
Headache (167)
Dyspnoea (163)
Dizziness (161)
Chest Pain (152)
Anxiety (134)
Fatigue (133)
Weight Decreased (127)
Off Label Use (122)
Injury (112)
Asthenia (111)
Abdominal Discomfort (107)
Abdominal Pain (105)
Depression (63)
Arthralgia (63)
Pain In Extremity (61)
Insomnia (60)
Dysphagia (59)
Feeling Abnormal (59)
Hiatus Hernia (56)
Incorrect Dose Administered (55)
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Gastric Disorder (53)
Back Pain (52)
Cough (52)
Hypertension (49)
Hypersensitivity (48)
Muscle Spasms (47)
Constipation (47)
Condition Aggravated (44)
Cholecystitis Chronic (43)
Fall (42)
Throat Irritation (41)
Pneumonia (40)
Pruritus (40)
Cholelithiasis (39)
Eructation (39)
Dysgeusia (39)
Rash (38)
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Palpitations (36)

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Hypothyroidism Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Management of Myocardial Injury After Noncardiac Surgery Trial
Condition: Myocardial Injury After Noncardiac Surgery (MINS)
Interventions: Drug: Dabigatran;   Drug: Placebo (for Dabigatran);   Drug: Omeprazole;   Drug: Placebo (for Omeprazole)
Outcome Measures: Major vascular complication (for Dabigatran);   Major upper gastrointestinal complication (for Omeprazole);   Individual secondary outcomes for Dabigatran;   Upper gastrointestinal complication for Omeprazole;   Major vascular complication for Omeprazole;   Individual secondary outcomes for Omeprazole;   Safety outcomes for Dabigatran;   Safety outcomes for Omeprazole
2 Unknown  Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding
Condition: Nonvariceal Upper Gastrointestinal Bleeding
Interventions: Drug: Intravenous Omeprazole;   Drug: Oral Rabeprazole
Outcome Measure: This study aims to compare the effect of three-day oral rabeprazole and iv omeprazole on bleeding control in patients with mild to moderate non-variceal UGIB.
3 Not yet recruiting Omeprazole and Pantoprazole Antiplatelet Effect of Clopidogrel Clinical Trials(OPEN)
Condition: Acute Coronary Syndromes
Interventions: Drug: omeprazole;   Drug: Pantoprazole
Outcome Measures: Platelet aggregation rate(AA 、ADP);   clinical adverse events
4 Recruiting Pilot Trial Of Omeprazole in Idiopathic Pulmonary Fibrosis (IPF)
Condition: Idiopathic Pulmonary Fibrosis
Interventions: Drug: Omeprazole;   Drug: Matched placebo
Outcome Measures: objectively measured cough frequency;   symptoms of cough;   reflux symptoms;   acid and non-acid reflux;   vital capacity (VC) & transfer factor for carbon monoxide (Tco);   6 minute walk distance;   assess amount of inflammation in lung;   lung infection rate;   adverse events rate
5 Recruiting Gastroesophageal Reflux Treatment in Scleroderma
Conditions: Gastroesophageal Reflux Disease;   Systemic Sclerosis;   Scleroderma
Interventions: Drug: Alginic acid;   Drug: placebo (for domperidone);   Drug: Domperidone;   Drug: placebo (of alginic acid)
Outcome Measures: Changing severity of heart burn and regurgitation of SSc related omeprazole resistant GERD evaluated by visual analogue score (VAS);   changing of frequency of symptoms in SSc related omeprazole resistant GERD evaluated by frequency scale for the symptoms of GERD (FSSG) and the quality of life which is evaluated by EQ-5DTM (by EuroQol Group);   the prevalence of omeprazole-resistant GERD in SSc after 4 weeks treatment with omeprazole
6 Recruiting Comparison of the Gastric Acid Suppressive Effects of Esomeprazole and Generic Omeprazole
Condition: Gastric Acid
Interventions: Drug: Esomeprazole first;   Drug: Generic omeprazole first
Outcome Measures: Median intragastric pH and percentage of time that intragastric pH is above 4;   Nocturnal acid breakthrough, defined as at least 60 continuous minutes of intragastric pH below 4 occurring between 10pm and 6 am and adverse events
7 Recruiting Compliance With Antidepressant Medication in Treatment of Functional Dyspepsia
Conditions: Dyspepsia;   Compliance;   Depression
Interventions: Drug: Omeprazole;   Drug: Flupentixol and Melitracen Tablets(for dyspepsia symptoms) + Omeprazole;   Drug: Flupentixol and Melitracen Tablets(for depression symptoms) + Omeprazole;   Drug: Flupentixol and Melitracen Tablets(without explanation) + Omeprazole
Outcome Measures: compliance of antidepressant medication;   dyspepsia symptom questionnaire;   psychiatric symptom on Hospital Anxiety and Depression Scale;   quality of life rating;   adverse reaction
8 Unknown  Impact of Omeprazole and Fluvoxamine on Platelet Response to Clopidogrel
Condition: Drug Interaction of Clopidogrel
Interventions: Drug: omeprazole;   Drug: fluvoxamine;   Drug: placebo
Outcome Measure: platlet reactivity in response to clopidogrel
9 Recruiting Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study
Condition: Barrett's Esophagus
Interventions: Drug: Omeprazole;   Drug: Melatonin
Outcome Measures: Oxidative stress;   Biological markers of diseases progression;   The presence of DNA anomalies (tetraploidy and aneuploidy.
10 Recruiting CYP2C19 Genotype Predictor of Gastric Acid Suppression
Condition: Esophagitis
Intervention: Drug: Omeprazole
Outcome Measures: The correlation specific to CYP2C19 genotype with gastric acid suppression by omeprazole.;   To assess patients gastrointestinal symptoms, in patients with EoE by means of standard validated questionnaires
11 Unknown  Evaluation of Omeprazole Effect on Glaucoma
Condition: Glaucoma
Interventions: Drug: Omeprazole;   Drug: Placebo
Outcome Measure:
12 Not yet recruiting "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER-
Condition: Coronary Artery Disease
Interventions: Drug: Pantoprazole,;   Drug: Omeprazole
Outcome Measures: Assessment of platelet reaction units;   Frequency of high platelet reactivity
13 Not yet recruiting Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC
Condition: CDA Type I
Intervention: Drug: omeprazole
Outcome Measure: evaluate number of adverse effects per patient treated with LOSEC + levels of iron, ferritin,complete blood count and chemistry panel.
14 Recruiting Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.
Conditions: Gastroesophageal Reflux;   Esophageal Atresia;   Hernia, Diaphragmatic
Intervention: Drug: Omeprazole suppository
Outcome Measures: Therapeutic efficacy;   Intragastric pH, Pharmacokinetic parameters, PK-PD-relation,;   Pharmacogenetic parameters
15 Unknown  Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus
Conditions: Barrett Esophagus;   Gastroesophageal Reflux
Interventions: Drug: Zegerid (proton pump inhibitor);   Procedure: Bravo pH monitoring
Outcome Measures: Control of esophageal pH;   Control of GERD symptoms
16 Unknown  Role of CYP2C19 Polymorphism in the Drug Interaction Between Clopidogrel and Omeprazole
Condition: Coronary Artery Disease
Outcome Measures: To test whether concomitant administration of omeprazole will decrease the platelet inhibitory properties of clopidogrel in subjects with loss of function (LOF) mutation of CYP2C19 (known as *2 and *3).;   To test whether concomitant administration of omeprazole will decrease the conversion of clopidogrel to its active metabolite in subjects with loss of function (LOF) mutation of CYP2C19 (known as *2 and *3).
17 Not yet recruiting Laryngomalacia Study
Condition: Laryngomalacia
Interventions: Drug: Omeprazole;   Drug: Placebo
Outcome Measures: Laryngomalacia Symptom Score;   Caring For a Child with Laryngomalacia Family Impact Questionnaire;   Revised Infant Gastro-Esophageal Reflux Questionnaire;   Reflux Finding Score;   End of treatment 24-hour double-probe pH monitoring;   Weight
18 Not yet recruiting Placebo In Chronic Pain
Condition: Chronic Back Pain
Interventions: Drug: Naproxen;   Drug: Placebo;   Drug: Omeprazole
Outcome Measure: VAS pain scale
19 Unknown  Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, or Famotidine
Conditions: Coronary Heart Disease;   GI Bleeding
Intervention: Drug: PPI Platelet Inhibitory
Outcome Measure: Platelet function as assessed by a CPA system
20 Not yet recruiting The Effect of NSAIDs After a Rotator Cuff Repair Surgery.
Condition: Rotator Cuff Tear
Interventions: Procedure: Rotator cuff repair;   Drug: Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole;   Drug: Hydrocodone/Acetaminophen
Outcome Measures: American Shoulder and Elbow Surgeons (ASES) Shoulder Score;   Ultrasound evaluation of retear rate