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Infusion and Baclofen

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Infusion Symptoms and Causes

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic myeloid leukemia (CML), there are too many granulocytes, a type of white blood cell.

Most people with CML have a gene mutation (change) called the Philadelphia chromosome.

Sometimes CML does not cause any symptoms. If you have symptoms, they may include:

  • Fatigue
  • Weight loss
  • Night sweats
  • Fever
  • Pain or a feeling of fullness below the ribs on the left side

Tests that examine the blood and bone marrow diagnose CML. Treatments include chemotherapy, stem cell transplants, Infusion of donated white blood cells following stem cell transplants, surgery to remove the spleen, and biologic and targeted therapies. Biologic therapy boosts your body's own ability to fight cancer. Targeted therapy uses substances that attack cancer cells without harming normal cells.

NIH: National Cancer Institute

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Baclofen Side Effects

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Respiratory Failure (42)
Disorientation (40)
Muscular Weakness (39)
Toxicity To Various Agents (39)

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Recent Reviews

Alopecia areata

Had reclast infusion in Jan 2010, diagnosed with Anaemia August this year. What is the best treatment and how long will this symptom last. No other problems as yet.

Husbnd is a 15 yr. stroke survivor who had a baclofen pump since about 2001. It was replaced Nov. 2009 and nothing but trouble... passing out, weakness, falling, etc. 4 ER trips and not one dr. ever mentioned b

I had a devastating experience with this drug. I had been using Flexeril for back and neck pain but found it no longer as effective. I asked my doctor if there was something stronger. He prescribed Baclofen. Having not read the label carefully, m

I have experience hads spasm,diziness,headaches,shallow or hard breathing,slepiness,pain in the side (new)

I have gotten 2 Reclast Infusions in the past 2 year and haven,t had any side effects.

I too had a nasty bite from baclofen.I had a craving for alcohol and was on 10 mg TID.I took 90mg at once. within one hour I feel like i was on shrooms! Very vivid CEVs(closed eyed visuals) and some ope eyed visuals(OEVs).Actually I enjoyed this.But

I took reclast infusion in July 2009. My nurse said that if I experienced any sickness it would take 3 days for it to set in. I had my treatment at 11:00 and by 7:00 pm I was very sick with the flu. I mean sick. It lasted for 3 days. I will have it d

Just was looking around and saw your post. We experienced a very similar situation with our child. Was the pump just installed?

Male 42 prescribed baclofen 30-60mg daily for the control of cervical dystonia, great for first week then started to get pain and discumfort in my bowels by week two i was being physicaly sick and unable to control the pain , had to stop taking the m

I just had the infusion two days ago (1/19/10) and was surprised with the intensity of muscle pain the day after the treatment. My pain was localized to my rib cage, neck, shoulders and upper back. In addition I was very fatiqued...slept most of

"Association does not equal causation": posters seem to assume that any symptom occurring within a year of the Reclast infusion is caused by Reclast (just noticing that, and wondering whether the manufacturer needs to do a better jo

Tell women not to take this drug. I for see huge lawsuits in the future. I may not live that long but it will happen! I was told to report to the hospital for my infusion. No one told me mu

<span style='color: #1f00ff;'><span style='font-family: Verdana; color: #000000;'> Infusion seemed to go fine, then had dark pungent urine just before conclusion of infusion. Got home, was very wea

<span style='color: #808080;'>I just had 5 days of one venofir infusion a day.My hands and arms swelled up like balloons. They are very painful and feel like they are on fire. Ice packs helped the burning sensation but the swelling is still ver

<strong></strong><span style='color: #808080;'>I had my first Reclast infusion last Thursday morning. I am a nurse so am on my feet a lot and at work Thursday evening I started having pain across the back of my

09/22/10. Have been on Orencia for a little over a year. Was doing fine, until this month; I started with hives and now a rash all over arms and neck. Trying about everything. I am having another infusion next week; will

2 months after injection . I want to say I was extremely ill the day, about 10 hours afterwards , I got my Iv infusion of this medication . About 10 hours after the IV infusion I became very sick , Flu like symptoms , 103.6 temperture , thought

2 weeks after second infusion for Hodgkin's Lymphome (&amp; RA), I had an extreme respiratory problem (BOOP). I was hospitalized twice &amp; had high steroid does IV along with IV antiobiotics administered. After 1 year of decreasing steroi

4-5 hours after venofer infusion developed fever 100 F ,pulse 120/min,palpatation and bronchospasm.i took ventolin inhaler but was of no use i remained in that condition for 3 more hours when brochospasm was not relieved and worsened i went to emerge

Infusion Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Safety Study of 3 mg/mL Baclofen Injection (Intrathecal) Using A Programmable Pump
Condition: Severe Spasticity
Intervention: Drug: Gablofen® 3 mg/mL (Baclofen injection)
Outcome Measures: The rate of inflammatory granulomas in patients given 3 mg/mL Gablofen® (Baclofen injection) 3mg/mL by the intrathecal route of administration.;   Overall safety of 3 mg/mL Gablofen® (Baclofen injection) given by the intrathecal route of administration
2 Recruiting Preventing Alcohol Withdrawal With Oral Baclofen
Conditions: Alcoholism;   Alcohol Withdrawal
Intervention: Drug: Baclofen
Outcome Measures: Alcohol withdrawal severity as measured on CIWA-AR (Clinical Institute for Withdrawal Assessment) scale;   Total benzodiazepine dose required
3 Not yet recruiting Oral and IV Baclofen in Adult Volunteers
Condition: Baclofen Withdrawal Syndrome
Interventions: Drug: Oral Baclofen;   Drug: Intervenous Baclofen
Outcome Measures: oral bioavailability;   Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - ∞)];   Plasma Decay Half-Life (t1/2);   Maximum concentration (Cmax);   Tmax;   assessment of sedation;   Ataxia;   Nystagmus;   blood pressure
4 Not yet recruiting Dose Escalation Study of Intravenous Baclofen in Healthy Adult Volunteers
Condition: Safety and Pharmacokinetics of Intravenous Baclofen
Intervention: Drug: Intravenous Baclofen
Outcome Measures: Safety assessments;   Maximum Concentration(Cmax);   AUC(0-inf);   Plasma Decay Half-life (T1/2)
5 Not yet recruiting Action of Baclofen Capsules in Spasticity Due to Multiple Sclerosis
Condition: Spasticity
Interventions: Drug: Baclofen dose 1;   Drug: Baclofen dose 2;   Drug: Placebo
Outcome Measures: Primary efficacy outcome: Improvement in Ashworth score;   Spasm frequency;   Nighttime awakening score;   Clinical global impression of change;   Subject's global impression of change
6 Recruiting Baclofen Effects in Cigarette Smokers
Condition: Nicotine Dependence
Interventions: Drug: Baclofen;   Drug: placebo
Outcome Measures: fMRI response in the ventral striatum/medial orbitofrontal cortex during smoking cue exposure;   Urine cotinine;   Cigarettes smoked per day
7 Recruiting Efficacy and Safety of Baclofen ER Capsules (GRS) in Subjects With Spasticity Due to Multiple Sclerosis
Condition: Spasticity
Interventions: Drug: Baclofen ER Capsules;   Drug: Placebo GRS
Outcome Measures: The primary efficacy outcome is the proportion of subjects who become a treatment failure during double-blind randomized withdrawal;   Determining the safety profile when administered over >12 weeks;   Subject Global Impression of Severity (SGIS)assessment
8 Recruiting Efficacy and Safety of High Dose Baclofen for Alcohol Dependence
Condition: Alcoholism
Interventions: Drug: Baclofen;   Drug: Placebo
Outcome Measures: Mean % Heavy Drinking Days;   Mean % Abstinent Drinking Days;   Anxiety level based on Spielberger Scale for State Anxiety
9 Recruiting Baclofen Effects on Marijuana Dependence
Condition: Marijuana Dependence
Interventions: Drug: Baclofen;   Behavioral: Psychosocial;   Drug: Placebo
Outcome Measure: Change in brain and behavioral responses during reward and inhibitory tasks at fMRI 1, fMRI 2, and fMRI 3; A composite measure
10 Recruiting A Clinical Evaluation Of The Safety Of Baclofen Er Capsules (Grs) When Administered Once Daily To Subjects With Spasticity Due To Multiple Sclerosis (Ms): An Open Label, Long Term, Safety Trial
Condition: Spasticity
Intervention: Drug: Baclofen
Outcome Measures: No. of participants with adverse events;   No. of participants with adverse vital signs;   Number of participants with adverse laboratory parameters
11 Not yet recruiting Preventing Alcohol Withdrawal Syndrome With Oral Baclofen
Condition: Alcohol Withdrawal Syndrome
Interventions: Drug: Baclofen;   Drug: Placebo
Outcome Measures: Prevention of Progression to Severe Alcohol withdrawal;   Reduced Severity of alcohol withdrawal (measured be SEWS score);   Reduced benzodiazepine administration in treatment group
12 Unknown  Baclofen as Add-On to Standard Treatment of Alcohol- Dependent Patients
Condition: Alcohol Dependence
Intervention: Drug: Baclofen (as add-on to standard treatment of alcohol dependence)
Outcome Measures: clinical efficacy and safe side-effect profile of Baclofen in patients suffering from alcohol dependence;   an improvement of the quality of life and associated psychosocial variables such as self-perceptions
13 Not yet recruiting A Study of Baclofen ER
Condition: Cocaine Dependence
Interventions: Drug: Baclofen ER;   Drug: Placebo
Outcome Measure: Urines positive for benzoylecgonine (BE), (a metabolite of cocaine)
14 Unknown  Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy
Conditions: Cerebral Palsy;   GERD
Interventions: Drug: Baclofen;   Drug: placebo
Outcome Measures: Symptom control;   GERD control;   side effects of Baclofen
15 Recruiting A Study to Examine the, Safety, Tolerability and Pharmacokinetics Co-Administered Baclofen and Memantine in Obese and Lean, Otherwise Healthy Adults
Conditions: Healthy Volunteers;;   Obese, Otherwise Healthy Volunteers
Interventions: Drug: Baclofen;   Drug: Memantine;   Drug: Placebo
Outcome Measures: Safety and tolerability of co-administered Baclofen and memantine via C-SSRS;   Safety and tolerability of co-administered Baclofen and memantine via Adverse Events;   Safety and tolerability of co-administered Baclofen and memantine via Vital Signs;   Safety and tolerability of co-administered Baclofen and memantine via ECG;   Safety and tolerability of co-administered Baclofen and memantine via Clinical Laboratory Tests;   Pharmacokinetic parameters of co-administered Baclofen and memantine via Cmax;   Pharmacokinetic parameters of co-administered Baclofen and memantine via Tmax;   Pharmacokinetic parameters of co-administered Baclofen and memantine via AUC;   Pharmacokinetic parameters of co-administered Baclofen and memantine via MRT;   Pharmacokinetic parameters of co-administered Baclofen and memantine via CL/F;   Pharmacokinetic parameters of co-administered Baclofen and memantine via T1/2;   Pharmacokinetic parameters of co-administered Baclofen and memantine via CLR
16 Recruiting Baclofen in the Treatment of Alcoholic Liver Disease
Condition: Alcoholic Liver Disease
Interventions: Drug: Baclofen 30mg/day;   Drug: Baclofen 75mg/day;   Drug: Placebo
Outcome Measures: alcohol consumption;   clinical markers of liver injury;   incidence of hepatic side effects;   craving for alcohol;   early termination due to side effects
17 Recruiting Baclofen for Treating Anxiety and Alcoholism
Conditions: Alcoholism;   Alcohol Dependence;   Alcohol Drinking Related Problems;   Alcohol Drinking;   Anxiety Disorder
Intervention: Drug: Baclofen
Outcome Measures: Alcohol drinking during the Alcohol Self-Administration, expressed as Standard Drinking Units (SDUs) will be measured as the primary outcome during the CR/ASA session.;   Secondary objectives include Baclofen s effects on alcohol cue-induced responses (urge to drink, attention to cues, blood pressure, heart rate, saliva), on the subjective effects of alcohol and on anxiety levels.
18 Unknown  Open Label Treatment of Severe Tactile Defensiveness With Intrathecal Baclofen
Conditions: Tactile Defensiveness;   Autism Spectrum Disorder
Intervention: Drug: Baclofen, intrathecal
Outcome Measures: Modified Short Sensory Profile.;   Clinical Global Impression of Change in Autism Symptoms
19 Unknown  Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes?
Condition: Cerebral Palsy
Interventions: Drug: oral Baclofen + placebo;   Drug: placebo + oral Baclofen
Outcome Measure: care and comport questionnaires
20 Recruiting GABA-B Receptor Function in Healthy Volunteers
Conditions: No Condition;   Brain GABA-B Function
Interventions: Drug: Baclofen 10mg;   Drug: Baclofen 60mg;   Drug: placebo
Outcome Measure: EEG spectral power in theta band