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Metastatic and Betahistine

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Metastatic Symptoms and Causes

What are painful periods?

Menstruation, or period, is normal vaginal bleeding that happens as part of a woman's monthly cycle. Many women have painful periods, also called dysmenorrhea. The pain is most often menstrual cramps, which are a throbbing, cramping pain in your lower abdomen. You may also have other symptoms, such as lower back pain, nausea, diarrhea, and headaches. Period pain is not the same as premenstrual syndrome (PMS). PMS causes many different symptoms, including weight gain, bloating, irritability, and fatigue. PMS often starts one to two weeks before your period starts.

What causes painful periods?

There are two types of dysmenorrhea: primary and secondary. Each type has different causes.

Primary dysmenorrhea is the most common kind of period pain. It is period pain that is not caused by another condition. The cause is usually having too many prostaglandins, which are chemicals that your uterus makes. These chemicals make the muscles of your uterus tighten and relax, and this causes the cramps.

The pain can start a day or two before your period. It normally lasts for a few days, though in some women it can last longer.

You usually first start having period pain when you are younger, just after you begin getting periods. Often, as you get older, you have less pain. The pain may also get better after you have given birth.

Secondary dysmenorrhea often starts later in life. It is caused by conditions that affect your uterus or other reproductive organs, such as endometriosis and uterine fibroids. This kind of pain often gets worse over time. It may begin before your period starts, and continue after your period ends.

What can I do about period pain?

To help ease your period pain, you can try

  • Using a heating pad or hot water bottle on your lower abdomen
  • Getting some exercise
  • Taking a hot bath
  • Doing relaxation techniques, including yoga and meditation

You might also try taking over-the-counter pain relievers such as nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs include ibuprofen and naproxen. Besides relieving pain, NSAIDs reduce the amount of prostaglandins that your uterus makes, and lessen their effects. This helps to lessen the cramps. You can take NSAIDs when you first have symptoms, or when your period starts. You can keep taking them for a few days. You should not take NSAIDS if you have ulcers or other stomach problems, bleeding problems, or liver disease. You should also not take them if you are allergic to aspirin. Always check with your health care provider if you are not sure whether or not you should take NSAIDs.

It may also help to get enough rest and avoid using alcohol and tobacco.

When should I get medical help for my period pain?

For many women, some pain during your period is normal. However, you should contact your health care provider if

  • NSAIDs and self-care measures don't help, and the pain interferes with your life
  • Your cramps suddenly get worse
  • You are over 25 and you get severe cramps for the first time
  • You have a fever with your period pain
  • You have the pain even when you are not getting your period
How is the cause of severe period pain diagnosed?

To diagnose severe period pain, your health care provider will ask you about your medical history and do a pelvic exam. You may also have an ultrasound or other imaging test. If your health care provider thinks you have secondary dysmenorrhea, you might have laparoscopy. It is a surgery that that lets your health care provider look inside your body.

What are treatments for severe period pain?

If your period pain is primary dysmenorrhea and you need medical treatment, your health care provider might suggest using hormonal birth control, such as the pill, patch, ring, or IUD. Another treatment option might be prescription pain relievers.

If you have secondary dysmenorrhea, your treatment depends upon the condition that is causing the problem. In some cases, you may need surgery.

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Metastatic Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gain in Adolescents and Young Adults
Conditions: Schizophrenia;   Schizoaffective Disorder;   Schizophreniform;;   Bipolar I Disorder;   Bipolar II;   Bipolar NOS;   Psychotic Disorder Not Otherwise Specified;   Autism
Intervention: Drug: Betahistine
Outcome Measures: Changes in weight and BMI;   Changes in satiety after a standardized meal, cholesterol, insulin, glucose and leptin levels as well as waist and hip measurements
2 Recruiting Comparison of the Effect of Ondansetron and Combined Ondansetron and Betahistine on Postoperative Nausea and Vomiting After Gynecological Laparoscopy
Condition: Nausea and Vomiting
Interventions: Drug: ondansetron;   Drug: ondansetron-Betahistine
Outcome Measure: postoperative nausea and vomiting
3 Recruiting Effectiveness of the Epley Manoeuvre Performed in Primary Care to Treat Benign Paroxysmal Positional Vertigo
Condition: Benign Positional Paroxysmal Vertigo
Interventions: Procedure: PROCEDURE: EPLEY MANOEUVRE;   Procedure: PROCEDURE: SHAM MANOEUVRE
Outcome Measures: PERSISTENCE OF VERTIGO;   Betahistine TABLET COUNT;   NEW EPISODES OF BENIGN PAROXYSMAL POSITIONAL VERTIGO IN THE ANNUAL VISIT;   SEVERITY OF VERTIGO MEASURED ON A LIKERT SCALE;   DIZZINESS HANDICAP INVENTORY SHORT FORM (DHI-S);   PATIENTS REPORTING PERSISTENCE OF VERTIGO
4 Recruiting Axillary Node Dissection Versus no Dissection in Breast Cancer With Positive Sentinel Lymph Node
Condition: Invasive Breast Cancer
Interventions: Procedure: Surgery for standard axillary node dissection;   Other: No axillary lymph node dissection
Outcome Measures: Disease Free survival;   axillary recurrence rate;   Overall survival
5 Not yet recruiting Effect of Docosa-hexaenoic Acid (DHA) Supplementation During Pregnancy on Newborn Outcome in India
Condition: Pregnancy
Interventions: Dietary Supplement: Docosa-hexaenoic acid (DHA);   Dietary Supplement: Placebo
Outcome Measures: Birth Weight;   Gestational Age;   Head circumference of the baby;   Crown-heel length;   APGAR score