Myocardial ischaemia and Moxonidine


Myocardial Ischaemia Symptoms and Causes

Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death in the United States in both men and women.

CAD happens when the arteries that supply blood to heart muscle become hardened and narrowed. This is due to the buildup of cholesterol and other material, called plaque, on their inner walls. This buildup is called atherosclerosis. As it grows, less blood can flow through the arteries. As a result, the heart muscle can't get the blood or oxygen it needs. This can lead to chest pain (angina) or a heart attack. Most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage.

Over time, CAD can also weaken the heart muscle and contribute to heart failure and arrhythmias. Heart failure means the heart can't pump blood well to the rest of the body. Arrhythmias are changes in the normal beating rhythm of the heart.

NIH: National Heart, Lung, and Blood Institute

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myocardial ischaemia treatment research studies

Moxonidine clinical trials, surveys and public health registries

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Moxonidine Side Effects

Blood Creatinine Increased (11)
Blood Iron Increased (7)
Blood Bilirubin Increased (5)
Asthenia (5)
Tremor (4)
Pneumonia (4)
Aspartate Aminotransferase Increased (4)
Blood Cholinesterase Decreased (4)
Renal Failure (3)
Somnolence (3)
Hypertension (3)
Aortic Arteriosclerosis (2)
Antinuclear Antibody Positive (2)
Basophil Count Increased (2)
Anti-erythrocyte Antibody (2)
Blood Pressure Diastolic Decreased (2)
Blood Lactate Dehydrogenase Increased (2)
Blood Count Abnormal (2)
Angina Pectoris (2)
Blood Urea Increased (2)
Bradyarrhythmia (2)
Blast Cell Count Increased (2)
Anisocytosis (2)
Hyperkalaemia (2)
Loss Of Consciousness (2)
Fatigue (2)
Electrocardiogram Qrs Complex Prolonged (2)
Breast Cancer (2)
Myocardial Infarction (2)
Haemoglobin Decreased (2)
Nausea (2)
Constipation (2)
Dizziness (2)
Vision Blurred (2)
Renal Failure Acute (2)
Graft Haemorrhage (1)
Intentional Overdose (1)
Hallucination, Visual (1)
Hypokalaemia (1)
Left Ventricular Hypertrophy (1)
Hypoglycaemia (1)
Hyperglycaemia (1)
Leukopenia (1)
Malaise (1)
Lethargy (1)
Melaena (1)
Mitral Valve Disease (1)
Muscular Weakness (1)
Mobility Decreased (1)
Neutropenia (1)

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Myocardial Ischaemia Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity
Conditions: Obesity;   Overweight
Interventions: Drug: Moxonidine (Physiotens);   Other: Dietary intervention
Outcome Measure: To determine whether Moxonidine is able to reverse the early organ damage compared to the effect of weight loss alone, and whether the addition of Moxonidine during a weight loss program confers greater beneficial effect.
2 Unknown  The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension
Conditions: Abdominal Obesity;   Hypertension
Interventions: Drug: Moxonidine;   Drug: Irbesartan
Outcome Measures: Microneurography (nerve recording);   Blood test
3 Recruiting Alleviating the Metabolic Side Effects of Antipsychotic Medications
Condition: Schizophrenia
Interventions: Drug: Moxonidine;   Drug: Placebo
Outcome Measures: To determine the association between sympathetic nervous system and metabolic abnormalities (eg, weight gain) observed with antipsychotic treatment.;   Change from baseline in sympathetic nervous system activity.
4 Recruiting Sympathetic Nervous System Inhibition for the Treatment of Diabetic Kidney Disease
Condition: Diabetic Nephropathies
Interventions: Drug: Moxonidine;   Drug: Placebo
Outcome Measures: Urine albumin/creatinine ratio (UACR);   muscle sympathetic nerve activity (MSNA)
5 Recruiting Polycystic Ovary Syndrome - Improving Outcomes
Condition: Polycystic Ovary Syndrome
Interventions: Drug: Moxonidine;   Drug: Placebo
Outcome Measures: Microneurography;   Blood biochemistry measurement;   Oral glucose tolerance test