Nephropathy and Moxonidine


Nephropathy Symptoms and Causes

A cyst is a fluid-filled sac. You may get simple kidney cysts as you age; they are usually harmless. There are also some diseases which cause kidney cysts. One type is polycystic kidney disease (PKD). It runs in families. In PKD, many cysts grow in the kidneys. This can enlarge the kidneys and make them work poorly. About half of people with the most common type of PKD end up with kidney failure. PKD also causes cysts in other parts of the body, such as the liver.

Often, there are no symptoms at first. Later, symptoms include

  • Pain in the back and lower sides
  • Headaches
  • Blood in the urine

Doctors diagnose PKD with imaging tests and family history. There is no cure. Treatments can help with symptoms and complications. They include medicines and lifestyle changes, and if there is kidney failure, dialysis or kidney transplants.

Acquired cystic kidney disease (ACKD) happens in people who have chronic kidney disease, especially if they are on dialysis. Unlike PKD, the kidneys are normal sized, and cysts do not form in other parts of the body. ACKD often has no symptoms. Usually, the cysts are harmless and do not need treatment. If they do cause complications, treatments include medicines, draining the cysts, or surgery.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

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Moxonidine Side Effects

Blood Creatinine Increased (11)
Blood Iron Increased (7)
Blood Bilirubin Increased (5)
Asthenia (5)
Tremor (4)
Pneumonia (4)
Aspartate Aminotransferase Increased (4)
Blood Cholinesterase Decreased (4)
Renal Failure (3)
Somnolence (3)
Hypertension (3)
Aortic Arteriosclerosis (2)
Antinuclear Antibody Positive (2)
Basophil Count Increased (2)
Anti-erythrocyte Antibody (2)
Blood Pressure Diastolic Decreased (2)
Blood Lactate Dehydrogenase Increased (2)
Blood Count Abnormal (2)
Angina Pectoris (2)
Blood Urea Increased (2)
Bradyarrhythmia (2)
Blast Cell Count Increased (2)
Anisocytosis (2)
Hyperkalaemia (2)
Loss Of Consciousness (2)
Fatigue (2)
Electrocardiogram Qrs Complex Prolonged (2)
Breast Cancer (2)
Myocardial Infarction (2)
Haemoglobin Decreased (2)
Nausea (2)
Constipation (2)
Dizziness (2)
Vision Blurred (2)
Renal Failure Acute (2)
Graft Haemorrhage (1)
Intentional Overdose (1)
Hallucination, Visual (1)
Hypokalaemia (1)
Left Ventricular Hypertrophy (1)
Hypoglycaemia (1)
Hyperglycaemia (1)
Leukopenia (1)
Malaise (1)
Lethargy (1)
Melaena (1)
Mitral Valve Disease (1)
Muscular Weakness (1)
Mobility Decreased (1)
Neutropenia (1)

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Nephropathy Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity
Conditions: Obesity;   Overweight
Interventions: Drug: Moxonidine (Physiotens);   Other: Dietary intervention
Outcome Measure: To determine whether Moxonidine is able to reverse the early organ damage compared to the effect of weight loss alone, and whether the addition of Moxonidine during a weight loss program confers greater beneficial effect.
2 Unknown  The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension
Conditions: Abdominal Obesity;   Hypertension
Interventions: Drug: Moxonidine;   Drug: Irbesartan
Outcome Measures: Microneurography (nerve recording);   Blood test
3 Recruiting Alleviating the Metabolic Side Effects of Antipsychotic Medications
Condition: Schizophrenia
Interventions: Drug: Moxonidine;   Drug: Placebo
Outcome Measures: To determine the association between sympathetic nervous system and metabolic abnormalities (eg, weight gain) observed with antipsychotic treatment.;   Change from baseline in sympathetic nervous system activity.
4 Recruiting Sympathetic Nervous System Inhibition for the Treatment of Diabetic Kidney Disease
Condition: Diabetic Nephropathies
Interventions: Drug: Moxonidine;   Drug: Placebo
Outcome Measures: Urine albumin/creatinine ratio (UACR);   muscle sympathetic nerve activity (MSNA)
5 Recruiting Polycystic Ovary Syndrome - Improving Outcomes
Condition: Polycystic Ovary Syndrome
Interventions: Drug: Moxonidine;   Drug: Placebo
Outcome Measures: Microneurography;   Blood biochemistry measurement;   Oral glucose tolerance test