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Pleural and Oxygen

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Pleural Symptoms and Causes

Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. Between the layers of the pleura is a very thin space. Normally it's filled with a small amount of fluid. The fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out.

Disorders of the pleura include

  • Pleurisy - inflammation of the pleura that causes sharp pain with breathing
  • Pleural effusion - excess fluid in the Pleural space
  • Pneumothorax - buildup of air or gas in the Pleural space
  • Hemothorax - buildup of blood in the Pleural space

Many different conditions can cause Pleural problems. Viral infection is the most common cause of pleurisy. The most common cause of Pleural effusion is congestive heart failure. Lung diseases, like COPD, tuberculosis, and acute lung injury, cause pneumothorax. Injury to the chest is the most common cause of hemothorax. Treatment focuses on removing fluid, air, or blood from the Pleural space, relieving symptoms, and treating the underlying condition.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for pleural

pleural treatment research studies

Oxygen clinical trials, surveys and public health registries


Find Drug Side Effect reports



Oxygen Side Effects

Dyspnoea (30)
Death (16)
Headache (14)
Pneumonia (13)
Hypotension (12)
Thermal Burn (12)
Chronic Obstructive Pulmonary Disease (12)
Oxygen Saturation Decreased (10)
Loss Of Consciousness (9)
Respiratory Failure (9)
Nausea (9)
Pyrexia (8)
Respiratory Distress (7)
Cough (7)
Cardiac Arrest (6)
Condition Aggravated (6)
Accident (6)
Hypoxia (6)
Pain (6)
Malaise (6)
Aspartate Aminotransferase Increased (5)
Alanine Aminotransferase Increased (5)
Disease Progression (5)
Chest Pain (5)
Diarrhoea (5)
Cardiac Failure Congestive (5)
Asthenia (5)
Swelling (5)
Oedema (5)
Dizziness (5)
Pulmonary Arterial Hypertension (5)
Injury (5)
Renal Failure Acute (5)
Vomiting (5)
Gamma-glutamyltransferase Increased (4)
Decreased Appetite (4)
Cardiac Failure (4)
Haemoglobin Decreased (4)
Back Pain (4)
Cardio-respiratory Arrest (4)
Product Quality Issue (4)
Oedema Peripheral (4)
Syncope (4)
Weight Increased (4)
Suicidal Ideation (4)
Sepsis (4)
Interstitial Lung Disease (3)
Lung Disorder (3)
Nasal Congestion (3)
Medical Device Complication (3)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Can it make you liht headed if too much

Does oxygen have any side effects on athletes? >:o

Hey, the same ting happened to me but i was almost killed of that stuff :(

I am using home oxygen levels between 1 and 2. I am having bad headaches, stomach pains, and leg pains. When I am not using the oxygen I dont have the horrible headaches. Once I use the oxgyen again i have the headaches. I feel as if I dont need the

I have a friend that has currently been treated with steriods and is on oxygen 24/7 and her gums appear sunburn and are peeling is this a side affect of the O2?

I have been on 2 litres of oxygen just at night along with a CPAP macchine and have noticed my voice is sounding horse and somewhat weak. :)

I know it was u Mitchell and Madesion

I wonce breathed the air and it hurt. i tried to warn the others buut it was to late. :(

Preciso de um representante da alliance healthdyne technologies no brasil

When people receive a lung transplant, the pleural cavity is destroyed. How are people able to breathe following a lung transplant when there is no pleural cavity???

Unresponsive to 5mg/kg q 8wks; increased to 10mg/kg q6wks. After 3 doses at that strength noted fatigue, occasional night sweats, joint aches, sudden onset of chest pain and dyspnea (pleurisy, small pleuraleffusion) Had just taper

54y/o, WM, Status post quadruple coronary artery bypass graft surgery(10 months ago). Surgery went well, only complication was a pretty large left pleural effusion requiring chest tube placement. Resolved well, no further problems

Hi am a nursing student and my pt has pneumonia and pleural effusion and empyema withlarge abcessand the hostpital is giving him perfalgan is that wrong?

My father died last week after suffering from: fluid buildup in the lining of the lungs (pleural effusion), heart (pericardial effusion), led to hard breathing, fatigueandvery low oxygen in

When people receive a lung transplant, the pleural cavity is destroyed. How are people able to breathe following a lung transplant when there is no pleural cavity???

Pleural Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery
Condition: Post Operative Surgical Site Infection
Intervention: Procedure: Supplemental Perioperative Oxygen
Outcome Measures: Surgical Site Infection;   Catalog and Compare Bacterial Species;   Risk Factors for Infection;   Resource Utilization and Cost
2 Not yet recruiting Home Oxygen Therapy in Bronchiolitis
Condition: Bronchiolitis
Intervention: Other: Oxygen Therapy
Outcome Measures: Home Oxygen therapy in the ambulatory treatment of bronchiolitis;   daycare(patients) and work (parents) lost because of the illness.
3 Recruiting Estimating Apnea Phenotypes From Polysomnography: Oxygen
Condition: Sleep Apnea
Intervention: Drug: Inspired Oxygen (40%)
Outcome Measures: The reduction in severity of sleep apnea (Apnea-Hypopnea Index, Events/hour);   Overnight change in chemosensitivity;   Subjective sleepiness/alertness (Stanford Sleepiness Scale);   Overnight change in blood pressure;   Subjective sleep quality (Oxygen vs sham);   Frequency of EEG arousals (events per hour)
4 Recruiting Study on the Effects of Oxygen-ozone Therapy on Back Pain in Subjects Aged 65 or Older
Condition: Back Pain
Interventions: Drug: Intramuscular/paravertebral injections of Oxygen-Ozone;   Other: Simulated intramuscular/paravertebral injections
Outcome Measures: Oswestry Disability Index(ODI);   Oswestry Disability Index (ODI);   Comprehensive geriatric assessment by INTERRAI-MDS-HC/VAOR-ADI instrument;   intake of paracetamol;   oxidative stress
5 Recruiting Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Breathing and Sleep
Conditions: Precapillary Pulmonary Hypertension;   Interstitial Lung Disease
Interventions: Behavioral: Moderate altitude sojourn;   Behavioral: Low altitude sojourn;   Drug: Oxygen;   Drug: Sham Oxygen (room air)
Outcome Measures: Mean nocturnal Oxygen saturation measured by pulse oximetry;   Apnea/hypopnea index measured by polysomnography;   Apnea/hypopnea index measured by polygraphy;   Sleep quality visual analog scale score;   Psychomotor vigilance test reaction time;   Severe hypoxemia;   Subjective sleep quality visual analog scale score
6 Recruiting Ambulatory Oxygen for ILD
Condition: Interstitial Lung Disease
Interventions: Device: Portable Oxygen concentrator;   Device: Portable Oxygen cylinder
Outcome Measures: Nadir SpO2;   6-min walk distance;   Borg dyspnoea score;   Borg fatigue score;   Partial pressure of Oxygen in arterial blood (PaO2) at rest;   Proportion of participants who desaturate to less than 80%
7 Unknown  Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU)
Conditions: Nervous System Diseases;   Respiratory Tract Diseases;   Cardiovascular Diseases;   Immune System Diseases
Intervention: Drug: Oxygen
Outcome Measures: Mortality in ICU;   Rate of organ dysfunctions (respiratory, circulation, renal, liver);   Rate of nosocomial blood and respiratory infections in intensive care unit and surgery site infections in hospital.
8 Recruiting Extubation Failure Prevention in High Risk Patients by High-flow Conditioned Oxygen Therapy vs. Standard Oxygen Therapy
Condition: Respiratory Failure
Interventions: Device: Optiflow (Fisher&Paykel);   Device: Nasal cannulae or controlled Oxygen concentration mask
Outcome Measures: Respiratory failure after extubation;   Survival
9 Recruiting Use of Oxygen Nebulizer for Preventing Post-operative Sore Throat
Condition: Pain, Postoperative
Intervention: Other: Oxygen
Outcome Measures: The effect of Oxygen nebulizer therapy on post-operative sore throat;   To evaluate the adverse events (pulmonary complications, wound infection, and mortality) of post-operative complications related to Oxygen therapy
10 Recruiting Trial of Portable Oxygen Cylinders Versus Battery Powered Portable Oxygen Concentrators
Condition: COPD
Intervention: Device: Portable Oxygen
Outcome Measures: Quality of life as measured through Chronic Respiratory Questionniar and PsyQol and;   Dyspnoea as measured through the Borg Scale;   Patient Prefterence;   Adverse Events through self report;   Mortality;   Cost effectiveness
11 Recruiting Solar Powered Oxygen Delivery
Conditions: Pneumonia;   Hypoxemia
Interventions: Device: Solar powered Oxygen;   Device: Oxygen from cylinders
Outcome Measures: Length of hospital stay;   Mortality;   Duration of supplemental Oxygen therapy;   Proportion of patients successfully Oxygenated;   Oxygen delivery system failure;   Cost;   Lambaréné Organ Dysfunction Score (LODS)
12 Recruiting STIT-2: Evaluation of Safety and Efficacy of Short-time TNI® Treatment in Patients With COPD and Hypercapnia
Conditions: COPD;   Hypercapnia
Interventions: Device: Nasal Oxygen insufflation with a TNI® 20 oxy device;   Device: Nasal insufflation of Oxygen
Outcome Measures: PaO2;   O2%;   PaCO2;   AaDO2;   RV and TLC
13 Recruiting The Performance of Two Oxygen Delivery Devices Used After General Anesthesia.
Condition: Hypoxemia
Interventions: Device: Oxygen mask;   Device: Oxygen cannula
Outcome Measures: The incidences of hypoxemia in both groups;   The causes of hypoxemia
14 Not yet recruiting Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)
Conditions: Post-Concussion Syndrome;   Traumatic Brain Injury
Interventions: Drug: Hyperbaric Oxygen;   Drug: No Hyperbaric Oxygen
Outcome Measures: Working Memory;   Neurobehavioral Symptom Inventory (NSI);   Wechsler Abbreviated Scale of Intelligence II (WASI-II);   Wechsler Memory Scale-IV (WMS-IV;   Rey Auditory Verbal Learning Test (RAVLT);   Benton Visual Retention Test with Alternate Forms (Benton VRT);   Stroop Color-Word Interference Test;   Controlled Oral Word Association Test, Letters F, A, and S (COWAT-FAS);   Category Fluency Test (Animal);   Automated Neuropsychological Assessment Metrics-4 (ANAM-4);   Pittsburgh Sleep Quality Index (PSQI);   Quality of Life After Brain Injury (QOLIBRI)
15 Unknown  Using a Closed-loop System for Oxygen Delivery (FreeO2) to Optimize Oxygentherapy in Patients With COPD Exacerbation
Condition: COPD Exacerbation
Interventions: Device: Automated settings on the Oxygen delivery device;   Device: Manual settings with FreeO2 system in collection mode
Outcome Measures: Possibility to use a new closed-loop system for Oxygen delivery in common practice;   Time of Oxygen weaning between common Oxygen delivery and closed-loop automatic titration of Oxygen flow based on SpO2.;   Percentage of time with desaturation during the Oxygentherapy;   Percentage of time with hyperoxia during the Oxygentherapy
16 Recruiting Closed-loop System for Oxygen Delivery and Exercise in Chronic Obstructive Pulmonary Disease
Conditions: COPD;   Oxygen Therapy;   Hypercapnia
Interventions: Device: Automated settings on the Oxygen delivery device;   Device: Manual settings with FreeO2 system in collection mode
Outcome Measures: Change in Endurance time;   Change in Dyspnea during ESWT;   Change in Muscle fatigue during ESWT;   Change in Respiratory frequency during ESWT;   Change in PaCO2 during ESWT;   Hypercapnia level at baseline;   Change in Cardiac frequency during ESWT;   Change in SpO2 during ESWT
17 Recruiting Study of High-flow Oxygen Therapy Against Standard Therapy in Bronchiolitis
Condition: Bronchiolitis
Interventions: Procedure: High Flow Nasal Cannula Oxygen Therapy;   Other: Standard low flow Oxygen
Outcome Measures: Length of hospital stay;   Admission to Intensive Care Unit;   Work of breathing
18 Recruiting Evaluation of Safety and Efficacy of Shorttime TNI Treatment in Patients With COPD
Condition: Oxygen Inhalation Therapy
Interventions: Device: Nasal Oxygen insufflation with a TNI 20 oxy device;   Device: Standard Nasal Insufflation of Oxygen
Outcome Measures: PaO2;   O2 %;   PaCO2;   AaDO2;   RV and TLC
19 Recruiting Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep
Condition: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: Drug: Oxygen;   Drug: sham Oxygen (room air)
Outcome Measures: Mean nocturnal Oxygen saturation measured by pulse oximetry;   Apnea/hypopnea index measured by polysomnography;   Apnea/hypopnea index measured by polygraphy;   Subjective sleep quality visual analog scale score;   Psychomotor vigilance test reaction time;   Severe hypoxemia
20 Unknown  Effect of Establishing Functional Residual Capacity During Newborn Resuscitation on Oxygenation
Condition: Transition at Birth
Interventions: Other: continuous positive airway pressure;   Other: Free flow Oxygen
Outcome Measures: The primary outcome measure is the proportion of infants achieving a stable Oxygen saturation of ≥80%. To be considered stable, the Oxygen saturation must remain at or above the predetermined target saturation for at least 30 seconds.;   The secondary outcome measure is the proportion of infants achieving a stable Oxygen saturation of ≥90%.