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Polyarthritis and Ebetrexat

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Polyarthritis Symptoms and Causes

Juvenile arthritis (JA) is arthritis that happens in children. It causes joint swelling, pain, stiffness, and loss of motion. It can affect any joint, but is more common in the knees, hands, and feet. In some cases it can affect internal organs as well.

The most common type of JA that children get is juvenile idiopathic arthritis. There are several other forms of arthritis affecting children.

One early sign of JA may be limping in the morning. Symptoms can come and go. Some children have just one or two flare-ups. Others have symptoms that never go away. JA can cause growth problems and eye inflammation in some children.

No one knows exactly what causes JA. Most types are autoimmune disorders. This means that your immune system, which normally helps your body fight infection, attacks your body's own tissues.

JA can be hard to diagnose. Your health care provider may do a physical exam, lab tests, and x-rays. A team of providers usually treats JA. Medicines and physical therapy can help maintain movement and reduce swelling and pain. They may also help prevent and treat complications.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

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Recent Reviews

Polyarthritis Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Prognostic Evaluation of Inflammatory Polyarthritis of Recent Onset(EUPA)
Conditions: Rheumatoid Arthritis;   Inflammatory Arthritis
Intervention:
Outcome Measures: Role of anti-Sa antibodies as predictor of severe outcomes;   Role of psychosocial determinants as predictors of severe outcomes
2 Not yet recruiting VACcination In Methotrexate Treated Rheumatoid Arthritis Patients
Condition: Rheumatoid Arthritis
Interventions: Biological: Prevenar 13;   Biological: Pneumo23;   Drug: Methotrexate
Outcome Measures: rate of immunological positive answer 1 month after antipneumococcal vaccination by the conjugated vaccine Prevenar13 ® in patients suffering from rheumatoid Polyarthritis.;   Number of patients in each group who will know fully immunological answer to 5 interest serotypes after the first antipneumococcal vaccination (Prevenar13);   Number of patients in each group who will know an immunological answer to 13 serotypes after the first antipneumococcal vaccination (Prevenar13);   Number of patients who will know a fully immunological answer (13 serotypes of vaccine) after a antipneumococcal revaccination with Pneumo 23.;   Number of patients who will suffer from adverse events in relation with the antipneumococcal vaccination;   Frequency of occurence of disease spurts from the first vaccination until the end of the study;   occurence of the pneumococcal disease from the first vaccination to the end of the study.
3 Unknown  Targeting Synovitis in Early Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis;   Polyarthritis
Interventions: Other: Musculoskeletal Ultrasound;   Other: 28 Joint Disease Activity Score
Outcome Measures: MRI RAMRIS Erosion Score;   44 Joint Disease Activity Score;   Plain Xray - Hands and Feet - modified Sharp score;   Health Assessment Questionnaire;   Euro-Qol 5D;   EULAR response and remission rates;   Biomarker analysis - correlation between baseline values and 18 month radiological outcomes;   Adverse event rates
4 Recruiting Zimmer POLAR - Total Knee Arthroplasty (TKA)
Conditions: Osteoarthritis,;   Rheumatoid Arthritis,;   Traumatic Arthritis,;   Polyarthritis
Intervention: Device: Zimmer Persona Total Knee System
Outcome Measures: Knee Society Scores;   EQ-5D
5 Recruiting Rituximab in Systemic Sclerosis
Condition: Systemic Sclerosis
Interventions: Drug: Rituximab;   Drug: Placebo (NaCl)
Outcome Measures: Number of tender and swollen joints;   Quality of life: SSc-HAQ;   Scleroderma;   Lung fibrosis;   Quality of life: SF-36;   Quality of life: Duruöz index
6 Unknown  Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo
Condition: Polyarthritis
Interventions: Drug: Methotrexate;   Drug: Placebo
Outcome Measures: pain assessed with EVA;   Quality of life survey : SF-36
7 Unknown  Italian Registry of Arthritis on Biologic Therapy
Condition: Rheumatoid Arthritis
Intervention:
Outcome Measure:
8 Recruiting Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
Intervention:
Outcome Measure:
9 Unknown  High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms
Conditions: Abnormality;   Inflammation;   Rheumatism
Intervention: Other: high-field MRI (3 Teslas)
Outcome Measures: can be obtained, one could expect an early detection of joint abnormalities;   will be to develop a quantitative analyse of the corresponding high-resolution images.