Polio is an infectious disease caused by a virus. The virus lives in an infected person's throat and intestines. It is most often spread by contact with the stool of an infected person. You can also get it from droplets if an infected person sneezes or coughs. It can contaminate food and water if people do not wash their hands.
Most people have no symptoms. If you have symptoms, they may include fever, fatigue, nausea, headache, flu-like symptoms, stiff neck and back, and pain in the limbs. A few people will become paralyzed. There is no treatment to reverse the paralysis of polio.
Some people who've had polio develop Post-polio syndrome (PPS) years later. Symptoms include tiredness, new muscle weakness, and muscle and joint pain. There is no way to prevent or cure PPS.
The polio vaccine has wiped out polio in the United States and most other countries.
Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Procedure: no distractor control group; Procedure: visual and sound attentional distractors; Procedure: sound attentional distractor alone; Procedure: additional cognitive task
The main goal of the present project is to investigate the contribution of attentional processes in Postural control and locomotion of CP children as compared to control healthy children.; Without attentional distractor and without additional cognitive task (control condition); With visual and sound attentional distractors (video film).; With sound attentional distractor alone (sound track of the video film).; With an additional cognitive task (adapted Stroop task with animals).
reaction time of limits of stability test; one-leg-stance time; pull test; fall rate; movement velocity of limit of stability test; end point excursion of limits of stability test; Unified Parkinson`s Disease rating scale- motor examination subscale; Gait velocity; Stride length; Cadence
Drug: Losartan; Drug: Ascorbic Acid (Vitamin C); Drug: Normal Saline
Orthostatic tolerance measured by the heart rate and blood pressure response to upright tilt; Sympathetic activation and blood flow measured by sympathetic nerve recordings and Doppler blood flow in the leg
Radiation: Total Blood Volume; Procedure: Exercise Capacity Test - Bicycle; Procedure: Posture Study
Urinary sodium; Urinary dopamine; Blood Volume; Change in Heart Rate with Standing; Orthostatic Symptoms; Change in Urinary Sodium following Change in Dietary Sodium; Change in Urinary Dopamine following Change in Dietary Sodium
Immediate Postural control with tape on ankle.; Subjective evaluation of the effect of taping on pain; Subjective evaluation of the effect of taping on difficulty level.; Subject evaluation of the effect of taping on instability feelings.
Relative contributions of vestibular and visual information to Postural control in PSP; Postural Response Latencies; Gait patterns and Postural transitions; Perception of vertical and horizontal references