Rectal and Fluorouracil


Rectal Symptoms and Causes

The rectum is the lower part of your large intestine where your body stores stool. Problems with rectum are common. They include hemorrhoids, abscesses, incontinence and cancer.

Many people are embarrassed to talk about Rectal troubles. But seeing your doctor about problems in this area is important. This is especially true if you have pain or bleeding. Treatments vary depending on the particular problem.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

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rectal treatment research studies

Fluorouracil clinical trials, surveys and public health registries

Find Drug Side Effect reports

Fluorouracil Side Effects

Diarrhoea (463)
Nausea (335)
Dehydration (273)
Vomiting (266)
Neutropenia (243)
Febrile Neutropenia (207)
Pyrexia (187)
Mucosal Inflammation (179)
Asthenia (158)
Abdominal Pain (152)
Stomatitis (143)
Fatigue (134)
Dyspnoea (131)
Interstitial Lung Disease (117)
Decreased Appetite (116)
Pulmonary Embolism (111)
Chest Pain (110)
Anaemia (106)
Thrombocytopenia (106)
Hypotension (106)
Neutrophil Count Decreased (99)
Hypokalaemia (95)
Leukopenia (83)
Sepsis (78)
White Blood Cell Count Decreased (78)
Renal Failure Acute (75)
Pneumonia (75)
Malaise (74)
Haemoglobin Decreased (72)
Neuropathy Peripheral (69)
Pain (69)
Renal Failure (64)
Disease Progression (64)
Respiratory Failure (62)
Cardiotoxicity (62)
Dysphagia (61)
Confusional State (57)
Platelet Count Decreased (57)
Pancytopenia (55)
Fall (55)
Deep Vein Thrombosis (54)
Myocardial Infarction (53)
Arteriospasm Coronary (51)
Hyponatraemia (51)
Weight Decreased (51)
Tachycardia (48)
Chills (46)
Dizziness (46)
Septic Shock (46)
Hyperammonaemia (46)

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Cipro (8580)
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Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
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Medrol (650)
Mirena (41254)
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Recent Reviews

Why do doctors keep the availabilty of the test for DPD deficiency a secret??? My sister is a doctor, infectious disease, at St Francis in Charleston, SC. Our father was treated by an oncologist well known to my sister, a 'colleague' you might s

I feel like I have to have a bowel movement and very little comes out

Its not 1%---more like 14% and that may even be a conservative estimate--Your doctor is lieing to you--surprised???

My fiancee passed away on 3/7/2011 after her second round of 5FU. The oncologist had used the words 'surprised' and 'out of the ordinary' on her reaction to the first round because of the amount and severity of her side effects. H

After 14 days on 50 mg/day Casodex (plus Lupron) I experienced rectal bleeding . Again on day 16 and day 23. It was minor in all three cases. Stopped taking 81mg aspirin on day15.Have stopped Casodex and will review in 2 weeks.The literature says thi

Bone pain, stomach pain, muscle pain, hip and joint pain, rectal sphincter pain, quit taking August 2009, still having pain as of May 2010

Frequent urge to urinate with abdominal cramping, coupled with extreme gas and digestive pain, bloating of abdomen, rectaldiscomfort... this after 3rd week of Avodart use... particularly severe after lying down for any extended time... Fati

Have GERD and am having abdominal pain and some rectal bleeding. Have been taking 2 a day...Citracal Calcium + D Plus Bond Density Builder with Genistein. Am taking mediation for GERD.

I am pharmacist and my father in law developed the rectal bleed and wanted to see if others had similar problem. thanks for sharing with me as this is very helpful in me couseling my patients on this new med. He was on coumadin with no problem but ha

I had severe bladder infection (with blood in urine) and was on 500 mg twice a day for over two wks. I then had rectal/colon bleed (maroon lumps) and was hospitalized for four days. While in hospital I was given intravenous cipro

I have just finished a 28 day course of Xeloda with radiation therapy for high rectal tumor. 5 days on, two days off. Cruised thru with no problems. However, I have now developed a sudden and severe ulcerative dermatitis of my glans penis. Any though

I took one pill and a few hours later I get severe stomach cramps (which I expected). Later I start seeing rectal bleeding, not severe but little clots every once and a while. I become nauseous and I feel my heart rate slow down. I become light heade

I'm three months post -op rectal surgery. Took two dulcolax tablets,which worked on me,howeverthree hours I'm experiencing anal pain to the point of taking 15mg oxycodone to subdue the effects.

Looking for medications for Rectal Pain that work and that don't require multiple prescriptions that work and sometimes don't work. I know this isn't an exact science so it does take time. Tired of living in my current existence. Would like to sta

Rectal Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Rectal BOOST Study
Condition: Rectal Cancer (Locally Advanced)
Intervention: Radiation: Boost
Outcome Measures: pathological complete response rate;   Acute toxicity in common toxicity criteria for adverse events (CTCAE).;   Patient reported quality of life;   Tumor response on Magnetic resonance imaging (MRI);   Patient reported workability;   Surgical complication;   (disease-free) survival
2 Recruiting Randomized Trial on Robotic Assisted Resection for Rectal Cancer
Conditions: Rectal Cancer;   Adenocarcinoma
Interventions: Procedure: robotic assisted Rectal resection;   Procedure: laparoscopic Rectal resection
Outcome Measures: Bladder function;   tumor status;   Quality of life
3 Recruiting Observation Versus Surgical Resection in Patients With Rectal Cancer Who Achieved Complete Clinical Response After Neoadjuvant Chemoradiotherapy
Condition: Rectal Cancer
Interventions: Procedure: Rectal resection;   Other: Observation
Outcome Measures: Disease-free survival (DFS);   Operative complication rate
4 Recruiting The Value of Botox-A for Management of Low Anterior Resection Syndrome
Conditions: Low Anterior Resection Syndrome;   Rectal Cancer
Intervention: Drug: intra-Rectal Botulinum toxin A injection
Outcome Measures: Efficacy of intra-Rectal Botox-A injection on anoRectal function as documented with standardized Wexner score;   Efficacy of intra-Rectal Botox-A injection on anoRectal function as documented with a visual scale for tenesmus and completeness of stool evacuation;   Efficacy of intra-Rectal Botox-A injection on quality of life as documented with EORTC-QlQ standardized questionnaires;   Efficacy of intra-Rectal Botox-A injection as documented with a patient medicine calender;   Efficacy of intra-Rectal Botox-A injection on anoRectal function as documented with standardized anoRectal manometry readings;   Long term efficacy of intra-Rectal Botox-A injection on anoRectal function as documented with Wexner score, EORTC-QLQ questionnaire and visual scale;   Safety of intra-Rectal Botox-A injections as documented with adverse events monitoring
5 Recruiting Endoluminal and Needlescopic Assisted Repair of Rectal Prolapse With Abdominal Fixation Under Sedation and Local Anesthesia
Condition: Rectal Prolapse
Intervention: Procedure: endoluminal Rectal prolapse repair under sedation and local anesthesia
Outcome Measure: Rectal prolapse recurrence
6 Recruiting Quality of Life in Rectal Cancer - a Prospective Multicenter Cohort Study
Conditions: Rectal Cancer;   Quality of Life;   Surgery
Outcome Measures: To describe QoL, symptoms and functional impairments in an unselected population of Rectal cancer patients;   To explore potential differences in QoL, symptoms and functional impairments between subgroups of the population;   To identify symptoms and functional impairments and other risk factors that have great impact on QoL;   To identify patient and environmental factors with an impact on QoL;   To analyse how clinical factors like oncologic result of operation, morbidity, recurrence and survival influence QoL;   To initiate interventional studies when appropriate;   To generate basic descriptive data of the Rectal cancer patient population: demography, socioeconomic data, disease stage at diagnosis, fashion of treatment, recurrence, survival;   To analyse health economy aspects of QoL and morbidity in the patient population;   To explore the presence and impact of intrusive thoughts on QoL;   QoL in an unselected population of Rectal cancer patients
7 Recruiting Drainage After Rectal Excision for Rectal Cancer
Conditions: Rectal Cancer Surgery;   Randomized Clinical Trial;   Multicenter Study;   Pelvic Drainage
Interventions: Procedure: Laying and management of the drain (strictly randomized arm with drainage);   Procedure: No pelvic drainage
Outcome Measures: Pelvic sepsis;   Overall sepsis;   Peri-operative mortality;   Surgical morbidity according to Dindo classification;   Re-surgery during the hospitalization;   Rate of closure of stoma
8 Recruiting Quality of Life (QOL) Following Surgical Treatment for Rectal Cancer
Condition: Rectal Cancer
Intervention: Behavioral: Questionnaires
Outcome Measure: Health state Utilities Among Patients with Rectal Cancer
9 Recruiting Low Rectal Cancer Study (MERCURY II)
Conditions: Adenocarcinoma;   Adenocarcinoma, Mucinous;   Carcinoma;   Neoplasms, Glandular and Epithelial;   Neoplasms by Histologic Type;   Neoplasms;   Neoplasms, Cystic, Mucinous, and Serous;   ColoRectal Neoplasms;   Intestinal Neoplasms;   Gastrointestinal Neoplasms;   Digestive System Neoplasms;   Neoplasms by Site;   Digestive System Diseases;   Gastrointestinal Diseases;   Intestinal Diseases;   Rectal Diseases
Outcome Measures: To assess the rate of CRM positivity rate in low Rectal cancer.;   To compare global quality of life at two years post surgery in patients according to plane of surgery with or without sphincter preservation.;   To compare patient reported outcomes in patients according to plane of surgery with or without sphincter preservation.;   Analysis of the clinical and radiological factors influencing the decision by surgeons to carry out Anterior Resections, APE or extralevator APE.;   Comparison of time to local recurrence, disease-free and overall survival between patients undergoing different types of surgery.;   Comparison of imaging and pathology staging assessment, patient characteristics and complication rates, between different types of surgery and surgical approaches.;   Investigation of potential associations between imaging and pathology assessment of radial and distal margins, neo-adjuvant chemoradiotherapy, perineal complications and sphincter preservation rates.;   Investigation of potential association between length of operation with number of complications and length of post-operative ITU/HDU stay.
10 Recruiting Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer
Conditions: Recurrent Rectal Cancer;   Stage IIA Rectal Cancer;   Stage IIB Rectal Cancer;   Stage IIC Rectal Cancer;   Stage IIIA Rectal Cancer;   Stage IIIB Rectal Cancer;   Stage IIIC Rectal Cancer
Interventions: Drug: trametinib;   Drug: fluorouracil;   Radiation: radiation therapy
Outcome Measures: Identify the maximally tolerated dose of Trametinib to be used in combination with 5FU and radiation in patients with Rectal cancers.;   Frequency of dose-limiting toxicities, assessed according to the NCI CTCAE version 4;   Local failure rate;   Progression free survival;   Overall survival;   Pathological response rate, defined as extent of tumor in the resected specimen that is classified by tumor, lymph node, metastasis (TNM) staging of the AJCC/International Union Against Cancer (UICC);   Frequency of patients undergoing sphincter preserving surgery
11 Recruiting RObotic Versus LAparoscopic Resection for Rectal Cancer
Condition: Rectal Cancer
Intervention: Procedure: Surgical Resection of the ColoRectal Cancer
Outcome Measures: End of Conversion to Open Surgery;   Oncological Efficacy
12 Unknown  Clinical Outcome After Close Rectal Ileo Pouch Anal Anastomosis for Colitis Ulcerosa(CU)
Condition: Ulcerative Colitis
Intervention: Procedure: Close Rectal Dissection - IPAA
Outcome Measures: To determine the clinical outcome (functional outcome and morbidity) after CR-IPAA compared to C-IPAA and INRA and to compare quality of life in these three different groups.;   Secondary objectives are the inflammatory responses (pouchitis), ano-Rectal function, meso-Rectal development on MRI, endoscopy results and histopathology.
13 Unknown  Safety, Tolerability, Biomarker and Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis
Conditions: Left-Sided Ulcerative Colitis;   Proctosigmoiditis
Interventions: Drug: PUR 0110 Rectal Enema 250 mg;   Drug: PUR 0110 Rectal Enema 500 mg;   Drug: PUR 0110 Rectal Enema 1000 mg;   Drug: Placebo Enema
Outcome Measure: Incidence, nature and severity of adverse events and abnormal clinical laboratory test results
14 Not yet recruiting Side-to-end Anastomosis Versus Colon J Pouch for Reconstruction After Low Anterior Resection for Rectal Cancer (SAVE)
Condition: Rectal Cancer
Interventions: Procedure: side-to-end anastomosis;   Procedure: colon j pouch
Outcome Measures: Side-to-end anastomosis is not inferior not colon J pouch in terms of fecal incontinence. fecal incontinence (Wexner score);   anoRectal function;   quality of life;   postoperative complications;   sexual function;   urinary function;   operation time;   institutional costs;   local recurrence;   cancer related deaths
15 Recruiting Optimal Surgery and MRI Based Radiochemotherapy in Rectal Carcinoma
Conditions: Rectal Cancer Stage II;   Rectal Cancer Stage III
Intervention: Procedure: total mesoRectal excision
Outcome Measures: Locoregional recurrence rate;   Rate of involvement of circumferential resection margin (pCRM positive of resected specimens
16 Recruiting Immunoscore in Rectal Cancer
Conditions: Cancer of the Rectum;   Neoplasms, Rectal;   Rectal Cancer;   Rectal Tumors;   Rectal Adenocarcinoma
Interventions: Procedure: Diagnostic Biopsy and Surgical Procedure;   Procedure: Intravoxel incoherent motion MRI (IVIM);   Procedure: Dynamic Contrast Enhanced MRI (DCE-MRI);   Genetic: RNA gene expression analysis
Outcome Measure: Correlation of the number of infiltrating leukocytes within a biopsy sample with pathologic response
17 Unknown  Study of Unsutured Versus Sutured Closure of Rectal Defects After Rectal Lesion Excisions Using Transanal Endoscopic Microsurgery
Conditions: Post-operative Pain;   Complications
Interventions: Procedure: Defect Unsutured;   Procedure: Defect Sutured
Outcome Measures: Postoperative Pain;   Complications
18 Recruiting Detection and Enumeration of Circulating Tumor Cells in Rectal Cancer
Condition: Rectal Cancer
Interventions: Radiation: radiation therapy;   Drug: capecitabine (625mg/m2,bid,d1-5 qw)and oxaliplatin (85mg/m2 d1 qw)
Outcome Measures: circulating tumor cells level changes after radiotherapy;   overall survival;   disease-free survival;   serum carcinoembryonic antigen (CEA) level;   pathological response (tumor regression grade)if surgery;   RECIST-based tumor response at 10 week after radiotherapy
19 Recruiting A Comparative Effectiveness Study Between Two Methods of Reconstruction of Pelvic Floor After Rectal Excision in Advanced Rectal Cancer
Conditions: Rectal Cancer;   Defect of Floor of Lesser Pelvis
Interventions: Procedure: Reconstruction of floor of lesser pelvis with an acellular porcine collagen implant;   Procedure: Reconstruction of floor of lesser pelvis with a gluteus maximus flap
Outcome Measures: Performance in Timed-Stands Test;   Change in physical performance;   Primary wound healing assessed with the Southampton Wound Assessment Scale;   Complications according to classification by Dindo-Clavien;   Proportion of persistent perineal sinus or fistula;   Ability to sit;   Change of pain and discomfort in gluteal region measured with VAS;   Change of quality of life measured with EQ-5D and EORTC forms C30 and CR29;   Quality of life spot measures;   Length of hospital stay, costs of surgical treatments and QALYs gained
20 Recruiting A Randomized Controlled Clinical Trial Comparing Oncological Results and Functional Recovery Between Laparoscopic and Open Method for the Treatment of Advanced Rectal Cancer After Concurrent Chemoradiation Therapy (CCRT)
Condition: Rectal Cancer
Interventions: Procedure: Laparoscopic surgery;   Procedure: Traditional open surgery
Outcome Measures: Oncologic Results;   Functional recovery of patients