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Squamous cell carcinoma of the oral cavity and Fluorouracil

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Squamous Cell Carcinoma Of The Oral Cavity Symptoms and Causes

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Fluorouracil Side Effects

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Recent Reviews

Why do doctors keep the availabilty of the test for DPD deficiency a secret??? My sister is a doctor, infectious disease, at St Francis in Charleston, SC. Our father was treated by an oncologist well known to my sister, a 'colleague' you might s

Its not 1%---more like 14% and that may even be a conservative estimate--Your doctor is lieing to you--surprised???

My fiancee passed away on 3/7/2011 after her second round of 5FU. The oncologist had used the words 'surprised' and 'out of the ordinary' on her reaction to the first round because of the amount and severity of her side effects. H

<b><span style='font-weight: normal;'><b>After 6 weeks of oral lamisil I experienced</b>eczema, muscle weakness, asthma, bloody bowels, lower abdominal pain, dizziness, extreme f

<span style='text-decoration: underline; text-underline: single;'>How it stop you getting haemophilia<span style='mso-spacerun: yes;'> or sickle cell?

48 years of age. I was diagnosed with urinary tract infection. Had one dose of monuril 3 gr. After 7 hours developed skin rash on the back, arms and neck, generally swelling of the face, specially below the eyes, Had oral antihistamine and went to

im 39 years old & i just want to know if it is still ok for me to take contraceptive oral pills?

&amp;gt;:o I was given Narcan in the recovery room by the PA. I went from 0-60 in pain and came up screaming after having a 90% rotator cuff tear fixed. It took them 20 minutes to get me oral medicine as well as a med pump before the pain was br

<strong></strong>Do you think that the sickle-cell trait will continue to be present in high percentages in future descendants of African slaves? If so, why? If not, why not? In other words, a sim

1200mg first month was fine no problems, after that i was negative and feelin fine. then things started to get worst because my red and white blood cell started to fall, plus platletes and hemegloben. I have 48 days to go It's rough but a lot better

A few months back while I was still brushing with Sensodyne Pronamel, I developed a cavity (toothache) I believe that the toothpaste pushed this infection back up into my cheek. I was told by an Oral surgeon that the infection was heading towards my

After a urinalisis the doctor told me there were no white blood cells, only red blood cells in urine. drew blood and had cat scan and revealed a 7mm kidney stone. but i'm worried about having no white blood cell count in my urine

After having extraction carrying on using colgate ever since I have dry lips dry mouth. Burning in face I have changed to oral b 2 days now does seem less not sure if it will heal also dentist keeps complianing at me she thinks I have an infection my

Squamous Cell Carcinoma Of The Oral Cavity Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Random P2 Study of Postoperative Interferon/Fluorouracil vs Low-dose Cisplatin/Fluorouracil for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus.
Condition: Hepatocellular Carcinoma
Interventions: Drug: Interferon Alfa、Fluorouracil;   Drug: Cisplatin、Fluorouracil
Outcome Measures: Two-year overall survival rate;   Progression free survival time;   Overall survival time;   toxicity
2 Recruiting Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer
Conditions: Recurrent Rectal Cancer;   Stage IIA Rectal Cancer;   Stage IIB Rectal Cancer;   Stage IIC Rectal Cancer;   Stage IIIA Rectal Cancer;   Stage IIIB Rectal Cancer;   Stage IIIC Rectal Cancer
Interventions: Drug: trametinib;   Drug: Fluorouracil;   Radiation: radiation therapy
Outcome Measures: Identify the maximally tolerated dose of Trametinib to be used in combination with 5FU and radiation in patients with rectal cancers.;   Frequency of dose-limiting toxicities, assessed according to the NCI CTCAE version 4;   Local failure rate;   Progression free survival;   Overall survival;   Pathological response rate, defined as extent of tumor in the resected specimen that is classified by tumor, lymph node, metastasis (TNM) staging of the AJCC/International Union Against Cancer (UICC);   Frequency of patients undergoing sphincter preserving surgery
3 Unknown  Pralatrexate and Fluorouracil in Treating Patients With Recurrent Solid Tumors
Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: pralatrexate;   Drug: Fluorouracil;   Other: laboratory biomarker analysis;   Genetic: DNA analysis;   Other: high performance liquid chromatography;   Genetic: polymerase chain reaction;   Genetic: nucleic acid sequencing;   Other: pharmacological study;   Other: pharmacogenomic studies;   Genetic: polymorphism analysis
Outcome Measures: Recommended dose of PDX given in combination with a fixed dose of 5-FU administered as a 48-hour infusion given every other week;   Clinical response to therapy in subjects with measurable disease and time to disease progression in all subjects;   Toxicity profile of the combination of PDX and 5-FU;   Pharmacokinetics of PDX and 5-FU and correlate with clinical toxicity;   Polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and correlate with clinical toxicity
4 Recruiting Pre-operative 5-Fluorouracil (5-FU) and Sorafenib With External Radiation in Locally Advanced Rectal Cancer
Condition: Rectal Cancer
Interventions: Drug: Sorafenib;   Drug: 5-Fluorouracil (5-FU);   Radiation: Radiation
Outcome Measures: Maximum Tolerated Dose (MTD);   Number of Participants With Pathologic Response;   Number of Participants With Serious Adverse Events (SAEs)
5 Recruiting A Phase III Study of Comparing Paclitaxel Plus 5-Fluorouracil Versus Cisplatin Plus 5-Fluorouracil in Chemoradiotherapy for Locally Advanced Esophageal Carcinoma
Condition: Esophageal Squamous Cell Carcinoma
Interventions: Drug: Paclitaxel plus 5-Fluorouracil;   Drug: Cisplatin plus 5-Fluorouracil;   Radiation: Radiation therapy
Outcome Measures: 1-yr overall survivals;   2-yr overall survival;   3-yr overall survival;   Disease progression-free survival;   Local progression-free survival;   Number and grade of Participants with Adverse Events
6 Recruiting Modified Folinic Acid-Fluorouracil-Oxaliplatin Regimen + Capecitabine for Elderly With Metastatic Gastric Cancer
Condition: Metastatic Gastric Cancer
Interventions: Drug: folinic acid+Fluorouracil+oxaliplatin;   Drug: Capecitabine
Outcome Measures: progression-free survival;   PFS on capecitabine maintenance;   overall survival;   number of patients with adverse events;   tolerability;   time to treatment failure;   Quality of life
7 Recruiting Induction Therapy-Docetaxel, Cisplatin and Fluorouracil in Untreated Advanced Squamous Cell or Undifferentiated Carcinoma of the Paranasal Sinuses
Conditions: Paranasal Sinus Neoplasms;   Squamous Cell Carcinoma
Interventions: Drug: Docetaxel;   Drug: 5-Fluorouracil;   Drug: Cisplatin
Outcome Measure: Number of Patients with Complete + Partial Response
8 Recruiting Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer
Condition: Second Line Metastatic Pancreatic Adenocarcinoma
Interventions: Drug: Glufosfamide;   Drug: Fluorouracil
Outcome Measure: Overall Survival
9 Not yet recruiting Imiquimod, Fluorouracil, or Observation in Treating Patients With High-Grade Anal Squamous Skin Lesions Who Are HIV-Positive
Conditions: Anal Intraepithelial Neoplasia;   High-grade Squamous Intraepithelial Lesion;   HIV Infection
Interventions: Drug: imiquimod;   Drug: Fluorouracil;   Other: questionnaire administration;   Other: laboratory biomarker analysis
Outcome Measures: Proportion of participants achieving complete response (Arm A and B);   Proportion of participants with spontaneous regression (Arm C);   Presence of intra-anal HSIL on cytology or histology;   Incidence of adverse events, graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0;   Proportion of participants achieving complete response or spontaneous regression;   Number of quadrants with HSIL found on biopsies;   Proportion of patients achieving complete or partial responses;   Persistence of HPV type specific infections
10 Recruiting Phase I Study of 5-Fluorouracil in Children and Young Adults With Recurrent Ependymoma
Conditions: Central Nervous System Malignancies;   Ependymoma
Intervention: Drug: 5-Fluorouracil
Outcome Measures: Estimate the maximum tolerated dose determined using the Rolling 6 design using the CTCAEv4 to assess DLT.;   Pharmacokinetic modeling of 5-Fluorouracil concentrations;   Estimate the maximum tolerated dose in less heavily pre-treated children;   Descriptive report of toxicities.;   Tumor response and progression-free survival;   Expression level of TYMS in FFPE tumor samples;   Description of association between genetic polymorphism and pharmacokinetics
11 Recruiting Paclitaxel, Carboplatin and Cetuximab (PCC) Versus Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
Condition: Head and Neck Squamous Cell Carcinoma
Interventions: Drug: Paclitaxel;   Drug: Carboplatin;   Drug: Cetuximab;   Drug: Docetaxel;   Drug: Cisplatin;   Drug: Fluorouracil;   Radiation: Radiotherapy (RT);   Other: Chemotherapy
Outcome Measure: Number of Patients with Progression-free survival (PFS)
12 Recruiting Efficacy Study of Neoadjuvant Chemotherapy With Chemoradiation Therapy for Nasopharyngeal Carcinoma
Conditions: Chemoradiation;   Nasopharyngeal Carcinoma
Interventions: Drug: PF (cisplatin and 5-Fluorouracil) group;   Drug: TPF (docetaxel plus cisplatin and 5-Fluorouracil) group
Outcome Measures: 3-year progress free survival(PFS);   overall survival(OS);   Adverse events;   local control rate (LCR)
13 Recruiting Everolimus, Fluorouracil, Leucovorin, Panitumumab, and Oxaliplatin in Treating Patients With Solid Tumors That Did Not Respond to Treatment
Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Biological: panitumumab;   Drug: everolimus;   Drug: Fluorouracil;   Drug: leucovorin calcium;   Drug: oxaliplatin
Outcome Measures: Maximum tolerated dose of everolimus in combination with sequential Fluorouracil (5-FU) and leucovorin calcium, panitumumab, modified 5-FU, leucovorin calcium, and oxaliplatin (mFOLFOX6), and mFOLFOX6 with panitumumab;   Toxicity as assessed by CTC version 3.0 at the beginning of each treatment course;   Tumor response;   Correlation of response with S6-phosphorylation and AKT-phosphorylation in archived tumor samples
14 Recruiting The Efficacy of 5-Fluorouracil/Mitomycin for the Patients With Pulmonary Metastasis of Hepatocellular Carcinoma
Conditions: Hepatocellular Carcinoma;   Lung Metastasis
Interventions: Drug: 5-Fluorouracil;   Drug: Mitomycin
Outcome Measures: Time-to-progression(TTP)of lung metastasis;   Overall survival;   Response rates(CR + PR)of lung metastasis;   progression free survival;   Time to recurrence of intrahepatic tumor;   Disease control rates (CR + PR + SD)of lung metastasis
15 Recruiting Neoadjuvant FOLFOX6 Chemotherapy With or Without Radiation in Rectal Cancer
Condition: Rectal Cancer
Interventions: Drug: Fluorouracil;   Drug: Fluorouracil, oxaliplatin
Outcome Measures: 3-year disease free survival;   objective response rate,pathologic complete response rate, sphincter-saving surgery rate, biomarkers, quality of life, toxic profile, convenience
16 Recruiting A Trial of Gemcitabine, Infusional 5-Fluorouracil and Cisplatin for Advanced Pancreatic and Biliary Cancers
Conditions: Pancreatic Cancer;   Biliary Cancer
Intervention: Drug: Gemcitabine, 5-FU and Cisplatin
Outcome Measures: Response rate;   Survival
17 Recruiting The Effect of Fluorouracil Implants Regional Chemotherapy During the Surgical Treatment for Early Stage Hepatocellular Carcinoma
Condition: Early Stage Hepatocellular Carcinoma
Interventions: Procedure: Radical resection;   Drug: Fluorouracil Implants
Outcome Measures: To assess the clinical benefit of Fluorouracil implants regional chemotherapy during the radical resection in early stage hepatocellular carcinoma patients. The primary endpoint is disease-free survival (DFS).;   Quality of Life;   Incidence Rate of Complications;   Adverse Events
18 Recruiting Study of Eniluracil + 5-Fluorouracil (5-FU) + Leucovorin Versus Capecitabine in Metastatic Breast Cancer
Condition: Metastatic Breast Cancer
Interventions: Drug: Eniluracil;   Drug: 5-Fluorouracil;   Drug: Leucovorin;   Drug: Capecitabine
Outcome Measures: Progression-free survival;   To compare the tolerability and toxicity of orally administered eniluracil/5 FU/leucovorin regimen vs. capecitabine monotherapy
19 Recruiting PD-0332991, 5-FU, and Oxaliplatin for Advanced Colorectal Cancer
Condition: Colorectal Cancer
Intervention: Drug: PD-0332991, 5-FU, oxaliplatin
Outcome Measures: Recommended Phase 2 dose and schedule;   Toxicity;   Pharmacodynamics;   Response rate;   Disease control rate;   Trough level of PD-0332991 on Day 1 of Cycles 1-4
20 Recruiting Intra-operative Chemotherapy With 5-FU for Colorectal Cancer Patients Receiving Curative Resection: Efficacy and Safety
Condition: Colorectal Cancer
Interventions: Procedure: curative resection for colorectal cancer;   Drug: intra-operative 5-FU chemotherapy
Outcome Measures: disease-free survival;   safety profiles