Systolic hypertension and Nebivolol


Systolic Hypertension Symptoms and Causes

Blood pressure is the force of your blood pushing against the walls of your arteries. Each time your heart beats, it pumps blood into the arteries. Your blood pressure is highest when your heart beats, pumping the blood. This is called systolic pressure. When your heart is at rest, between beats, your blood pressure falls. This is called diastolic pressure.

Your blood pressure reading uses these two numbers. Usually the systolic number comes before or above the diastolic number. A reading of

  • 119/79 or lower is normal blood pressure
  • 140/90 or higher is high blood pressure
  • Between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. Prehypertension means you may end up with high blood pressure, unless you take steps to prevent it.

High blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure.

You can control high blood pressure through healthy lifestyle habits such as exercise and the DASH diet and taking medicines, if needed.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for systolic hypertension

systolic hypertension treatment research studies

Nebivolol clinical trials, surveys and public health registries

Find Drug Side Effect reports

Nebivolol Side Effects

Bradycardia (41)
Hypotension (32)
Malaise (26)
Asthenia (19)
Dizziness (19)
Dyspnoea (19)
Syncope (18)
Fall (17)
Renal Failure Acute (16)
Hyperkalaemia (15)
Fatigue (15)
Orthostatic Hypotension (15)
Diarrhoea (13)
Loss Of Consciousness (13)
Hyponatraemia (12)
Pruritus (11)
Renal Failure (11)
Nausea (11)
Dehydration (10)
Blood Pressure Increased (10)
White Blood Cell Count Increased (10)
Hypertension (10)
Sinus Bradycardia (9)
Hypothyroidism (9)
Thrombocytopenia (9)
Anaemia (9)
Cytolytic Hepatitis (9)
Haemoglobin Decreased (9)
Blood Creatinine Increased (9)
Cardiac Failure (8)
Condition Aggravated (8)
Decreased Appetite (8)
Presyncope (8)
Hepatitis (8)
Headache (8)
Weight Decreased (7)
Disturbance In Attention (7)
Vomiting (7)
Palpitations (7)
Hypokalaemia (7)
Confusional State (7)
Oedema Peripheral (6)
Insomnia (6)
Atrioventricular Block First Degree (6)
Neutropenia (6)
Overdose (6)
Off Label Use (6)
Aspartate Aminotransferase Increased (6)
Arrhythmia (6)
Altered State Of Consciousness (6)

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Recent Reviews

sometI am given so many medication for my heart problem, one of them is Nebivolol new addition.while I was warded. asprin,digoxin,perindopril indapamide,coversyl.frusemide, sprionolactone for water retention Allopurinol for gout.i sometime

Feet and hands feel very hot. they feel as if they are swollen. but do not look it. my lips feel swollen but do not look it.

I am taking 5mg of bystolic. The hot pain in my hands and feet does not feel like the regular P M that I normally get. I am 64 and work out over 2 hours a day.

I got off insulin about a month ago. I do not know how to operate a pc very well. do not know how to use this kind of web site. Is there a doc out there. I have had some funny chest pains

I have been change from my usaual bp table to nebivolol. i am currently taking 2.5mg, the side effects that i am experiencing is feeling very hot, unable to sleep or switch off. mood swings, dont feel hungry, just a sence of loss, unable to motiva

I have sucessfuly been on 2X100mg Lopressor beta blockers daily for 10 years and doctor now suggest 2X5mgs of Nevibolol instead. Is Nevibolol a good substitute? Can I swap safely? Is 10 mg daily equal to 200mg of Lopressor? THANKS BOB

Nebivolol reduce the sex power

Started taking around12-1-09 I am a diabetic. Have P M in feet. I thougtv the pain was from that Help

Have been taking Kliovance for approx 5 years. I am aged 55 years and have been diagnosed with hypertension. I have a sedentary lifestyle, a poor diet, and a stressful job. I have been getting a difference of opinion between 2 doctors. One says th

Have been taking Kliovance for approx 5 years. I am aged 55 years and have been diagnosed with hypertension. I have a sedentary lifestyle, a poor diet, and a stressful job. I have been getting a difference of opinion between 2 doctors. One says that

53 yrs.old, 125 lb. female,otherwise healthy and active person (non-smoker, good fitness level, active, eats healthy food, no underlying health issues)diagnosed with hypertension in Feb./08 Prescribed Marcardis Plus initially for the first 3 mos.

After being discharged from eER I saw in my file that the doppler impression shows mild tricuspid regurgitation and mild pulmonary hypertension =-O scared should I be worried

After taking several famous brands of hypertension meds. Calblock has exceeded expectations. The problem is that I cant find them available in the USA. Does anyone know of a source where they can be ordered online?

Although Karvezide controlled my hypertension, it leaves me with dry mouth and I find it difficult to sleep well during the nights, so my doctor switched me back to Karvea. After switching for 2 days, I already notice the increase in my blood pressu

Amlodpine is a dihydropyridine group Ca channel blocker usually prescribed to controll hypertension (Males) or prinz metal angina (Females) trade names Norvasac Quvasac ..... Ca channels are universally present in our b

As a 58 year old correction officer with hypertension and moderate TAA could restraining an inmate or fight endanger the aneurysm bursting?


Been on Istin 5mg for four years for Hypertension. Ankle swelling left leg mostly but some times right ankle also. Occasional feelings of anxiety. Feet and hands cold by times. Soreness in spinal column especially upper area. General feeling of out o

Systolic Hypertension Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Comparative Effects of Nebivolol and Metoprolol on Femal Sexual Function
Conditions: Hypertension;   Female Sexual Dysfunction
Interventions: Drug: Nebivolol and metoprolol succinate;   Drug: metoprolol succinate and Nebivolol
Outcome Measures: Change in FSF and CSFQ, two validated questionnaires for assessment of sexual function.;   The effects of Nebivolol and metoprolol on sexual function and to compare the effects of both drugs on vitality, work and life performance, and work and life satisfaction.
2 Unknown  Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients
Condition: Marfan Syndrome
Interventions: Drug: Losartan and Nebivolol;   Drug: Losartan;   Drug: Nebivolol
Outcome Measures: BSA and age-adjusted aortic root diameter (sinuses of Valsalva);   The pharmacokinetics of the two drugs by age and dosages;   Comparative evaluation of the serum levels of total and active TGFb;   Quantitative assessment of the expression of the mutated gene (FBN1, both 5' and 3');   Pharmacogenetic bases of drug responsiveness (Losartan: CYP2C9 gene) (Nebivolol: CYP2D6 gene);   Aortic valve regurgitation severity;   Left ventricular end-diastolic diameter;   Left ventricular ejection fraction;   Spirometric lung volumes and flows;   QoL evaluation basing on SF-36 questionnaire;   Arterial stiffness (carotids)
3 Unknown  Comparative Effects of Nebivolol Versus Placebo on Sodium Sensitivity of Blood Pressure in Hispanic Postmenopausal Women With Hypertension
Condition: Hypertension
Interventions: Drug: Nebivolol;   Drug: Nebivolol
Outcome Measures: Change and percentage change in systolic, diastolic and mean blood pressure by ABPM from final day of low sodium to the final day of high sodium in Nebivolol versus placebo;   Differences in renal sodium excretion in response to an acute sodium load during treatment with either Nebivolol or placebo.
4 Recruiting Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
Condition: Hypertension
Interventions: Drug: Metoprolol succinate;   Drug: Nebivolol;   Drug: Hydrochlorothiazide;   Drug: DEFINITY®;   Procedure: Non-invasive measurement of Cardiac Output (CO);   Procedure: Flow mediated vasodilation;   Procedure: Endothelial cell collection;   Procedure: Microvascular perfusion assessment using Definity
Outcome Measures: Endothelial cell protein expression;   Microvascular blood flow;   Flow mediated dilation (FMD)
5 Recruiting Nebivolol Effects on Endothelial Function and Erectile Function
Condition: Erectile Dysfunction
Interventions: Drug: Nebivolol;   Drug: Sugar Pill
Outcome Measures: Primary objective is to determine if treatment with Nebivolol improves endothelial function and erectile function in men with pre-hypertension and stage 1 hypertension. This will be assessed by change in IIEF-5 at baseline, 2 and 3 months;   Change in Endopat score;   Change in SphygmoCor results;   Change in SQOLM score
6 Recruiting Study to Evaluate Effect of Nebivolol on Angina in Women With Microvascular Disease
Condition: Microvascular Angina
Intervention: Drug: Nebivolol
Outcome Measures: Seattle Angina Questionnaire Score;   peak VO2 measured by cardiopulmonary exercise testing;   resource utilization questionnaire;   SF36
7 Recruiting Comparative Study of the Effects of Telmisartan and Nebivolol
Condition: Hypertension
Interventions: Drug: TELMISARTAN;   Drug: Nebivolol
Outcome Measures: Change from baseline in 24h blood pressure;   Change from baseline in arterial stiffness
8 Recruiting A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function
Condition: Hypertension
Interventions: Drug: Nebivolol;   Drug: atenolol;   Drug: placebo
Outcome Measures: Comparing effects of Nebivolol against atenolol and placebo on endothelial function;   Evaluate effects of Nebivolol as compared to atenolol and placebo
9 Unknown  Regression of Myocardial Steatosis by Nebivolol
Condition: Cardiac Steatosis and Lipotoxicity
Intervention: Drug: Nebivolol
Outcome Measures: Myocardial triglyceride content;   Cardiac function;   Regression of concentric cardiac remodeling;   Regression of steatosis in other non-adipocyte tissue;   Regression of subcutaneous fat
10 Recruiting Nebivolol for the Prevention of Left Ventricular Systolic Dysfunction in Patients With Duchenne Muscular Dystrophy
Conditions: Duchenne Muscular Dystrophy;   Cardiomyopathy;   Heart Failure
Interventions: Drug: Nebivolol;   Drug: Placebo
Outcome Measures: Left ventricular systolic dysfunction;   Right ventricular ejection fraction;   NT-ProBNP;   Left ventricular dysfunction;   Hospitalizations;   Mortality
11 Recruiting Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart
Conditions: Hypertension;   Left Ventricular Diastolic Dysfunction
Intervention: Drug: Nebivolol
Outcome Measures: Improvement in exercise tolerance;   E velocity indexed to e' (E/e' ratio) of the left ventricle;   Untwist rate of the left ventricle
12 Not yet recruiting CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients.
Conditions: Hypertension;   Endothelial Dysfunction;   Obstructive Sleep Apnea
Interventions: Drug: Nebivolol;   Device: Continuous positive airway pressure (CPAP)
Outcome Measures: change in mean arterial blood pressure;   change in endothelial function
13 Unknown  Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
Conditions: Prehypertension;   Hypertension
Interventions: Drug: Nebivolol;   Drug: Metoprolol;   Drug: Placebo
Outcome Measure: Changes from baseline in endothelial t-PA release
14 Unknown  Nebivolol and the Endothelin (ET)-1 System
Conditions: Prehypertension;   Hypertension
Interventions: Drug: Nebivolol;   Drug: Metoprolol;   Drug: Placebo
Outcome Measure: ET-1-mediated vasoconstrictor tone
15 Recruiting Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure
Conditions: Peripheral Artery Disease;   Hypertension
Interventions: Drug: Nebivolol;   Drug: Metoprolol succinate
Outcome Measures: Peak Walking Time;   Walking Impairment Questionnaire;   Ankle-brachial index;   markers of inflammation.;   Claudication Onset Time
16 Recruiting Safety Study of Nebivolol for COPD Patients
Condition: High Blood Pressure
Interventions: Drug: Placebo;   Drug: Nebivolol
Outcome Measures: to assess blood pressure control;   to assess pulmonary function tests
17 Unknown  Influence of Nebivolol on Postmenopausal Women
Conditions: Hot Flashes;   Heart Rate;   Blood Pressure;   Endostatin;   Sexual Function
Outcome Measures: Number of hot flashes/palpitations;   Hemodynamic changes;   Sexual function;   Endostatin;   Quality of life
18 Recruiting Nebivolol Versus Sustained Release Metoprolol Succinate in Patients With Chronic Kidney Disease
Condition: Chronic Kidney Disease
Outcome Measures: Primary Efficacy;   Secondary Efficacy
19 Recruiting Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure
Conditions: Pulmonary Hypertension;   Diastolic Heart Failure;   Heart Failure With Preserved Ejection Fraction
Intervention: Drug: Nebivolol
Outcome Measures: Changes in pulmonary vascular pressure;   Changes in 6-minute walk distance
20 Recruiting Treatment of Supine Hypertension in Autonomic Failure
Condition: Hypertension
Interventions: Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: Nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
Outcome Measures: Decrease in supine systolic blood pressure;   Decrease in pressure natriuresis