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Type 2 diabetes mellitus and Amaryl

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Type 2 Diabetes Mellitus Symptoms and Causes

Diabetes means your blood glucose, or blood sugar, levels are too high. With type 2 diabetes, the more common type, your body does not make or use insulin well. Insulin is a hormone that helps glucose get into your cells to give them energy. Without insulin, too much glucose stays in your blood. Over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth.

You have a higher risk of type 2 diabetes if you are older, have obesity, have a family history of diabetes, or do not exercise. Having prediabetes also increases your risk. Prediabetes means that your blood sugar is higher than normal but not high enough to be called diabetes. If you are at risk for type 2 diabetes, you may be able to delay or prevent developing it by making some lifestyle changes.

The symptoms of type 2 diabetes appear slowly. Some people do not notice symptoms at all. The symptoms can include

  • Being very thirsty
  • Urinating often
  • Feeling very hungry or tired
  • Losing weight without trying
  • Having sores that heal slowly
  • Having blurry eyesight

Blood tests can show if you have diabetes. One type of test, the A1C, can also check on how you are managing your diabetes. Many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. Some people also need to take diabetes medicines.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Check out the latest treatments for type 2 diabetes mellitus

type 2 diabetes mellitus treatment research studies

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Amaryl Side Effects

Hypoglycaemia (149)
Hypoglycaemic Coma (74)
Blood Glucose Increased (52)
Hyperglycaemia (41)
Myocardial Infarction (38)
Renal Failure Acute (36)
Loss Of Consciousness (30)
Blood Creatine Phosphokinase Increased (30)
Depressed Level Of Consciousness (29)
Cardiac Failure Congestive (28)
Diarrhoea (28)
Cerebrovascular Accident (28)
Nausea (28)
Fall (28)
Renal Failure (27)
Coronary Artery Disease (27)
Malaise (25)
Cardiac Failure (23)
Dyspnoea (23)
Rhabdomyolysis (23)
Coma (22)
Vomiting (21)
Diabetes Mellitus Inadequate Control (20)
Dizziness (20)
Altered State Of Consciousness (19)
Oedema Peripheral (19)
Glycosylated Haemoglobin Increased (19)
Hypertension (18)
Death (18)
Hyperkalaemia (18)
Confusional State (17)
Blood Creatinine Increased (17)
Asthenia (16)
Fatigue (16)
Pneumonia (16)
Somnolence (16)
Renal Impairment (16)
Hypoglycaemic Encephalopathy (15)
Syncope (15)
Pyrexia (14)
Bladder Cancer (14)
Blood Potassium Increased (14)
Hepatic Function Abnormal (14)
Lactic Acidosis (14)
Cardio-respiratory Arrest (13)
Blood Glucose Decreased (13)
Chest Pain (13)
Weight Decreased (13)
Interstitial Lung Disease (13)
Convulsion (13)

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Zoloft(6792)
Zyrtec(1669)

Recent Reviews

I am a diabetic peson,recently I am seeing this unsual skin rashes all over my body particularly in my stomach and arms, wanted to know is it because of amarly or because of the pumpkin nuts that I am eating. I would highly appreciate a quick reply i

Inadequate control of blood sugar, have to starve myself to get lower blood sugar even on two types of insulin, diarrhoea, dizziness, syncope, dyspnoea, severe malaise, nausea, tremors.

Hello, I was given Azastin or Avastin for macular edema. I also have retinopathy from diabetes. I was given this shot in my eye in April of this yr. Within 2 days, I had cellulitis in both legs. Horrible pain. Dark red all over from my knees to my

Hi! am looking Operational and Installation manual for this type of x-ray machine Summit AmeriComp control console, with power module SHF 310 and other accessories of it. Well! let me give you this control console picture may be you will aware of

I WANT FRIENDS WHO HAVE TYPE 1DIABETIC

sorry type errors if i could do it over i would have never taken this drug if i had only know .. wahtever you do don't just trust your doctor is doing the right thing or even a good thing for you like i did do

My grand father was diagnosed with dementiaalzheimer's type and was prescribed Aricept. After he started taking Aricept, his condition have gotten worse and he actually died yesterday. He was 83 years old.

<span style='color: #808080;'><b>Describe Your Henoch-Schonlein purpura from INFLUENZA (H1N1) (H1N1 (MONOVALENT) SANOFI) 2010 Experience Here:</b> Vicious headaches, rash on legs and trunk, transient, cystitis type fee

After being exposed to bright light my vision field is spotty with bright lights. I have a similar experince when I'm hypoglycemic often my first sympto but this type is unrelated to my BLOOD SUGAR. mY LATEST MEDS ADDED ARE Cardizem for A-fib, coumad

After just 7 days of starting pioglitazone(15 mg.daily) ,I developed loss of taste for mainly sugar and salt,but unfortunatyely i couldnot guess pioglitazone as possible cause. I am type 2 diabetic and hypertensive and taking metformin,glimeperide,li

After taking 500mg of fortamet for two weeks i am having blured vision . i am type 2 diabetic.

Another thing, can a patient with diabetes type 1 and previously suffered and recovered from Multiple sclerosis ( M-S ) use Spasfon ???

Type 2 Diabetes Mellitus Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Efficacy/Safety Study of Glimepiride to Type 2 Diabetes Patients Based on Metformin And Basal Insulin Treatment
Condition: Diabetes Mellitus, Type 2
Interventions: Drug: glimepiride;   Drug: glargine and metformin
Outcome Measures: 24 weeks after treatment, HbA1c values' change compared with baseline;   hypoglycemia events
2 Recruiting Study of the Durability of Glycemic Control With Nateglinide
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Nateglinide;   Drug: Glimepiride
Outcome Measures: The durability of nateglinide in comparison with those of glimepiride based on the withdrawal rate;   1. HbA1c, Fasting blood sugar, 2hours postprandial blood sugar 2. insulin secretion(C-peptide), insulin sensitivity(HOMA-IR), lipid profile
3 Not yet recruiting Phase III Trial to Evaluate the Efficacy and Safety of Gemigliptin 50mg qd Added to Ongoing Glimepiride as Fix-dose Combination in Patients With Type 2 Diabetes
Condition: Type 2 Diabetes Mellitus
Intervention: Drug: Gemigliptin/Glimepiride combination
Outcome Measure: HbA1c Changes
4 Recruiting MK-8835/PF-04971729 vs. Glimepiride in Type 2 Diabetes Mellitus (T2DM) Participants on Metformin (MK-8835-002)
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Ertugliflozin;   Drug: Glimepiride;   Drug: Placebo to Ertugliflozin;   Drug: Placebo to Glimepiride;   Drug: Metformin;   Drug: Sitagliptin
Outcome Measures: Change from Baseline in Hemoglobin A1C at Week 52;   Number of Participants Experiencing An Adverse Event (AE);   Number of Participants Discontinuing Study Treatment Due to an AE;   Number of Participants with an Adverse Event of Symptomatic Hypoglycemia;   Change from Baseline in Body Weight at Week 52;   Change from Baseline in Systolic Blood Pressure at Week 52
5 Recruiting Glycemic Excursions in Type 2 Diabetic Patients With Vildagliptin and Metformin Versus Vildagliptin and Glimepiride
Conditions: Type 2 Diabetes;   Hypoglycemia
Interventions: Drug: vildagliptin and metformin (combination);   Drug: glimepiride;   Drug: Metformin
Outcome Measures: glycemic variability measured by Mean Amplitude of Average Glucose Excursions (MAGE);   glycemic variability measured by Continuous Overlapping Net Glycemic Action (CONGA);   Percentage of patients who achieve a decrease equal to or greater than 0.3% in value of HbA1c at week 12 of treatment in comparison to HbA1c value at screening visit;   Percentage of reduction achieved in the mean HbA1c at week 12 of treatment in comparison to HbA1c at screening visit;   Degree of correlation between MAGE value and hypoglycemia incidence;   percentage of patients with incidence of hypoglycemia;   Glycemic variability measured by Total Standard Deviation (TSD);   Number of patients with adverse events, serious adverse events and death
6 Recruiting Comparison of Vildagliptin vs. Glimepiride on Glucose Variability in Metformin Uncontrolled Type 2 Diabetic Patients
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Vildagliptin;   Drug: Glimepiride;   Drug: Metformin
Outcome Measures: Mean amplitude of glycemic excursions (MAGE) using continuous glucose monitoring system (CGMS);   Percent glycosylated hemoglobin reduction from baseline at 16 weeks;   Time to glycemic control assessed through CGMS;   Percentage of patients reaching the glycemic targets after 16 weeks treatment, in the overall study population;   Number of unrecognized hypoglycemia events recognized by CGMS;   Number of patients with adverse events, serious adverse events and death
7 Recruiting Impact of Sitagliptin on Cardiovascular Exercise Performance in Type 2 Diabetes
Conditions: Type 2 Diabetes;   Cardiovascular Disease
Interventions: Drug: Sitagliptin;   Drug: Glimepiride;   Drug: Placebo
Outcome Measures: One primary outcome will be change in peak oxygen consumption (VO2peak).;   Changes from baseline in 31P measurement: phosphocreatine;   One primary outcome will be oxygen uptake kinetics (VO2 kinetics);   Changes from baseline in 31P measurement: free Pi;   Changes from baseline in 31P measurement: adenosine triphosphate (ATP) peaks;   Changes from baseline in 31P measurement: adenosine diphosphate (ADP);   Changes from baseline in 31P measurement: pH;   Changes from baseline in echocardiographic measures;   Change from baseline in peak dilation of brachial artery diameter;   Change in (non-invasively measured) deoxygenated hemoglobin concentration in the vastus lateralis during exercise
8 Unknown  Effect of Linagliptin in Comparison With Glimepiride as Add on to Metformin on Postprandial Beta Cell Function, Postprandial Metabolism and Oxidative Stress in Patients With Type 2 Diabetes Mellitus
Condition: Diabetes Mellitus Type 2
Interventions: Drug: Linagliptin;   Drug: Glimepiride
Outcome Measures: Postprandial increase in intact Proinsulin levels (Peak, AUC);   Postprandial Proinsulin/Insulin Ratio;   Fasting intact Proinsulin levels;   Fasting Proinsulin/Insulin Ratio;   Fasting Blood Glucose;   Postprandial Blood Glucose Excursions (Peak; AUC);   Fasting Lipids;   Postprandial Lipids;   Fasting Erythrocyte Flexibility;   Postprandial Erythrocyte Flexibility;   Fasting GLP-1 levels;   Postprandial GLP-1 levels;   Fasting cGMP;   Postprandial cGMP;   Fasting Calcitonin;   Fasting PAI-1 levels;   Postprandial PAI-1 levels;   Fasting ADMA levels;   Postprandial ADMA levels;   Fasting Malonyldialdehyd;   fasting oxidatively modified nucleosides 8-oxodG and 8-oxoGuo;   Hypoglycemic events;   Body Weight
9 Recruiting START-J: SiTAgliptin in eldeRly Trial in Japan
Condition: Type 2 Diabetes
Intervention: Drug: Sitagliptin, Glimepiride
Outcome Measures: HbA1c change from baseline as efficacy and incidence of hypoglycaemia as safety;   Comparison between two groups in the following parameters at 52W as well as 24 W as interim analysis
10 Recruiting A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007)
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Ertugliflozin 5 mg;   Drug: Ertugliflozin 15 mg;   Drug: Placebo to Ertugliflozin;   Other: Glimepiride;   Drug: Placebo to Glimepiride;   Biological: Basal Insulin;   Drug: Metformin
Outcome Measures: Change from Baseline in Hemoglobin A1c;   Number of Participants Experiencing An Adverse Event (AE);   Number of Participants Discontinuing Study Treatment Due to an AE;   Change from Baseline in Fasting Plasma Glucose;   Change from Baseline in Body Weight at Week 26;   Number of participants with a HbA1c of <7% (53 mmol/mol) at Week 26;   Change from Baseline in Systolic Blood Pressure;   Change from Baseline in Diastolic Blood Pressure;   Change from Baseline in Bone Mineral Density at Week 26;   Change from Baseline in Bone Mineral Density at Week 52;   Change from Baseline in Bone Mineral Density at Week 104;   Number of participants with HbA1c <=6.5% (48 mmol/mol) at Week 26;   Number of participants requiring glycemic rescue therapy up to Week 26;   Time to glycemic rescue therapy up to Week 26;   Change from baseline in bone biomarkers at Week 26;   Change from baseline in bone biomarkers at Week 52;   Change from baseline in bone biomarkers at Week 104
11 Recruiting Effects of Gemigliptin Versus Sitagliptin or Glimepiride With Metformin on MAGE in Patients With Type 2 DM
Condition: Type 2 Diabetes Mellitus
Intervention: Drug: Gemigliptin + Metformin / Sitagliptin + Metformin / Glimepiride + Metformin
Outcome Measures: Mean Amplitude Glycemic Excursion;   Glucagon;   Active GLP-1;   CRP;   Nitrotyrosine;   Glycated albumin;   Fructosamine
12 Recruiting Effects of Vildagliptine and Glimepiride on Glucose Variability
Condition: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: Drug: Glimepiride;   Drug: Vildagliptin
Outcome Measures: Glycemic variability index;   Cardiovascular disease risk factor;   glucose profile and lipid profile;   hypoglycemic index
13 Recruiting Study of Comparing the Different Effect of DPP-4 Inhibitors and Sulfonylurea by Using "Biphase-Hyperglycemic Clamp"
Condition: Type 2 Diabetes
Interventions: Drug: Sitagliptin;   Drug: Saxagliptin;   Drug: Glimepiride;   Drug: Blank control
Outcome Measures: The acute phase and second phase of insulin secretion and C peptide secretion;   Alpha cell function,GLP-1 response
14 Recruiting Renal Effects of DPP-4 Inhibitor Linagliptin in Type 2 Diabetes
Condition: Type 2 Diabetes
Interventions: Drug: Linagliptin 5 mg QD;   Drug: Glimepiride 1 mg QD
Outcome Measures: Changes from baseline following 8-week treatment with a DPP-4i versus SU derivative on renal hemodynamics, measured as Glomerular Filtration Rate / Effective Renal Plasma Flow (determined by the combined inulin/para-aminohippuric-acid clearance method);   Renal tubular function;   Renal damage, measured by urine biomarkers;   Blood Pressure and Heart Rate
15 Recruiting Liraglutide and Heart Failure in Type 2 Diabetes
Conditions: Congestive Heart Failure;   Type 2 Diabetes Mellitus
Interventions: Drug: liraglutide;   Drug: glimepiride;   Drug: Metformin
Outcome Measures: Left ventricle longitudinal function and/or functional reserve during rest and/or after exercise using tissue Doppler echocardiography;   24-hour blood pressure;   Energy delivering from the carotid artery;   N-terminal pro b-type natriuretic peptide (NT-proBNP) levels in serum over time and symptoms of dyspnea or fatigue as assessed by patient and clinician using established scoring systems;   Gene and protein expression (Affymetrix/proteomics);   Plasma markers of inflammation i.e. hsCRP, IL-6, TNF-α and PAI-1;   Plasma markers of endothelial activation i.e. E-selectin, VCAM-1, ICAM-1 and plasma levels of nitrate/nitrite;   Lipids;   A1c;   Body weight;   Adverse events in terms of hypoglycaemia;   Quality of life (SF 36);   Exercise ECG, including working capacity;   Global LV function (echocardiography) expressed as ejection fraction (EF)
16 Unknown  Effect of Adding Vildagliptin on Beta Cell Function and Cardiovascular Risk Markers in Patients With Moderate Metabolic Control During Metformin Monotherapy
Condition: Diabetes Mellitus Type II
Interventions: Drug: Metformin;   Drug: Vildagliptin;   Drug: Glimepiride
Outcome Measures: Postprandial increase in intact proinsulin levels in patient treated with Vildagliptin and Metformin compared to intact proinsulin levels in patients treated with Glimepiride and Metformin (Area under the curve 0-300 min);   Fasting intact proinsulin levels;   Max postprandial intact proinsulin levels;   Retinal endothelial response to flicker light stimulation;   Mean 24h systolic and diastolic blood pressure;   Erythrocyte deformability;   E-selectin;   Change in body weight;   hsCRP;   HbA1c;   Fasting blood glucose;   Number of hypoglycemic events;   Adverse events;   Drug related adverse events
17 Recruiting Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006)
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Ertugliflozin (5 mg);   Drug: Ertugliflozin (15 mg);   Drug: Placebo;   Drug: Metformin;   Drug: Sitagliptin;   Drug: Glimepiride;   Biological: Insulin
Outcome Measures: Change from baseline in hemoglobin A1C at Week 26;   Number of Participants Experiencing An Adverse Event (AE);   Number of Participants Discontinuing Study Treatment Due to an AE;   Change from baseline in fasting plasma glucose (FPG) at Week 26;   Change from baseline in body weight at Week 26;   Number of participants with an A1C <7% (53 mmol/mol) at Week 26;   Change from baseline in systolic blood pressure at Week 26
18 Unknown  Effect of Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability and Oxidative Stress
Condition: Type 2 Diabetes
Interventions: Drug: Sitagliptin;   Drug: Glimepiride
Outcome Measures: Glucose variability;   oxidative stress markers (oxidized LDL, N-carboxymethyl-lysine(CML), nitrotyrosine, 8-iso-prostaglandinF2α, 8-OhDG)
19 Recruiting Ertugliflozin and Sitagliptin Co-administration Factorial Study (MK-8835-005)
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Matching Placebo to Ertugliflozin 5 mg;   Drug: Matching Placebo to Ertugliflozin 10 mg;   Drug: Matching Placebo to sitagliptin 100 mg;   Drug: Ertugliflozin 5 mg;   Drug: Ertugliflozin 10 mg;   Drug: Sitagliptin 100 mg;   Drug: Metformin >= 1500 mg/day;   Biological: Insulin Glargine Rescue Medication;   Drug: Glimepiride Rescue Medication
Outcome Measures: Change from Baseline in A1C;   Number of Participants Who Experience an Adverse Event (AE);   Number of Participants Who Discontinue Study Medication due to an AE;   Change from Baseline in Body Weight;   Change from Baseline in Fasting Plasma Glucose;   Change from Baseline in Systolic Blood Pressure;   Percentage of Participants Achieving a Hemoglobin A1C of <7%;   Change from Baseline in Parameters of Beta-cell Function
20 Recruiting A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes
Conditions: Type 2 Diabetes;   Comparative Effectiveness of Glycemia-lowering Medications
Interventions: Drug: Sulfonylurea (glimepiride);   Drug: DPP-4 inhibitor (sitagliptin);   Drug: GLP-1 receptor agonist (liraglutide);   Drug: Insulin (glargine)
Outcome Measures: Time to HbA1c>=7%, while receiving metformin and the randomly assigned study medication;   Time to HbA1c>7.5%, while receiving metformin and the randomly assigned study medication.