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Confusion (3)
Fits (3)
Unable To Pass Water It Dribbles And Takes Ages (3)
Blurred Visison (2)
Needles (2)
Pins And Needles (2)
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Acupan Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Pancytopenia, Hypotension, Overdose, Rectal Haemorrhage, Encephalopathy (8477965-4)
on Jun 18, 2012 Female from FRANCE , 67 years of age, was treated with Acupan. Directly after, patient experienced the unwanted or unexpected Acupan side effects: pancytopenia, hypotension, overdose, rectal haemorrhage, encephalopathy. Acupan dosage: N/A.
Associated medications used:
  • Gentamicin
  • Omeprazole
  • Oxycodone Hcl
  • Rabeprazole Sodium
  • Levothyroxine Sodium
  • Cefepime
  • Folic Acid
  • Piperacillin
Patient was hospitalized.

Muckle-wells Syndrome, Vertigo, Glaucoma, C-reactive Protein Increased, Iridectomy, Sciatica, Fatigue, Back Pain, Headache (8323417-1)
Patient was taking Acupan. Patient felt the following Acupan side effects: muckle-wells syndrome, vertigo, glaucoma, c-reactive protein increased, iridectomy, sciatica, fatigue, back pain, headache on Apr 11, 2012 from FRANCE Additional patient health information: Female , weighting 110.2 lb, . Acupan dosage: N/A.
Multiple prescriptions taken:
  • Ilaris (Every 8 Weeks.)
  • Tanganil
Patient was hospitalized and became disabled.

Intestinal Perforation, Pneumoperitoneum (8323097-5)
Adverse event was reported on Apr 19, 2012 by a Male taking Acupan (Dosage: Unk) . Location: FRANCE , 75 years of age, weighting 191.8 lb, After Acupan was administered, patient encountered several Acupan side effects: intestinal perforation, pneumoperitoneum.
Multiple concurrent drugs taken:
  • Amlodipine Besylate (Unk)
  • Prednisolone (40 Mg, 1x/day)
  • Imovane (36 Mg, 1x/day)
  • Transipeg (11.8 Mg, 1x/day)
  • Sutent (50 Mg, Unk)
  • Augmentin (2000 Mg, Daily)
  • Nexium (40 Mg, 1x/day)
  • Flector (2 Without Units)
Patient was hospitalized.

Colonoscopy (8174649-7)
on Feb 21, 2012 Female from FRANCE , 85 years of age, was treated with Acupan. Directly after, patient experienced the unwanted or unexpected Acupan side effects: colonoscopy. Acupan dosage: N/A.
Associated medications used:
  • Forteo (20 Ug, Qd)
Patient was hospitalized.


Erythema, Hepatitis Cholestatic, Cytolytic Hepatitis (8105762-8)
on Jan 23, 2012 Female from FRANCE , 23 years of age, was treated with Acupan. Patient felt the following Acupan side effects: erythema, hepatitis cholestatic, cytolytic hepatitis. Acupan dosage: N/A.
Multiple prescriptions taken:
  • Xyzal
  • Rocuronium Bromide
  • Ultiva
  • Tiberal (Daily)
  • Cefamandole Sodium
  • Morphine
  • Xylocaine
  • Nexium (Daily)
Patient was hospitalized.

Anaphylactic Shock (8065775-1)
Patient was taking Acupan. After Acupan was administered, patient encountered several Acupan side effects: anaphylactic shock on Jan 06, 2012 from FRANCE Additional patient health information: Male , 70 years of age, . Acupan dosage: Iv.
Multiple concurrent drugs taken:
  • Morphine Sulfate (Po)
  • Acetaminophen (Iv)


Tooth Fracture, Tooth Disorder (8023835-5)
Adverse event was reported on Dec 28, 2011 by a Female taking Acupan (Dosage: N/A) . Location: FRANCE , 38 years of age, weighting 185.2 lb, Directly after, patient experienced the unwanted or unexpected Acupan side effects: tooth fracture, tooth disorder.
Associated medications used:
  • Remicade (Dose Also Reported As 7.5 Mg/kg)
  • Lamaline
  • Remicade
  • Voltaren
  • Remicade (19th Infliximab Infusion)
  • Remicade (Dose Also Reported As 7.5 Mg/kg)
  • Remicade (19th Infliximab Infusion)
  • Remicade


Oedema Peripheral, Anuria, Vomiting, Lactic Acidosis, Pain In Extremity, Renal Failure Acute, Hyperkalaemia, Nausea (7978953-4)
on Dec 05, 2011 Male from FRANCE , 71 years of age, was treated with Acupan. Patient felt the following Acupan side effects: oedema peripheral, anuria, vomiting, lactic acidosis, pain in extremity, renal failure acute, hyperkalaemia, nausea. Acupan dosage: Unk.
Multiple prescriptions taken:
  • Thiocolchicoside (Unk)
  • Ramipril (5 Mg, 1x/day)
  • Metformin Hcl (Unk)
  • Stablon (Unk)
  • Furosemide (20 Mg, 2x/day)
  • Januvia (Unk)
  • Aspirin (Unk)
  • Voltaren (100 Mg, 2x/day)
Patient was hospitalized.

Venous Thrombosis Limb (7942380-6)
on Nov 23, 2011 Female from FRANCE , weighting 149.9 lb, was diagnosed with
  • pain
  • knee arthroplasty
and was treated with Acupan. After Acupan was administered, patient encountered several Acupan side effects: venous thrombosis limb. Acupan dosage: N/A.
Multiple concurrent drugs taken:
  • Pradaxa (150 Mg)
  • Tramadol Hcl (300 Mg)
  • Acetaminophen (3 G)
  • Levothyroxine Sodium


Anaphylactoid Shock (7897517-4)
Patient was taking Acupan. Directly after, patient experienced the unwanted or unexpected Acupan side effects: anaphylactoid shock on Nov 03, 2011 from FRANCE Additional patient health information: Male , 56 years of age, . Acupan dosage: 4 Df Total Daily (1df, 1 In 6 Hours).
Associated medications used:
  • Piperacillin And Tazobactam (12 G Total Daily (4 G, 1 In 8 Hours))
  • Primperan Tab (3 Df Total Daily (1 Df (10 Mg/2 Ml), 1 In 8 Hours))
  • Vitamin K1 (10 Mg, 1x/day)
  • Proglycem (Unk; Increased Dose)
  • Vancomycin (2 G, 1x/day)
  • Ciprofloxacin (800 Mg Total Daily (400 Mg, 1 In 12 Hours))
  • Lovenox
  • Proglycem (200 Mg, 4x/day)


Deep Vein Thrombosis (7864985-3)
Adverse event was reported on Oct 24, 2011 by a Female taking Acupan (Dosage: 60 Mg) . Location: FRANCE , weighting 172.0 lb, Patient felt the following Acupan side effects: deep vein thrombosis.
Multiple prescriptions taken:
  • Enalapril Maleate (20 Mg)
  • Befizal (200 Mg)
  • Pradaxa (150 Mg)
  • Imovane
  • Naropin (2 Mg/ml: 4ml/hour)
  • Acetaminophen (4000 Mg)
Patient was hospitalized.

Epilepsy, Anosmia (7750772-3)
on Sep 08, 2011 Female from FRANCE , 41 years of age, was treated with Acupan. After Acupan was administered, patient encountered several Acupan side effects: epilepsy, anosmia. Acupan dosage: N/A.
Multiple concurrent drugs taken:
  • Omeprazole
  • Clorazepate Dipotassium
  • Bisoprolol Fumarate
  • Valium
  • Abilify
  • Abilify
  • Abilify
  • Atarax


International Normalised Ratio Increased, Subcutaneous Haematoma (7690696-3)
on Aug 09, 2011 Female from FRANCE , 89 years of age, was treated with Acupan. Directly after, patient experienced the unwanted or unexpected Acupan side effects: international normalised ratio increased, subcutaneous haematoma. Acupan dosage: N/A.
Associated medications used:
  • Esomeprazole Magnesium
  • Nitroglycerin
  • Lasix
  • Previscan
  • Effexor
  • Acetaminophen
  • Ketoconazole
Patient was hospitalized.

Suicidal Ideation, Pain, Self Esteem Decreased, Depression (7679579-2)
Patient was taking Acupan. Patient felt the following Acupan side effects: suicidal ideation, pain, self esteem decreased, depression on Jul 25, 2011 from FRANCE Additional patient health information: Male , 55 years of age, weighting 198.4 lb, . Acupan dosage: N/A.
Multiple prescriptions taken:
  • Oxycontin
  • Prialt (0.21 Ug, Once/hour, Intrathecal)
  • Morphine Sulfate (Once/hour, Intrathecal)


Loss Of Consciousness, Hyponatraemia, Malaise, Disease Prodromal Stage, Anxiety (7671167-7)
Adverse event was reported on Jul 19, 2011 by a Female taking Acupan (nefopam Hydrochloride) (nefopam Hydrochloride) (Dosage: N/A) . Location: UNITED STATES , 77 years of age, After Acupan was administered, patient encountered several Acupan side effects: loss of consciousness, hyponatraemia, malaise, disease prodromal stage, anxiety.
Multiple concurrent drugs taken:
  • Hyperium (rilmenidine Phosphate) (rilmenidine Phosphate)
  • Olmesartan Medoxomil And Hydrochlorothizide (Oral)
  • Myolastan (tetrazepam) (tetrazepam)
  • Topalgic (tramadol Hydrochloride) (tramadol Hydrochloride)
Patient was hospitalized.

Venous Thrombosis, Dyspnoea (7651574-9)
on Jul 28, 2011 Female from FRANCE , weighting 145.5 lb, was treated with Acupan. Directly after, patient experienced the unwanted or unexpected Acupan side effects: venous thrombosis, dyspnoea. Acupan dosage: Start Date: 25 May 2011, Dose: 4 Amp, Frequency: Daily.
Associated medications used:
  • Actemra
  • Arava (Frequency: Day)
Patient was hospitalized.

Oral Herpes, Bronchial Obstruction, Fatigue (7574234-1)
on Jun 22, 2011 Female from FRANCE , weighting 132.3 lb, was treated with Acupan. Patient felt the following Acupan side effects: oral herpes, bronchial obstruction, fatigue. Acupan dosage: N/A.
Multiple prescriptions taken:
  • Bevacizumab (Last Dose Prior To Sae: 19 May 2011)
  • Motilium
  • Oxazepam (Total Daily Dose: 20)
  • Acebutolol (Total Daily Dose: 600)
  • Moduretic 5-50
  • Temozolomide (Date Of Last Dose Prior To Sae: 4 May 2011, Route Per Os.)
  • Prednisone
  • Nexium
Patient was hospitalized.

Thrombocytopenia, Haematoma (7567905-4)
Patient was taking Acupan. After Acupan was administered, patient encountered several Acupan side effects: thrombocytopenia, haematoma on Jun 01, 2011 from FRANCE Additional patient health information: Male , 71 years of age, . Acupan dosage: N/A.
Multiple concurrent drugs taken:
  • Xalatan
  • Pravastatin Sodium
  • Vastarel
  • Acetaminophen (1 Gm;1 Day;iv)
Patient was hospitalized.

Thrombocytopenia (7458505-5)
Adverse event was reported on Apr 29, 2011 by a Female taking Acupan (Dosage: N/A) . Location: FRANCE , 64 years of age, Directly after, patient experienced the unwanted or unexpected Acupan side effects: thrombocytopenia.
Associated medications used:
  • Calciparine (1 Df, 2x/day)
  • Avlocardyl (40 Mg, 2x/day)
  • Relistor
  • Debridat ^jouveinal^
  • Solu-medrol (60 Mg, 1x/day)
  • Tiapridal (5 Df, 2x/day)
Patient was hospitalized.

Haemorrhage, Shock Haemorrhagic, Thrombocytopenia (7245020-7)
on Jan 21, 2011 Male from FRANCE , 75 years of age, was treated with Acupan. Patient felt the following Acupan side effects: haemorrhage, shock haemorrhagic, thrombocytopenia. Acupan dosage: N/A.
Multiple prescriptions taken:
  • Oxacillin
  • Propofan
  • Previscan
  • Daflon
  • Effexor
  • Budesonide/formoterol
  • Heparine Choay
  • Spiriva


Heparin-induced Thrombocytopenia, Thrombosis (7232706-3)
on Jan 14, 2011 Male from FRANCE , 63 years of age, was treated with Acupan. After Acupan was administered, patient encountered several Acupan side effects: heparin-induced thrombocytopenia, thrombosis. Acupan dosage: N/A.
Multiple concurrent drugs taken:
  • Topalgic Lp
  • Perfalgan
  • Morphine
  • Heparine Choay
  • Lovenox


Toxic Epidermal Necrolysis (7225973-3)
Patient was taking Acupan. Directly after, patient experienced the unwanted or unexpected Acupan side effects: toxic epidermal necrolysis on Jan 06, 2011 from FRANCE Additional patient health information: Female , 54 years of age, . Acupan dosage: Unk.
Associated medications used:
  • Lovenox (Unk)
  • Xanax (Unk)
  • Dafalgan (Unk)
  • Topalgic (Unk)
  • Profenid (Unk)
  • Paracetamol (Unk)
  • Spasfon (Unk)
  • Topalgic (Unk)
Patient was hospitalized.

Anorexia, Blood Pressure Diastolic Decreased, Confusional State, Dehydration, Fall, Fluid Replacement, Head Injury, Hypokalaemia, Hyponatraemia (5245016-0)
Adverse event was reported on Feb 12, 2007 by a Female taking Acupan (Dosage: 20 Mg, Qd) was diagnosed with
  • neck pain
  • hypertension
and. Location: FRANCE , 69 years of age, weighting 108.0 lb, Patient felt the following Acupan side effects: anorexia, blood pressure diastolic decreased, confusional state, dehydration, fall, fluid replacement, head injury, hypokalaemia, hyponatraemia.
Multiple prescriptions taken:
  • Tareg (1 Df, Qd)
  • Practazin (1 Df, Qd)
  • Kerlone (20 Mg, Qd)
Patient was hospitalized.

Balance Disorder, Blood Lactic Acid Increased, Concomitant Disease Aggravated, Deafness, Headache, Leukoencephalopathy, Metabolic Acidosis, Status Epilepticus, Visual Acuity Reduced (4836410-8)
on Nov 08, 2005 Male from FRANCE , 40 years of age, weighting 163.1 lb, was treated with Acupan. After Acupan was administered, patient encountered several Acupan side effects: balance disorder, blood lactic acid increased, concomitant disease aggravated, deafness, headache, leukoencephalopathy, metabolic acidosis, status epilepticus, visual acuity reduced. Acupan dosage: 20 Mg, Qid.
Multiple concurrent drugs taken:
  • Primperan Inj
  • Cellcept (1 G, Bid)
  • Cellcept
  • Cortancyl (5 Mg, Daily)
  • Cortancyl (5 Mg, Daily)
  • Gynergene Cafeine (1 Df, Bid)
Patient was hospitalized.

Balance Disorder, Blood Lactic Acid Increased, Concomitant Disease Aggravated, Deafness, Headache, Leukoencephalopathy, Metabolic Acidosis, Status Epilepticus, Visual Acuity Reduced (4836404-2)
on Nov 08, 2005 Male from FRANCE , 40 years of age, weighting 163.1 lb, was treated with Acupan. Directly after, patient experienced the unwanted or unexpected Acupan side effects: balance disorder, blood lactic acid increased, concomitant disease aggravated, deafness, headache, leukoencephalopathy, metabolic acidosis, status epilepticus, visual acuity reduced. Acupan dosage: 20 Mg, Qid.
Associated medications used:
  • Primperan Inj
  • Cellcept (1 G, Bid)
  • Cellcept
  • Cortancyl (5 Mg, Daily)
  • Cortancyl (5 Mg, Daily)
  • Gynergene Cafeine (1 Df, Bid)
Patient was hospitalized.

Acupan Health Episodes

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Acupan Information

More About Acupan

Side Effects reported to FDA: 25. View Acupan Adverse Reports

Acupan safety alerts: No

Reported deaths: 5

Reported hospitalizations: 16

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