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Acupan Side Effects

Common Acupan Side Effects


The most commonly reported Acupan side effects (click to view or check a box to report):

Headache (3)
Thrombocytopenia (3)
Leukoencephalopathy (2)
Status Epilepticus (2)
Hyponatraemia (2)
Metabolic Acidosis (2)
Visual Acuity Reduced (2)
Fatigue (2)
Blood Lactic Acid Increased (2)
Balance Disorder (2)
Deafness (2)
Concomitant Disease Aggravated (2)
Anuria (1)
Anosmia (1)
Self Esteem Decreased (1)
Fluid Replacement (1)
Vomiting (1)
Shock Haemorrhagic (1)
Anorexia (1)
Anxiety (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Acupan Side Effects Reported to FDA

The following Acupan reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Acupan on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Pancytopenia, Hypotension, Overdose, Rectal Haemorrhage, Encephalopathy
This is a report of a 67-year-old female patient (weight: NA) from FRANCE, suffering from the following symptoms/conditions: NA, who was treated with Acupan (dosage: NA, start time: Jun 03, 2012), combined with:
  • Gentamicin
  • Omeprazole
  • Oxycodone Hcl
  • Rabeprazole Sodium
  • Levothyroxine Sodium
  • Cefepime
  • Folic Acid
  • Piperacillin
and developed a serious reaction and side effect(s). The consumer presented with:
  • Pancytopenia
  • Hypotension
  • Overdose
  • Rectal Haemorrhage
  • Encephalopathy
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in female patients, resulting in pancytopenia side effect. The patient was hospitalized.

Muckle-wells Syndrome, Vertigo, Glaucoma, C-reactive Protein Increased, Iridectomy, Sciatica, Fatigue, Back Pain, Headache
This report suggests a potential Acupan Muckle-wells Syndrome, Vertigo, Glaucoma, C-reactive Protein Increased, Iridectomy, Sciatica, Fatigue, Back Pain, Headache side effect(s) that can have serious consequences. A female patient (weight: NA) from FRANCE was diagnosed with the following symptoms/conditions: NA and used Acupan (dosage: NA) starting Sep 14, 2007. Soon after starting Acupan the patient began experiencing various side effects, including:
  • Muckle-wells Syndrome
  • Vertigo
  • Glaucoma
  • C-reactive Protein Increased
  • Iridectomy
  • Sciatica
  • Fatigue
  • Back Pain
  • Headache
Drugs used concurrently:
  • Ilaris (Every 8 Weeks.)
  • Tanganil
The patient was hospitalized and became disabled. Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as muckle-wells syndrome, may still occur.

Intestinal Perforation, Pneumoperitoneum
This Intestinal Perforation, Pneumoperitoneum problem was reported by a physician from FRANCE. A 75-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Mar 26, 2012 this consumer started treatment with Acupan (dosage: Unk). The following drugs were being taken at the same time:
  • Amlodipine Besylate (Unk)
  • Prednisolone (40 Mg, 1x/day)
  • Imovane (36 Mg, 1x/day)
  • Transipeg (11.8 Mg, 1x/day)
  • Sutent (50 Mg, Unk)
  • Augmentin (2000 Mg, Daily)
  • Nexium (40 Mg, 1x/day)
  • Flector (2 Without Units)
When commencing Acupan, the patient experienced the following unwanted symptoms/side effects:
  • Intestinal Perforation
  • Pneumoperitoneum
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as intestinal perforation, may become evident only after a product is in use by the general population.

Colonoscopy
This is a report of a 85-year-old female patient (weight: NA) from FRANCE. The patient developed the following symptoms/conditions: NA and was treated with Acupan (dosage: NA) starting Sep 26, 2011. Concurrently used drugs:
  • Forteo (20 Ug, Qd)
Soon after that, the consumer experienced the following side effects:
  • Colonoscopy
The patient was hospitalized. This opens a possibility that Acupan treatment could cause the above reactions, including colonoscopy, and some female subjects may be more susceptible.


Erythema, Hepatitis Cholestatic, Cytolytic Hepatitis
A 23-year-old female patient (weight: NA) from FRANCE with the following symptoms/conditions: NA started Acupan treatment (dosage: NA) on Jun 22, 2010. Soon after starting Acupan treatment, the subject experienced various side effects, including:
  • Erythema
  • Hepatitis Cholestatic
  • Cytolytic Hepatitis
Concurrently used drugs:
  • Xyzal
  • Rocuronium Bromide
  • Ultiva
  • Tiberal (Daily)
  • Cefamandole Sodium
  • Morphine
  • Xylocaine
  • Nexium (Daily)
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Acupan.

Anaphylactic Shock
A 70-year-old male patient from FRANCE (weight: NA) experienced symptoms, such as: NA and was treated with Acupan(dosage: Iv). The treatment was initiated on Dec 21, 2011. After that a consumer reported the following side effect(s):
  • Anaphylactic Shock
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Acupan efficacy:
  • Morphine Sulfate (Po)
  • Acetaminophen (Iv)


Tooth Fracture, Tooth Disorder
In this report, Acupan was administered for the following condition: NA.A 38-year-old female consumer from FRANCE (weight: NA) started Acupan treatment (dosage: NA) on Oct 07, 2011.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Tooth Fracture
  • Tooth Disorder
A possible interaction with other drugs could have contributed to this reaction:
  • Remicade (Dose Also Reported As 7.5 Mg/kg)
  • Lamaline
  • Remicade
  • Voltaren
  • Remicade (19th Infliximab Infusion)
  • Remicade (Dose Also Reported As 7.5 Mg/kg)
  • Remicade (19th Infliximab Infusion)
  • Remicade
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Acupan treatment could be related to the listed above side effect(s).

Oedema Peripheral, Anuria, Vomiting, Lactic Acidosis, Pain In Extremity, Renal Failure Acute, Hyperkalaemia, Nausea
This is a report of the following Acupan side effect(s):
  • Oedema Peripheral
  • Anuria
  • Vomiting
  • Lactic Acidosis
  • Pain In Extremity
  • Renal Failure Acute
  • Hyperkalaemia
  • Nausea
A 71-year-old male patient from FRANCE (weight: NA) presented with the following condition: NA and received a treatment with Acupan (dosage: Unk) starting: May 11, 2011.The following concurrently used drugs could have generated interactions:
  • Thiocolchicoside (Unk)
  • Ramipril (5 Mg, 1x/day)
  • Metformin Hcl (Unk)
  • Stablon (Unk)
  • Furosemide (20 Mg, 2x/day)
  • Januvia (Unk)
  • Aspirin (Unk)
  • Voltaren (100 Mg, 2x/day)
The patient was hospitalized.This report suggests that a Acupan treatment could be associated with the listed above side effect(s).

Venous Thrombosis Limb
This Acupan report was submitted by a female consumer from FRANCE (weight: NA). The patient was diagnosed with: pain,knee arthroplasty and Acupan was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Venous Thrombosis Limb
Other drugs used simultaneously:
  • Pradaxa (150 Mg)
  • Tramadol Hcl (300 Mg)
  • Acetaminophen (3 G)
  • Levothyroxine Sodium
Those unexpected symptoms could be linked to a Acupan treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Anaphylactoid Shock
This is a report of a possible correlation between Acupan use and the following symptoms/side effect(s):
  • Anaphylactoid Shock
which could contribute to an assessment of Acupan risk profile.A 56-year-old male consumer from FRANCE (weight: NA) was suffering from NA and was treated with Acupan (dosage: 4 Df Total Daily (1df, 1 In 6 Hours)) starting Feb 01, 2011.Other concurrent medications:
  • Piperacillin And Tazobactam (12 G Total Daily (4 G, 1 In 8 Hours))
  • Primperan Tab (3 Df Total Daily (1 Df (10 Mg/2 Ml), 1 In 8 Hours))
  • Vitamin K1 (10 Mg, 1x/day)
  • Proglycem (Unk; Increased Dose)
  • Vancomycin (2 G, 1x/day)
  • Ciprofloxacin (800 Mg Total Daily (400 Mg, 1 In 12 Hours))
  • Lovenox
  • Proglycem (200 Mg, 4x/day)


Deep Vein Thrombosis
A female patient from FRANCE (weight: NA) presented with the following symptoms: NA and after a treatment with Acupan (dosage: 60 Mg) experienced the following side effect(s):
  • Deep Vein Thrombosis
The treatment was started on Dec 16, 2010. Acupan was used in combination with the following drugs:
  • Enalapril Maleate (20 Mg)
  • Befizal (200 Mg)
  • Pradaxa (150 Mg)
  • Imovane
  • Naropin (2 Mg/ml: 4ml/hour)
  • Acetaminophen (4000 Mg)
The patient was hospitalized.This report could alert potential Acupan consumers.

Epilepsy, Anosmia
In this report, a 41-year-old female patient from FRANCE (weight: NA) was affected by a possible Acupan side effect.The patient was diagnosed with NA. After a treatment with Acupan (dosage: NA, start date: NS), the patient experienced the following side effect(s):
  • Epilepsy
  • Anosmia
The following simultaneously used drugs could have led to this reaction:
  • Omeprazole
  • Clorazepate Dipotassium
  • Bisoprolol Fumarate
  • Valium
  • Abilify
  • Abilify
  • Abilify
  • Atarax
The findings here stress that side effects should be taken into consideration when evaluating a Acupan treatment.

International Normalised Ratio Increased, Subcutaneous Haematoma
This is a report of a 89-year-old female patient from FRANCE (weight: NA), who used Acupan (dosage: NA) for a treatment of NA. After starting a treatment on Jun 21, 2011, the patient experienced the following side effect(s):
  • International Normalised Ratio Increased
  • Subcutaneous Haematoma
The following drugs could possibly have interacted with the Acupan treatment
  • Esomeprazole Magnesium
  • Nitroglycerin
  • Lasix
  • Previscan
  • Effexor
  • Acetaminophen
  • Ketoconazole
The patient was hospitalized.Taken together, these observations suggest that a Acupan treatment could be related to side effect(s), such as International Normalised Ratio Increased, Subcutaneous Haematoma.

Suicidal Ideation, Pain, Self Esteem Decreased, Depression
This suicidal ideation side effect was reported by a physician from FRANCE. A 55-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Acupan (dosage: NA), which was started on Apr 15, 2011. Concurrently used drugs:
  • Oxycontin
  • Prialt (0.21 Ug, Once/hour, Intrathecal)
  • Morphine Sulfate (Once/hour, Intrathecal)
When starting to take Acupan the consumer reported the following symptoms:
  • Suicidal Ideation
  • Pain
  • Self Esteem Decreased
  • Depression
These side effects may potentially be related to Acupan.

Loss Of Consciousness, Hyponatraemia, Malaise, Disease Prodromal Stage, Anxiety
This is a Acupan (nefopam Hydrochloride) (nefopam Hydrochloride) side effect report of a 77-year-old female patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Acupan (nefopam Hydrochloride) (nefopam Hydrochloride) (dosage:NA, start time: May 01, 2011), combined with:
  • Hyperium (rilmenidine Phosphate) (rilmenidine Phosphate)
  • Olmesartan Medoxomil And Hydrochlorothizide (Oral)
  • Myolastan (tetrazepam) (tetrazepam)
  • Topalgic (tramadol Hydrochloride) (tramadol Hydrochloride)
, and developed a serious reaction and a loss of consciousness side effect. The patient presented with:
  • Loss Of Consciousness
  • Hyponatraemia
  • Malaise
  • Disease Prodromal Stage
  • Anxiety
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Acupan (nefopam Hydrochloride) (nefopam Hydrochloride) treatment in female patients suffering from NA, resulting in loss of consciousness.

Venous Thrombosis, Dyspnoea
This report suggests a potential Acupan venous thrombosis side effect(s) that can have serious consequences. A female patient from FRANCE (weight:NA) was diagnosed with the following health condition(s): NA and used Acupan (dosage: Start Date: 25 May 2011, Dose: 4 Amp, Frequency: Daily) starting Jan 01, 2004. Soon after starting Acupan the patient began experiencing various side effects, including:
  • Venous Thrombosis
  • Dyspnoea
Drugs used concurrently:
  • Actemra
  • Arava (Frequency: Day)
The patient was hospitalized. Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as venous thrombosis, may still occur.

Oral Herpes, Bronchial Obstruction, Fatigue
This oral herpes problem was reported by a physician from FRANCE. A female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On May 04, 2011 a consumer started treatment with Acupan (dosage: NA). The following drugs/medications were being taken at the same time:
  • Bevacizumab (Last Dose Prior To Sae: 19 May 2011)
  • Motilium
  • Oxazepam (Total Daily Dose: 20)
  • Acebutolol (Total Daily Dose: 600)
  • Moduretic 5-50
  • Temozolomide (Date Of Last Dose Prior To Sae: 4 May 2011, Route Per Os.)
  • Prednisone
  • Nexium
When commencing Acupan, the patient experienced the following unwanted symptoms /side effects:
  • Oral Herpes
  • Bronchial Obstruction
  • Fatigue
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as oral herpes, may become evident only after a product is in use by the general population.

Thrombocytopenia, Haematoma
This is a Acupan side effect report of a 71-year-old male patient (weight: NA) from FRANCE. The patient developed the following symptoms/conditions: NA and was treated with Acupan (dosage: NA) starting Apr 14, 2011. Concurrently used drugs:
  • Xalatan
  • Pravastatin Sodium
  • Vastarel
  • Acetaminophen (1 Gm;1 Day;iv)
Soon after that, the consumer experienced the following of symptoms:
  • Thrombocytopenia
  • Haematoma
The patient was hospitalized. This opens a possibility that Acupan could cause thrombocytopenia and that some male patients may be more susceptible.

Thrombocytopenia
A 64-year-old female patient (weight: NA) from FRANCE with the following symptoms: NA started Acupan treatment (dosage: NA) on Mar 10, 2011. Soon after starting Acupan treatment, the consumer experienced several side effects, including:
  • Thrombocytopenia
. Concurrently used drugs:
  • Calciparine (1 Df, 2x/day)
  • Avlocardyl (40 Mg, 2x/day)
  • Relistor
  • Debridat ^jouveinal^
  • Solu-medrol (60 Mg, 1x/day)
  • Tiapridal (5 Df, 2x/day)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Acupan side effects, such as thrombocytopenia.

Haemorrhage, Shock Haemorrhagic, Thrombocytopenia
This haemorrhage side effect was reported by a health professional from FRANCE. A 75-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acupan (dosage: NA), which was started on Dec 10, 2010. Concurrently used drugs:
  • Oxacillin
  • Propofan
  • Previscan
  • Daflon
  • Effexor
  • Budesonide/formoterol
  • Heparine Choay
  • Spiriva
.When starting to take Acupan the consumer reported symptoms, such as:
  • Haemorrhage
  • Shock Haemorrhagic
  • Thrombocytopenia
These side effects may potentially be related to Acupan.

Heparin-induced Thrombocytopenia, Thrombosis
This is a report of a 63-year-old male patient (weight: NA) from FRANCE, suffering from the following symptoms/conditions: NA, who was treated with Acupan (dosage: NA, start time: Nov 21, 2010), combined with:
  • Topalgic Lp
  • Perfalgan
  • Morphine
  • Heparine Choay
  • Lovenox
and developed a serious reaction and side effect(s). The consumer presented with:
  • Heparin-induced Thrombocytopenia
  • Thrombosis
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in male patients, resulting in heparin-induced thrombocytopenia side effect.

Toxic Epidermal Necrolysis
This report suggests a potential Acupan Toxic Epidermal Necrolysis side effect(s) that can have serious consequences. A 54-year-old female patient (weight: NA) from FRANCE was diagnosed with the following symptoms/conditions: NA and used Acupan (dosage: Unk) starting Jun 06, 2010. Soon after starting Acupan the patient began experiencing various side effects, including:
  • Toxic Epidermal Necrolysis
Drugs used concurrently:
  • Lovenox (Unk)
  • Xanax (Unk)
  • Dafalgan (Unk)
  • Topalgic (Unk)
  • Profenid (Unk)
  • Paracetamol (Unk)
  • Spasfon (Unk)
  • Topalgic (Unk)
The patient was hospitalized. Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as toxic epidermal necrolysis, may still occur.

Anorexia, Blood Pressure Diastolic Decreased, Confusional State, Dehydration, Fall, Fluid Replacement, Head Injury, Hypokalaemia, Hyponatraemia
This Anorexia, Blood Pressure Diastolic Decreased, Confusional State, Dehydration, Fall, Fluid Replacement, Head Injury, Hypokalaemia, Hyponatraemia problem was reported by a consumer or non-health professional from FRANCE. A 69-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: neck pain,hypertension. On Jan 17, 2007 this consumer started treatment with Acupan (dosage: 20 Mg, Qd). The following drugs were being taken at the same time:
  • Tareg (1 Df, Qd)
  • Practazin (1 Df, Qd)
  • Kerlone (20 Mg, Qd)
When commencing Acupan, the patient experienced the following unwanted symptoms/side effects:
  • Anorexia
  • Blood Pressure Diastolic Decreased
  • Confusional State
  • Dehydration
  • Fall
  • Fluid Replacement
  • Head Injury
  • Hypokalaemia
  • Hyponatraemia
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as anorexia, may become evident only after a product is in use by the general population.

Balance Disorder, Blood Lactic Acid Increased, Concomitant Disease Aggravated, Deafness, Headache, Leukoencephalopathy, Metabolic Acidosis, Status Epilepticus, Visual Acuity Reduced
This is a report of a 40-year-old male patient (weight: NA) from FRANCE. The patient developed the following symptoms/conditions: NA and was treated with Acupan (dosage: 20 Mg, Qid) starting Aug 26, 2005. Concurrently used drugs:
  • Primperan Inj
  • Cellcept (1 G, Bid)
  • Cellcept
  • Cortancyl (5 Mg, Daily)
  • Cortancyl (5 Mg, Daily)
  • Gynergene Cafeine (1 Df, Bid)
Soon after that, the consumer experienced the following side effects:
  • Balance Disorder
  • Blood Lactic Acid Increased
  • Concomitant Disease Aggravated
  • Deafness
  • Headache
  • Leukoencephalopathy
  • Metabolic Acidosis
  • Status Epilepticus
  • Visual Acuity Reduced
The patient was hospitalized. This opens a possibility that Acupan treatment could cause the above reactions, including balance disorder, and some male subjects may be more susceptible.

Balance Disorder, Blood Lactic Acid Increased, Concomitant Disease Aggravated, Deafness, Headache, Leukoencephalopathy, Metabolic Acidosis, Status Epilepticus, Visual Acuity Reduced
A 40-year-old male patient (weight: NA) from FRANCE with the following symptoms/conditions: NA started Acupan treatment (dosage: 20 Mg, Qid) on Aug 26, 2005. Soon after starting Acupan treatment, the subject experienced various side effects, including:
  • Balance Disorder
  • Blood Lactic Acid Increased
  • Concomitant Disease Aggravated
  • Deafness
  • Headache
  • Leukoencephalopathy
  • Metabolic Acidosis
  • Status Epilepticus
  • Visual Acuity Reduced
Concurrently used drugs:
  • Primperan Inj
  • Cellcept (1 G, Bid)
  • Cellcept
  • Cortancyl (5 Mg, Daily)
  • Cortancyl (5 Mg, Daily)
  • Gynergene Cafeine (1 Df, Bid)
The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Acupan.



Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    Side Effects reported to FDA: 25

    Acupan safety alerts: No

    Reported deaths: 5

    Reported hospitalizations: 17

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