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Acupan Side Effects

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Common Acupan Side Effects


The most commonly reported Acupan side effects (click to view or check a box to report):

Headache (3)
Thrombocytopenia (3)
Leukoencephalopathy (2)
Status Epilepticus (2)
Hyponatraemia (2)
Metabolic Acidosis (2)
Visual Acuity Reduced (2)
Fatigue (2)
Blood Lactic Acid Increased (2)
Balance Disorder (2)
Deafness (2)
Concomitant Disease Aggravated (2)
Anuria (1)
Anosmia (1)
Self Esteem Decreased (1)
Fluid Replacement (1)
Vomiting (1)
Shock Haemorrhagic (1)
Anorexia (1)
Anxiety (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Acupan Side Effects Reported to FDA



Acupan Side Effect Report#8477965-4
Pancytopenia, Hypotension, Overdose, Rectal Haemorrhage, Encephalopathy
This is a report of a 67-year-old female patient (weight: NA) from France, suffering from the following health symptoms/conditions: NA, who was treated with Acupan (dosage: NA, start time:
Jun 03, 2012), combined with:
  • Gentamicin
  • Omeprazole
  • Oxycodone Hcl
  • Rabeprazole Sodium
  • Levothyroxine Sodium
  • Cefepime
  • Folic Acid
  • Piperacillin
and developed a serious reaction and side effect(s): Pancytopenia, Hypotension, Overdose, Rectal Haemorrhage, Encephalopathy after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in female patients, resulting in Pancytopenia side effect. The patient was hospitalized.
Acupan Side Effect Report#8323417-1
Muckle-wells Syndrome, Vertigo, Glaucoma, C-reactive Protein Increased, Iridectomy, Sciatica, Fatigue, Back Pain, Headache
This report suggests a potential Acupan Muckle-wells Syndrome side effect(s) that can have serious consequences. A female patient (weight: NA) from France was diagnosed with the following symptoms/conditions: NA and used Acupan (dosage: NA) starting
Sep 14, 2007. After starting Acupan the patient began experiencing various side effects, including: Muckle-wells Syndrome, Vertigo, Glaucoma, C-reactive Protein Increased, Iridectomy, Sciatica, Fatigue, Back Pain, HeadacheAdditional drugs used concurrently:
  • Ilaris (Every 8 Weeks.)
  • Tanganil
The patient was hospitalized and became disabled. Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Muckle-wells Syndrome, may still occur.
Acupan Side Effect Report#8323097-5
Intestinal Perforation, Pneumoperitoneum
This Intestinal Perforation problem was reported by a physician from France. A 75-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Mar 26, 2012 this consumer started treatment with Acupan (dosage: Unk). The following drugs were being taken at the same time:
  • Amlodipine Besylate (Unk)
  • Prednisolone (40 Mg, 1x/day)
  • Imovane (36 Mg, 1x/day)
  • Transipeg (11.8 Mg, 1x/day)
  • Sutent (50 Mg, Unk)
  • Augmentin (2000 Mg, Daily)
  • Nexium (40 Mg, 1x/day)
  • Flector (2 Without Units)
When using Acupan, the patient experienced the following unwanted symptoms/side effects: Intestinal Perforation, PneumoperitoneumThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Intestinal Perforation, may become evident only after a product is in use by the general population.
Acupan Side Effect Report#8174649-7
Colonoscopy
This Colonoscopy side effect was reported by a consumer or non-health professional from France. A 85-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acupan (drug dosage: NA), which was initiated on
Sep 26, 2011. Concurrently used drugs:
  • Forteo (20 Ug, Qd)
.After starting to take Acupan the consumer reported adverse symptoms, such as: ColonoscopyThese side effects may potentially be related to Acupan. The patient was hospitalized.
Acupan Side Effect Report#8105762-8
Erythema, Hepatitis Cholestatic, Cytolytic Hepatitis
This is a report of a 23-year-old female patient (weight: NA) from France, suffering from the following health symptoms/conditions: NA, who was treated with Acupan (dosage: NA, start time:
Jun 22, 2010), combined with:
  • Xyzal
  • Rocuronium Bromide
  • Ultiva
  • Tiberal (Daily)
  • Cefamandole Sodium
  • Morphine
  • Xylocaine
  • Nexium (Daily)
and developed a serious reaction and side effect(s): Erythema, Hepatitis Cholestatic, Cytolytic Hepatitis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in female patients, resulting in Erythema side effect. The patient was hospitalized.
Acupan Side Effect Report#8065775-1
Anaphylactic Shock
This report suggests a potential Acupan Anaphylactic Shock side effect(s) that can have serious consequences. A 70-year-old male patient (weight: NA) from France was diagnosed with the following symptoms/conditions: NA and used Acupan (dosage: Iv) starting
Dec 21, 2011. After starting Acupan the patient began experiencing various side effects, including: Anaphylactic ShockAdditional drugs used concurrently:
  • Morphine Sulfate (Po)
  • Acetaminophen (Iv)
Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Anaphylactic Shock, may still occur.
Acupan Side Effect Report#8023835-5
Tooth Fracture, Tooth Disorder
This Tooth Fracture problem was reported by a health professional from France. A 38-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Oct 07, 2011 this consumer started treatment with Acupan (dosage: NA). The following drugs were being taken at the same time:
  • Remicade (Dose Also Reported As 7.5 Mg/kg)
  • Lamaline
  • Remicade
  • Voltaren
  • Remicade (19th Infliximab Infusion)
  • Remicade (Dose Also Reported As 7.5 Mg/kg)
  • Remicade (19th Infliximab Infusion)
  • Remicade
When using Acupan, the patient experienced the following unwanted symptoms/side effects: Tooth Fracture, Tooth DisorderAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Tooth Fracture, may become evident only after a product is in use by the general population.
Acupan Side Effect Report#7978953-4
Oedema Peripheral, Anuria, Vomiting, Lactic Acidosis, Pain In Extremity, Renal Failure Acute, Hyperkalaemia, Nausea
This Oedema Peripheral side effect was reported by a health professional from France. A 71-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acupan (drug dosage: Unk), which was initiated on
May 11, 2011. Concurrently used drugs:
  • Thiocolchicoside (Unk)
  • Ramipril (5 Mg, 1x/day)
  • Metformin Hcl (Unk)
  • Stablon (Unk)
  • Furosemide (20 Mg, 2x/day)
  • Januvia (Unk)
  • Aspirin (Unk)
  • Voltaren (100 Mg, 2x/day)
.After starting to take Acupan the consumer reported adverse symptoms, such as: Oedema Peripheral, Anuria, Vomiting, Lactic Acidosis, Pain In Extremity, Renal Failure Acute, Hyperkalaemia, NauseaThese side effects may potentially be related to Acupan. The patient was hospitalized.
Acupan Side Effect Report#7942380-6
Venous Thrombosis Limb
This is a report of a female patient (weight: NA) from France, suffering from the following health symptoms/conditions: pain,knee arthroplasty, who was treated with Acupan (dosage: NA, start time: NS), combined with:
  • Pradaxa (150 Mg)
  • Tramadol Hcl (300 Mg)
  • Acetaminophen (3 G)
  • Levothyroxine Sodium
and developed a serious reaction and side effect(s): Venous Thrombosis Limb after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in female patients, resulting in Venous Thrombosis Limb side effect.
Acupan Side Effect Report#7897517-4
Anaphylactoid Shock
This report suggests a potential Acupan Anaphylactoid Shock side effect(s) that can have serious consequences. A 56-year-old male patient (weight: NA) from France was diagnosed with the following symptoms/conditions: NA and used Acupan (dosage: 4 Df Total Daily (1df, 1 In 6 Hours)) starting
Feb 01, 2011. After starting Acupan the patient began experiencing various side effects, including: Anaphylactoid ShockAdditional drugs used concurrently:
  • Piperacillin And Tazobactam (12 G Total Daily (4 G, 1 In 8 Hours))
  • Primperan Tab (3 Df Total Daily (1 Df (10 Mg/2 Ml), 1 In 8 Hours))
  • Vitamin K1 (10 Mg, 1x/day)
  • Proglycem (Unk; Increased Dose)
  • Vancomycin (2 G, 1x/day)
  • Ciprofloxacin (800 Mg Total Daily (400 Mg, 1 In 12 Hours))
  • Lovenox
  • Proglycem (200 Mg, 4x/day)
Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Anaphylactoid Shock, may still occur.
Acupan Side Effect Report#7864985-3
Deep Vein Thrombosis
This Deep Vein Thrombosis problem was reported by a health professional from France. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Dec 16, 2010 this consumer started treatment with Acupan (dosage: 60 Mg). The following drugs were being taken at the same time:
  • Enalapril Maleate (20 Mg)
  • Befizal (200 Mg)
  • Pradaxa (150 Mg)
  • Imovane
  • Naropin (2 Mg/ml: 4ml/hour)
  • Acetaminophen (4000 Mg)
When using Acupan, the patient experienced the following unwanted symptoms/side effects: Deep Vein ThrombosisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Deep Vein Thrombosis, may become evident only after a product is in use by the general population.
Acupan Side Effect Report#7750772-3
Epilepsy, Anosmia
This Epilepsy side effect was reported by a consumer or non-health professional from France. A 41-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acupan (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Omeprazole
  • Clorazepate Dipotassium
  • Bisoprolol Fumarate
  • Valium
  • Abilify
  • Abilify
  • Abilify
  • Atarax
.After starting to take Acupan the consumer reported adverse symptoms, such as: Epilepsy, AnosmiaThese side effects may potentially be related to Acupan.
Acupan Side Effect Report#7690696-3
International Normalised Ratio Increased, Subcutaneous Haematoma
This is a report of a 89-year-old female patient (weight: NA) from France, suffering from the following health symptoms/conditions: NA, who was treated with Acupan (dosage: NA, start time:
Jun 21, 2011), combined with:
  • Esomeprazole Magnesium
  • Nitroglycerin
  • Lasix
  • Previscan
  • Effexor
  • Acetaminophen
  • Ketoconazole
and developed a serious reaction and side effect(s): International Normalised Ratio Increased, Subcutaneous Haematoma after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in female patients, resulting in International Normalised Ratio Increased side effect. The patient was hospitalized.
Acupan Side Effect Report#7679579-2
Suicidal Ideation, Pain, Self Esteem Decreased, Depression
This report suggests a potential Acupan Suicidal Ideation side effect(s) that can have serious consequences. A 55-year-old male patient (weight: NA) from France was diagnosed with the following symptoms/conditions: NA and used Acupan (dosage: NA) starting
Apr 15, 2011. After starting Acupan the patient began experiencing various side effects, including: Suicidal Ideation, Pain, Self Esteem Decreased, DepressionAdditional drugs used concurrently:
  • Oxycontin
  • Prialt (0.21 Ug, Once/hour, Intrathecal)
  • Morphine Sulfate (Once/hour, Intrathecal)
Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Suicidal Ideation, may still occur.
Acupan Side Effect Report#7671167-7
Loss Of Consciousness, Hyponatraemia, Malaise, Disease Prodromal Stage, Anxiety
This Loss Of Consciousness problem was reported by a consumer or non-health professional from United States. A 77-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
May 01, 2011 this consumer started treatment with Acupan (nefopam Hydrochloride) (nefopam Hydrochloride) (dosage: NA). The following drugs were being taken at the same time:
  • Hyperium (rilmenidine Phosphate) (rilmenidine Phosphate)
  • Olmesartan Medoxomil And Hydrochlorothizide (Oral)
  • Myolastan (tetrazepam) (tetrazepam)
  • Topalgic (tramadol Hydrochloride) (tramadol Hydrochloride)
When using Acupan (nefopam Hydrochloride) (nefopam Hydrochloride), the patient experienced the following unwanted symptoms/side effects: Loss Of Consciousness, Hyponatraemia, Malaise, Disease Prodromal Stage, AnxietyThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Loss Of Consciousness, may become evident only after a product is in use by the general population.
Acupan Side Effect Report#7651574-9
Venous Thrombosis, Dyspnoea
This Venous Thrombosis side effect was reported by a health professional from France. A female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acupan (drug dosage: Start Date: 25 May 2011, Dose: 4 Amp, Frequency: Daily), which was initiated on
Jan 01, 2004. Concurrently used drugs:
  • Actemra
  • Arava (Frequency: Day)
.After starting to take Acupan the consumer reported adverse symptoms, such as: Venous Thrombosis, DyspnoeaThese side effects may potentially be related to Acupan. The patient was hospitalized.
Acupan Side Effect Report#7574234-1
Oral Herpes, Bronchial Obstruction, Fatigue
This is a report of a female patient (weight: NA) from France, suffering from the following health symptoms/conditions: NA, who was treated with Acupan (dosage: NA, start time:
May 04, 2011), combined with:
  • Bevacizumab (Last Dose Prior To Sae: 19 May 2011)
  • Motilium
  • Oxazepam (Total Daily Dose: 20)
  • Acebutolol (Total Daily Dose: 600)
  • Moduretic 5-50
  • Temozolomide (Date Of Last Dose Prior To Sae: 4 May 2011, Route Per Os.)
  • Prednisone
  • Nexium
and developed a serious reaction and side effect(s): Oral Herpes, Bronchial Obstruction, Fatigue after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in female patients, resulting in Oral Herpes side effect. The patient was hospitalized.
Acupan Side Effect Report#7567905-4
Thrombocytopenia, Haematoma
This report suggests a potential Acupan Thrombocytopenia side effect(s) that can have serious consequences. A 71-year-old male patient (weight: NA) from France was diagnosed with the following symptoms/conditions: NA and used Acupan (dosage: NA) starting
Apr 14, 2011. After starting Acupan the patient began experiencing various side effects, including: Thrombocytopenia, HaematomaAdditional drugs used concurrently:
  • Xalatan
  • Pravastatin Sodium
  • Vastarel
  • Acetaminophen (1 Gm;1 Day;iv)
The patient was hospitalized. Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Thrombocytopenia, may still occur.
Acupan Side Effect Report#7458505-5
Thrombocytopenia
This Thrombocytopenia problem was reported by a health professional from France. A 64-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Mar 10, 2011 this consumer started treatment with Acupan (dosage: NA). The following drugs were being taken at the same time:
  • Calciparine (1 Df, 2x/day)
  • Avlocardyl (40 Mg, 2x/day)
  • Relistor
  • Debridat ^jouveinal^
  • Solu-medrol (60 Mg, 1x/day)
  • Tiapridal (5 Df, 2x/day)
When using Acupan, the patient experienced the following unwanted symptoms/side effects: ThrombocytopeniaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Thrombocytopenia, may become evident only after a product is in use by the general population.
Acupan Side Effect Report#7245020-7
Haemorrhage, Shock Haemorrhagic, Thrombocytopenia
This Haemorrhage side effect was reported by a health professional from France. A 75-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acupan (drug dosage: NA), which was initiated on
Dec 10, 2010. Concurrently used drugs:
  • Oxacillin
  • Propofan
  • Previscan
  • Daflon
  • Effexor
  • Budesonide/formoterol
  • Heparine Choay
  • Spiriva
.After starting to take Acupan the consumer reported adverse symptoms, such as: Haemorrhage, Shock Haemorrhagic, ThrombocytopeniaThese side effects may potentially be related to Acupan.
Acupan Side Effect Report#7232706-3
Heparin-induced Thrombocytopenia, Thrombosis
This is a report of a 63-year-old male patient (weight: NA) from France, suffering from the following health symptoms/conditions: NA, who was treated with Acupan (dosage: NA, start time:
Nov 21, 2010), combined with:
  • Topalgic Lp
  • Perfalgan
  • Morphine
  • Heparine Choay
  • Lovenox
and developed a serious reaction and side effect(s): Heparin-induced Thrombocytopenia, Thrombosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in male patients, resulting in Heparin-induced Thrombocytopenia side effect.
Acupan Side Effect Report#7225973-3
Toxic Epidermal Necrolysis
This report suggests a potential Acupan Toxic Epidermal Necrolysis side effect(s) that can have serious consequences. A 54-year-old female patient (weight: NA) from France was diagnosed with the following symptoms/conditions: NA and used Acupan (dosage: Unk) starting
Jun 06, 2010. After starting Acupan the patient began experiencing various side effects, including: Toxic Epidermal NecrolysisAdditional drugs used concurrently:
  • Lovenox (Unk)
  • Xanax (Unk)
  • Dafalgan (Unk)
  • Topalgic (Unk)
  • Profenid (Unk)
  • Paracetamol (Unk)
  • Spasfon (Unk)
  • Topalgic (Unk)
The patient was hospitalized. Although Acupan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Toxic Epidermal Necrolysis, may still occur.
Acupan Side Effect Report#5245016-0
Anorexia, Blood Pressure Diastolic Decreased, Confusional State, Dehydration, Fall, Fluid Replacement, Head Injury, Hypokalaemia, Hyponatraemia
This Anorexia problem was reported by a consumer or non-health professional from France. A 69-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: neck pain,hypertension. On
Jan 17, 2007 this consumer started treatment with Acupan (dosage: 20 Mg, Qd). The following drugs were being taken at the same time:
  • Tareg (1 Df, Qd)
  • Practazin (1 Df, Qd)
  • Kerlone (20 Mg, Qd)
When using Acupan, the patient experienced the following unwanted symptoms/side effects: Anorexia, Blood Pressure Diastolic Decreased, Confusional State, Dehydration, Fall, Fluid Replacement, Head Injury, Hypokalaemia, HyponatraemiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anorexia, may become evident only after a product is in use by the general population.
Acupan Side Effect Report#4836410-8
Balance Disorder, Blood Lactic Acid Increased, Concomitant Disease Aggravated, Deafness, Headache, Leukoencephalopathy, Metabolic Acidosis, Status Epilepticus, Visual Acuity Reduced
This Balance Disorder side effect was reported by a consumer or non-health professional from France. A 40-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acupan (drug dosage: 20 Mg, Qid), which was initiated on
Aug 26, 2005. Concurrently used drugs:
  • Primperan Inj
  • Cellcept (1 G, Bid)
  • Cellcept
  • Cortancyl (5 Mg, Daily)
  • Cortancyl (5 Mg, Daily)
  • Gynergene Cafeine (1 Df, Bid)
.After starting to take Acupan the consumer reported adverse symptoms, such as: Balance Disorder, Blood Lactic Acid Increased, Concomitant Disease Aggravated, Deafness, Headache, Leukoencephalopathy, Metabolic Acidosis, Status Epilepticus, Visual Acuity ReducedThese side effects may potentially be related to Acupan. The patient was hospitalized.
Acupan Side Effect Report#4836404-2
Balance Disorder, Blood Lactic Acid Increased, Concomitant Disease Aggravated, Deafness, Headache, Leukoencephalopathy, Metabolic Acidosis, Status Epilepticus, Visual Acuity Reduced
This is a report of a 40-year-old male patient (weight: NA) from France, suffering from the following health symptoms/conditions: NA, who was treated with Acupan (dosage: 20 Mg, Qid, start time:
Aug 26, 2005), combined with:
  • Primperan Inj
  • Cellcept (1 G, Bid)
  • Cellcept
  • Cortancyl (5 Mg, Daily)
  • Cortancyl (5 Mg, Daily)
  • Gynergene Cafeine (1 Df, Bid)
and developed a serious reaction and side effect(s): Balance Disorder, Blood Lactic Acid Increased, Concomitant Disease Aggravated, Deafness, Headache, Leukoencephalopathy, Metabolic Acidosis, Status Epilepticus, Visual Acuity Reduced after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acupan treatment in male patients, resulting in Balance Disorder side effect. The patient was hospitalized.


The appearance of Acupan on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.


Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Acupan reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Acupan Safety Alerts, Active Ingredients, Usage Information

    More About Acupan

    Side Effects reported to FDA: 25

    Acupan safety alerts: No

    Reported deaths: 5

    Reported hospitalizations: 17

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