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Acyclovir Side Effects

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Common Acyclovir Side Effects


The most commonly reported Acyclovir side effects (click to view or check a box to report):

Renal Failure Acute (111)
Nausea (55)
Confusional State (52)
Neurotoxicity (52)
Blood Creatinine Increased (51)
Pyrexia (48)
Herpes Zoster (38)
Hallucination, Visual (38)
Vomiting (37)
Pain (37)
Fatigue (36)
Somnolence (36)
Renal Failure (35)
Diarrhoea (34)
Agitation (31)
Rash (31)
Dyspnoea (30)
Renal Impairment (30)
Haemodialysis (28)
Neutropenia (28)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Acyclovir Side Effects Reported to FDA



Acyclovir Side Effect Report#9989833
Injection Site Pain
This is a report of a 40-year-old female patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: antiviral prophylaxis,crohn^s disease, who was treated with Acyclovir (dosage: 400 Mg Daily, start time:
Jul 01, 2013), combined with:
  • Uceris
  • Humira
  • Humira
  • Humira
  • Lialda
  • Synthroid
  • Ortho Novum (135 Mg Daily)
and developed a serious reaction and side effect(s): Injection Site Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acyclovir treatment in female patients, resulting in Injection Site Pain side effect.
Acyclovir Side Effect Report#9958646
Herpes Zoster, Slow Speech
This report suggests a potential Acyclovir Herpes Zoster side effect(s) that can have serious consequences. A female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: arthritis and used Acyclovir (dosage: 4 Capsules By Mouth 5 Times Daily?mouth) starting NS. After starting Acyclovir the patient began experiencing various side effects, including: Herpes Zoster, Slow SpeechAdditional drugs used concurrently:
  • Dilantin
  • Gabapentin
The patient was hospitalized. Although Acyclovir demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Herpes Zoster, may still occur.
Acyclovir Side Effect Report#9925087
Dizziness, Malaise, Oral Herpes, Product Quality Issue, Product Contamination
This Dizziness problem was reported by a consumer or non-health professional from US. A 77-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: herpes zoster. On
Feb 20, 2014 this consumer started treatment with Acyclovir (dosage: 100 Pills/400 Mg 800 Mg/five Daily Taken By Mouth). The following drugs were being taken at the same time: NA. When using Acyclovir, the patient experienced the following unwanted symptoms/side effects: Dizziness, Malaise, Oral Herpes, Product Quality Issue, Product ContaminationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dizziness, may become evident only after a product is in use by the general population.
Acyclovir Side Effect Report#9891170
Swollen Tongue, Glossodynia
This Swollen Tongue side effect was reported by a physician from GB. A 70-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acyclovir (drug dosage: NA), which was initiated on
May 17, 2013. Concurrently used drugs:
  • Indapamide (indapamide)
  • Simvastatin (simvastatin)
  • Cetirizine Hydrochloride (cetirizine Hydrochloride)
.After starting to take Acyclovir the consumer reported adverse symptoms, such as: Swollen Tongue, GlossodyniaThese side effects may potentially be related to Acyclovir.
Acyclovir Side Effect Report#9885972
Abortion Spontaneous, Vaginal Haemorrhage
This is a report of a 36-year-old female patient (weight: NA) from GB, suffering from the following health symptoms/conditions: genital herpes, who was treated with Acyclovir (dosage: 1200mg Per Day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Abortion Spontaneous, Vaginal Haemorrhage after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acyclovir treatment in female patients, resulting in Abortion Spontaneous side effect.
Acyclovir Side Effect Report#9870277
Dyspnoea, Palpitations, Respiratory Disorder, Product Quality Issue, Product Substitution Issue, Cardiac Disorder
This report suggests a potential Acyclovir Dyspnoea side effect(s) that can have serious consequences. A 55-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: prophylaxis,herpes simplex and used Acyclovir (dosage: 1 Pill Once Daily Taken By Mouth) starting
Jan 12, 2014. After starting Acyclovir the patient began experiencing various side effects, including: Dyspnoea, Palpitations, Respiratory Disorder, Product Quality Issue, Product Substitution Issue, Cardiac DisorderAdditional drugs used concurrently: NA. Although Acyclovir demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dyspnoea, may still occur.
Acyclovir Side Effect Report#9867194
Acanthamoeba Infection, Pseudomonal Sepsis
This Acanthamoeba Infection problem was reported by a health professional from US. A 63-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: antibiotic prophylaxis. On NS this consumer started treatment with Acyclovir (dosage: NA). The following drugs were being taken at the same time:
  • Fluconazole
  • Mycophenolate Mofetil (1000 Mg, Tid)
  • Prednisone
  • Voriconazole
  • Rituximab (Unk)
  • Rituximab (375 Mg/m2, 1/week)
  • Vincristine (Unk)
  • Etoposide (Unk)
When using Acyclovir, the patient experienced the following unwanted symptoms/side effects: Acanthamoeba Infection, Pseudomonal SepsisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Acanthamoeba Infection, may become evident only after a product is in use by the general population.
Acyclovir Side Effect Report#9856728
Herpes Simplex Encephalitis, Neurological Symptom, Confusional State, Abnormal Behaviour, Brain Injury, White Blood Cell Count Increased, Red Blood Cell Count Increased, Protein Total Increased
This Herpes Simplex Encephalitis side effect was reported by a physician from BE. A 50-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Acyclovir (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Levetiracetam
  • Ceftriaxone
  • Ampicillin
  • Adalimumab
.After starting to take Acyclovir the consumer reported adverse symptoms, such as: Herpes Simplex Encephalitis, Neurological Symptom, Confusional State, Abnormal Behaviour, Brain Injury, White Blood Cell Count Increased, Red Blood Cell Count Increased, Protein Total IncreasedThese side effects may potentially be related to Acyclovir.
Acyclovir Side Effect Report#9845187
Rash, Escherichia Sepsis, Haemoglobin Decreased, Blood Sodium Decreased, Protein Total Decreased
This is a report of a 80-year-old male patient (weight: NA) from GB, suffering from the following health symptoms/conditions: chronic lymphocytic leukaemia, who was treated with Acyclovir (dosage: NA, start time:
May 22, 2013), combined with:
  • Prednisolone
  • Allopurinol
  • Ofatumumab
  • Chlorambucil
  • Paracetamol
  • Chlorpheniramine
  • Metoclopramide
  • Granulocyte Colony-stimulating Factor Nos
and developed a serious reaction and side effect(s): Rash, Escherichia Sepsis, Haemoglobin Decreased, Blood Sodium Decreased, Protein Total Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acyclovir treatment in male patients, resulting in Rash side effect. The patient was hospitalized.
Acyclovir Side Effect Report#9845013
Psoriasis, Pneumonia, Encephalopathy
This report suggests a potential Acyclovir Psoriasis side effect(s) that can have serious consequences. A 81-year-old female patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: NA and used Acyclovir (dosage: NA) starting
Jul 04, 2012. After starting Acyclovir the patient began experiencing various side effects, including: Psoriasis, Pneumonia, EncephalopathyAdditional drugs used concurrently: NA.The patient was hospitalized. Although Acyclovir demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Psoriasis, may still occur.
Acyclovir Side Effect Report#9844921
Application Site Pain
This Application Site Pain problem was reported by a consumer or non-health professional from US. A 78-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: oral herpes. On
Dec 17, 2013 this consumer started treatment with Acyclovir Ointment Usp (dosage: NA). The following drugs were being taken at the same time:
  • Nexium
  • Atenolol
  • Lisinopril
  • Lipitor
When using Acyclovir Ointment Usp, the patient experienced the following unwanted symptoms/side effects: Application Site PainAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Application Site Pain, may become evident only after a product is in use by the general population.
Acyclovir Side Effect Report#9844919
Oral Herpes
This Oral Herpes side effect was reported by a consumer or non-health professional from US. A 69-year-old female patient (weight:NA) experienced the following symptoms/conditions: oral herpes.The patient was prescribed Acyclovir Ointment Usp (drug dosage: NA), which was initiated on
Nov 29, 2013. Concurrently used drugs: NA..After starting to take Acyclovir Ointment Usp the consumer reported adverse symptoms, such as: Oral HerpesThese side effects may potentially be related to Acyclovir Ointment Usp.
Acyclovir Side Effect Report#9844691
Autoimmune Haemolytic Anaemia
This is a report of a 57-year-old patient (weight: NA) from JP, suffering from the following health symptoms/conditions: infection prophylaxis,non-hodgkin^s lymphoma,gastritis prophylaxis, who was treated with Acyclovir (dosage: NA, start time:
Nov 15, 2012), combined with:
  • Bendamustine (bendamustine) (bendamustine)
  • Lansoprazole (lansoprazole)
  • Fluconazole (fluconazole)
  • Co-trimoxazole (1 Tab)
  • Febuxostat
  • Pregabalin (pregabalin)
  • Magnesium Oxide (magnesium Oxide)
  • Paracetamol (paracetamol)
and developed a serious reaction and side effect(s): Autoimmune Haemolytic Anaemia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acyclovir treatment in patients, resulting in Autoimmune Haemolytic Anaemia side effect. The patient was hospitalized.
Acyclovir Side Effect Report#9785256
Hypersensitivity, Nausea, Syncope, Loss Of Consciousness, Diarrhoea
This report suggests a potential Acyclovir Hypersensitivity side effect(s) that can have serious consequences. A 56-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: oral herpes and used Acyclovir (dosage: NA) starting
Dec 12, 2013. After starting Acyclovir the patient began experiencing various side effects, including: Hypersensitivity, Nausea, Syncope, Loss Of Consciousness, DiarrhoeaAdditional drugs used concurrently:
  • Amitriptyline
  • Zolpidem
Although Acyclovir demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypersensitivity, may still occur.
Acyclovir Side Effect Report#9747098
This Death problem was reported by a consumer or non-health professional from Country Not Specified. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jun 06, 2013 this consumer started treatment with Acyclovir (dosage: NA). The following drugs were being taken at the same time:
  • Multi-vit
  • Stool Softener
  • Tasigna (400 Mg, Bid)
  • Tasigna
  • Sprycel//dasatinib (100 Mg, Qd)
When using Acyclovir, the patient experienced the following unwanted symptoms/side effects:Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Acyclovir Side Effect Report#9736087
Renal Failure Acute, Crystal Nephropathy, Nephropathy, Mucosal Dryness, Blister, Incorrect Dose Administered
This Renal Failure Acute side effect was reported by a physician from DE. A 72-year-old patient (weight:NA) experienced the following symptoms/conditions: herpes zoster.The patient was prescribed Acyclovir (drug dosage: 800mg Five Times Per Day), which was initiated on NS. Concurrently used drugs: NA..After starting to take Acyclovir the consumer reported adverse symptoms, such as: Renal Failure Acute, Crystal Nephropathy, Nephropathy, Mucosal Dryness, Blister, Incorrect Dose AdministeredThese side effects may potentially be related to Acyclovir. The patient was hospitalized.
Acyclovir Side Effect Report#9713884
Renal Failure, Dysaesthesia
This is a report of a 51-year-old male patient (weight: NA) from ES, suffering from the following health symptoms/conditions: epstein-barr virus infection, who was treated with Acyclovir (dosage: 10mgk Three Times Per Day, start time: NS), combined with:
  • Amoxicillin/clavulanic Acid
and developed a serious reaction and side effect(s): Renal Failure, Dysaesthesia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acyclovir treatment in male patients, resulting in Renal Failure side effect.
Acyclovir Side Effect Report#9690414
Hypomagnesaemia, Tremor, Grand Mal Convulsion, Pain, Renal Disorder, Muscular Weakness, Irritability, Muscle Contractions Involuntary
This report suggests a potential Acyclovir Hypomagnesaemia side effect(s) that can have serious consequences. A 76-year-old female patient (weight: NA) from ES was diagnosed with the following symptoms/conditions: infection and used Acyclovir (dosage: NA) starting NS. After starting Acyclovir the patient began experiencing various side effects, including: Hypomagnesaemia, Tremor, Grand Mal Convulsion, Pain, Renal Disorder, Muscular Weakness, Irritability, Muscle Contractions InvoluntaryAdditional drugs used concurrently:
  • Amikacin
  • Vancomycin
  • Pantoprazole
Although Acyclovir demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypomagnesaemia, may still occur.
Acyclovir Side Effect Report#9664824
Abortion Spontaneous, Vaginal Haemorrhage
This Abortion Spontaneous problem was reported by a consumer or non-health professional from GB. A 36-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: genital herpes. On NS this consumer started treatment with Acyclovir (dosage: 400 Mg, Tid). The following drugs were being taken at the same time: NA. When using Acyclovir, the patient experienced the following unwanted symptoms/side effects: Abortion Spontaneous, Vaginal HaemorrhageAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Abortion Spontaneous, may become evident only after a product is in use by the general population.
Acyclovir Side Effect Report#9646121
Genital Herpes
This Genital Herpes side effect was reported by a pharmacist from US. A 23-year-old female patient (weight:NA) experienced the following symptoms/conditions: genital herpes.The patient was prescribed Acyclovir Ointment Usp (drug dosage: Apply To The Affected Area Every 4-6 Hours As Needed.), which was initiated on
Jul 25, 2013. Concurrently used drugs: NA..After starting to take Acyclovir Ointment Usp the consumer reported adverse symptoms, such as: Genital HerpesThese side effects may potentially be related to Acyclovir Ointment Usp.
Acyclovir Side Effect Report#9645431
Liver Function Test Abnormal, Dilatation Intrahepatic Duct Acquired, Hepatotoxicity, Venoocclusive Disease, Blood Bilirubin Increased, Alanine Aminotransferase Increased
This is a report of a 19-year-old female patient (weight: NA) from GB, suffering from the following health symptoms/conditions: NA, who was treated with Acyclovir (dosage: NA, start time:
Sep 21, 2007), combined with:
  • Ondansetron Hydrochloride
  • Acetaminophen
  • Allopurinol
  • Morphine
  • Chlorpheniramine Maleate
  • Norethisterone (5 Mg, 3 In 1 D)
  • Cyclosporin
  • Caspofungin (70 Mg, 1 In 1 D)
and developed a serious reaction and side effect(s): Liver Function Test Abnormal, Dilatation Intrahepatic Duct Acquired, Hepatotoxicity, Venoocclusive Disease, Blood Bilirubin Increased, Alanine Aminotransferase Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acyclovir treatment in female patients, resulting in Liver Function Test Abnormal side effect.
Acyclovir Side Effect Report#9639347
Oropharyngeal Pain, Rash, Varicella, Hypersensitivity, Toxic Epidermal Necrolysis
This report suggests a potential Acyclovir (aciclovir) (aciclovir) Oropharyngeal Pain side effect(s) that can have serious consequences. A 11-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Acyclovir (aciclovir) (aciclovir) (dosage: NA) starting
Sep 27, 2012. After starting Acyclovir (aciclovir) (aciclovir) the patient began experiencing various side effects, including: Oropharyngeal Pain, Rash, Varicella, Hypersensitivity, Toxic Epidermal NecrolysisAdditional drugs used concurrently:
  • Diclofenac
  • Ibuprofen
  • Nuropen
  • Ibuprofen
  • Augmentin (augmentin) (amoxicillin Sodium, Clavulanate Potassium)
  • Calpol (paracetamol) (paracetamol)
  • Celluvisc (carmellose Sodium) (carmellose Sodium)
  • Lacri-lube (lacri-lube) (wool Fat, Petrolatum, Mineral Oil Light)
The patient was hospitalized. Although Acyclovir (aciclovir) (aciclovir) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Oropharyngeal Pain, may still occur.
Acyclovir Side Effect Report#9638928
Hepatitis Acute, Lymphocyte Stimulation Test Positive
This Hepatitis Acute problem was reported by a health professional from JP. A 23-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: herpes zoster,herpes virus infection. On NS this consumer started treatment with Acyclovir (dosage: NA). The following drugs were being taken at the same time: NA. When using Acyclovir, the patient experienced the following unwanted symptoms/side effects: Hepatitis Acute, Lymphocyte Stimulation Test PositiveAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hepatitis Acute, may become evident only after a product is in use by the general population.
Acyclovir Side Effect Report#9635209
No Therapeutic Response, Nausea, Vomiting, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased
This No Therapeutic Response side effect was reported by a consumer or non-health professional from IR. A 36-year-old female patient (weight:NA) experienced the following symptoms/conditions: meningoencephalitis herpetic.The patient was prescribed Acyclovir Sodium (drug dosage: Not Otherwise Specified), which was initiated on NS. Concurrently used drugs: NA..After starting to take Acyclovir Sodium the consumer reported adverse symptoms, such as: No Therapeutic Response, Nausea, Vomiting, Aspartate Aminotransferase Increased, Alanine Aminotransferase IncreasedThese side effects may potentially be related to Acyclovir Sodium.
Acyclovir Side Effect Report#9631159
Lethargy, Fatigue
This is a report of a 58-year-old female patient (weight: NA) from GB, suffering from the following health symptoms/conditions: herpes zoster, who was treated with Acyclovir (dosage: NA, start time:
Aug 28, 2013), combined with:
  • Felodipine
  • Paracetamol
  • Ibuprofen
and developed a serious reaction and side effect(s): Lethargy, Fatigue after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Acyclovir treatment in female patients, resulting in Lethargy side effect.


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The appearance of Acyclovir on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Acyclovir Side Effects for Women?

Women Side EffectsReports
Renal Failure Acute 45
Nausea 34
Somnolence 29
Pain 28
Neurotoxicity 25
Agitation 21
Blood Creatinine Increased 21
Pyrexia 19
Vomiting 19
Dyspnoea 18

What are common Acyclovir Side Effects for Men?

Men Side EffectsReports
Renal Failure Acute 63
Confusional State 35
Blood Creatinine Increased 30
Pyrexia 29
Neurotoxicity 27
Herpes Zoster 24
Nausea 21
Neutropenia 21
Renal Failure 21
Hallucination, Visual 20

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Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Acyclovir reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Acyclovir Safety Alerts, Active Ingredients, Usage Information

    NDC0054-0114
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameValacyclovir
    NameValacyclovir
    Dosage FormTABLET
    RouteORAL
    On market since20100524
    LabelerRoxane Laboratories, Inc
    Active Ingredient(s)VALACYCLOVIR HYDROCHLORIDE
    Strength(s)500
    Unit(s)mg/1
    Pharma ClassDNA Polymerase Inhibitors [MoA],Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC

    Acyclovir Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1220

    Acyclovir safety alerts: No

    Reported deaths: 168

    Reported hospitalizations: 548

    Latest Acyclovir clinical trials