Common Allopurinol Side Effects


The most commonly reported Allopurinol side effects (click to view or check a box to report):

Pyrexia (120)
Renal Failure Acute (119)
Stevens-johnson Syndrome (109)
Rash (102)
Dyspnoea (93)
Toxic Epidermal Necrolysis (87)
Diarrhoea (83)
Renal Failure (71)
Pruritus (66)
Nausea (65)
Asthenia (65)
Fatigue (60)
Blood Creatinine Increased (59)
Oedema Peripheral (56)
Alanine Aminotransferase Increased (56)
Hypotension (54)
Anaemia (47)
Pneumonia (47)
Malaise (46)
Gout (45)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Allopurinol Side Effects Reported to FDA



Allopurinol Side Effect Report#9976218
Tubulointerstitial Nephritis
This is a report of a 63-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: gout,abscess limb, who was treated with Allopurinol (dosage: NA, start time:
Oct 23, 2013), combined with:
  • Cefepime (2 G, Qd)
  • Dalacine (2.4 G, Qd)
  • Calciparine (0.5 Ml, Tid)
  • Perindopril (4 Mg, Qd)
  • Lasilix
  • Tahor (20 Mg, Unk)
  • Lyrica (150 Mg, Bid)
  • Omeprazole (20 Mg, Unk)
and developed a serious reaction and side effect(s): Tubulointerstitial Nephritis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Allopurinol treatment in male patients, resulting in Tubulointerstitial Nephritis side effect. The patient was hospitalized.
Allopurinol Side Effect Report#9972206
Subacute Cutaneous Lupus Erythematosus
This report suggests a potential Allopurinol Subacute Cutaneous Lupus Erythematosus side effect(s) that can have serious consequences. A 80-year-old female patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: NA and used Allopurinol (dosage: Df) starting NS. After starting Allopurinol the patient began experiencing various side effects, including: Subacute Cutaneous Lupus ErythematosusAdditional drugs used concurrently: NA. Although Allopurinol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Subacute Cutaneous Lupus Erythematosus, may still occur.
Allopurinol Side Effect Report#9959851
Vasculitis Cerebral, Depressed Level Of Consciousness
This Vasculitis Cerebral problem was reported by a physician from NZ. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: gout. On NS this consumer started treatment with Allopurinol (dosage: NA). The following drugs were being taken at the same time:
  • Spironolactone
  • Furosemide
  • Aspirin (acetylsalicylic Acid)
  • Metoprolol
  • Warfarin
  • Amiodarone
  • Potassium
When using Allopurinol, the patient experienced the following unwanted symptoms/side effects: Vasculitis Cerebral, Depressed Level Of ConsciousnessThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Vasculitis Cerebral, may become evident only after a product is in use by the general population.
Allopurinol Side Effect Report#9931439
Vasculitis Cerebral
This Vasculitis Cerebral side effect was reported by a health professional from IT. A 31-year-old male patient (weight:NA) experienced the following symptoms/conditions: hyperuricaemia,pulmonary tuberculosis.The patient was prescribed Allopurinol (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Pyrazinamide
  • Isoniazid/isoniazid Calcium Pyruvinate/isoniazid Sodium Glucuronate
  • Ethambutol
  • Rifampicin
.After starting to take Allopurinol the consumer reported adverse symptoms, such as: Vasculitis CerebralThese side effects may potentially be related to Allopurinol. The patient was hospitalized.
Allopurinol Side Effect Report#9928675
Rash Maculo-papular, Pyrexia
This is a report of a 50-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: acute myeloid leukaemia, who was treated with Allopurinol (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Rash Maculo-papular, Pyrexia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Allopurinol treatment in female patients, resulting in Rash Maculo-papular side effect. The patient was hospitalized.
Allopurinol Side Effect Report#9928060
Fall, Nausea, Vomiting, Malaise, Muscular Weakness, Rhabdomyolysis, Gait Disturbance
This report suggests a potential Allopurinol Fall side effect(s) that can have serious consequences. A 72-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Allopurinol (dosage: NA) starting 201107. After starting Allopurinol the patient began experiencing various side effects, including: Fall, Nausea, Vomiting, Malaise, Muscular Weakness, Rhabdomyolysis, Gait DisturbanceAdditional drugs used concurrently:
  • Furosemide (7.1429 Mg, 25 Mg Twice Weekly, Oral)
  • Ranolazine
  • Atorvastatin(atorvastatin)(40 Milligram, Tablets)(atorvastatin)
  • Valsartan(valsartan)
  • Nitroglycerin(glyceryl Trinitrate)(10 Milligram, Transdermal Patch)(glyceryl Trinitrate)
  • Bisoprolol(bisoprolol)
  • Ethylic Esters Of Polyunsaturated Fatty Acids(fatty Acids Nos)
  • Omeprazole(omeprazole)
The patient was hospitalized. Although Allopurinol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Fall, may still occur.
Allopurinol Side Effect Report#9924994
Vasculitis Cerebral, Hyperthyroidism, Pyrexia, Gait Disturbance, Hemianopia Homonymous, Blood Pressure Decreased, Heart Rate Decreased, Viith Nerve Paralysis
This Vasculitis Cerebral problem was reported by a health professional from NZ. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: gout. On NS this consumer started treatment with Allopurinol (allopurinol) (dosage: NA). The following drugs were being taken at the same time:
  • Amiodarone (amiodarone)
  • Aspirin (acetylsalicylic Acid)
  • Spironolactone (spironolactone)
  • Furosemide (furosemide)
  • Metopolol(metoprolol)
  • Warfrin (warfarin)
When using Allopurinol (allopurinol), the patient experienced the following unwanted symptoms/side effects: Vasculitis Cerebral, Hyperthyroidism, Pyrexia, Gait Disturbance, Hemianopia Homonymous, Blood Pressure Decreased, Heart Rate Decreased, Viith Nerve ParalysisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Vasculitis Cerebral, may become evident only after a product is in use by the general population.
Allopurinol Side Effect Report#9918734
Dyspnoea
This Dyspnoea side effect was reported by a physician from GB. A 64-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Allopurinol/allopurinol Sodium (drug dosage: NA), which was initiated on
Sep 19, 2013. Concurrently used drugs:
  • Salbutamol
  • Cetirizine
  • Capsaicin
  • Tiotropium/tiotropium Bromide
  • Xylocaine
  • Paracetamol
  • Simvastatin
  • Warfarin/warfarin Potassium/warfarin Sodium/warfarin Sodium Clathrate
.After starting to take Allopurinol/allopurinol Sodium the consumer reported adverse symptoms, such as: DyspnoeaThese side effects may potentially be related to Allopurinol/allopurinol Sodium.
Allopurinol Side Effect Report#9918732
Myocardial Infarction
This is a report of a 58-year-old male patient (weight: NA) from GB, suffering from the following health symptoms/conditions: gout, who was treated with Allopurinol/allopurinol Sodium (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Myocardial Infarction after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Allopurinol/allopurinol Sodium treatment in male patients, resulting in Myocardial Infarction side effect.
Allopurinol Side Effect Report#9918721
Sepsis, Agranulocytosis
This report suggests a potential Allopurinol Sepsis side effect(s) that can have serious consequences. A 79-year-old female patient (weight: NA) from CH was diagnosed with the following symptoms/conditions: NA and used Allopurinol (dosage: NA) starting NS. After starting Allopurinol the patient began experiencing various side effects, including: Sepsis, AgranulocytosisAdditional drugs used concurrently:
  • Azathioprine
Although Allopurinol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Sepsis, may still occur.
Allopurinol Side Effect Report#9918212
Vasculitis Cerebral, Hyperthyroidism
This Vasculitis Cerebral problem was reported by a physician from NZ. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: gout. On NS this consumer started treatment with Allopurinol (dosage: 200mg Daily). The following drugs were being taken at the same time:
  • Amiodarone
  • Aspirin
  • Spironolactone
  • Furosemide
  • Metoprolol
  • Warfarin
When using Allopurinol, the patient experienced the following unwanted symptoms/side effects: Vasculitis Cerebral, HyperthyroidismThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Vasculitis Cerebral, may become evident only after a product is in use by the general population.
Allopurinol Side Effect Report#9918211
Vasculitis Cerebral, Hyperthyroidism
This Vasculitis Cerebral side effect was reported by a physician from NZ. A 63-year-old female patient (weight:NA) experienced the following symptoms/conditions: gout.The patient was prescribed Allopurinol (drug dosage: 200mg Daily), which was initiated on NS. Concurrently used drugs:
  • Amiodarone
  • Aspirin
  • Spironolactone
  • Furosemide
  • Metoprolol
  • Warfarin
.After starting to take Allopurinol the consumer reported adverse symptoms, such as: Vasculitis Cerebral, HyperthyroidismThese side effects may potentially be related to Allopurinol. The patient was hospitalized.
Allopurinol Side Effect Report#9915700
Tendon Rupture, Local Swelling, Pain In Extremity, Asthenia, Gait Disturbance
This is a report of a 62-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: gout, who was treated with Allopurinol/zyloprim 300 Mg (dosage: NA, start time:
Nov 22, 2013), combined with:
  • Enalapril Hctz
  • Simvastatin
  • Multivitamin
  • Vit C
  • Niacin
  • Low Dose Aspirin
  • Glucosamine
and developed a serious reaction and side effect(s): Tendon Rupture, Local Swelling, Pain In Extremity, Asthenia, Gait Disturbance after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Allopurinol/zyloprim 300 Mg treatment in male patients, resulting in Tendon Rupture side effect.
Allopurinol Side Effect Report#9913935
Acute Hepatic Failure
This report suggests a potential Allopurinol Acute Hepatic Failure side effect(s) that can have serious consequences. A 48-year-old male patient (weight: NA) from MX was diagnosed with the following symptoms/conditions: renal failure chronic and used Allopurinol (dosage: /24h) starting NS. After starting Allopurinol the patient began experiencing various side effects, including: Acute Hepatic FailureAdditional drugs used concurrently:
  • Furosemide (furosemide)(furosemide)
  • Calcitriol (calcitriol)(calcitriol)
  • Enalapril (enalapril)(enalapril)
  • Ferrous Fumarate (ferrous Fumarate)(ferrous Fumarate)
The patient was hospitalized. Although Allopurinol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Acute Hepatic Failure, may still occur.
Allopurinol Side Effect Report#9913100
Cough, Tachycardia, Tachypnoea, Hypotension, Disorientation, Rales, Blood Glucose Increased
This Cough problem was reported by a physician from MX. A 49-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: renal failure chronic. On NS this consumer started treatment with Allopurinol (dosage: NA). The following drugs were being taken at the same time:
  • Furosemide Tablets 20 Mg (fuosemide) (20 Milligram, Tablets) (furosemide)
  • Calcitriol (calcitriol) (calcitriol)
  • Enalapril (enalapril)
  • Ferrous Fumarate (ferrous Fumarate)
When using Allopurinol, the patient experienced the following unwanted symptoms/side effects: Cough, Tachycardia, Tachypnoea, Hypotension, Disorientation, Rales, Blood Glucose IncreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cough, may become evident only after a product is in use by the general population.
Allopurinol Side Effect Report#9912649
Vasculitis Cerebral, Sinus Bradycardia, Thyroxine Increased, Troponin T Increased, Red Blood Cells Urine, Electrocardiogram T Wave Inversion, Torsade De Pointes, Cardiac Disorder
This Vasculitis Cerebral side effect was reported by a health professional from NZ. A 63-year-old female patient (weight:NA) experienced the following symptoms/conditions: gout.The patient was prescribed Allopurinol (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Amiodarone(amiodarone)(amiodarone)
  • Aspirin(aspirin)(aspirin)
  • Spironolactone(spironolactone)(spironolactone)
  • Furosemide(furosemide)(furosemide)
  • Metoprolol(metoprolol)(metoprolol)
  • Warfarin(warfarin)(warfarin)
  • Potassium Supplements(potassium)(potassium)
.After starting to take Allopurinol the consumer reported adverse symptoms, such as: Vasculitis Cerebral, Sinus Bradycardia, Thyroxine Increased, Troponin T Increased, Red Blood Cells Urine, Electrocardiogram T Wave Inversion, Torsade De Pointes, Cardiac DisorderThese side effects may potentially be related to Allopurinol. The patient was hospitalized.
Allopurinol Side Effect Report#9912541
Dermatitis Exfoliative, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased
This is a report of a 45-year-old patient (weight: NA) from IN, suffering from the following health symptoms/conditions: hyperuricaemia, who was treated with Allopurinol (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Dermatitis Exfoliative, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Allopurinol treatment in patients, resulting in Dermatitis Exfoliative side effect. The patient was hospitalized.
Allopurinol Side Effect Report#9912527
Stevens-johnson Syndrome, Strongyloidiasis
This report suggests a potential Allopurinol Stevens-johnson Syndrome side effect(s) that can have serious consequences. A 79-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Allopurinol (dosage: Unk) starting NS. After starting Allopurinol the patient began experiencing various side effects, including: Stevens-johnson Syndrome, StrongyloidiasisAdditional drugs used concurrently:
  • Hydrochlorothiazide (Unk)
  • Bandamustine (Unk)
  • Rituximab (Unk)
Although Allopurinol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Stevens-johnson Syndrome, may still occur.
Allopurinol Side Effect Report#9911715
Reversible Ischaemic Neurological Deficit, Altered State Of Consciousness, Gliosis, Viith Nerve Paralysis, Hypotonia, Craniocerebral Injury, Hemianopia, Vasculitis Cerebral, Cerebral Infarction
This Reversible Ischaemic Neurological Deficit problem was reported by a health professional from NZ. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: gout. On NS this consumer started treatment with Allopurinol (dosage: 200 Mg, Qd). The following drugs were being taken at the same time:
  • Aspirin
  • Spironolactone
  • Furosemide
  • Metoprolol
  • Warfarin
  • Potassium
  • Amiodarone
When using Allopurinol, the patient experienced the following unwanted symptoms/side effects: Reversible Ischaemic Neurological Deficit, Altered State Of Consciousness, Gliosis, Viith Nerve Paralysis, Hypotonia, Craniocerebral Injury, Hemianopia, Vasculitis Cerebral, Cerebral InfarctionThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Reversible Ischaemic Neurological Deficit, may become evident only after a product is in use by the general population.
Allopurinol Side Effect Report#9909032
Toxic Epidermal Necrolysis, Oesophageal Stenosis, Pallor, Scar, Aspiration
This Toxic Epidermal Necrolysis side effect was reported by a consumer or non-health professional from US. A 70-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Allopurinol (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Metoprolol
  • Ferrous Sulfate
  • Lansoprazole
.After starting to take Allopurinol the consumer reported adverse symptoms, such as: Toxic Epidermal Necrolysis, Oesophageal Stenosis, Pallor, Scar, AspirationThese side effects may potentially be related to Allopurinol.
Allopurinol Side Effect Report#9908546
Anxiety, Blood Pressure Systolic Increased, Lung Infiltration, Atelectasis, Pneumonia, Confusional State
This is a report of a 73-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: hyperuricaemia, who was treated with Allopurinol (dosage: NA, start time: NS), combined with:
  • Aspirin (aspirin) (aspirin)
  • Atenolol (atenolol) (atenolol)
  • Simvastatin (simvastatin) (simvastatin)
  • Bezafibrate (bezafibrate) (bezafibrate)
and developed a serious reaction and side effect(s): Anxiety, Blood Pressure Systolic Increased, Lung Infiltration, Atelectasis, Pneumonia, Confusional State after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Allopurinol treatment in male patients, resulting in Anxiety side effect. The patient was hospitalized.
Allopurinol Side Effect Report#9901695
Pyrexia, Tachycardia, Tachypnoea, Hypotension, Skin Exfoliation, Face Oedema, Ocular Icterus
This report suggests a potential Allopurinol Pyrexia side effect(s) that can have serious consequences. A 48-year-old male patient (weight: NA) from MX was diagnosed with the following symptoms/conditions: NA and used Allopurinol (dosage: 300 Mg, Unk) starting NS. After starting Allopurinol the patient began experiencing various side effects, including: Pyrexia, Tachycardia, Tachypnoea, Hypotension, Skin Exfoliation, Face Oedema, Ocular IcterusAdditional drugs used concurrently:
  • Furosemide (20 Mg, Bid)
  • Calcitriol (0.25 Ug, Unk)
  • Enalapril (10 Mg, Unk)
  • Ferrous Fumarate (200 Mg, Unk)
Although Allopurinol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pyrexia, may still occur.
Allopurinol Side Effect Report#9901230
Rhabdomyolysis
This Rhabdomyolysis problem was reported by a physician from IT. A 72-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On 201107 this consumer started treatment with Allopurinol (dosage: 150 Milligram Daily;). The following drugs were being taken at the same time:
  • Omeprazole (20 Milligram Daily;)
  • Quetiapine (50 Milligram Daily;)
  • Sertraline
  • Ranolazine (100 Milligram Daily;)
  • Acetylsalicyilic Acid (100 Milligram Daily;)
  • Bisoprolol (2.5 Milligram Daily;)
  • Furosemide
  • Atorvastatin (40 Milligram Daily;)
When using Allopurinol, the patient experienced the following unwanted symptoms/side effects: RhabdomyolysisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Rhabdomyolysis, may become evident only after a product is in use by the general population.
Allopurinol Side Effect Report#9891596
Myocardial Infarction, Vomiting, Diarrhoea, Abdominal Pain, Oedema, Oedema Peripheral, Blood Uric Acid Increased, Lipase Increased
This Myocardial Infarction side effect was reported by a consumer or non-health professional from US. A 84-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Allopurinol (drug dosage: Day), which was initiated on NS. Concurrently used drugs:
  • Hydralazine
  • Clopidogrel
  • Amlodipine
  • Metoprolol
  • Acetaminophen
  • Ferrous Sulfate
  • Vitamin D3 Supplement
  • Pantoprazole
.After starting to take Allopurinol the consumer reported adverse symptoms, such as: Myocardial Infarction, Vomiting, Diarrhoea, Abdominal Pain, Oedema, Oedema Peripheral, Blood Uric Acid Increased, Lipase IncreasedThese side effects may potentially be related to Allopurinol. The patient was hospitalized.
Allopurinol Side Effect Report#9891213
Acute Hepatic Failure
This is a report of a 49-year-old male patient (weight: NA) from MX, suffering from the following health symptoms/conditions: renal failure chronic, who was treated with Allopurinol (dosage: NA, start time: NS), combined with:
  • Furosemide (furosemide)
  • Calcitriol (calcitriol)
  • Enalapril (enalapril)
  • Ferrous Fumarate (ferrous Fumarate)
and developed a serious reaction and side effect(s): Acute Hepatic Failure after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Allopurinol treatment in male patients, resulting in Acute Hepatic Failure side effect.


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The appearance of Allopurinol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Allopurinol Side Effects for Women?

Women Side Effects Reports
Stevens-johnson Syndrome 54
Renal Failure Acute 47
Pyrexia 44
Toxic Epidermal Necrolysis 42
Pruritus 31
Rash 31
Diarrhoea 29
Renal Failure 28
Oedema Peripheral 27
Dyspnoea 26

What are common Allopurinol Side Effects for Men?

Men Side Effects Reports
Pyrexia 75
Renal Failure Acute 71
Rash 70
Dyspnoea 67
Stevens-johnson Syndrome 50
Diarrhoea 49
Fatigue 42
Gout 41
Asthenia 40
Renal Failure 40

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    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Allopurinol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Allopurinol Safety Alerts, Active Ingredients, Usage Information

    NDC 0378-0137
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name Allopurinol
    Name allopurinol
    Dosage Form TABLET
    Route ORAL
    On market since 19861024
    Labeler Mylan Pharmaceuticals Inc.
    Active Ingredient(s) ALLOPURINOL