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Amaryl Side Effects

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Common Amaryl Side Effects


The most commonly reported Amaryl side effects (click to view or check a box to report):

Hypoglycaemia (149)
Hypoglycaemic Coma (74)
Blood Glucose Increased (52)
Hyperglycaemia (41)
Myocardial Infarction (38)
Renal Failure Acute (36)
Loss Of Consciousness (30)
Blood Creatine Phosphokinase Increased (30)
Depressed Level Of Consciousness (29)
Cardiac Failure Congestive (28)
Cerebrovascular Accident (28)
Nausea (28)
Fall (28)
Diarrhoea (28)
Renal Failure (27)
Coronary Artery Disease (27)
Malaise (25)
Cardiac Failure (23)
Rhabdomyolysis (23)
Dyspnoea (23)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Amaryl Side Effects Reported to FDA



Amaryl Side Effect Report#9999540
Retinal Disorder, Vision Blurred, Effusion, Hypoglycaemia, Accidental Overdose
This is a report of a 56-year-old male patient (weight: NA) from BR, suffering from the following health symptoms/conditions: type 2 diabetes mellitus, who was treated with Amaryl (dosage: NA, start time: 2013), combined with: NA. and developed a serious reaction and side effect(s): Retinal Disorder, Vision Blurred, Effusion, Hypoglycaemia, Accidental Overdose after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amaryl treatment in male patients, resulting in Retinal Disorder side effect.
Amaryl Side Effect Report#9995902
Pancreatitis Acute, Abdominal Pain
This report suggests a potential Amaryl Pancreatitis Acute side effect(s) that can have serious consequences. A 66-year-old female patient (weight: NA) from IL was diagnosed with the following symptoms/conditions: diabetes mellitus and used Amaryl (dosage: NA) starting NS. After starting Amaryl the patient began experiencing various side effects, including: Pancreatitis Acute, Abdominal PainAdditional drugs used concurrently:
  • Levemir
  • Metformin
  • Glucophage
The patient was hospitalized. Although Amaryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pancreatitis Acute, may still occur.
Amaryl Side Effect Report#9858581
Pneumonia, Influenza, Dysphonia, Malaise
This Pneumonia problem was reported by a consumer or non-health professional from US. A 67-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On 200804 this consumer started treatment with Amaryl (dosage: NA). The following drugs were being taken at the same time:
  • Lantus Solostar (Dose:40 Unit(s))
  • Solostar
When using Amaryl, the patient experienced the following unwanted symptoms/side effects: Pneumonia, Influenza, Dysphonia, MalaiseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pneumonia, may become evident only after a product is in use by the general population.
Amaryl Side Effect Report#9858050
Loss Of Consciousness, Suspected Counterfeit Product, Hyperglycaemia
This Loss Of Consciousness side effect was reported by a consumer or non-health professional from RU. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus.The patient was prescribed Amaryl (drug dosage: NA), which was initiated on 201311. Concurrently used drugs: NA..After starting to take Amaryl the consumer reported adverse symptoms, such as: Loss Of Consciousness, Suspected Counterfeit Product, HyperglycaemiaThese side effects may potentially be related to Amaryl.
Amaryl Side Effect Report#9849230
Inappropriate Antidiuretic Hormone Secretion, Blood Sodium Decreased, Blood Osmolarity Decreased, Urine Osmolarity Increased
This is a report of a 79-year-old male patient (weight: NA) from JP, suffering from the following health symptoms/conditions: diabetes mellitus, who was treated with Amaryl (dosage: NA, start time:
Jun 01, 2013), combined with: NA. and developed a serious reaction and side effect(s): Inappropriate Antidiuretic Hormone Secretion, Blood Sodium Decreased, Blood Osmolarity Decreased, Urine Osmolarity Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amaryl treatment in male patients, resulting in Inappropriate Antidiuretic Hormone Secretion side effect. The patient was hospitalized.
Amaryl Side Effect Report#9818633
Peripheral Nerve Palsy, Rash
This report suggests a potential Amaryl Peripheral Nerve Palsy side effect(s) that can have serious consequences. A 68-year-old male patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: diabetes mellitus and used Amaryl (dosage: NA) starting
Jan 10, 2012. After starting Amaryl the patient began experiencing various side effects, including: Peripheral Nerve Palsy, RashAdditional drugs used concurrently: NA. Although Amaryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Peripheral Nerve Palsy, may still occur.
Amaryl Side Effect Report#9815670
Pneumonia
This Death problem was reported by a consumer or non-health professional from MX. A 70-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus. On 201309 this consumer started treatment with Amaryl (dosage: NA). The following drugs were being taken at the same time:
  • Lantus Solostar
When using Amaryl, the patient experienced the following unwanted symptoms/side effects: PneumoniaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Amaryl Side Effect Report#9791780
Hypoglycaemia, Encephalopathy
This Hypoglycaemia side effect was reported by a physician from JP. A 86-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Amaryl (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Metformin
  • Actos
.After starting to take Amaryl the consumer reported adverse symptoms, such as: Hypoglycaemia, EncephalopathyThese side effects may potentially be related to Amaryl.
Amaryl Side Effect Report#9785167
Humerus Fracture, Dizziness, Fall, Bone Disorder, Hyperglycaemia
This is a report of a 67-year-old female patient (weight: NA) from MX, suffering from the following health symptoms/conditions: type 2 diabetes mellitus, who was treated with Amaryl (dosage: NA, start time: 201308), combined with: NA. and developed a serious reaction and side effect(s): Humerus Fracture, Dizziness, Fall, Bone Disorder, Hyperglycaemia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amaryl treatment in female patients, resulting in Humerus Fracture side effect. The patient was hospitalized and became disabled.
Amaryl Side Effect Report#9759170
Trachoma, Ocular Hyperaemia, Feeling Hot
This report suggests a potential Amaryl Trachoma side effect(s) that can have serious consequences. A 61-year-old female patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: diabetes mellitus and used Amaryl (dosage: NA) starting 201311. After starting Amaryl the patient began experiencing various side effects, including: Trachoma, Ocular Hyperaemia, Feeling HotAdditional drugs used concurrently:
  • Metformin Hydrochloride
  • Voglibose
Although Amaryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Trachoma, may still occur.
Amaryl Side Effect Report#9752628
Tremor, Hyperglycaemia
This Tremor problem was reported by a physician from IT. A 69-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: diabetes mellitus. On
Nov 08, 2013 this consumer started treatment with Amaryl (dosage: NA). The following drugs were being taken at the same time:
  • Metformin
  • Bentelan
  • Nebilox
  • Totalip
  • Giant
When using Amaryl, the patient experienced the following unwanted symptoms/side effects: Tremor, HyperglycaemiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Tremor, may become evident only after a product is in use by the general population.
Amaryl Side Effect Report#9748514
Hypoglycaemia, Cold Sweat, Blood Pressure Decreased
This Hypoglycaemia side effect was reported by a physician from JP. A 85-year-old female patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus.The patient was prescribed Amaryl (drug dosage: NA), which was initiated on
Oct 21, 2013. Concurrently used drugs: NA..After starting to take Amaryl the consumer reported adverse symptoms, such as: Hypoglycaemia, Cold Sweat, Blood Pressure DecreasedThese side effects may potentially be related to Amaryl.
Amaryl Side Effect Report#9745427
Pancreatitis, Lipase Increased, Gallbladder Disorder, Abdominal Pain Upper, Aphagia, Weight Decreased, Diarrhoea, Blood Glucose Increased
This is a report of a 76-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: type 2 diabetes mellitus,gastrooesophageal reflux disease,cardiac operation, who was treated with Amaryl (dosage: NA, start time:
May 05, 2005), combined with:
  • Prilosec
  • Lipitor
  • Centrum Silver
  • Aspirin
and developed a serious reaction and side effect(s): Pancreatitis, Lipase Increased, Gallbladder Disorder, Abdominal Pain Upper, Aphagia, Weight Decreased, Diarrhoea, Blood Glucose Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amaryl treatment in female patients, resulting in Pancreatitis side effect.
Amaryl Side Effect Report#9681076
Hypoglycaemia, Off Label Use, Renal Failure Acute, Blood Creatinine Increased
This report suggests a potential Amaryl Hypoglycaemia side effect(s) that can have serious consequences. A 71-year-old male patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: diabetes mellitus,bladder cancer and used Amaryl (dosage: Tablet 1 Mg; Morning And Evening) starting
Jun 12, 2013. After starting Amaryl the patient began experiencing various side effects, including: Hypoglycaemia, Off Label Use, Renal Failure Acute, Blood Creatinine IncreasedAdditional drugs used concurrently:
  • Cisplatin
  • Alogliptin Benzoate (Dose: 6.25 Mg/min., After Lunch)
  • Bezafibrate
  • Bezafibrate
  • Gemcitabine
  • Voglibose (At 0.9 Mg/min After Meals)
The patient was hospitalized. Although Amaryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypoglycaemia, may still occur.
Amaryl Side Effect Report#9677861
Hypotension, Bradycardia, Hypoglycaemia
This Hypotension problem was reported by a physician from IT. A 76-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus,atrial fibrillation,hypertension. On 2013 this consumer started treatment with Amaryl (dosage: NA). The following drugs were being taken at the same time:
  • Flecainide (Strength: 100 Mg Tablet)
  • Blopresid (Dose:1 Unit(s))
  • Cardura (Modified Release Tablet)
  • Lansox (Orodispersible Tablet Dose:1 Unit(s))
  • Coumadin
  • Furosemide (Dose:1 Unit(s))
When using Amaryl, the patient experienced the following unwanted symptoms/side effects: Hypotension, Bradycardia, HypoglycaemiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypotension, may become evident only after a product is in use by the general population.
Amaryl Side Effect Report#9669329
Hypoglycaemia, Coma, Dyspnoea, Brain Injury, Atrioventricular Block, Renal Failure
This Hypoglycaemia side effect was reported by a pharmacist from DE. A 89-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Amaryl (drug dosage: NA), which was initiated on 201307. Concurrently used drugs:
  • Delix
  • Decortin
  • Melperone
  • Furosemide
.After starting to take Amaryl the consumer reported adverse symptoms, such as: Hypoglycaemia, Coma, Dyspnoea, Brain Injury, Atrioventricular Block, Renal FailureThese side effects may potentially be related to Amaryl. The patient was hospitalized.
Amaryl Side Effect Report#9628899
Dementia, Hypoglycaemia
This is a report of a 86-year-old female patient (weight: NA) from JP, suffering from the following health symptoms/conditions: NA, who was treated with Amaryl (dosage: NA, start time: 200607), combined with: NA. and developed a serious reaction and side effect(s): Dementia, Hypoglycaemia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amaryl treatment in female patients, resulting in Dementia side effect.
Amaryl Side Effect Report#9607432
Convulsion, Diarrhoea
This report suggests a potential Amaryl Convulsion side effect(s) that can have serious consequences. A 89-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Amaryl (dosage: NA) starting NS. After starting Amaryl the patient began experiencing various side effects, including: Convulsion, DiarrhoeaAdditional drugs used concurrently: NA.The patient was hospitalized. Although Amaryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Convulsion, may still occur.
Amaryl Side Effect Report#9570971
Hypoglycaemia, Overdose, Hypokalaemia
This Hypoglycaemia problem was reported by a physician from JP. A 42-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Aug 27, 2013 this consumer started treatment with Amaryl (dosage: NA). The following drugs were being taken at the same time:
  • Goodmin (Strength-0.25)
  • Gaslon
  • Depakene
  • Calonal
When using Amaryl, the patient experienced the following unwanted symptoms/side effects: Hypoglycaemia, Overdose, HypokalaemiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypoglycaemia, may become evident only after a product is in use by the general population.
Amaryl Side Effect Report#9539110
Gastric Haemorrhage, Cardiac Failure Congestive, Joint Injury, Hypoglycaemia, Urinary Tract Infection
This Gastric Haemorrhage side effect was reported by a consumer or non-health professional from US. A 75-year-old male patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus.The patient was prescribed Amaryl (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Novolog
.After starting to take Amaryl the consumer reported adverse symptoms, such as: Gastric Haemorrhage, Cardiac Failure Congestive, Joint Injury, Hypoglycaemia, Urinary Tract InfectionThese side effects may potentially be related to Amaryl. The patient was hospitalized.
Amaryl Side Effect Report#9507674
Interstitial Lung Disease
This is a report of a 60-year-old male patient (weight: NA) from JP, suffering from the following health symptoms/conditions: NA, who was treated with Amaryl (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Interstitial Lung Disease after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amaryl treatment in male patients, resulting in Interstitial Lung Disease side effect.
Amaryl Side Effect Report#9453127
Macular Oedema, Glycosylated Haemoglobin Increased
This report suggests a potential Amaryl Macular Oedema side effect(s) that can have serious consequences. A 65-year-old male patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus and used Amaryl (dosage: NA) starting
Dec 19, 2009. After starting Amaryl the patient began experiencing various side effects, including: Macular Oedema, Glycosylated Haemoglobin IncreasedAdditional drugs used concurrently:
  • Tanatril
  • Basen
  • Actos
  • Januvia
  • Metgluco
  • Euglucon
Although Amaryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Macular Oedema, may still occur.
Amaryl Side Effect Report#9434373
Macular Oedema
This Macular Oedema problem was reported by a health professional from JP. A 65-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus. On
Aug 10, 2012 this consumer started treatment with Amaryl (dosage: NA). The following drugs were being taken at the same time:
  • Tanatril (Start: 4 Years)
  • Basen (Started: 4 Years)
  • Actos
  • Januvia
  • Metgluco
  • Metgluco
When using Amaryl, the patient experienced the following unwanted symptoms/side effects: Macular OedemaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Macular Oedema, may become evident only after a product is in use by the general population.
Amaryl Side Effect Report#9409232
Arthropathy, Thyroid Disorder, Staphylococcal Infection, Lipids Increased, Sluggishness, Abdominal Discomfort, Blood Glucose Increased, Glycosylated Haemoglobin Increased
This Arthropathy side effect was reported by a consumer or non-health professional from US. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus.The patient was prescribed Amaryl (drug dosage: NA), which was initiated on 201306. Concurrently used drugs:
  • Lantus Solostar (Dose:40 Unit(s))
  • Solostar
  • Synthroid
  • Janumet
.After starting to take Amaryl the consumer reported adverse symptoms, such as: Arthropathy, Thyroid Disorder, Staphylococcal Infection, Lipids Increased, Sluggishness, Abdominal Discomfort, Blood Glucose Increased, Glycosylated Haemoglobin IncreasedThese side effects may potentially be related to Amaryl. The patient was hospitalized.
Amaryl Side Effect Report#9391151
Gastric Ulcer, Hypothyroidism, Hyperglycaemia, Blood Glucose Decreased
This is a report of a 71-year-old female patient (weight: NA) from MX, suffering from the following health symptoms/conditions: type 2 diabetes mellitus, who was treated with Amaryl (dosage: NA, start time: 201211), combined with: NA. and developed a serious reaction and side effect(s): Gastric Ulcer, Hypothyroidism, Hyperglycaemia, Blood Glucose Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amaryl treatment in female patients, resulting in Gastric Ulcer side effect.


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The appearance of Amaryl on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Amaryl reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Amaryl Side Effects

    Did You Have a Amaryl Side Effect?

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    Yes, Moderate
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    How Effective is Amaryl for You?

    Exceeded Expectations
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    Amaryl Safety Alerts, Active Ingredients, Usage Information

    NDC0039-0221
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameAMARYL
    Nameglimepiride
    Dosage FormTABLET
    RouteORAL
    On market since20090618
    LabelerSanofi-Aventis U.S. LLC
    Active Ingredient(s)GLIMEPIRIDE
    Strength(s)1
    Unit(s)mg/1
    Pharma ClassSulfonylurea [EPC],Sulfonylurea Compounds [Chemical/Ingredient]

    Amaryl Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1064

    Amaryl safety alerts: 2004

    Reported deaths: 147

    Reported hospitalizations: 592

    Amaryl (glimepiride)

    Audience: Neuropsychiatric healthcare professionals and pharmacists 

    [October 26, 2004] FDA, Janssen Pharmaceutica Products, and Johnson & Johnson Pharmaceutical Research & Development notified healthcare professionals of reports of medication errors involving confusion between Reminyl, a drug approved for the treatment of mild to moderate dementia of the Alzheimer's type, and Amaryl (glimepiride), a product of Aventis Pharmaceuticals, indicated for the treatment of non-insulin dependent (Type 2) diabetes mellitus. These reports include instances in which Reminyl was prescribed but Amaryl was incorrectly dispensed and administered instead, leading to various adverse events including severe hypoglycemia and one death.

    [UPDATE 12/23/2004] Letter to Pharmacists from Aventis Pharmaceuticals posted.

    [October 15, 2004 - Letter to Healthcare Professionals - Janssen]
    [October 19, 2004 - Letter to Pharmacists - Janssen] PDF Format
    [November 5, 2004 - Letter to Pharmacists - Aventis] PDF Format 

    Latest Amaryl clinical trials