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Amoxicillin Trihydrate Side Effects

Common Amoxicillin Trihydrate Side Effects


The most commonly reported Amoxicillin Trihydrate side effects are:
Abdominal Pain (4)
Tooth Ache (3)
Diarrhea (3)
Sore Throat (2)
Stomach Pains (2)
Headache (2)
Nausea (1)
Stomach Pain (1)
I Have Something Like Eczema On My Skin (1)
High Blood Pressure (1)
Constipation (1)

If you have experienced a side effect listed above, you can check a box to report it.


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If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Amoxicillin Trihydrate Side Effects Reported to FDA

The following Amoxicillin Trihydrate reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Amoxicillin Trihydrate on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Cardiac Arrest, Haematemesis, Hypocoagulable State, Macrocytosis, Thrombocytopenia, Biliary Sepsis, Hepatitis, Cholelithiasis
This is a report of a 77-year-old male patient (weight: NA) from IT, suffering from the following symptoms/conditions: upper respiratory tract infection,atrial fibrillation, who was treated with Amoxicillin Trihydrate (dosage: NA, start time: Jan 01, 2012), combined with:
  • Sintrom - 4 Mg Compresse Novartis Farma S.p.a. (1 Df As Necessary)
  • Sutent
  • Omnic
  • Pariet
  • Deltacortene - 25 Mg Compresse
  • Contramal - 50 Mg Capsule Rigide
and developed a serious reaction and side effect(s). The consumer presented with:
  • Cardiac Arrest
  • Haematemesis
  • Hypocoagulable State
  • Macrocytosis
  • Thrombocytopenia
  • Biliary Sepsis
  • Hepatitis
  • Cholelithiasis
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amoxicillin Trihydrate treatment in male patients, resulting in cardiac arrest side effect. The patient was hospitalized.

Nausea, Rash, Tachycardia, Dyspnoea
This report suggests a potential Amoxicillin Trihydrate Nausea, Rash, Tachycardia, Dyspnoea side effect(s) that can have serious consequences. A 52-year-old male patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: helicobacter infection and used Amoxicillin Trihydrate (dosage: 1000 Mg Total Po) starting Oct 31, 2013. Soon after starting Amoxicillin Trihydrate the patient began experiencing various side effects, including:
  • Nausea
  • Rash
  • Tachycardia
  • Dyspnoea
Drugs used concurrently:
  • Clarithyromycin (500 Mg Total, Po)
  • Lobivon (nebivolol)
  • Pantoprazole Sodium (pantoprazole Sodium)
  • Mesalazine (mesalazine)
The patient was hospitalized. Although Amoxicillin Trihydrate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as nausea, may still occur.

Circulatory Collapse, Syncope
This Circulatory Collapse, Syncope problem was reported by a physician from IT. A 60-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: toothache. On Nov 21, 2013 this consumer started treatment with Amoxicillin Trihydrate/clavulanate Potassium (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Amoxicillin Trihydrate/clavulanate Potassium, the patient experienced the following unwanted symptoms/side effects:
  • Circulatory Collapse
  • Syncope
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as circulatory collapse, may become evident only after a product is in use by the general population.

Hypersensitivity, Lip Oedema, Oedema Mucosal
This is a report of a 84-year-old male patient (weight: NA) from IT. The patient developed the following symptoms/conditions: NA and was treated with Amoxicillin Trihydrate (dosage: 1 Gram Daily;) starting Jul 20, 2012. Concurrently used drugs:
  • Xatral 2.5mg
  • Tapazole 5mg
  • Ramipril
  • Pantorc 40mg (Gastroresistant Tablet)
Soon after that, the consumer experienced the following side effects:
  • Hypersensitivity
  • Lip Oedema
  • Oedema Mucosal
This opens a possibility that Amoxicillin Trihydrate treatment could cause the above reactions, including hypersensitivity, and some male subjects may be more susceptible.


Pleural Effusion, Hepatomegaly, Splenomegaly, Condition Aggravated, Lymphadenopathy, Rash, Rash Pruritic, Blister
A 53-year-old female patient (weight: NA) from IT with the following symptoms/conditions: oropharyngeal pain,pyrexia,lymphadenopathy,spinal osteoarthritis started Amoxicillin Trihydrate/clavulanate Potassium treatment (dosage: Unk) on NS. Soon after starting Amoxicillin Trihydrate/clavulanate Potassium treatment, the subject experienced various side effects, including:
  • Pleural Effusion
  • Hepatomegaly
  • Splenomegaly
  • Condition Aggravated
  • Lymphadenopathy
  • Rash
  • Rash Pruritic
  • Blister
Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Amoxicillin Trihydrate/clavulanate Potassium.

Bronchospasm, Angioedema
A 66-year-old female patient from NL (weight: NA) experienced symptoms, such as: helicobacter infection and was treated with Amoxicillin Trihydrate(dosage: 1000 Mg, 2x/day). The treatment was initiated on Mar 09, 2007. After that a consumer reported the following side effect(s):
  • Bronchospasm
  • Angioedema
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Amoxicillin Trihydrate efficacy:
  • Clarithromycin (500 Mg, 2x/day)
  • Pantoprazole (40 Mg, 2x/day)
  • Ranitidine (75 Mg, Unk)
  • Verapamil (40 Mg, 4x/day)
  • Acesistem (Unk)


Jaundice Cholestatic, Hepatitis, Acute Hepatic Failure
In this report, Amoxicillin Trihydrate was administered for the following condition: NA.A 55-year-old female consumer from US (weight: NA) started Amoxicillin Trihydrate treatment (dosage: NA) on Jan 22, 2013.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Jaundice Cholestatic
  • Hepatitis
  • Acute Hepatic Failure
A possible interaction with other drugs could have contributed to this reaction:
  • Doxycycline Hydrochloride
  • Metformin Hydrochloride (metformin Hydrochloride)
  • Roxithromycin
  • Aspirin (acetylsalicylic Acid)
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Amoxicillin Trihydrate treatment could be related to the listed above side effect(s).

Vomiting, Aphagia
This is a report of the following Amoxicillin Trihydrate+potassium Clavulanate Sandoz side effect(s):
  • Vomiting
  • Aphagia
A 3.-year-old female patient from BR (weight: NA) presented with the following condition: sinusitis and received a treatment with Amoxicillin Trihydrate+potassium Clavulanate Sandoz (dosage: 4 Ml, Bid) starting: Apr 07, 2013.The following concurrently used drugs could have generated interactions: NA.The patient was hospitalized.This report suggests that a Amoxicillin Trihydrate+potassium Clavulanate Sandoz treatment could be associated with the listed above side effect(s).

Skin Necrosis, Skin Lesion, Condition Aggravated, Vasculitis, Skin Ulcer, Oedema Peripheral, Contusion, Blister, Inflammation
This Amoxicillin Trihydrate/clavulanate Potassium report was submitted by a 74-year-old male consumer from GB (weight: NA). The patient was diagnosed with: infection,ulcer and Amoxicillin Trihydrate/clavulanate Potassium was administered (dosage: 625 Mg, 3x/day) starting: NS. The consumer developed a set of symptoms:
  • Skin Necrosis
  • Skin Lesion
  • Condition Aggravated
  • Vasculitis
  • Skin Ulcer
  • Oedema Peripheral
  • Contusion
  • Blister
  • Inflammation
Other drugs used simultaneously: NA.The patient was hospitalized.Those unexpected symptoms could be linked to a Amoxicillin Trihydrate/clavulanate Potassium treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Hepatitis, Jaundice Cholestatic
This is a report of a possible correlation between Amoxicillin Trihydrate use and the following symptoms/side effect(s):
  • Hepatitis
  • Jaundice Cholestatic
which could contribute to an assessment of Amoxicillin Trihydrate risk profile.A 55-year-old female consumer from AU (weight: NA) was suffering from NA and was treated with Amoxicillin Trihydrate (dosage: 1.5 Mg, Qd) starting Jan 22, 2013.Other concurrent medications:
  • Acetylsalicylic Acid (100 Mg, Unk)
  • Doxycycline (100 Mg, Qd)
  • Roxithromycin (300 Mg, Unk)
  • Metformin (2 G, Unk)
The patient was hospitalized.


A 39-year-old male patient from US (weight: NA) presented with the following symptoms: NA and after a treatment with Amoxicillin Trihydrate (dosage: NA) experienced the following side effect(s):
    The treatment was started on NS. Amoxicillin Trihydrate was used in combination with the following drugs:
    • Ranitidine Hydrochloride
    • Trazodone
    • Hydrocodone + Paracetamol
    • Methadone Hydrochloride
    This report could alert potential Amoxicillin Trihydrate consumers.

    Arthralgia, Joint Swelling, Syncope, Pain, Local Swelling, Abdominal Pain Upper, Feeling Abnormal, Aphagia, Dysphagia
    In this report, a 54-year-old female patient from GB (weight: NA) was affected by a possible Amoxicillin Trihydrate side effect.The patient was diagnosed with NA. After a treatment with Amoxicillin Trihydrate (dosage: 500 Mg, start date: Jan 21, 2013), the patient experienced the following side effect(s):
    • Arthralgia
    • Joint Swelling
    • Syncope
    • Pain
    • Local Swelling
    • Abdominal Pain Upper
    • Feeling Abnormal
    • Aphagia
    • Dysphagia
    The following simultaneously used drugs could have led to this reaction:
    • Levothyroxine
    The findings here stress that side effects should be taken into consideration when evaluating a Amoxicillin Trihydrate treatment.

    Homicidal Ideation, Intentional Self-injury, Suicidal Ideation, Toxicity To Various Agents, Malaise, Pain, Acute Psychosis, Aggression
    This is a report of a 28-year-old male patient from PT (weight: NA), who used Amoxicillin Trihydrate+potassium Clavulanate (dosage: 1 Df, Bid) for a treatment of infection,prophylaxis,pain,anxiety. After starting a treatment on Feb 07, 2012, the patient experienced the following side effect(s):
    • Homicidal Ideation
    • Intentional Self-injury
    • Suicidal Ideation
    • Toxicity To Various Agents
    • Malaise
    • Pain
    • Acute Psychosis
    • Aggression
    The following drugs could possibly have interacted with the Amoxicillin Trihydrate+potassium Clavulanate treatment
    • Sucralfato Mylan (1 Df, Bid)
    • Buscopan Compositum N
    • Lorazepam
    • Diazepam
    • Ultramidol
    The patient was hospitalized and became disabled.Taken together, these observations suggest that a Amoxicillin Trihydrate+potassium Clavulanate treatment could be related to side effect(s), such as Homicidal Ideation, Intentional Self-injury, Suicidal Ideation, Toxicity To Various Agents, Malaise, Pain, Acute Psychosis, Aggression.

    Hyperhidrosis, Thirst, Tic, Suicidal Ideation, Anxiety, Eating Disorder, Anger, Homicidal Ideation, Condition Aggravated
    This hyperhidrosis side effect was reported by a health professional from PT. A 27-year-old male patient (weight:NA) experienced the following symptoms/conditions: infection. The patient was prescribed Amoxicillin Trihydrate+potassium Clavulanate (dosage: 1 Df, Bid), which was started on Aug 06, 2011. Concurrently used drugs:
    • Metamizol (575 Mg, Qd)
    • Xumadol (1 Df, Tid)
    • Sucralfato Mylan (1 Df, Bid)
    When starting to take Amoxicillin Trihydrate+potassium Clavulanate the consumer reported the following symptoms:
    • Hyperhidrosis
    • Thirst
    • Tic
    • Suicidal Ideation
    • Anxiety
    • Eating Disorder
    • Anger
    • Homicidal Ideation
    • Condition Aggravated
    These side effects may potentially be related to Amoxicillin Trihydrate+potassium Clavulanate.

    Suicidal Ideation, Panic Disorder, Abnormal Behaviour, Bulimia Nervosa, Homicidal Ideation, Acute Psychosis, Fatigue, Abdominal Pain, Constipation
    This is a Amoxicillin Trihydrate+potassium Clavulanate Sandoz side effect report of a 28-year-old male patient (weight:NA) from PT, suffering from the following symptoms/conditions: infection, who was treated with Amoxicillin Trihydrate+potassium Clavulanate Sandoz (dosage:1 Df, Bid, start time: Aug 04, 2012), combined with:
    • Nimesulida Basi (100 Mg, Qd)
    • Diazepam (5 Mg, Tid)
    • Ultramidol (1 Df, Bid)
    • Seroquel (100 Mg, Qd)
    , and developed a serious reaction and a suicidal ideation side effect. The patient presented with:
    • Suicidal Ideation
    • Panic Disorder
    • Abnormal Behaviour
    • Bulimia Nervosa
    • Homicidal Ideation
    • Acute Psychosis
    • Fatigue
    • Abdominal Pain
    • Constipation
    which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Amoxicillin Trihydrate+potassium Clavulanate Sandoz treatment in male patients suffering from infection, resulting in suicidal ideation.

    Dyspnoea, Rash Pruritic
    This report suggests a potential Amoxicillin Trihydrate+potassium Clavulanate dyspnoea side effect(s) that can have serious consequences. A 35-year-old male patient from IT (weight:NA) was diagnosed with the following health condition(s): tooth abscess and used Amoxicillin Trihydrate+potassium Clavulanate (dosage: Unk) starting Aug 16, 2012. Soon after starting Amoxicillin Trihydrate+potassium Clavulanate the patient began experiencing various side effects, including:
    • Dyspnoea
    • Rash Pruritic
    Drugs used concurrently:NA. The patient was hospitalized. Although Amoxicillin Trihydrate+potassium Clavulanate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as dyspnoea, may still occur.

    Asthenia, Hyperpyrexia, Diarrhoea, Rash Morbilliform, Pruritus
    This asthenia problem was reported by a health professional from IT. A 17-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): pharyngotonsillitis.On Sep 19, 2012 a consumer started treatment with Amoxicillin Trihydrate+potassium Clavulanate (dosage: Unk Ukn, Unk). The following drugs/medications were being taken at the same time: NA. When commencing Amoxicillin Trihydrate+potassium Clavulanate, the patient experienced the following unwanted symptoms /side effects:
    • Asthenia
    • Hyperpyrexia
    • Diarrhoea
    • Rash Morbilliform
    • Pruritus
    Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as asthenia, may become evident only after a product is in use by the general population.

    Diarrhoea, Staphylococcal Infection, Malaise, Decreased Appetite, Weight Decreased
    This is a Amoxicillin Trihydrate, Clavulanic Acid side effect report of a 89-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: appendicectomy and was treated with Amoxicillin Trihydrate, Clavulanic Acid (dosage: Unk) starting NS. Concurrently used drugs:
    • Piperacillin/tazobactam (Unk)
    • Nitrofurantoin (Unk)
    Soon after that, the consumer experienced the following of symptoms:
    • Diarrhoea
    • Staphylococcal Infection
    • Malaise
    • Decreased Appetite
    • Weight Decreased
    The patient was hospitalized. This opens a possibility that Amoxicillin Trihydrate, Clavulanic Acid could cause diarrhoea and that some male patients may be more susceptible.

    Pemphigus
    A 69-year-old female patient (weight: NA) from IT with the following symptoms: abscess started Amoxicillin Trihydrate/clavulanic Acid treatment (dosage: 2 G/day) on NS. Soon after starting Amoxicillin Trihydrate/clavulanic Acid treatment, the consumer experienced several side effects, including:
    • Pemphigus
    . Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Amoxicillin Trihydrate/clavulanic Acid side effects, such as pemphigus.

    Cholestatic Liver Injury
    This cholestatic liver injury side effect was reported by a health professional from PL. A 8-year-old male patient (weight:NA) experienced the following symptoms/conditions: upper respiratory tract infection,liver transplant.The patient was prescribed Amoxicillin Trihydrate/clavulanic Acid (dosage: 25/3.6 Mg/kg/day), which was started on NS. Concurrently used drugs:
    • Tacrolimus (Unk)
    .When starting to take Amoxicillin Trihydrate/clavulanic Acid the consumer reported symptoms, such as:
    • Cholestatic Liver Injury
    These side effects may potentially be related to Amoxicillin Trihydrate/clavulanic Acid. The patient was hospitalized.

    Organising Pneumonia, Lymphocyte Stimulation Test Positive
    This is a report of a 77-year-old female patient (weight: NA) from JAPAN, suffering from the following symptoms/conditions: helicobacter infection,gastric ulcer, who was treated with Amoxicillin Trihydrate (dosage: Per Oral, start time: NS), combined with:
    • Lansoprazole (Per Oral)
    • Clarithromycin (Per Oral)
    and developed a serious reaction and side effect(s). The consumer presented with:
    • Organising Pneumonia
    • Lymphocyte Stimulation Test Positive
    which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amoxicillin Trihydrate treatment in female patients, resulting in organising pneumonia side effect.

    Agitation, Nystagmus, Cerebrovascular Accident, Vomiting, Abdominal Pain Upper, Oxygen Saturation Decreased, Hypertension, Hydrocephalus, Cerebral Gas Embolism
    This report suggests a potential Amoxicillin Trihydrate Agitation, Nystagmus, Cerebrovascular Accident, Vomiting, Abdominal Pain Upper, Oxygen Saturation Decreased, Hypertension, Hydrocephalus, Cerebral Gas Embolism side effect(s) that can have serious consequences. A 33-year-old male patient (weight: NA) from FRANCE was diagnosed with the following symptoms/conditions: NA and used Amoxicillin Trihydrate (dosage: NA) starting May 03, 2012. Soon after starting Amoxicillin Trihydrate the patient began experiencing various side effects, including:
    • Agitation
    • Nystagmus
    • Cerebrovascular Accident
    • Vomiting
    • Abdominal Pain Upper
    • Oxygen Saturation Decreased
    • Hypertension
    • Hydrocephalus
    • Cerebral Gas Embolism
    Drugs used concurrently:
    • Derinox (prednisolone, Naphazoline) (derinox /06053201/) (;nas)
    • Nasonex
    • Prednisolone
    The patient was hospitalized. Although Amoxicillin Trihydrate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as agitation, may still occur.

    Dysphagia, Pharyngeal Inflammation, Palpitations
    This Dysphagia, Pharyngeal Inflammation, Palpitations problem was reported by a physician from PORTUGAL. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: influenza,insomnia. On Jan 01, 2007 this consumer started treatment with Amoxicillin Trihydrate (dosage: 1000mg Twice Per Day). The following drugs were being taken at the same time:
    • Olcadil (2mg Per Day)
    • Fluticasone Propionate
    • Ginkgo Biloba (40mg Per Day)
    • Moduretic 5-50
    • Varfine (7.5mg Per Day)
    • Lanoxin (.25mg Four Times Per Week)
    • Crestor (5mg Per Day)
    When commencing Amoxicillin Trihydrate, the patient experienced the following unwanted symptoms/side effects:
    • Dysphagia
    • Pharyngeal Inflammation
    • Palpitations
    Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as dysphagia, may become evident only after a product is in use by the general population.

    Anti Factor V Antibody Positive, Coagulation Factor V Level Decreased
    This is a report of a 24-year-old male patient (weight: NA) from FRANCE. The patient developed the following symptoms/conditions: NA and was treated with Amoxicillin Trihydrate (dosage: NA) starting Mar 06, 2012. Concurrently used drugs:
    • Primaxin
    • Tachosil
    • Cefotaxime Sodium
    • Gentamicin
    • Tazobactam
    Soon after that, the consumer experienced the following side effects:
    • Anti Factor V Antibody Positive
    • Coagulation Factor V Level Decreased
    The patient was hospitalized. This opens a possibility that Amoxicillin Trihydrate treatment could cause the above reactions, including anti factor v antibody positive, and some male subjects may be more susceptible.

    Dysphagia, Pharyngeal Inflammation, Palpitations
    A female patient (weight: NA) from PORTUGAL with the following symptoms/conditions: influenza,hypercholesterolaemia started Amoxicillin Trihydrate treatment (dosage: 1000mg Twice Per Day) on Jan 01, 2005. Soon after starting Amoxicillin Trihydrate treatment, the subject experienced various side effects, including:
    • Dysphagia
    • Pharyngeal Inflammation
    • Palpitations
    Concurrently used drugs:
    • Crestor (5mg Per Day)
    • Ginkgo Biloba (40mg Per Day)
    • Olcadil (2mg Per Day)
    • Fluticasone Propionate
    • Moduretic 5-50
    • Varfine (7.5mg Per Day)
    • Lanoxin (.25mg Four Times Per Week)
    This finding indicates that some female patients could be more vulnerable to Amoxicillin Trihydrate.

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    Top 10 Amoxicillin Trihydrate Side Effects for Women

    Women Side EffectsReports
    Pyrexia 15
    Renal Failure Acute 13
    Erythema 12
    Diarrhoea 11
    Rash 10
    Alanine Aminotransferase Increased 9
    Abdominal Pain 8
    Dermatitis Exfoliative 8
    Urticaria 8
    Angioedema 7

    Top 10 Amoxicillin Trihydrate Side Effects for Men

    Men Side EffectsReports
    Abdominal Pain 9
    Diarrhoea 8
    Enterocolitis Haemorrhagic 8
    Rash 8
    Pruritus 7
    Urticaria 7
    Pyrexia 6
    Anaphylactic Shock 5
    Dyspnoea 5
    Erythema 5

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    Amoxicillin Trihydrate Safety Alerts, Active Ingredients, Usage Information

    More About Amoxicillin trihydrate

    Side Effects reported to FDA: 251

    Amoxicillin Trihydrate safety alerts: No

    Reported deaths: 15

    Reported hospitalizations: 152

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