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Trembling (2)
Burning Throat (1)
Burning Throat Laryngites (1)
Orgasm (1)
Unsleeping (1)
Xanax (1)
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Anafranil Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 116 

Maternal Exposure During Pregnancy, Pre-eclampsia (7796057-0)
on Sep 27, 2011 Female from NETHERLANDS , 26 years of age, weighting 110.2 lb, was diagnosed with
  • panic disorder
and was treated with Anafranil Cap. Directly after, patient experienced the unwanted or unexpected Anafranil side effects: maternal exposure during pregnancy, pre-eclampsia. Anafranil Cap dosage: 50 Mg, Daily Dose.

Epilepsy, Staphylococcal Sepsis, Thrombosis, Progressive Multifocal Leukoencephalopathy, Immune Reconstitution Syndrome (7766271-9)
Patient was taking Anafranil. Patient felt the following Anafranil side effects: epilepsy, staphylococcal sepsis, thrombosis, progressive multifocal leukoencephalopathy, immune reconstitution syndrome on Sep 09, 2011 from FRANCE Additional patient health information: Female , 42 years of age, . Anafranil dosage: N/A.
Multiple prescriptions taken:
  • Tysabri
  • Ferrous Sulfate Tab
  • Clonazepam
  • Lyrica
  • Amantadine Hcl
Patient was hospitalized.

Overdose, Suicide Attempt (7764723-9)
Adverse event was reported on Sep 06, 2011 by a Female taking Anafranil (Dosage: 750 Mg (75 Mg)) . Location: ITALY , 65 years of age, After Anafranil was administered, patient encountered several Anafranil side effects: overdose, suicide attempt.
Multiple concurrent drugs taken:
  • Actos (420 Mg (15 Mg))
  • Risperdal (20 Mg (2 Mg))
  • Micardis (1120 Mg (80 Mg))
Patient was hospitalized.

Agranulocytosis, Hepatitis (7740806-4)
on Aug 31, 2011 Male from TURKEY , 67 years of age, was treated with Anafranil Cap. Directly after, patient experienced the unwanted or unexpected Anafranil side effects: agranulocytosis, hepatitis. Anafranil Cap dosage: Unk.


Aspartate Aminotransferase Increased, Hepatotoxicity, Alanine Aminotransferase Increased (7731478-3)
on Aug 24, 2011 Female from TURKEY , 18 years of age, was treated with Anafranil Cap. Patient felt the following Anafranil side effects: aspartate aminotransferase increased, hepatotoxicity, alanine aminotransferase increased. Anafranil Cap dosage: 25 Mg, Qd.

Hypochloraemia, Inappropriate Antidiuretic Hormone Secretion, Hypokalaemia, Mania, Somnolence, Hyponatraemia, Choreoathetosis (7730095-9)
Patient was taking Anafranil. After Anafranil was administered, patient encountered several Anafranil side effects: hypochloraemia, inappropriate antidiuretic hormone secretion, hypokalaemia, mania, somnolence, hyponatraemia, choreoathetosis on Sep 01, 2011 from FRANCE Additional patient health information: Female , 60 years of age, . Anafranil dosage: 75 Mg, 2x/day.
Multiple concurrent drugs taken:
  • Xanax (0.25 Mg, 3x/day)
Patient was hospitalized.

Pulmonary Fibrosis, Depression, Blood Pressure Decreased, Fall, Pneumonia, Osteoporosis, Skin Papilloma, Stress, Bronchitis (7719731-0)
Adverse event was reported on Aug 19, 2011 by a Female taking Anafranil (Dosage: 75 Mg, Unk) was diagnosed with
  • depression
and. Location: GERMANY , 69 years of age, weighting 132.3 lb, Directly after, patient experienced the unwanted or unexpected Anafranil side effects: pulmonary fibrosis, depression, blood pressure decreased, fall, pneumonia, osteoporosis, skin papilloma, stress, bronchitis.
Associated medications used:
  • Enbrel (Unk)
  • Enbrel (25 Mg, Weekly)
Patient was hospitalized.

Hiatus Hernia, Oesophageal Ulcer, Insomnia, Crying (7707291-X)
on Aug 22, 2011 Male from BRAZIL , 31 years of age, was treated with Anafranil. Patient felt the following Anafranil side effects: hiatus hernia, oesophageal ulcer, insomnia, crying. Anafranil dosage: 2 Df, Daily.
Multiple prescriptions taken:
  • Depakene (2 Df, Daily)
  • Clozapine (100 Mg, 5 A Day)
  • Neozine (2 Df, Daily)
  • Clonazepam (2 Or 3 Tablets Daily)
  • Phenergan (1 Df, Unk)


Depression, Stress, Pulmonary Fibrosis, Blood Pressure Decreased, Pneumonia, Osteoporosis, Skin Papilloma, Bronchitis, Fall (7676488-X)
on Aug 04, 2011 Female from GERMANY , 69 years of age, weighting 132.3 lb, was diagnosed with
  • depression
and was treated with Anafranil. After Anafranil was administered, patient encountered several Anafranil side effects: depression, stress, pulmonary fibrosis, blood pressure decreased, pneumonia, osteoporosis, skin papilloma, bronchitis, fall. Anafranil dosage: 75 Mg, Unk.
Multiple concurrent drugs taken:
  • Enbrel (25 Mg, Weekly)
Patient was hospitalized.

Self Injurious Behaviour (7671087-8)
Patient was taking Anafranil. Directly after, patient experienced the unwanted or unexpected Anafranil side effects: self injurious behaviour on Jul 30, 2011 from ITALY Additional patient health information: Female , 65 years of age, . Anafranil dosage: 750 Mg.
Associated medications used:
  • Actos (420 Mg)
  • Risperdal (20 Mg)
  • Micardis (40-80 Mg)


Staphylococcal Sepsis, Thrombosis, Immune Reconstitution Syndrome, Epilepsy, Progressive Multifocal Leukoencephalopathy (7640365-0)
Adverse event was reported on Jul 15, 2011 by a Female taking Anafranil (Dosage: N/A) . Location: FRANCE , 42 years of age, Patient felt the following Anafranil side effects: staphylococcal sepsis, thrombosis, immune reconstitution syndrome, epilepsy, progressive multifocal leukoencephalopathy.
Multiple prescriptions taken:
  • Amantadine Hcl
  • Tysabri
  • Clonazepam
  • Lyrica
  • Ferrous Sulfate Tab
Patient was hospitalized.

Progressive Multifocal Leukoencephalopathy, Immune Reconstitution Syndrome, Device Related Sepsis, Staphylococcal Sepsis, Thrombosis (7621798-5)
on Jul 07, 2011 Female from FRANCE , 42 years of age, was treated with Anafranil. After Anafranil was administered, patient encountered several Anafranil side effects: progressive multifocal leukoencephalopathy, immune reconstitution syndrome, device related sepsis, staphylococcal sepsis, thrombosis. Anafranil dosage: N/A.
Multiple concurrent drugs taken:
  • Lyrica
  • Tysabri
  • Amantadine Hcl
  • Clonazepam
  • Ferrous Sulfate Tab
Patient was hospitalized.

Suicide Attempt (7577583-6)
on Jun 20, 2011 Female from TURKEY , 30 years of age, was treated with Anafranil. Directly after, patient experienced the unwanted or unexpected Anafranil side effects: suicide attempt. Anafranil dosage: N/A.
Associated medications used:
  • Invega
  • Paroxetine Hcl
  • Aripiprazole


Progressive Multifocal Leukoencephalopathy (7504880-2)
Patient was taking Anafranil. Patient felt the following Anafranil side effects: progressive multifocal leukoencephalopathy on May 19, 2011 from ITALY Additional patient health information: Female , 51 years of age, weighting 121.3 lb, was diagnosed with
  • depression
  • neuralgia
  • multiple sclerosis
and. Anafranil dosage: N/A.
Multiple prescriptions taken:
  • Dintoina
  • Tysabri
  • Neurontin
Patient was hospitalized and became disabled.

Weight Decreased, Hepatic Failure, Altered State Of Consciousness, Hyperammonaemia (7471533-9)
Adverse event was reported on Apr 25, 2011 by a Female taking Anafranil (Dosage: N/A) . Location: JAPAN , 75 years of age, After Anafranil was administered, patient encountered several Anafranil side effects: weight decreased, hepatic failure, altered state of consciousness, hyperammonaemia.
Multiple concurrent drugs taken:
  • Lactulose
  • Cymbalta
  • Mirtazapine (15 Mg;qd;po)
  • Ursodeoxycholic Ac
Patient was hospitalized.

Malaise, Hyperammonaemia, Altered State Of Consciousness, Hepatic Failure (7394606-8)
on Mar 15, 2011 Female from JAPAN , 75 years of age, was treated with Anafranil. Directly after, patient experienced the unwanted or unexpected Anafranil side effects: malaise, hyperammonaemia, altered state of consciousness, hepatic failure. Anafranil dosage: N/A.
Associated medications used:
  • Ursodeoxycholic Ac
  • Cymbalta
  • Lactulose
  • Reflex (mirtazapine /01293201/) (15 Mg; Qd; Po)
Patient was hospitalized.

Type I Hypersensitivity, Rash Macular, Purpura, Pruritus (7384193-2)
on Mar 23, 2011 Male from SWITZERLAND , 88 years of age, weighting 253.5 lb, was treated with Anafranil. Patient felt the following Anafranil side effects: type i hypersensitivity, rash macular, purpura, pruritus. Anafranil dosage: 20mg Per Day.
Multiple prescriptions taken:
  • Tavanic
  • Rimactane
  • Dalacin
  • Mephanol
  • Amaryl (2mg Per Day)
  • Augmentin


Torsade De Pointes (7367427-X)
Patient was taking Anafranil. After Anafranil was administered, patient encountered several Anafranil side effects: torsade de pointes on Mar 17, 2011 from LEBANON Additional patient health information: Female , 80 years of age, was diagnosed with
  • frontotemporal dementia
  • agitation
and. Anafranil dosage: N/A.
Multiple concurrent drugs taken:
  • Seroquel


Blood Amylase Increased, Lipase Increased (7350414-5)
Adverse event was reported on Mar 08, 2011 by a Male taking Anafranil (Dosage: N/A) . Location: FRANCE , 40 years of age, Directly after, patient experienced the unwanted or unexpected Anafranil side effects: blood amylase increased, lipase increased.
Associated medications used:
  • Depakote


Pain In Extremity, Venous Insufficiency, Hypotension, Back Pain, Diverticulum, Ulcer, Cellulitis, Diabetic Retinopathy, Gallbladder Disorder (7325137-9)
on Feb 23, 2011 Female from UNITED STATES , 45 years of age, weighting 244.9 lb, was treated with Anafranil. Patient felt the following Anafranil side effects: pain in extremity, venous insufficiency, hypotension, back pain, diverticulum, ulcer, cellulitis, diabetic retinopathy, gallbladder disorder. Anafranil dosage: N/A.
Multiple prescriptions taken:
  • Ativan (0.5 Mg To 1 Mg)
  • Seroquel
  • Seroquel
  • Furosemide (20 Mg Tablet Orally Every Other Day)
  • Ferrous Sulfate Tab
  • Darvon Hydrochloride (1 Tablet Orally Q4h Prn During Day Then 2 Qhs)
  • Vitamin D
  • Seroquel
Patient was hospitalized.

Abdominal Distension, Oedema Peripheral (7319448-0)
on Mar 23, 2010 Male from UNITED STATES , 48 years of age, was treated with Anafranil. After Anafranil was administered, patient encountered several Anafranil side effects: abdominal distension, oedema peripheral. Anafranil dosage: N/A.
Multiple concurrent drugs taken:
  • Prozac
  • Lamictal (400mg Per Day)


Akathisia, Restlessness, Feeling Hot, Mania, Diabetes Mellitus, Insomnia (7307543-1)
Patient was taking Anafranil. Directly after, patient experienced the unwanted or unexpected Anafranil side effects: akathisia, restlessness, feeling hot, mania, diabetes mellitus, insomnia on Feb 14, 2011 from UNITED STATES Additional patient health information: Male , 34 years of age, weighting 189.6 lb, was diagnosed with
  • depression
and. Anafranil dosage: N/A.
Associated medications used:
  • Clobetasol Propionate (Cream Bid To Affected Area)
  • Apidra Solostar (1df=100unit/ml Ij Soln)
  • Klonopin (Tabs)
  • Alprazolam (Tabs,1 Pill By Mouth)
  • Zyrtec (Tab,1pill By Mouth)
  • Depakote
  • Abilify
  • Albuterol Sulfate (1df=108mcg/act In Aers.)


Hepatocellular Injury, Asthenia, Blood Lactate Dehydrogenase Increased, Pyrexia, Hepatitis (7279344-4)
Adverse event was reported on Feb 02, 2011 by a Female taking Anafranil (Dosage: N/A) . Location: ITALY , 77 years of age, Patient felt the following Anafranil side effects: hepatocellular injury, asthenia, blood lactate dehydrogenase increased, pyrexia, hepatitis.
Multiple prescriptions taken:
  • Diazepam
  • Depakene (1000 Mg Daily)
Patient was hospitalized.

Diabetes Mellitus, Mania, Insomnia, Feeling Hot, Restlessness, Akathisia (7242708-9)
on Jan 19, 2011 Male from UNITED STATES , 34 years of age, weighting 189.6 lb, was diagnosed with
  • depression
and was treated with Anafranil. After Anafranil was administered, patient encountered several Anafranil side effects: diabetes mellitus, mania, insomnia, feeling hot, restlessness, akathisia. Anafranil dosage: N/A.
Multiple concurrent drugs taken:
  • Abilify


Anaemia, Catatonia, Delusion, Depression, Hallucinations, Mixed, Serotonin Syndrome, Suicide Attempt (6957440-6)
on Aug 19, 2010 Male from JAPAN , 66 years of age, was diagnosed with
  • major depression
and was treated with Anafranil Cap. Directly after, patient experienced the unwanted or unexpected Anafranil side effects: anaemia, catatonia, delusion, depression, hallucinations, mixed, serotonin syndrome, suicide attempt. Anafranil Cap dosage: Unk. Patient was hospitalized.

Showing 1-25 of 116 

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Anafranil Information

Alternative ANAFRANIL Names:CLOMIPRAM

Active Ingredient: CLOMIPRAM

Anafranil Dosage, Warnings, Usage.

Side Effects reported to FDA: 116. View Anafranil Adverse Reports

Anafranil safety alerts: No

Reported deaths: 10

Reported hospitalizations: 47

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