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Anafranil Side Effects

Common Anafranil Side Effects


The most commonly reported Anafranil side effects (click to view or check a box to report):

Neuroleptic Malignant Syndrome (9)
Depression (8)
Dyspnoea (8)
Convulsion (8)
Confusional State (7)
Anxiety (7)
Depressed Level Of Consciousness (7)
Asthenia (7)
Tremor (7)
Suicide Attempt (7)
Fall (7)
Hyperhidrosis (6)
Blood Pressure Decreased (6)
Hyponatraemia (6)
Coma (6)
Nausea (6)
Serotonin Syndrome (6)
Overdose (6)
Multi-organ Failure (6)
Progressive Multifocal Leukoencephalopathy (5)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Anafranil Side Effects Reported to FDA

The following Anafranil reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Anafranil on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Vomiting, Nausea
This is a report of a 32-year-old female patient (weight: NA) from GB, suffering from the following symptoms/conditions: anxiety, who was treated with Anafranil (dosage: 100 Mg, Unk, start time: May 01, 2011), combined with:
  • Codeine Phosphate (Unk Ukn, Unk)
  • Opioids (Unk Ukn, Unk)
  • Oramorph (5 Ml, Unk)
  • Diazepam (4 Mg, Qd)
  • Tramadol (Unk Ukn, Unk)
  • Buscopan (Unk Ukn, Unk, 2-4 Tablets 5-10 Min Prior To Opiate)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Vomiting
  • Nausea
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in female patients, resulting in vomiting side effect.

Hypertension
This report suggests a potential Anafranil Hypertension side effect(s) that can have serious consequences. A 57-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: obsessive-compulsive disorder and used Anafranil (dosage: 25 Mg, Qd) starting 201312. Soon after starting Anafranil the patient began experiencing various side effects, including:
  • Hypertension
Drugs used concurrently:
  • Atorvastatin (10 Mg, Qd)
  • Sensipar (30 Mg, Qd)
  • Alprazolam (1 Mg, Tid)
  • Enalapril (20 Mg, Bid)
  • Diovan (150 Mg, Bid)
  • Atenolol (50 Mg, Bid)
  • Fosrenol (1000 Mg X 3, Qd)
  • Renvela (800 Mg, X 3, Tid-qid)
Although Anafranil demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hypertension, may still occur.

Completed Suicide, Cardio-respiratory Arrest
This Completed Suicide, Cardio-respiratory Arrest problem was reported by a pharmacist from US. A 73-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Anafranil (dosage: NA). The following drugs were being taken at the same time:
  • Bupropion
  • Bupropion Hcl Er
  • Quetiapine
When commencing Anafranil, the patient experienced the following unwanted symptoms/side effects:
  • Completed Suicide
  • Cardio-respiratory Arrest
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as completed suicide, may become evident only after a product is in use by the general population.

Cerebral Haemorrhage
This is a report of a 35-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: obsessive-compulsive disorder and was treated with Anafranil (dosage: 175 Mg Qd) starting 201310. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Cerebral Haemorrhage
The patient was hospitalized. This opens a possibility that Anafranil treatment could cause the above reactions, including cerebral haemorrhage, and some male subjects may be more susceptible.


Snoring, Sopor, Speech Disorder, Tachycardia
A 33-year-old male patient (weight: NA) from IT with the following symptoms/conditions: NA started Anafranil treatment (dosage: Unk) on Jul 13, 2012. Soon after starting Anafranil treatment, the subject experienced various side effects, including:
  • Snoring
  • Sopor
  • Speech Disorder
  • Tachycardia
Concurrently used drugs:
  • Olanzapine (Unk)
  • Rivotril (Unk)
  • Depakin (Unk)
  • Haldol (Unk)
  • Lantanon (Unk)
  • Trittico (Unk)
The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Anafranil.

Multi-organ Failure, Cardiotoxicity, Circulatory Collapse, Toxicity To Various Agents, Intentional Overdose, Suicidal Ideation, Bezoar, Cardiovascular Insufficiency, Altered State Of Consciousness
A 42-year-old female patient from PL (weight: NA) experienced symptoms, such as: intentional overdose and was treated with Anafranil Sr(dosage: Df = 75mg Tablet, Controlled Release). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Multi-organ Failure
  • Cardiotoxicity
  • Circulatory Collapse
  • Toxicity To Various Agents
  • Intentional Overdose
  • Suicidal Ideation
  • Bezoar
  • Cardiovascular Insufficiency
  • Altered State Of Consciousness
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Anafranil Sr efficacy:
  • Doxepin (Df = 25mg Capsule)
The patient was hospitalized.

Toxicity To Various Agents, Intentional Overdose, Suicidal Ideation, Cardiovascular Insufficiency, Multi-organ Failure, Bezoar, Altered State Of Consciousness, Respiratory Failure, Convulsion
In this report, Anafranil Sr was administered for the following condition: intentional overdose.A 42-year-old female consumer from PL (weight: NA) started Anafranil Sr treatment (dosage: Df = 75mg Tablet) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Toxicity To Various Agents
  • Intentional Overdose
  • Suicidal Ideation
  • Cardiovascular Insufficiency
  • Multi-organ Failure
  • Bezoar
  • Altered State Of Consciousness
  • Respiratory Failure
  • Convulsion
A possible interaction with other drugs could have contributed to this reaction:
  • Doxepin (Df = 25mg Capsule)
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Anafranil Sr treatment could be related to the listed above side effect(s).

Multi-organ Failure, Circulatory Collapse, Cardiotoxicity, Respiratory Failure, Renal Failure, Cardiovascular Insufficiency, Blood Pressure Decreased, Sinus Tachycardia, Anuria
This is a report of the following Anafranil side effect(s):
  • Multi-organ Failure
  • Circulatory Collapse
  • Cardiotoxicity
  • Respiratory Failure
  • Renal Failure
  • Cardiovascular Insufficiency
  • Blood Pressure Decreased
  • Sinus Tachycardia
  • Anuria
A 42-year-old female patient from PL (weight: NA) presented with the following condition: NA and received a treatment with Anafranil (dosage: 60 Df, Unk) starting: NS.The following concurrently used drugs could have generated interactions:
  • Doxepin (30 Df, Unk)
The patient was hospitalized.This report suggests that a Anafranil treatment could be associated with the listed above side effect(s).

Hyponatraemia, Malaise
This Anafranil report was submitted by a 62-year-old male consumer from FR (weight: NA). The patient was diagnosed with: depression,hypertension and Anafranil was administered (dosage: 75 Mg, Qd (once A Day In Evening)) starting: NS. The consumer developed a set of symptoms:
  • Hyponatraemia
  • Malaise
Other drugs used simultaneously:
  • Spironolactone (25 Mg, A Day)
  • Fludex (2.5 Mg, A Day)
  • Metformin Hydrochloride (1 (500) Df, Bid (one Dosage Form In The))
  • Atenolol (100 Mg, Qd (a Day In Morning))
  • Fenofibrate (67 Mg, Qd (in The Morning))
  • Kardegic (75 Mg, Qd (at Noon))
The patient was hospitalized.Those unexpected symptoms could be linked to a Anafranil treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Rash, Cough, Prurigo, Pruritus, Diarrhoea, Dyspnoea, Skin Lesion
This is a report of a possible correlation between Anafranil use and the following symptoms/side effect(s):
  • Rash
  • Cough
  • Prurigo
  • Pruritus
  • Diarrhoea
  • Dyspnoea
  • Skin Lesion
which could contribute to an assessment of Anafranil risk profile.A 38-year-old female consumer from IT (weight: NA) was suffering from major depression and was treated with Anafranil (dosage: Unk Ukn, Unk) starting NS.Other concurrent medications: NA.The patient was hospitalized.

Cough, Choking, Dry Mouth, Throat Irritation, Malaise
A 39-year-old female patient from US (weight: NA) presented with the following symptoms: obsessive-compulsive disorder and after a treatment with Anafranil (dosage: NA) experienced the following side effect(s):
  • Cough
  • Choking
  • Dry Mouth
  • Throat Irritation
  • Malaise
The treatment was started on Jun 15, 2012. Anafranil was used in combination with the following drugs:
  • Bupropion Hydrochloride
  • Bupropion Hydrochloride
  • Nexium
  • Zyrtec
  • Iron
  • Ibuprofen
This report could alert potential Anafranil consumers.

Tooth Loss, Aphagia, Formication, Muscle Spasms, Abasia, Learning Disorder, Weight Decreased, Fear Of Eating
In this report, a 9-year-old male patient from BR (weight: NA) was affected by a possible Anafranil side effect.The patient was diagnosed with phobia. After a treatment with Anafranil (dosage: 1 Df, Qhs (25 Mg), start date: 201002), the patient experienced the following side effect(s):
  • Tooth Loss
  • Aphagia
  • Formication
  • Muscle Spasms
  • Abasia
  • Learning Disorder
  • Weight Decreased
  • Fear Of Eating
The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Anafranil treatment.

Dysphemia, Dysarthria, Tremor
This is a report of a 45-year-old female patient from IT (weight: NA), who used Anafranil (dosage: 75 Mg, Daily) for a treatment of NA. After starting a treatment on Mar 01, 2013, the patient experienced the following side effect(s):
  • Dysphemia
  • Dysarthria
  • Tremor
The following drugs could possibly have interacted with the Anafranil treatment NA.The patient was hospitalized.Taken together, these observations suggest that a Anafranil treatment could be related to side effect(s), such as Dysphemia, Dysarthria, Tremor.

Serotonin Syndrome, Hallucination, Pyrexia, Confusional State, Agitation, Musculoskeletal Stiffness
This serotonin syndrome side effect was reported by a health professional from PT. A 82-year-old male patient (weight:NA) experienced the following symptoms/conditions: depression. The patient was prescribed Anafranil (dosage: NA), which was started on Sep 20, 2012. Concurrently used drugs:
  • Venlafaxine Hydrochloride
  • Amitriptyline Hydrochloride
When starting to take Anafranil the consumer reported the following symptoms:
  • Serotonin Syndrome
  • Hallucination
  • Pyrexia
  • Confusional State
  • Agitation
  • Musculoskeletal Stiffness
These side effects may potentially be related to Anafranil.

Weight Increased
This is a Anafranil side effect report of a 54-year-old female patient (weight:NA) from IT, suffering from the following symptoms/conditions: obsessive-compulsive disorder, who was treated with Anafranil (dosage:37.5 Mg, Daily, start time: 2010), combined with: NA., and developed a serious reaction and a weight increased side effect. The patient presented with:
  • Weight Increased
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Anafranil treatment in female patients suffering from obsessive-compulsive disorder, resulting in weight increased.

Interstitial Lung Disease, Pyrexia, Dyspnoea, Inflammation, Eosinophilia
This report suggests a potential Anafranil interstitial lung disease side effect(s) that can have serious consequences. A 64-year-old female patient from FR (weight:NA) was diagnosed with the following health condition(s): NA and used Anafranil (dosage: 75 Mg, Qd) starting 2012. Soon after starting Anafranil the patient began experiencing various side effects, including:
  • Interstitial Lung Disease
  • Pyrexia
  • Dyspnoea
  • Inflammation
  • Eosinophilia
Drugs used concurrently:
  • Paroxetine (10 Mg, Qd)
  • Seresta (10 Mg, Daily)
  • Nebivolol (5 Mg, Daily)
  • Femara (1 Df, Daily)
  • Spironolactone (50 Mg, Daily)
  • Topalgic (200 Mg, Daily)
  • Forlax (1 Df, Daily)
The patient was hospitalized. Although Anafranil demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as interstitial lung disease, may still occur.

Interstitial Lung Disease, Pyrexia, Dyspnoea, Inflammation, Eosinophilia
This interstitial lung disease problem was reported by a health professional from FR. A 64-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On 2012 a consumer started treatment with Anafranil (dosage: 75 Mg, Qd). The following drugs/medications were being taken at the same time:
  • Paroxetine (10 Mg, Qd)
  • Seresta (10 Mg, Daily)
  • Nebivolol (5 Mg, Daily)
  • Femara (1 Df, Daily)
  • Spironolactone (50 Mg, Daily)
  • Topalgic (200 Mg, Daily)
  • Forlax (1 Df, Daily)
When commencing Anafranil, the patient experienced the following unwanted symptoms /side effects:
  • Interstitial Lung Disease
  • Pyrexia
  • Dyspnoea
  • Inflammation
  • Eosinophilia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as interstitial lung disease, may become evident only after a product is in use by the general population.

Coma, Coma Scale Abnormal, Long Qt Syndrome, Intentional Overdose
This is a Anafranil side effect report of a 59-year-old female patient (weight: NA) from ES. The patient developed the following symptoms/conditions: intentional overdose and was treated with Anafranil (dosage: 12 Df, Daily) starting Jun 30, 2012. Concurrently used drugs:
  • Clotiapine (Unk Ukn, Unk)
  • Escitalopram (Unk Ukn, Unk)
  • Quetiapine (Unk Ukn, Unk)
  • Flunitrazepam (Unk Ukn, Unk)
  • Levomepromazine Maleate (Unk Ukn, Unk)
  • Diazepam
  • Calodis
  • Loxifan
Soon after that, the consumer experienced the following of symptoms:
  • Coma
  • Coma Scale Abnormal
  • Long Qt Syndrome
  • Intentional Overdose
The patient was hospitalized. This opens a possibility that Anafranil could cause coma and that some female patients may be more susceptible.

Posterior Reversible Encephalopathy Syndrome, Convulsion
A 66-year-old female patient (weight: NA) from IT with the following symptoms: major depression started Anafranil treatment (dosage: Unk Ukn, Unk) on 2010. Soon after starting Anafranil treatment, the consumer experienced several side effects, including:
  • Posterior Reversible Encephalopathy Syndrome
  • Convulsion
. Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Anafranil side effects, such as posterior reversible encephalopathy syndrome.

Muscle Rigidity, Tremor
This muscle rigidity side effect was reported by a health professional from IT. A 71-year-old female patient (weight:NA) experienced the following symptoms/conditions: bipolar disorder,anxiety.The patient was prescribed Anafranil (dosage: 75 Mg/day), which was started on Jan 01, 2011. Concurrently used drugs:
  • Alprazolam (30 Gtt/day)
  • Lamictal (50 Mg/day)
  • Fevarin (500 Mg/day)
  • Metformine (3000 Mg/day)
  • Provisacor
  • Cardioaspirin
.When starting to take Anafranil the consumer reported symptoms, such as:
  • Muscle Rigidity
  • Tremor
These side effects may potentially be related to Anafranil. The patient was hospitalized.

Apathy, Delirium
This is a report of a 91-year-old female patient (weight: NA) from BR, suffering from the following symptoms/conditions: decreased appetite,abnormal behaviour, who was treated with Anafranil (dosage: 4 Df Daily First Day, start time: 2002), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Apathy
  • Delirium
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in female patients, resulting in apathy side effect.

Choking, Dry Mouth, Cough
This report suggests a potential Anafranil Capsules Choking, Dry Mouth, Cough side effect(s) that can have serious consequences. A 39-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Anafranil Capsules (dosage: Unk) starting NS. Soon after starting Anafranil Capsules the patient began experiencing various side effects, including:
  • Choking
  • Dry Mouth
  • Cough
Drugs used concurrently: NA. Although Anafranil Capsules demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as choking, may still occur.

Fibromyalgia, Panic Attack, Agoraphobia, Dyspnoea, Musculoskeletal Disorder, Asthenia, Pain, Somnolence
This Fibromyalgia, Panic Attack, Agoraphobia, Dyspnoea, Musculoskeletal Disorder, Asthenia, Pain, Somnolence problem was reported by a consumer or non-health professional from BR. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: agoraphobia. On NS this consumer started treatment with Anafranil (dosage: 25 Mg, Daily). The following drugs were being taken at the same time: NA. When commencing Anafranil, the patient experienced the following unwanted symptoms/side effects:
  • Fibromyalgia
  • Panic Attack
  • Agoraphobia
  • Dyspnoea
  • Musculoskeletal Disorder
  • Asthenia
  • Pain
  • Somnolence
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as fibromyalgia, may become evident only after a product is in use by the general population.

Hyponatraemia
This is a report of a 93-year-old female patient (weight: NA) from IT. The patient developed the following symptoms/conditions: depression and was treated with Anafranil (dosage: 12.5 Mg, Qd) starting Oct 25, 2012. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Hyponatraemia
The patient was hospitalized. This opens a possibility that Anafranil treatment could cause the above reactions, including hyponatraemia, and some female subjects may be more susceptible.

Fall, Pelvic Fracture, Clavicle Fracture, Osteopenia
A female patient (weight: NA) from CH with the following symptoms/conditions: NA started Anafranil treatment (dosage: 37.5 Mg (in The Morning) Daily) on Jul 04, 2012. Soon after starting Anafranil treatment, the subject experienced various side effects, including:
  • Fall
  • Pelvic Fracture
  • Clavicle Fracture
  • Osteopenia
Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Anafranil.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Anafranil Side Effects

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    Anafranil Safety Alerts, Active Ingredients, Usage Information

    NDC0406-9906
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameANAFRANIL
    Nameclomipramine hydrochloride
    Dosage FormCAPSULE
    RouteORAL
    On market since20110318
    LabelerMallinckrodt, Inc.
    Active Ingredient(s)CLOMIPRAMINE HYDROCHLORIDE
    Strength(s)25
    Unit(s)mg/1
    Pharma ClassTricyclic Antidepressant [EPC]

    Anafranil Dosage, Warnings, Usage.

    Side Effects reported to FDA: 142

    Anafranil safety alerts: No

    Reported deaths: 14

    Reported hospitalizations: 65

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