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Anafranil Side Effects

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Common Anafranil Side Effects


The most commonly reported Anafranil side effects (click to view or check a box to report):

Neuroleptic Malignant Syndrome (9)
Depression (8)
Dyspnoea (8)
Convulsion (8)
Confusional State (7)
Anxiety (7)
Depressed Level Of Consciousness (7)
Asthenia (7)
Tremor (7)
Suicide Attempt (7)
Fall (7)
Hyperhidrosis (6)
Blood Pressure Decreased (6)
Hyponatraemia (6)
Coma (6)
Nausea (6)
Serotonin Syndrome (6)
Overdose (6)
Multi-organ Failure (6)
Progressive Multifocal Leukoencephalopathy (5)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Anafranil Side Effects Reported to FDA



Anafranil Side Effect Report#9871057
Vomiting, Nausea
This is a report of a 32-year-old female patient (weight: NA) from GB, suffering from the following health symptoms/conditions: anxiety, who was treated with Anafranil (dosage: 100 Mg, Unk, start time:
May 01, 2011), combined with:
  • Codeine Phosphate (Unk Ukn, Unk)
  • Opioids (Unk Ukn, Unk)
  • Oramorph (5 Ml, Unk)
  • Diazepam (4 Mg, Qd)
  • Tramadol (Unk Ukn, Unk)
  • Buscopan (Unk Ukn, Unk, 2-4 Tablets 5-10 Min Prior To Opiate)
and developed a serious reaction and side effect(s): Vomiting, Nausea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in female patients, resulting in Vomiting side effect.
Anafranil Side Effect Report#9867093
Hypertension
This report suggests a potential Anafranil Hypertension side effect(s) that can have serious consequences. A 57-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: obsessive-compulsive disorder and used Anafranil (dosage: 25 Mg, Qd) starting 201312. After starting Anafranil the patient began experiencing various side effects, including: HypertensionAdditional drugs used concurrently:
  • Atorvastatin (10 Mg, Qd)
  • Sensipar (30 Mg, Qd)
  • Alprazolam (1 Mg, Tid)
  • Enalapril (20 Mg, Bid)
  • Diovan (150 Mg, Bid)
  • Atenolol (50 Mg, Bid)
  • Fosrenol (1000 Mg X 3, Qd)
  • Renvela (800 Mg, X 3, Tid-qid)
Although Anafranil demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypertension, may still occur.
Anafranil Side Effect Report#9845229
Completed Suicide, Cardio-respiratory Arrest
This Completed Suicide problem was reported by a pharmacist from US. A 73-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Anafranil (dosage: NA). The following drugs were being taken at the same time:
  • Bupropion
  • Bupropion Hcl Er
  • Quetiapine
When using Anafranil, the patient experienced the following unwanted symptoms/side effects: Completed Suicide, Cardio-respiratory ArrestAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Completed Suicide, may become evident only after a product is in use by the general population.
Anafranil Side Effect Report#9808489
Cerebral Haemorrhage
This Cerebral Haemorrhage side effect was reported by a pharmacist from US. A 35-year-old male patient (weight:NA) experienced the following symptoms/conditions: obsessive-compulsive disorder.The patient was prescribed Anafranil (drug dosage: 175 Mg Qd), which was initiated on 201310. Concurrently used drugs: NA..After starting to take Anafranil the consumer reported adverse symptoms, such as: Cerebral HaemorrhageThese side effects may potentially be related to Anafranil. The patient was hospitalized.
Anafranil Side Effect Report#9775621
Snoring, Sopor, Speech Disorder, Tachycardia
This is a report of a 33-year-old male patient (weight: NA) from IT, suffering from the following health symptoms/conditions: NA, who was treated with Anafranil (dosage: Unk, start time:
Jul 13, 2012), combined with:
  • Olanzapine (Unk)
  • Rivotril (Unk)
  • Depakin (Unk)
  • Haldol (Unk)
  • Lantanon (Unk)
  • Trittico (Unk)
and developed a serious reaction and side effect(s): Snoring, Sopor, Speech Disorder, Tachycardia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in male patients, resulting in Snoring side effect. The patient was hospitalized.
Anafranil Side Effect Report#9742939
Multi-organ Failure, Cardiotoxicity, Circulatory Collapse, Toxicity To Various Agents, Intentional Overdose, Suicidal Ideation, Bezoar, Cardiovascular Insufficiency, Altered State Of Consciousness
This report suggests a potential Anafranil Sr Multi-organ Failure side effect(s) that can have serious consequences. A 42-year-old female patient (weight: NA) from PL was diagnosed with the following symptoms/conditions: intentional overdose and used Anafranil Sr (dosage: Df = 75mg Tablet, Controlled Release) starting NS. After starting Anafranil Sr the patient began experiencing various side effects, including: Multi-organ Failure, Cardiotoxicity, Circulatory Collapse, Toxicity To Various Agents, Intentional Overdose, Suicidal Ideation, Bezoar, Cardiovascular Insufficiency, Altered State Of ConsciousnessAdditional drugs used concurrently:
  • Doxepin (Df = 25mg Capsule)
The patient was hospitalized. Although Anafranil Sr demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Multi-organ Failure, may still occur.
Anafranil Side Effect Report#9738472
Toxicity To Various Agents, Intentional Overdose, Suicidal Ideation, Cardiovascular Insufficiency, Multi-organ Failure, Bezoar, Altered State Of Consciousness, Respiratory Failure, Convulsion
This Toxicity To Various Agents problem was reported by a health professional from PL. A 42-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: intentional overdose. On NS this consumer started treatment with Anafranil Sr (dosage: Df = 75mg Tablet). The following drugs were being taken at the same time:
  • Doxepin (Df = 25mg Capsule)
When using Anafranil Sr, the patient experienced the following unwanted symptoms/side effects: Toxicity To Various Agents, Intentional Overdose, Suicidal Ideation, Cardiovascular Insufficiency, Multi-organ Failure, Bezoar, Altered State Of Consciousness, Respiratory Failure, ConvulsionThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Toxicity To Various Agents, may become evident only after a product is in use by the general population.
Anafranil Side Effect Report#9737437
Multi-organ Failure, Circulatory Collapse, Cardiotoxicity, Respiratory Failure, Renal Failure, Cardiovascular Insufficiency, Blood Pressure Decreased, Sinus Tachycardia, Anuria
This Multi-organ Failure side effect was reported by a physician from PL. A 42-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Anafranil (drug dosage: 60 Df, Unk), which was initiated on NS. Concurrently used drugs:
  • Doxepin (30 Df, Unk)
.After starting to take Anafranil the consumer reported adverse symptoms, such as: Multi-organ Failure, Circulatory Collapse, Cardiotoxicity, Respiratory Failure, Renal Failure, Cardiovascular Insufficiency, Blood Pressure Decreased, Sinus Tachycardia, AnuriaThese side effects may potentially be related to Anafranil. The patient was hospitalized.
Anafranil Side Effect Report#9388790
Hyponatraemia, Malaise
This is a report of a 62-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: depression,hypertension, who was treated with Anafranil (dosage: 75 Mg, Qd (once A Day In Evening), start time: NS), combined with:
  • Spironolactone (25 Mg, A Day)
  • Fludex (2.5 Mg, A Day)
  • Metformin Hydrochloride (1 (500) Df, Bid (one Dosage Form In The))
  • Atenolol (100 Mg, Qd (a Day In Morning))
  • Fenofibrate (67 Mg, Qd (in The Morning))
  • Kardegic (75 Mg, Qd (at Noon))
and developed a serious reaction and side effect(s): Hyponatraemia, Malaise after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in male patients, resulting in Hyponatraemia side effect. The patient was hospitalized.
Anafranil Side Effect Report#9385811
Rash, Cough, Prurigo, Pruritus, Diarrhoea, Dyspnoea, Skin Lesion
This report suggests a potential Anafranil Rash side effect(s) that can have serious consequences. A 38-year-old female patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: major depression and used Anafranil (dosage: Unk Ukn, Unk) starting NS. After starting Anafranil the patient began experiencing various side effects, including: Rash, Cough, Prurigo, Pruritus, Diarrhoea, Dyspnoea, Skin LesionAdditional drugs used concurrently: NA.The patient was hospitalized. Although Anafranil demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rash, may still occur.
Anafranil Side Effect Report#9315107
Cough, Choking, Dry Mouth, Throat Irritation, Malaise
This Cough problem was reported by a consumer or non-health professional from US. A 39-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: obsessive-compulsive disorder. On
Jun 15, 2012 this consumer started treatment with Anafranil (dosage: NA). The following drugs were being taken at the same time:
  • Bupropion Hydrochloride
  • Bupropion Hydrochloride
  • Nexium
  • Zyrtec
  • Iron
  • Ibuprofen
When using Anafranil, the patient experienced the following unwanted symptoms/side effects: Cough, Choking, Dry Mouth, Throat Irritation, MalaiseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cough, may become evident only after a product is in use by the general population.
Anafranil Side Effect Report#9275095
Tooth Loss, Aphagia, Formication, Muscle Spasms, Abasia, Learning Disorder, Weight Decreased, Fear Of Eating
This Tooth Loss side effect was reported by a consumer or non-health professional from BR. A 9-year-old male patient (weight:NA) experienced the following symptoms/conditions: phobia.The patient was prescribed Anafranil (drug dosage: 1 Df, Qhs (25 Mg)), which was initiated on 201002. Concurrently used drugs: NA..After starting to take Anafranil the consumer reported adverse symptoms, such as: Tooth Loss, Aphagia, Formication, Muscle Spasms, Abasia, Learning Disorder, Weight Decreased, Fear Of EatingThese side effects may potentially be related to Anafranil.
Anafranil Side Effect Report#9262750
Dysphemia, Dysarthria, Tremor
This is a report of a 45-year-old female patient (weight: NA) from IT, suffering from the following health symptoms/conditions: NA, who was treated with Anafranil (dosage: 75 Mg, Daily, start time:
Mar 01, 2013), combined with: NA. and developed a serious reaction and side effect(s): Dysphemia, Dysarthria, Tremor after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in female patients, resulting in Dysphemia side effect. The patient was hospitalized.
Anafranil Side Effect Report#9252257
Serotonin Syndrome, Hallucination, Pyrexia, Confusional State, Agitation, Musculoskeletal Stiffness
This report suggests a potential Anafranil Serotonin Syndrome side effect(s) that can have serious consequences. A 82-year-old male patient (weight: NA) from PT was diagnosed with the following symptoms/conditions: depression and used Anafranil (dosage: NA) starting
Sep 20, 2012. After starting Anafranil the patient began experiencing various side effects, including: Serotonin Syndrome, Hallucination, Pyrexia, Confusional State, Agitation, Musculoskeletal StiffnessAdditional drugs used concurrently:
  • Venlafaxine Hydrochloride
  • Amitriptyline Hydrochloride
Although Anafranil demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Serotonin Syndrome, may still occur.
Anafranil Side Effect Report#9243201
Weight Increased
This Weight Increased problem was reported by a consumer or non-health professional from IT. A 54-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: obsessive-compulsive disorder. On 2010 this consumer started treatment with Anafranil (dosage: 37.5 Mg, Daily). The following drugs were being taken at the same time: NA. When using Anafranil, the patient experienced the following unwanted symptoms/side effects: Weight IncreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Weight Increased, may become evident only after a product is in use by the general population.
Anafranil Side Effect Report#9097283
Interstitial Lung Disease, Pyrexia, Dyspnoea, Inflammation, Eosinophilia
This Interstitial Lung Disease side effect was reported by a health professional from FR. A 64-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Anafranil (drug dosage: 75 Mg, Qd), which was initiated on 2012. Concurrently used drugs:
  • Paroxetine (10 Mg, Qd)
  • Seresta (10 Mg, Daily)
  • Nebivolol (5 Mg, Daily)
  • Femara (1 Df, Daily)
  • Spironolactone (50 Mg, Daily)
  • Topalgic (200 Mg, Daily)
  • Forlax (1 Df, Daily)
.After starting to take Anafranil the consumer reported adverse symptoms, such as: Interstitial Lung Disease, Pyrexia, Dyspnoea, Inflammation, EosinophiliaThese side effects may potentially be related to Anafranil. The patient was hospitalized.
Anafranil Side Effect Report#9097282
Interstitial Lung Disease, Pyrexia, Dyspnoea, Inflammation, Eosinophilia
This is a report of a 64-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: NA, who was treated with Anafranil (dosage: 75 Mg, Qd, start time: 2012), combined with:
  • Paroxetine (10 Mg, Qd)
  • Seresta (10 Mg, Daily)
  • Nebivolol (5 Mg, Daily)
  • Femara (1 Df, Daily)
  • Spironolactone (50 Mg, Daily)
  • Topalgic (200 Mg, Daily)
  • Forlax (1 Df, Daily)
and developed a serious reaction and side effect(s): Interstitial Lung Disease, Pyrexia, Dyspnoea, Inflammation, Eosinophilia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in female patients, resulting in Interstitial Lung Disease side effect. The patient was hospitalized.
Anafranil Side Effect Report#9088943
Coma, Coma Scale Abnormal, Long Qt Syndrome, Intentional Overdose
This report suggests a potential Anafranil Coma side effect(s) that can have serious consequences. A 59-year-old female patient (weight: NA) from ES was diagnosed with the following symptoms/conditions: intentional overdose and used Anafranil (dosage: 12 Df, Daily) starting
Jun 30, 2012. After starting Anafranil the patient began experiencing various side effects, including: Coma, Coma Scale Abnormal, Long Qt Syndrome, Intentional OverdoseAdditional drugs used concurrently:
  • Clotiapine (Unk Ukn, Unk)
  • Escitalopram (Unk Ukn, Unk)
  • Quetiapine (Unk Ukn, Unk)
  • Flunitrazepam (Unk Ukn, Unk)
  • Levomepromazine Maleate (Unk Ukn, Unk)
  • Diazepam
  • Calodis
  • Loxifan
The patient was hospitalized. Although Anafranil demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Coma, may still occur.
Anafranil Side Effect Report#9087963
Posterior Reversible Encephalopathy Syndrome, Convulsion
This Posterior Reversible Encephalopathy Syndrome problem was reported by a consumer or non-health professional from IT. A 66-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: major depression. On 2010 this consumer started treatment with Anafranil (dosage: Unk Ukn, Unk). The following drugs were being taken at the same time: NA. When using Anafranil, the patient experienced the following unwanted symptoms/side effects: Posterior Reversible Encephalopathy Syndrome, ConvulsionThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Posterior Reversible Encephalopathy Syndrome, may become evident only after a product is in use by the general population.
Anafranil Side Effect Report#9018078
Muscle Rigidity, Tremor
This Muscle Rigidity side effect was reported by a health professional from IT. A 71-year-old female patient (weight:NA) experienced the following symptoms/conditions: bipolar disorder,anxiety.The patient was prescribed Anafranil (drug dosage: 75 Mg/day), which was initiated on
Jan 01, 2011. Concurrently used drugs:
  • Alprazolam (30 Gtt/day)
  • Lamictal (50 Mg/day)
  • Fevarin (500 Mg/day)
  • Metformine (3000 Mg/day)
  • Provisacor
  • Cardioaspirin
.After starting to take Anafranil the consumer reported adverse symptoms, such as: Muscle Rigidity, TremorThese side effects may potentially be related to Anafranil. The patient was hospitalized.
Anafranil Side Effect Report#9018077
Apathy, Delirium
This is a report of a 91-year-old female patient (weight: NA) from BR, suffering from the following health symptoms/conditions: decreased appetite,abnormal behaviour, who was treated with Anafranil (dosage: 4 Df Daily First Day, start time: 2002), combined with: NA. and developed a serious reaction and side effect(s): Apathy, Delirium after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in female patients, resulting in Apathy side effect.
Anafranil Side Effect Report#8997484
Choking, Dry Mouth, Cough
This report suggests a potential Anafranil Capsules Choking side effect(s) that can have serious consequences. A 39-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Anafranil Capsules (dosage: Unk) starting NS. After starting Anafranil Capsules the patient began experiencing various side effects, including: Choking, Dry Mouth, CoughAdditional drugs used concurrently: NA. Although Anafranil Capsules demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Choking, may still occur.
Anafranil Side Effect Report#8958291
Fibromyalgia, Panic Attack, Agoraphobia, Dyspnoea, Musculoskeletal Disorder, Asthenia, Pain, Somnolence
This Fibromyalgia problem was reported by a consumer or non-health professional from BR. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: agoraphobia. On NS this consumer started treatment with Anafranil (dosage: 25 Mg, Daily). The following drugs were being taken at the same time: NA. When using Anafranil, the patient experienced the following unwanted symptoms/side effects: Fibromyalgia, Panic Attack, Agoraphobia, Dyspnoea, Musculoskeletal Disorder, Asthenia, Pain, SomnolenceAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Fibromyalgia, may become evident only after a product is in use by the general population.
Anafranil Side Effect Report#8955948
Hyponatraemia
This Hyponatraemia side effect was reported by a consumer or non-health professional from IT. A 93-year-old female patient (weight:NA) experienced the following symptoms/conditions: depression.The patient was prescribed Anafranil (drug dosage: 12.5 Mg, Qd), which was initiated on
Oct 25, 2012. Concurrently used drugs: NA..After starting to take Anafranil the consumer reported adverse symptoms, such as: HyponatraemiaThese side effects may potentially be related to Anafranil. The patient was hospitalized.
Anafranil Side Effect Report#8875970
Fall, Pelvic Fracture, Clavicle Fracture, Osteopenia
This is a report of a female patient (weight: NA) from CH, suffering from the following health symptoms/conditions: NA, who was treated with Anafranil (dosage: 37.5 Mg (in The Morning) Daily, start time:
Jul 04, 2012), combined with: NA. and developed a serious reaction and side effect(s): Fall, Pelvic Fracture, Clavicle Fracture, Osteopenia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Anafranil treatment in female patients, resulting in Fall side effect. The patient was hospitalized.


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The appearance of Anafranil on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Anafranil Side Effects for Women?

Women Side EffectsReports
Tremor 7
Coma 6
Depression 6
Fall 6
Nausea 6
Neuroleptic Malignant Syndrome 6
Suicide Attempt 6
Asthenia 5
Blood Pressure Decreased 5
Dyspnoea 5

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    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Anafranil reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Anafranil Safety Alerts, Active Ingredients, Usage Information

    NDC0406-9906
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameANAFRANIL
    Nameclomipramine hydrochloride
    Dosage FormCAPSULE
    RouteORAL
    On market since20110318
    LabelerMallinckrodt, Inc.
    Active Ingredient(s)CLOMIPRAMINE HYDROCHLORIDE
    Strength(s)25
    Unit(s)mg/1
    Pharma ClassTricyclic Antidepressant [EPC]

    Anafranil Dosage, Warnings, Usage.

    Side Effects reported to FDA: 142

    Anafranil safety alerts: No

    Reported deaths: 14

    Reported hospitalizations: 65

    Latest Anafranil clinical trials