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Benadryl Side Effects

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Common Benadryl Side Effects


The most commonly reported Benadryl side effects (click to view or check a box to report):

Off Label Use (140)
Dyspnoea (137)
Nausea (100)
Hypersensitivity (99)
Urticaria (85)
Somnolence (78)
Dizziness (76)
Vomiting (75)
Loss Of Consciousness (72)
Rash (68)
Headache (68)
Pruritus (67)
Pain (66)
Overdose (63)
Product Quality Issue (61)
Condition Aggravated (56)
Insomnia (50)
Feeling Abnormal (49)
Heart Rate Increased (49)
Hallucination (48)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Benadryl Side Effects Reported to FDA



Benadryl Side Effect Report#9977975
Jaundice, Hepatic Enzyme Increased, Hepatic Pain, Renal Pain, Off Label Use
This is a report of a 55-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: nasal congestion,multiple allergies, who was treated with Benadryl Allergy Dye-free (dosage: NA, start time:
Jan 11, 2014), combined with: NA. and developed a serious reaction and side effect(s): Jaundice, Hepatic Enzyme Increased, Hepatic Pain, Renal Pain, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Allergy Dye-free treatment in male patients, resulting in Jaundice side effect.
Benadryl Side Effect Report#9927416
Hypotension
This report suggests a potential Benadryl Allergy Hypotension side effect(s) that can have serious consequences. A 73-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Benadryl Allergy (dosage: Nightly At 9pm) starting
Oct 10, 2006. After starting Benadryl Allergy the patient began experiencing various side effects, including: HypotensionAdditional drugs used concurrently:
  • Bayer Aspirin
  • Amlodipine (3 Years Ago)
  • Coreg (2 Years Ago)
  • Simvastatin (3 Years Ago)
  • Doxazosin (5 Years Ago)
Although Benadryl Allergy demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypotension, may still occur.
Benadryl Side Effect Report#9925256
Cough, Wheezing, Swollen Tongue, Pharyngeal Oedema
This Cough problem was reported by a health professional from US. A 57-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Aug 28, 2013 this consumer started treatment with Benadryl (dosage: NA). The following drugs were being taken at the same time:
  • Solu-medrol
  • Albuterol
  • Plavix
  • Pepcid
  • Lexapro
  • Aspirin
  • Isovue 370
  • Lipitor
When using Benadryl, the patient experienced the following unwanted symptoms/side effects: Cough, Wheezing, Swollen Tongue, Pharyngeal OedemaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cough, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9925236
Confusional State
This Confusional State side effect was reported by a physician from US. A 72-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Benadryl (drug dosage: NA), which was initiated on
Feb 07, 2013. Concurrently used drugs:
  • Prednisone
  • Isovue 300
.After starting to take Benadryl the consumer reported adverse symptoms, such as: Confusional StateThese side effects may potentially be related to Benadryl. The patient was hospitalized.
Benadryl Side Effect Report#9869042
Perirectal Abscess, Urinary Retention, Constipation
This is a report of a 60-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Benadryl (dosage: NA, start time: NS), combined with:
  • Furosemide
  • Gabapentin
  • Diphenhydramine/paracetamol/ Pseudoephedrine
and developed a serious reaction and side effect(s): Perirectal Abscess, Urinary Retention, Constipation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl treatment in male patients, resulting in Perirectal Abscess side effect.
Benadryl Side Effect Report#9804872
Hallucination, Abnormal Behaviour
This report suggests a potential Benadryl Ultra Tab Hallucination side effect(s) that can have serious consequences. A 74-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: multiple allergies and used Benadryl Ultra Tab (dosage: NA) starting 2010. After starting Benadryl Ultra Tab the patient began experiencing various side effects, including: Hallucination, Abnormal BehaviourAdditional drugs used concurrently: NA. Although Benadryl Ultra Tab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hallucination, may still occur.
Benadryl Side Effect Report#9800429
Neuropathy Peripheral, Chills
This Neuropathy Peripheral problem was reported by a consumer or non-health professional from US. A 55-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Dec 26, 2013 this consumer started treatment with Benadryl Allergy Dye-free Soft Gel (dosage: NA). The following drugs were being taken at the same time:
  • Copaxone
When using Benadryl Allergy Dye-free Soft Gel, the patient experienced the following unwanted symptoms/side effects: Neuropathy Peripheral, ChillsAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Neuropathy Peripheral, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9791679
Blood Pressure Increased, Palpitations, Hyperhidrosis, Tremor
This Blood Pressure Increased side effect was reported by a consumer or non-health professional from US. A 74-year-old female patient (weight:NA) experienced the following symptoms/conditions: nasal congestion,sinus disorder.The patient was prescribed Benadryl D (drug dosage: Nightly), which was initiated on
Dec 18, 2013. Concurrently used drugs: NA..After starting to take Benadryl D the consumer reported adverse symptoms, such as: Blood Pressure Increased, Palpitations, Hyperhidrosis, TremorThese side effects may potentially be related to Benadryl D.
Benadryl Side Effect Report#9782225
Syncope, Thermal Burn
This is a report of a 27-year-old female patient (weight: NA) from CA, suffering from the following health symptoms/conditions: hypersensitivity,transient ischaemic attack,vitamin supplementation,blood pressure, who was treated with Benadryl Rs Allergy 25 Mg (dosage: Half Tablet As Needed Every 12 To 24 Hours, start time: NS), combined with:
  • Aspirin
  • Vitamin D3
  • Indapamide
  • Apo-ramipril
and developed a serious reaction and side effect(s): Syncope, Thermal Burn after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Rs Allergy 25 Mg treatment in female patients, resulting in Syncope side effect.
Benadryl Side Effect Report#9739092
Formication, Dysuria, Off Label Use, Pruritus
This report suggests a potential Benadryl Allergy Kapgels Formication side effect(s) that can have serious consequences. A 65-year-old female patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: headache,insomnia and used Benadryl Allergy Kapgels (dosage: 1 Kapgel 2 Or 3 Times) starting NS. After starting Benadryl Allergy Kapgels the patient began experiencing various side effects, including: Formication, Dysuria, Off Label Use, PruritusAdditional drugs used concurrently: NA. Although Benadryl Allergy Kapgels demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Formication, may still occur.
Benadryl Side Effect Report#9721473
This Death problem was reported by a consumer or non-health professional from CA. A 10-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Benadryl (dosage: NA). The following drugs were being taken at the same time: NA. When using Benadryl, the patient experienced the following unwanted symptoms/side effects:Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9720366
Suprapubic Pain, Nephropathy Toxic, Renal Impairment, Electrocardiogram Change, Urinary Retention
This Suprapubic Pain side effect was reported by a pharmacist from US. A 61-year-old male patient (weight:NA) experienced the following symptoms/conditions: pruritus.The patient was prescribed Benadryl (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Benadryl the consumer reported adverse symptoms, such as: Suprapubic Pain, Nephropathy Toxic, Renal Impairment, Electrocardiogram Change, Urinary RetentionThese side effects may potentially be related to Benadryl. The patient was hospitalized.
Benadryl Side Effect Report#9720212
Convulsion, Psychotic Disorder
This is a report of a 22-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Benadryl (dosage: NA, start time:
Oct 24, 2013), combined with: NA. and developed a serious reaction and side effect(s): Convulsion, Psychotic Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl treatment in male patients, resulting in Convulsion side effect. The patient was hospitalized.
Benadryl Side Effect Report#9715424
Diabetes Mellitus, Blood Cholesterol Abnormal, Dry Throat, Hunger
This report suggests a potential Benadryl Diabetes Mellitus side effect(s) that can have serious consequences. A female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: multiple allergies,depression,hypotonia,fluid retention,anxiety,dizziness and used Benadryl (dosage: NA) starting NS. After starting Benadryl the patient began experiencing various side effects, including: Diabetes Mellitus, Blood Cholesterol Abnormal, Dry Throat, HungerAdditional drugs used concurrently:
  • Pristiq
  • Zanaflex
  • Lasix
  • Vistaril (50 Mg Oral Capsule 3 Times A Day And 2 Capsules Of 50 Mg During Bed Time)
  • Meclizine (As Needed)
Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Diabetes Mellitus, may still occur.
Benadryl Side Effect Report#9706591
Blister, Pain In Extremity
This Blister problem was reported by a consumer or non-health professional from US. A 54-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: rash,gastrooesophageal reflux disease,routine health maintenance. On 2003 this consumer started treatment with Benadryl Topical Extra Strength Cream (dosage: A Pea Size). The following drugs were being taken at the same time:
  • Omeprazole
  • Centrum Nos
When using Benadryl Topical Extra Strength Cream, the patient experienced the following unwanted symptoms/side effects: Blister, Pain In ExtremityAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Blister, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9697006
Oxygen Saturation Decreased, Sensation Of Foreign Body, Off Label Use, Blood Pressure Decreased, Periorbital Oedema
This Oxygen Saturation Decreased side effect was reported by a health professional from CA. A 57-year-old female patient (weight:NA) experienced the following symptoms/conditions: hypersensitivity,psoriatic arthropathy.The patient was prescribed Benadryl (drug dosage: NA), which was initiated on
Feb 27, 2013. Concurrently used drugs:
  • Remicade
  • Epinephrine
.After starting to take Benadryl the consumer reported adverse symptoms, such as: Oxygen Saturation Decreased, Sensation Of Foreign Body, Off Label Use, Blood Pressure Decreased, Periorbital OedemaThese side effects may potentially be related to Benadryl.
Benadryl Side Effect Report#9689639
Mental Disorder, Disturbance In Attention, Memory Impairment, Dysarthria
This is a report of a 42-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Benadryl Allergy Dye Free (dosage: NA, start time: NS), combined with:
  • Ambien
  • Lamictal
  • Haldol
and developed a serious reaction and side effect(s): Mental Disorder, Disturbance In Attention, Memory Impairment, Dysarthria after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Allergy Dye Free treatment in female patients, resulting in Mental Disorder side effect.
Benadryl Side Effect Report#9687475
Neoplasm Malignant, Haemoglobin Decreased, Blood Creatinine Increased, Agitation, Pain In Extremity, Paraesthesia, Musculoskeletal Stiffness, Abdominal Discomfort
This report suggests a potential Benadryl Neoplasm Malignant side effect(s) that can have serious consequences. A 64-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Benadryl (dosage: NA) starting NS. After starting Benadryl the patient began experiencing various side effects, including: Neoplasm Malignant, Haemoglobin Decreased, Blood Creatinine Increased, Agitation, Pain In Extremity, Paraesthesia, Musculoskeletal Stiffness, Abdominal DiscomfortAdditional drugs used concurrently: NA. Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Neoplasm Malignant, may still occur.
Benadryl Side Effect Report#9680081
Faeces Discoloured, Hyperhidrosis
This Faeces Discoloured problem was reported by a consumer or non-health professional from US. A 70-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Oct 25, 2013 this consumer started treatment with Benadryl (dosage: NA). The following drugs were being taken at the same time: NA. When using Benadryl, the patient experienced the following unwanted symptoms/side effects: Faeces Discoloured, HyperhidrosisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Faeces Discoloured, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9677101
Mania, Insomnia, Logorrhoea, Formication
This Mania side effect was reported by a consumer or non-health professional from CA. A 50-year-old female patient (weight:NA) experienced the following symptoms/conditions: rhinorrhoea,eye pruritus,multiple allergies.The patient was prescribed Benadryl Nightime Es Allergy (drug dosage: Taken At Night), which was initiated on
Oct 29, 2013. Concurrently used drugs: NA..After starting to take Benadryl Nightime Es Allergy the consumer reported adverse symptoms, such as: Mania, Insomnia, Logorrhoea, FormicationThese side effects may potentially be related to Benadryl Nightime Es Allergy.
Benadryl Side Effect Report#9655586
Tremor, Off Label Use
This is a report of a 50-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: restlessness,psychotic disorder,anxiety, who was treated with Benadryl Allergy Ultratab (dosage: 1/4 Tablet, start time:
Oct 14, 2013), combined with:
  • Latuda
  • Zoloft
  • Zoloft
and developed a serious reaction and side effect(s): Tremor, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Allergy Ultratab treatment in male patients, resulting in Tremor side effect.
Benadryl Side Effect Report#9644244
Loss Of Consciousness, Urinary Incontinence
This report suggests a potential Benadryl Allergy Ultratab Loss Of Consciousness side effect(s) that can have serious consequences. A 40-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: urticaria and used Benadryl Allergy Ultratab (dosage: When Needed) starting
Oct 12, 2013. After starting Benadryl Allergy Ultratab the patient began experiencing various side effects, including: Loss Of Consciousness, Urinary IncontinenceAdditional drugs used concurrently:
  • Benadryl Topical Extra Strength (When Needed)
Although Benadryl Allergy Ultratab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Loss Of Consciousness, may still occur.
Benadryl Side Effect Report#9624859
Retinal Vascular Thrombosis, Optic Neuropathy, Hypotension, Product Label Issue
This Retinal Vascular Thrombosis problem was reported by a consumer or non-health professional from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: upper-airway cough syndrome,allergic sinusitis. On NS this consumer started treatment with Benadryl Liquid (dosage: Many Years Ago). The following drugs were being taken at the same time: NA. When using Benadryl Liquid, the patient experienced the following unwanted symptoms/side effects: Retinal Vascular Thrombosis, Optic Neuropathy, Hypotension, Product Label IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Retinal Vascular Thrombosis, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9618075
Intestinal Haemorrhage
This Intestinal Haemorrhage side effect was reported by a consumer or non-health professional from US. A 46-year-old male patient (weight:NA) experienced the following symptoms/conditions: seasonal allergy.The patient was prescribed Benadryl Allergy (drug dosage: 4-6 Hours), which was initiated on NS. Concurrently used drugs: NA..After starting to take Benadryl Allergy the consumer reported adverse symptoms, such as: Intestinal HaemorrhageThese side effects may potentially be related to Benadryl Allergy.
Benadryl Side Effect Report#9607260
Dyspnoea, Pharyngeal Oedema, Lip Swelling, Eye Swelling, Hypersensitivity
This is a report of a 25-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: seasonal allergy, who was treated with Benadryl Allergy Kapgels (dosage: 1 Kapgel Once, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Dyspnoea, Pharyngeal Oedema, Lip Swelling, Eye Swelling, Hypersensitivity after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Allergy Kapgels treatment in female patients, resulting in Dyspnoea side effect.


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The appearance of Benadryl on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Benadryl Side Effects for Women?

Women Side EffectsReports
Dyspnoea 99
Off Label Use 95
Hypersensitivity 77
Nausea 73
Urticaria 60
Dizziness 56
Headache 52
Vomiting 52
Somnolence 51
Pain 50

What are common Benadryl Side Effects for Men?

Men Side EffectsReports
Off Label Use 44
Dyspnoea 38
Loss Of Consciousness 32
Overdose 29
Nausea 27
Somnolence 27
Urticaria 25
Vomiting 23
Hypersensitivity 21
Infusion Related Reaction 21

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Benadryl reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Discuss Benadryl Side Effects

    Did You Have a Benadryl Side Effect?

    Yes, Severe
    Yes, Moderate
    Yes, Minor
    No

    How Effective is Benadryl for You?

    Exceeded Expectations
    Effective
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    Not Effective

    Benadryl Safety Alerts, Active Ingredients, Usage Information

    NDC21695-811
    TypeHUMAN OTC DRUG
    Proprietary NameBenadryl Allergy
    NameDiphenhydramine Hydrochloride
    Dosage FormTABLET, COATED
    RouteORAL
    On market since20090101
    LabelerRebel Distributors Corp
    Active Ingredient(s)DIPHENHYDRAMINE HYDROCHLORIDE
    Strength(s)25
    Unit(s)mg/1
    Pharma Class

    Benadryl Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1568

    Benadryl safety alerts: 2010

    Reported deaths: 82

    Reported hospitalizations: 340

    Benadryl Extra Strength Itch Stopping Gel: Packaging Changes to Reduce Use Errors

    Audience: Consumers, Pharmacists

    [Posted 05/12/2010] Johnson & Johnson and FDA notified consumers and healthcare professionals of changes to the graphics and information displayed on the front of the product container to reduce the risk of serious side effects from swallowing the topical Benadryl Extra Strength Itch Stopping Gel intended ??For Skin Use Only". FDA received reports of consumers ingesting the gel rather than using it topically. Swallowing the gel can result in people receiving dangerously large amounts of the active ingredient diphenhydramine.

    Between 2001 and 2009, 121 cases of ingestion of Benadryl Extra Strength Itch Relief Gel were reported to the manufacturer. Of these cases, 7 were considered serious because patients required treatment in the emergency room, hospitalization, or admission to the intensive care unit. Others reported adverse events included hallucinations, unconsciousness, sleepiness, difficulty walking, dizziness and inability to speak.

    [05/12/2010 - Drug Safety Communication - FDA]

    [05/12/2010 - Consumer Update - FDA]

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