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Benadryl Side Effects

Report Benadryl Side Effects

If you experienced any harmful or unwanted effects of Benadryl, please share your experience. This could help to raise awareness about Benadryl side effects, identify uknown risks and inform health professionals and patients taking Benadryl.

Examples: headache, dizziness


The most commonly reported Benadryl side effects are:
Swollen Eyes (10 reports)
Sleepy (8 reports)
Swolen Feet (7 reports)
Tremors (6 reports)
Acid Reflux (4 reports)
No Sexual Desire (4 reports)
Restlessness (4 reports)
Vision Problems (2 reports)
Water Retention (2 reports)
Water Retention And Vision Problems (2 reports)
Cold Feet (2 reports)
Eye Floaters (2 reports)

If you have experienced a side effect listed above, you can check a box to report it.


View a complete list of Benadryl side effects or compare Benadryl side effects

If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (eg, physician, pharmacist). Your health care provider can provide additional clinical information and complete a copy of the side effect reporting form.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

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Benadryl Side Effects Reported to FDA

The following Benadryl reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Benadryl on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Dyspnoea, Chest Pain, Swelling Face, Lip Swelling, Acne, Paraesthesia Oral, Off Label Use, Hypersensitivity, Chest Discomfort
on Nov 20, 2013 Female from US , 54 years of age, weighting 194.0 lb, was diagnosed with and was treated with Benadryl Allergy Ultratab. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: dyspnoea, chest pain, swelling face, lip swelling, acne, paraesthesia oral, off label use, hypersensitivity, chest discomfort. Benadryl Allergy Ultratab dosage: N/A. Patient was hospitalized.

Dyspnoea, Hypersensitivity
Patient was taking Benadryl Allergy Ultratab. Patient felt the following Benadryl side effects: dyspnoea, hypersensitivity on Oct 01, 2013 from US Additional patient health information: Female , 54 years of age, was diagnosed with and. Benadryl Allergy Ultratab dosage: N/A. Patient was hospitalized.

Unevaluable Event, Delusion, Heart Rate Increased
Adverse event was reported on Oct 09, 2013 by a Male taking Benadryl (Dosage: N/A) was diagnosed with and. Location: CA , 16 years of age, weighting 120.0 lb, After Benadryl was administered, patient encountered several Benadryl side effects: unevaluable event, delusion, heart rate increased.

Erectile Dysfunction, Product Label Issue
on Sep 25, 2013 Male from US , 38 years of age, weighting 280.0 lb, was treated with Benadryl. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: erectile dysfunction, product label issue. Benadryl dosage: N/A.


Cardiac Failure, Hypercapnia
on Sep 24, 2013 Male from US , 46 years of age, weighting 393.0 lb, was diagnosed with and was treated with Benadryl. Patient felt the following Benadryl side effects: cardiac failure, hypercapnia. Benadryl dosage: N/A.
Multiple prescriptions taken:
  • Unisom


Application Site Reaction, Swelling Face, Eye Swelling, Off Label Use, Rash
Patient was taking Benadryl Allergy Ultratab. After Benadryl was administered, patient encountered several Benadryl side effects: application site reaction, swelling face, eye swelling, off label use, rash on Oct 04, 2013 from US Additional patient health information: Female , 31 years of age, weighting 145.0 lb, was diagnosed with and. Benadryl Allergy Ultratab dosage: N/A.
Multiple concurrent drugs taken:
  • Prozac


Anaphylactic Shock, Condition Aggravated, Anxiety
Adverse event was reported on Oct 02, 2013 by a Female taking Benadryl Rs Allergy (Dosage: 1-2) was diagnosed with and. Location: CA , weighting 140.0 lb, Directly after, patient experienced the unwanted or unexpected Benadryl side effects: anaphylactic shock, condition aggravated, anxiety.

Anaphylactic Shock, Dyspnoea
on Sep 16, 2013 Female from US , 61 years of age, weighting 118.0 lb, was treated with Benadryl. Patient felt the following Benadryl side effects: anaphylactic shock, dyspnoea. Benadryl dosage: N/A.

Accidental Exposure To Product
on Sep 13, 2013 Female from US , child 3 years of age, was diagnosed with and was treated with Benadryl. After Benadryl was administered, patient encountered several Benadryl side effects: accidental exposure to product. Benadryl dosage: N/A. Patient was hospitalized.

Hypersensitivity, Swelling Face, Eye Swelling, Pruritus, Skin Exfoliation
Patient was taking Benadryl. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: hypersensitivity, swelling face, eye swelling, pruritus, skin exfoliation on Sep 10, 2013 from US Additional patient health information: Female , 55 years of age, weighting 165.0 lb, . Benadryl dosage: N/A.

Dysphemia, Fear
Adverse event was reported on Sep 10, 2013 by a Female taking Benadryl (Dosage: 1 Pill) was diagnosed with and. Location: US , 65 years of age, weighting 150.0 lb, Patient felt the following Benadryl side effects: dysphemia, fear.
Multiple prescriptions taken:
  • Enalapril
  • Hydrochlorothiazide
  • Arcapta
  • Evista
  • Fish Oil


Coeliac Disease
on Sep 11, 2013 Female from US , 48 years of age, weighting 349.0 lb, was treated with Benadryl Allergy Ultratab. After Benadryl was administered, patient encountered several Benadryl side effects: coeliac disease. Benadryl Allergy Ultratab dosage: N/A.

Pneumonia, Arthritis, Gait Disturbance, Off Label Use
on Sep 05, 2013 Female from US , 92 years of age, was treated with Benadryl. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: pneumonia, arthritis, gait disturbance, off label use. Benadryl dosage: N/A. Patient was hospitalized.

Food Allergy, Local Swelling, Arthralgia, Off Label Use, Urticaria, Diarrhoea, Dyspepsia, Headache
Patient was taking Benadryl Rs Allergy 25mg Caplets. Patient felt the following Benadryl side effects: food allergy, local swelling, arthralgia, off label use, urticaria, diarrhoea, dyspepsia, headache on Sep 11, 2013 from CA Additional patient health information: Female , 58 years of age, weighting 140.0 lb, was diagnosed with and. Benadryl Rs Allergy 25mg Caplets dosage: 1-2 Caplets.

Amphetamines Positive
Adverse event was reported on Aug 27, 2013 by a Female taking Benadryl Allergy Ultratab (Dosage: N/A) was diagnosed with and. Location: US , 47 years of age, weighting 200.0 lb, After Benadryl was administered, patient encountered several Benadryl side effects: amphetamines positive.

Lip Swelling, Respiratory Arrest
on Aug 26, 2013 Female from US , 52 years of age, weighting 124.0 lb, was diagnosed with and was treated with Benadryl. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: lip swelling, respiratory arrest. Benadryl dosage: N/A.

Dyspnoea, Local Swelling, Product Packaging Issue
on Aug 23, 2013 Female from US , 80 years of age, was diagnosed with and was treated with Benadryl Extra Strength Itch Cooling Spray.. Patient felt the following Benadryl side effects: dyspnoea, local swelling, product packaging issue. Benadryl Extra Strength Itch Cooling Spray. dosage: Covered Entire Ankle Area, Once.

Head Discomfort, Loss Of Consciousness, Gait Disturbance, Malaise
Patient was taking Benadryl Allergy Dye-free. After Benadryl was administered, patient encountered several Benadryl side effects: head discomfort, loss of consciousness, gait disturbance, malaise on Aug 20, 2013 from US Additional patient health information: Female , 80 years of age, weighting 124.0 lb, was diagnosed with and. Benadryl Allergy Dye-free dosage: One Softgel.
Multiple concurrent drugs taken:
  • Singulair
  • Claritin


Hypersensitivity, Blister, Rash, Local Swelling, Off Label Use, Therapeutic Response Unexpected, Pruritus
Adverse event was reported on Aug 14, 2013 by a Male taking Benadryl (Dosage: A Pea Size Amount On Each Hand Twice) was diagnosed with and. Location: US , 55 years of age, weighting 210.0 lb, Directly after, patient experienced the unwanted or unexpected Benadryl side effects: hypersensitivity, blister, rash, local swelling, off label use, therapeutic response unexpected, pruritus.

Disorientation, Euphoric Mood, Overdose
on Aug 13, 2013 Male from US , 16 years of age, weighting 140.0 lb, was treated with Benadryl Allergy. Patient felt the following Benadryl side effects: disorientation, euphoric mood, overdose. Benadryl Allergy dosage: N/A.

Anaphylactic Reaction
on Aug 13, 2013 Female from US , 62 years of age, was treated with Benadryl. After Benadryl was administered, patient encountered several Benadryl side effects: anaphylactic reaction. Benadryl dosage: N/A.

Completed Suicide, Mechanical Ventilation, Unresponsive To Stimuli, Overdose, Convulsion
Patient was taking Benadryl. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: completed suicide, mechanical ventilation, unresponsive to stimuli, overdose, convulsion on Aug 01, 2013 from US Additional patient health information: Female , 41 years of age, . Benadryl dosage: N/A.
Associated medications used:
  • Xanax
Patient was hospitalized.

Failure To Thrive, Cachexia, Malnutrition, Dehydration, Renal Failure Acute, Hepatorenal Syndrome
Adverse event was reported on Aug 31, 2013 by a Male taking Benadryl (Dosage: 50 Mg, Cyclic (day 1, 8 And 15) Every 21 Days) was diagnosed with and. Location: US , 51 years of age, weighting 120.9 lb, Patient felt the following Benadryl side effects: failure to thrive, cachexia, malnutrition, dehydration, renal failure acute, hepatorenal syndrome. Patient was hospitalized.

Urinary Tract Infection, Pruritus
on Sep 03, 2013 Female from US , 59 years of age, was diagnosed with and was treated with Benadryl. After Benadryl was administered, patient encountered several Benadryl side effects: urinary tract infection, pruritus. Benadryl dosage: N/A.

Dyspnoea
on Jul 30, 2013 Female from US , 63 years of age, weighting 170.0 lb, was diagnosed with and was treated with Benadryl Allergy Dye-free Soft. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: dyspnoea. Benadryl Allergy Dye-free Soft dosage: 2 Weeks.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:

     

    Side Effects

    Scale

    Date & Time

    Other Medicine(s) or Treatment(s)

     

     

     

     

    Scale: 1 = very mild to 10 = very bad


    Track Online

  • User Sign In
  • Register to track your side effects

  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Discuss Benadryl Side Effects

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    How Effective is Benadryl for You?

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    Safety Alerts, Active Ingredients, Usage Information

    CAMPHOR ( DIPHENHYD

    Active Ingredient: CAMPHOR ( DIPHENHYD

    Benadryl Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1568

    Benadryl safety alerts: 2010

    Reported deaths: 82

    Reported hospitalizations: 340

    Benadryl Extra Strength Itch Stopping Gel: Packaging Changes to Reduce Use Errors

    Audience: Consumers, Pharmacists

    [Posted 05/12/2010] Johnson & Johnson and FDA notified consumers and healthcare professionals of changes to the graphics and information displayed on the front of the product container to reduce the risk of serious side effects from swallowing the topical Benadryl Extra Strength Itch Stopping Gel intended ??For Skin Use Only". FDA received reports of consumers ingesting the gel rather than using it topically. Swallowing the gel can result in people receiving dangerously large amounts of the active ingredient diphenhydramine.

    Between 2001 and 2009, 121 cases of ingestion of Benadryl Extra Strength Itch Relief Gel were reported to the manufacturer. Of these cases, 7 were considered serious because patients required treatment in the emergency room, hospitalization, or admission to the intensive care unit. Others reported adverse events included hallucinations, unconsciousness, sleepiness, difficulty walking, dizziness and inability to speak.

    [05/12/2010 - Drug Safety Communication - FDA]

    [05/12/2010 - Consumer Update - FDA]

    Latest Benadryl clinical trials